Replication FailureMedicine
Shelton RC, Pizzagalli DA, Cohen EA et al. · 2025 · The Journal of clinical psychiatry
Objective: To assess proof-of-concept (PoC) for efficacy, tolerability, and safety of TRPC4/5 inhibitor BI 1358894 vs placebo in patients with major depressive disorder (MDD) with inadequate response to ongoing antidepressants. Methods: In…
View details →DOI: 10.4088/jcp.25m15868 Negative / Null Result ReportMedicine
Koonrungsesomboon N, Teeyakasem P, Dukaew N et al. · 2025 · International journal of clinical oncology
Background Osteosarcoma is a prevalent and aggressive bone malignancy primarily affecting young adults. Despite advances in standard treatment, the 5-year survival rate remains low, highlighting the need for new chemotherapy options.…
View details →DOI: 10.1007/s10147-025-02877-0 Negative / Null Result ReportMedicine
Liu J, Moura DS, Jones RL et al. · 2024 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose This exploratory analysis evaluated the tumor samples of the patients treated with doxorubicin (with or without olaratumab) in a negative phase III ANNOUNCE trial to better understand the complexity of advanced soft tissue sarcomas…
View details →DOI: 10.1158/1078-0432.ccr-23-3936 Negative / Null Result ReportMedicine
Bendetowicz D, Fabbri M, Sirna F et al. · 2024 · Current neurology and neuroscience reports
Purpose of review This review summarizes previous and ongoing neuroprotection trials in multiple system atrophy (MSA), a rare and fatal neurodegenerative disease characterized by parkinsonism, cerebellar, and autonomic dysfunction. It also…
View details →DOI: 10.1007/s11910-024-01335-0 Negative / Null Result ReportOpen accessMedicine
Van der Helm-van Mil AHM · 2023 · Joint bone spine
During the last decade, the outlook for patients with rheumatoid arthritis (RA) has improved greatly, especially for patients with autoantibody-positive RA. To further improve long-term disease outcomes, the field has turned to…
View details →DOI: 10.1016/j.jbspin.2023.105543 Failed Experiment Report
Gomeni R, Hopkins S, Bressolle-Gomeni F et al. · 2023 · Preprint
Abstract The objective of this study was to evaluate the performances of the propensity score weighted (PSW) methodology in a post-hoc re-analysis of a failed and a negative RCTs in major depressive disorders. The conventional study…
View details →DOI: 10.21203/rs.3.rs-3309369/v1 Negative / Null Result ReportMedicine
Asaithambi G, Castro-Pearson S, Meyer MK et al. · 2023 · Nutrition, metabolism, and cardiovascular diseases : NMCD
Background and aims Stroke is a major cause of mortality and disability, highlighting the importance of prevention. Clinical trials play an important role in evaluating interventions that can maximize stroke prevention. Traditional…
View details →DOI: 10.1016/j.numecd.2023.07.028 Negative / Null Result ReportMedicine
Poplin T, Kuplicki R, Walker EA et al. · 2025 · Biological psychiatry. Cognitive neuroscience and neuroimaging
Background Major depressive disorder (MDD) with comorbid anxiety presents significant treatment challenges, with high relapse rates and suboptimal outcomes. Transcranial direct current stimulation (tDCS) offers a scalable, noninvasive…
View details →DOI: 10.1016/j.bpsc.2025.10.020 Negative / Null Result ReportOpen accessMedicine
Webers C, Been M, van Tubergen A · 2023 · Current opinion in rheumatology
Purpose of review For almost a decade, treat-to-target (T2T) has been advocated as a management strategy for axial spondyloarthritis (axSpA), despite a lack of trial evidence. Recently, the first and only published T2T trial in axSpA did…
View details →DOI: 10.1097/bor.0000000000000941 Negative / Null Result ReportOpen accessMedicine
Gatto L, Di Nunno V, Tosoni A et al. · 2023 · Cancers
The lack of significant improvement in the prognosis of patients with GB over the last decades highlights the need for innovative treatments aimed at fighting this malignancy and increasing survival outcomes. The results of the phase III…
View details →DOI: 10.3390/cancers15123251 Negative / Null Result ReportOpen accessMedicine
Sciscione AC, Booker WA, Clifton RG et al. · 2026 · Obstetrics and gynecology
Objective Activity restriction is commonly recommended in pregnancy despite lacking evidence of benefit. We sought to evaluate the amount of physical activity in patients at high risk for preterm birth and pregnancy latency and preterm…
View details →DOI: 10.1097/aog.0000000000006225 Negative / Null Result ReportOpen accessMedicine
Aparajita, Barmon D, Baruah U et al. · 2025 · World journal of surgical oncology
Background Recent studies have found the presence of post- hysterectomy atypical glandular cells in upper vagina in ~ 30% patients of Endometrial Cancer (EC) with implications of causing isolated vaginal recurrence. The primary objective…
View details →DOI: 10.1186/s12957-025-04121-5 Negative / Null Result ReportOpen accessMedicine
Cai LY, Hoseinyazdi M, Lakhani DA et al. · 2025 · Stroke (Hoboken, N.J.)
