e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21350 results · page 580 of 712

Negative / Null Result ReportMedicine

Twenty-one days of bed rest alter motor unit properties and neuromuscular junction transmission in young adults.

Sarto F, Kalc M, Motanova ES et al. · 2025 · Journal of applied physiology (Bethesda, Md. : 1985)

Previous studies showed that properties of higher-threshold motor units (MUs) and neuromuscular junction (NMJ) function are preserved during short-term disuse. This study aimed to test how a longer disuse period affects MU properties, NMJ…

View details →DOI: 10.1152/japplphysiol.00178.2025
Negative / Null Result ReportOpen accessMedicine

Diagnostic Performance of Cardiac CT and Transthoracic Echocardiography in Congenital Heart Disease: A Surgical Correlation Study.

Bakhshaliyev S, Arslanoğlu E, Huseynov H et al. · 2026 · Diagnostics (Basel, Switzerland)

Background : This study evaluated the diagnostic efficacy of transthoracic echocardiography (TTE) and 128-slice multislice computed tomography (MSCT) angiography in congenital heart disease (CHD). Methods : Between January 2018 and August…

View details →DOI: 10.3390/diagnostics16020259
Negative / Null Result ReportMedicine

Significance of Variants of Uncertain Significance: The Human Cost of Genetic Uncertainty.

Gonullu-Rotman D · 2024 · American journal of medical genetics. Part C, Seminars in medical genetics

This piece narrates the journey of Maria (name of the mother has been altered to protect the family's privacy), a new mother confronting her newborn's unexpected diagnosis of very long chain acyl-CoA dehydrogenase (VLCAD) deficiency,…

View details →DOI: 10.1002/ajmg.c.32109
Negative / Null Result ReportOpen accessMedicine

Reevaluating the senolytic activity of a GLS1 inhibitor and an anti-PD-1 antibody: toward greater reproducibility and methodological rigor.

Kawamoto S, Horiguchi H, Torigoe D et al. · 2026 · EMBO reports

The discovery of the senescence-associated secretory phenotype (SASP) has reshaped our understanding of cellular senescence, shifting its role from a solely tumor-suppressive mechanism to a potential driver of chronic inflammation and…

View details →DOI: 10.1038/s44319-026-00740-5
Negative / Null Result ReportOpen accessMedicine

Double pyramidal lobe of the thyroid gland: report of two consecutive cases with surgical and oncologic implications.

Ağar ET, Yüksel C · 2026 · Journal of surgical case reports

The pyramidal lobe (PL) of the thyroid gland is a common embryological remnant; however, the presence of double PLs is an exceptionally rare anatomical variation. Failure to recognize this anomaly may result in incomplete thyroidectomy,…

View details →DOI: 10.1093/jscr/rjag049
Negative / Null Result ReportMedicine

Post-hoc out-of-distribution detection for cardiac MRI segmentation.

Arega TW, Bricq S, Meriaudeau F · 2025 · Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society

In real-world scenarios, medical image segmentation models encounter input images that may deviate from the training images in various ways. These differences can arise from changes in image scanners and acquisition protocols, or even the…

View details →DOI: 10.1016/j.compmedimag.2024.102476
Negative / Null Result ReportMedicine

Reliability of brain localization using task-based fMRI for late-life depression with suicidal risk.

Hsu AL, Wu CW, Huang CM et al. · 2025 · Journal of psychiatric research

Late-life depression (LLD) is a heterogeneous mental disorder with a high risk of suicide, often linked to abnormalities in brain networks, particularly the prefrontal cortex. While transcranial magnetic stimulation targeting the dorsal…

View details →DOI: 10.1016/j.jpsychires.2025.04.053
Negative / Null Result ReportOpen accessMedicine

False negativity for trisomy 18 in non-invasive prenatal testing: A case report.

Andová N, Repiská V, Priščáková P et al. · 2026 · Case reports in women's health

False-negative results in non-invasive prenatal testing are rare but clinically significant, particularly in the presence of biological factors such as feto-placental mosaicism. This report describes a pregnancy affected by fetal trisomy…

View details →DOI: 10.1016/j.crwh.2026.e00813
Negative / Null Result ReportOpen accessMedicine

The addition of sweetness reduces aversion to high salt concentrations in patients with chronic kidney disease.

