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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 580 of 725

Negative / Null Result ReportMedicine

Common Divalent Cations Elicit Sublethal Effects of Negatively Charged Nanoplastics on <i>Shewanella oneidensis</i> by Compromising Membrane Protein Functionality.

Zhang S, Jia B, Huang W et al. · 2025 · ACS nano

The toxicity of negatively charged nanoplastics (NNP) to bacteria is generally subtler than that of positively charged counterparts, owing to limited NNP-cell interaction. This study hypothesized that common environmental cations (Na + ,…

View details →DOI: 10.1021/acsnano.5c04610
Negative / Null Result ReportMedicine

Combination of Exercise and Group Occupational Therapy for Behavioural and Psychological Symptoms of Dementia: A Pilot Randomised Controlled Trial.

Yoshiura K, Murata M, Hamasuna M et al. · 2025 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Background The behavioural and psychological symptoms of dementia (BPSD) increase the burden for the caregiver, often leading to difficulties in maintaining home care and triggering psychiatric hospitalisation. Effective management of BPSD…

View details →DOI: 10.1111/psyg.70085
Negative / Null Result ReportMedicine

Oxidation of Platina(II)corrole to Platina(IV)corrole.

Kato S, Miwa K, Takano H et al. · 2025 · Inorganic chemistry

Recently, the aromaticity and antiaromaticity of organometallacycles have received much attention to understand the cyclic electronic delocalization through d orbitals on the metal center. Here, we prepared a Pd(II) platina(II)corrole…

View details →DOI: 10.1021/acs.inorgchem.5c00942
Negative / Null Result ReportMedicine

Retrospective analysis of early functional and radiological outcomes between robotic, navigated and conventional total knee arthroplasty: A single Surgeon's series.

Leong JWK, Lee BH, Haniball J et al. · 2025 · Journal of clinical orthopaedics and trauma

Background Achieving a neutral mechanical axis alignment (MAA) in Total Knee Arthroplasty (TKA) is associated with increased implant longevity and patient satisfaction, and robot-assisted (robotic) TKA is touted to improve implant…

View details →DOI: 10.1016/j.jcot.2025.103145
Negative / Null Result ReportOpen accessMedicine

Determining the Minimal Number of Passive Hip and Knee Joint Movement Repetitions Recommended for the Stiff Rectus Femoris Muscle Due to Osgood-Schlatter Disease.

Ikeda N, Yoshikawa A, Yamaguchi S et al. · 2026 · Children (Basel, Switzerland)

Background/objectives Osgood-Schlatter disease (OSD) is a common overuse condition in adolescents characterized by increased stiffness of the rectus femoris muscle, which contributes to pain and functional limitations around the knee. We…

View details →DOI: 10.3390/children13040460
Negative / Null Result ReportMedicine

Permitless Carry Laws and FIREARM-RELATED Injuries at a Level I Trauma Center.

Herrin J, Givens L, Jordan C et al. · 2025 · The American surgeon

Firearm-related injuries (FRI) are a public health issue in the United States. Permitless carry laws (PCL) eliminate the need for permits to carry firearms. This study evaluates the effects of Alabama's PCL implementation on FRI rates at a…

View details →DOI: 10.1177/00031348251358426
Negative / Null Result ReportOpen accessMedicine

Effect of ultraviolet surface treatment on color stability, surface water contact angle and bond strength of monolithic zirconia.

Yiğit E, Çulhaoğlu AK · 2026 · BMC oral health

BACKGROUND: This laboratory study investigated the impact of ultraviolet light exposure on the color, surface water contact angle, and resin cement–zirconia bond strength. METHODS: Fourty-five zirconia specimens were randomly divided into…

View details →DOI: 10.1186/s12903-026-07963-x
Negative / Null Result ReportMedicine

Vilobelimab to improve clinical outcomes in moderate-to-severe hidradenitis suppurativa through an adjunctive effect on draining tunnels: results of the SHINE double-blind placebo-controlled randomized trial.

Giamarellos-Bourboulis EJ, Jemec GBE, Prens EP et al. · 2026 · The British journal of dermatology

Background The results of a previous phase IIa trial suggested efficacy of the anti-C5a compound vilobelimab in a small number of patients with severe hidradenitis suppurativa (HS) refractory to adalimumab treatment. Objectives To study…

View details →DOI: 10.1093/bjd/ljaf398
Negative / Null Result ReportOpen accessMedicine

Cost-Effectiveness of an Antibacterial Envelope in Patients at High Risk of Cardiac Implantable Electronic Device Infection in the Australian Public Healthcare System.