Background Recent trials of endovascular thrombectomy (EVT) for acute distal medium vessel occlusions (DMVOs) were negative but also used inconsistent imaging-based inclusion criteria, whereas many successful large vessel occlusion (LVO)…
View details →DOI: 10.1161/svin.125.001900 Negative / Null Result ReportMedicine
Mol F, Scheltinga M, Roumen R et al. · 2023 · Neuromodulation : journal of the International Neuromodulation Society
Objectives Approximately 10% of patients who undergo inguinal hernia repair or Pfannenstiel incision develop chronic (> three months) postsurgical inguinal pain (PSIP). If medication or peripheral nerve blocks fail, a neurectomy is the…
View details →DOI: 10.1016/j.neurom.2022.09.014 Negative / Null Result ReportOpen accessMedicine
Nathan SD, Lacasse V, Bell H et al. · 2024 · Pulmonary circulation
The PERFECT study, a randomized, controlled, double-blind study of inhaled treprostinil in patients with COPD and associated pulmonary hypertension (PH-COPD) was a negative trial that was terminated early. The reason(s) for the negative…
View details →DOI: 10.1002/pul2.12430 Negative / Null Result ReportOpen accessMedicine
Ghimouz A, Dureau S, Carton M et al. · 2026 · Scientific reports
The value of music (MUS) and virtual reality (VR) in reducing pain or anxiety during central venous port implantation (CVPI) is controversial. We conducted a randomised multicenter controlled trial in 127 patients who received either MUS…
View details →DOI: 10.1038/s41598-026-42184-w Negative / Null Result ReportMedicine
Janeway KA, Chou AJ, Buxton A et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Mouse models demonstrate a role for RANK and its ligand, RANKL, in osteosarcoma. The primary objective of this single-arm, open-label phase 2 trial was to determine whether denosumab, a RANKL mAb, improved disease control in…
View details →DOI: 10.1158/1078-0432.ccr-24-2885 Negative / Null Result ReportMedicine
Savsani PK, Khan SH, Perkins AJ et al. · 2025 · Critical care medicine
Objectives To describe the performance of the Healthy Aging Brain Care Monitor Self Report (HABC-M SR) in assessment of post-intensive care syndrome (PICS) among Acute Respiratory Failure ICU survivors. Design Secondary data analysis of a…
View details →DOI: 10.1097/ccm.0000000000006522 Negative / Null Result ReportOpen accessMedicine
Chaudhari A, Almajali M, Khan N et al. · 2026 · Stroke (Hoboken, N.J.)
Background Endovascular thrombectomy (EVT) has transformed the management of acute ischemic stroke, but remains inaccessible to many patients due to anatomic, clinical, or logistical limitations. Treatment strategies for patients with…
View details →DOI: 10.1161/svin.125.002175 Negative / Null Result ReportOpen accessMedicine
Andersson Y, Løvstakken E, Herud TM et al. · 2025 · Annals of surgical oncology
Background Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery is a potentially curative treatment for patients with peritoneal metastases. Currently, there is no standardized protocol for performing HIPEC and…
View details →DOI: 10.1245/s10434-025-18025-x Negative / Null Result ReportOpen accessMedicine
Dubbelman MA, Vromen EM, Tijms BM et al. · 2024 · Alzheimer's & dementia (New York, N. Y.)