Okuno-Ozeki N, Kohama Y, Taguchi H et al. · 2025 · Scientific reports

Reducing salt intake is crucial for managing hypertension. While efforts to reduce salt intake are based on the assumption that people have a preference for salt, it is also important to acknowledge that there is an aversion to high levels…

View details →DOI: 10.1038/s41598-025-09602-x
Negative / Null Result ReportOpen accessMedicine

Establishing population-specific gestational weight gain ranges for twin pregnancies and comparing their performance with IOM recommendations: a retrospective cohort study from central China.

Yang R, Wang Y, Fu Q et al. · 2026 · BMJ open

Objectives To establish optimal pre-pregnancy body mass index (BMI)-specific gestational weight gain (GWG) ranges for twin pregnancies and compare their association with maternal and neonatal adverse outcomes against Institute of Medicine…

View details →DOI: 10.1136/bmjopen-2025-112189
Negative / Null Result ReportOpen accessMedicine

Clinical utility of the Oncomine Dx Target Test multi-CDx system and the possibility of utilizing those original sequence data.

Saito A, Terai H, Kim TJ et al. · 2024 · Cancer medicine

Background Companion diagnostic tests play a crucial role in guiding treatment decisions for patients with non-small cell lung cancer (NSCLC). The Oncomine Dx Target Test (ODxTT) Multi-CDx System has emerged as a prominent companion…

View details →DOI: 10.1002/cam4.7077
Negative / Null Result ReportOpen accessMedicine

Case Report: Novel likely pathogenic <i>MEN1</i> mosaic mutation in the family with MEN-1 syndrome.

Salimkhanov R, Utkina M, Bagirova H et al. · 2025 · Frontiers in endocrinology

Multiple endocrine neoplasia type 1 (MEN-1; OMIM 131100) is a rare, autosomal dominant syndrome caused by heterozygous inactivating mutations in the MEN1 tumor suppressor gene (11q13; OMIM 613733). MEN-1 is characterized by polyglandular…

View details →DOI: 10.3389/fendo.2025.1662871
Negative / Null Result ReportOpen accessMedicine

Measured and Estimated Glomerular Filtration Rate to Evaluate Rapid Progression and Changes over Time in Autosomal Polycystic Kidney Disease: Potential Impact on Therapeutic Decision-Making.

Miquel-Rodríguez R, González-Toledo B, Pérez-Gómez MV et al. · 2024 · International journal of molecular sciences

Autosomal polycystic kidney disease (ADPKD) is the most common genetic form of kidney failure, reflecting unmet needs in management. Prescription of the only approved treatment (tolvaptan) is limited to persons with rapidly progressing…

View details →DOI: 10.3390/ijms25095036
Failed Experiment ReportOpen accessMedicine

Domain-specific cognitive screening in acute first-ever stroke: a comparative study of the Oxford Cognitive Screen (OCS) and ACE-III.

Tanglay O, Jhunjhnuwala D, Huynh W · 2025 · Frontiers in human neuroscience

Introduction Post-stroke cognitive impairment (PSCI) is common and often under-recognized, particularly in the acute phase. Most cognitive screening tools provide only a global score, overlooking domain-specific deficits that influence…

View details →DOI: 10.3389/fnhum.2025.1678230
Negative / Null Result ReportMedicine

FilmArray® effectively detects all clades of F41 but encounters challenges with other adenovirus species.

Ito S, Takano C, Hoque SA et al. · 2025 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

The BioFire FilmArray® Gastrointestinal (GI) Panel, a widely used diagnostic tool, is designed to detect the genetic material of 22 common pathogens responsible for gastroenteritis, including viruses, bacteria, and parasites. It can detect…

View details →DOI: 10.1016/j.jiac.2025.102626
Negative / Null Result ReportOpen accessMedicine

Gastrointestinal cancer with indeterminate <sup>18</sup>F-FDG PET/CT findings: Diagnostic efficacy analysis of <sup>68</sup>Ga-FAPI-04 PET/MRI.

Miao J, Xu Y, Qiao F et al. · 2026 · Oncology letters

The present prospective study aimed to investigate whether gallium-68-labeled fibroblast activation protein inhibitor-04 ( 68 Ga-FAPI-04) positron emission tomography (PET)/magnetic resonance imaging (MRI) could provide notably increased…

View details →DOI: 10.3892/ol.2026.15647
Negative / Null Result ReportOpen accessMedicine

Antenatal Imaging and Neonatal Outcome in Infants with Congenital Cytomegalovirus Infection: The Effect of Valaciclovir.

