Association between triglycerides, known risk SNVs and conserved rare variation in SLC25A40 in a multi-ancestry cohort
Elisabeth A. Rosenthal; David R. Crosslin; Adam S. Gordon; David S. Carrell; Ian B. Stanaway; Eric B. Larson; Jane Grafton; Wei-Qi Wei · 2021 · BMC Medical Genomics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
Abstract Background Elevated triglycerides (TG) are associated with, and may be causal for, cardiovascular disease (CVD), and co-morbidities such as type II diabetes and metabolic syndrome. Pathogenic variants in APOA5 and APOC3 as well as risk SNVs in other genes [APOE (rs429358, rs7412), APOA1/C3/A4/A5 gene cluster (rs964184), INSR (rs7248104), CETP (rs7205804), GCKR (rs1260326)] have been shown to affect TG levels. Knowledge of genetic causes for elevated TG may lead to early intervention and targeted treatment for CVD. We previously identified linkage and association of a rare, highly cons
Abstract by Elisabeth A. Rosenthal; David R. Crosslin; Adam S. Gordon; David S. Carrell; Ian B. Stanaway; Eric B. Larson; Jane Grafton; Wei-Qi Wei, BMC Medical Genomics (2021) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s12920-020-00854-2