With the advent of the first generation of disease-modifying treatments for Alzheimer's disease, it is clearer now more than ever that the field needs to move toward personalized medicine. Pooling data from past trials may help identify…
View details →DOI: 10.1002/trc2.12485 Negative / Null Result ReportMedicine
Scahill L, Shillingsburg MA, Ousley O et al. · 2022 · Journal of the American Academy of Child and Adolescent Psychiatry
Objective To compare Direct Instruction Language for Learning (DI) plus treatment as usual (TAU) with TAU alone in children with autism spectrum disorder and moderate language delay. Method In this study, 83 children (age range, 4 years to…
View details →DOI: 10.1016/j.jaac.2021.11.034 Negative / Null Result ReportOpen accessMedicine
Bremhorst A, Mills DS, Würbel H et al. · 2022 · Animal cognition
Facial expressions potentially serve as indicators of animal emotions if they are consistently present across situations that (likely) elicit the same emotional state. In a previous study, we used the Dog Facial Action Coding System…
View details →DOI: 10.1007/s10071-021-01532-1 Negative / Null Result ReportOpen accessMedicine
Desai R, Tan F, Wu M et al. · 2026 · Arthritis care & research
Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large-scale comparison of US-based assessment with histologic markers of skin fibrosis has not been…
View details →DOI: 10.1002/acr.25658 Negative / Null Result ReportMedicine
Bedlack R, Barkhaus P, Carter G et al. · 2022 · Amyotrophic lateral sclerosis & frontotemporal degeneration
Vitamin C is one of the most common supplements taken by people with ALS. As an antioxidant, it has a plausible mechanism for slowing disease progression and there are some flawed pre-clinical studies and case reports suggesting benefit.…
View details →DOI: 10.1080/21678421.2021.1946088 Negative / Null Result ReportOpen accessMedicine
Aouad K, El-Zorkany B · 2022 · Mediterranean journal of rheumatology
The Treat-to-target (T2T) strategy in axial spondyloarthritis (axSpA) stipulates that treatment should reach a predefined target and if not reached, intensification of therapy is implemented aiming at best future outcomes. Clinical…
View details →DOI: 10.31138/mjr.33.1.137 Negative / Null Result ReportOpen accessMedicine
Turvill J, Haritakis M, Pygall S et al. · 2026 · Endoscopy international open
Background and study aims During the COVID-19 pandemic the National Health Service introduced colon capsule endoscopy (CCE) as an alternative to colonoscopy in patients awaiting 3-year post-polypectomy surveillance. We determined the…
View details →DOI: 10.1055/a-2779-1774 Negative / Null Result ReportOpen accessMedicine
Pepine CJ, Handberg E, Cooper-DeHoff R et al. · 2026 · Open heart
Importance Women with angina due to suspected ischaemia referred for coronary angiography often have no obstructive coronary artery disease (ANOCA/INOCA). Objective To determine if intensive medical treatment (IMT) reduces major ischaemic…
View details →DOI: 10.1136/openhrt-2026-004115 Failed Experiment ReportMedicine
Wessels AM, Edgar CJ, Nathan PJ et al. · 2021 · Drug discovery today
Go/No-Go decision making in early phase clinical trials is challenging for drug developers working in Alzheimer's disease. Recent negative trial results have been attributed to a lack of efficacy and important safety concerns. Furthermore,…
View details →DOI: 10.1016/j.drudis.2021.01.012 Negative / Null Result ReportMedicine
Chalak LF, Kang S, Kota S et al. · 2023 · Early human development
Background There is a critical need for development of physiological biomarkers in infants with birth asphyxia to identify the physiologic response to therapies in real time. This is an ancillary single site study of the High-Dose…
View details →DOI: 10.1016/j.earlhumdev.2023.105815 