Arcieri F, Vasta A, Sorrenti S et al. · 2026 · Journal of clinical medicine

Background: Congenital cytomegalovirus (cCMV) infection is a leading cause of neonatal morbidity. This retrospective study aimed to evaluate the efficacy of valacyclovir in reducing vertical transmission after primary maternal CMV…

View details →DOI: 10.3390/jcm15020809
Negative / Null Result ReportOpen accessMedicine

Clinicopathology of adenocarcinoma originating from the anal gland with immunohistochemical expressions of GATA3 and TTF-1: a case report and literature review.

Shi J, Li G, Tang W et al. · 2026 · Frontiers in oncology

Adenocarcinoma originating from the anal gland with immunohistochemical expression of GATA3 and TTF-1 (ACAGGT) is a rare entity. This report describes an 80-year-old female patient who detected a perianal mass without an obvious cause 10…

View details →DOI: 10.3389/fonc.2026.1673646
Negative / Null Result ReportMedicine

GC-MS quantification of fecal short-chain fatty acids and spectrophotometric detection of indole: Do rectal swabs produce comparable results as stool samples? - A pilot study.

K K V, P R A, Rao BK et al. · 2024 · Rapid communications in mass spectrometry : RCM

Rationale The exploration of the gut microbiome and related metabolites holds an exciting future in health science. The challenges associated with fecal sample testing are proper sample collection, sterile transportation, optimal transport…

View details →DOI: 10.1002/rcm.9923
Negative / Null Result ReportOpen accessMedicine

Association between in-hospital antibiotic use and long-term outcomes in critically ill patients.

Burrows P, Brown RA, Samuelsen A et al. · 2025 · Antimicrobial stewardship & healthcare epidemiology : ASHE

Objective To assess whether antibiotic duration (AD) and one-year antibiotic-free days (AFD) are associated with key in-hospital and post-discharge outcomes among critically ill adults. Design Prospective observational study. Setting…

View details →DOI: 10.1017/ash.2025.10054
Negative / Null Result ReportOpen accessMedicine

Renal safety of postoperative short-term use of flurbiprofen axetil in well-controlled hypertensive patients: a prospective multicenter cohort study.

Sun L, Jiang Y, Ma X et al. · 2026 · Frontiers in pharmacology

Background Currently, postoperative nonsteroidal anti-inflammatory drugs-associated kidney damage in hypertensive patients remains undetermined. This study aimed to examine renal safety of short-term post-surgery use of flurbiprofen axetil…

View details →DOI: 10.3389/fphar.2026.1773939
Negative / Null Result ReportOpen accessMedicine

Evaluation of the ability of commercial enzyme-linked immunosorbent assays to measure mouse tissue factor.

Sachetto ATA, Mackman N · 2024 · Research and practice in thrombosis and haemostasis

Background Tissue factor (TF) is the primary cellular initiator of the blood coagulation cascade. Increased levels of TF expression on circulating monocytes or on extracellular vesicles (EVs) are associated with thrombosis in a variety of…

View details →DOI: 10.1016/j.rpth.2024.102325
Negative / Null Result ReportOpen accessMedicine

CSF Aquaporin-4 levels in controls and in idiopathic normal pressure hydrocephalus before and after shunt surgery.

De Ryst JE, Bergström S, Mravinacova S et al. · 2026 · Fluids and barriers of the CNS

Background Aquaporin-4 (AQP4) is crucial for brain fluid regulation and glymphatic system function. Idiopathic normal pressure hydrocephalus (INPH) is characterized by impaired CSF flow and is treated with shunt surgery. This study…

View details →DOI: 10.1186/s12987-026-00809-2
Negative / Null Result ReportMedicine

Ultrafast kinetics of PSI-LHCI super-complex from the moss Physcomitrella patens.

Liu D, Yan Q, Qin X et al. · 2025 · Biochimica et biophysica acta. Bioenergetics

Photosystem I (PSI) is a large membrane photosynthetic complex that harvests sunlight and drives photosynthetic electron transport. In both green algae and higher plants, PSI's ultrafast energy transfer and charge separation kinetics have…

View details →DOI: 10.1016/j.bbabio.2024.149526