Hill M, Khalaj BH, Shawon MSR et al. · 2026 · Journal of arrhythmia

Background The Worldwide Randomized Antibiotic Envelope Infection Prevention Trial (WRAP-IT) demonstrated a 40% reduction of major cardiac implantable electronic device (CIED) infection with the use of an absorbable antibacterial envelope…

View details →DOI: 10.1002/joa3.70282
Negative / Null Result Report

Impact of an Integrated Intervention Package During Preconception, Pregnancy, and Early Childhood on inflammation, IGF-1, IGFBP3 during first 6 months of life: Findings from the WINGS Randomized Controlled Trial

Chowdhury R, Maiti U, Devi S et al. · 2025 · Preprint

Background Early-life interventions targeting maternal and child health, nutrition, and psychosocial care may influence infant growth and immune development by modulating systemic inflammation and growth factor pathways. However, causal…

View details →DOI: 10.1101/2025.08.10.25333400
Negative / Null Result ReportOpen accessMedicine

The impact paradox: mixed-methods evaluation of National Institute of Health and Care Research funding for intellectual disability research in the UK.

Goddard N, Dale M, Bishop R et al. · 2026 · BJPsych open

Background People with intellectual disability experience substantial health inequities, including higher multimorbidity, increased healthcare utilisation and markedly reduced life expectancy. High-quality research is essential to address…

View details →DOI: 10.1192/bjo.2026.11023
Negative / Null Result ReportMedicine

Exploitation of Saccharomyces cerevisiae as an alternative microencapsulation strategy of thymol via β-glucan based matrix for the development of multilayer LDPE active packaging films - comparison with zeolite- and activated carbon-based carriers.

Giotopoulou I, Stamatis H, Barkoula NM · 2025 · International journal of biological macromolecules

In the current study Saccharomyces cerevisiae (S. cerevisiae) was exploited as an alternative carrier of thymol with the aim of developing multilayer low-density polyethylene (LDPE) films with advanced bioactivity over time. The results…

View details →DOI: 10.1016/j.ijbiomac.2025.146017
Negative / Null Result Report

A Comprehensive Null Search for Prompt Radio Bursts Associated with 218 Gravitational Wave Events: The Strongest Constraints on Pre-Merger Fast Radio Burst Emission

Prajapati S · 2026 · Preprint

Abstract Binary neutron star mergers are known to produce gravitational waves and panchromatic electromagnetic afterglow emission hours to days after coalescence. However, a fundamental question remains unanswered: do these mergers…

View details →DOI: 10.21203/rs.3.rs-9595477/v1
Negative / Null Result ReportMedicine

Experimental and clinical evidence on radiofrequency electromagnetic field effects on the blood-brain barrier: a scoping review.

Simsek ET, Sumser K, Mansourinezhad P et al. · 2026 · Physics in medicine and biology

Objective. This scoping review evaluates evidence on whether radiofrequency electromagnetic field (RF-EMF) exposure influences blood-brain barrier (BBB) permeability. Given inconsistent findings across decades of research and expanding…

View details →DOI: 10.1088/1361-6560/ae6e17
Negative / Null Result ReportMedicine

Can ovarian cancer screening work? A secondary analysis of the UK collaborative trial of ovarian cancer screening.

Lange JM, Ahmad I, Dengos IJ et al. · 2026 · British journal of cancer

Background The UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS; 2001-2020) showed no reduction in disease mortality in its primary intervention arm using multimodal screening (MMS) with longitudinal Cancer Antigen 125 (CA125)…

View details →DOI: 10.1038/s41416-026-03490-2
Negative / Null Result ReportMedicine

Spectroscopic analysis of the N<sub>2</sub> B<sup>3</sup>Π<sub>g</sub>-A<sup>3</sup>Σ+u in radiation-induced air ionization.

Murzyn CM, Jans ER, Marshall GJ · 2026 · Physical chemistry chemical physics : PCCP

This article presents experimental results from probing atmospheric air irradiated by a Polonium-210 alpha particle source using both optical emission spectroscopy and continuous wave cavity ring down absorption spectroscopy to study the…

View details →DOI: 10.1039/d5cp03971a
Negative / Null Result Report

Assessing Brain-Behaviour Coupling in Non-invasive Brain Stimulation Using Reliable Change Indices: Evidence from pre-Supplementary Motor Area – right Inferior Frontal Gyrus transcranial Alternating Current Stimulation

Fujiyama H, Wansbrough K, Lebihan B et al. · 2026 · Preprint

Non-invasive brain stimulation (NiBS) studies frequently report exploratory correlations between individual-level changes in neurophysiological and behavioural measures. However, these analyses are typically underpowered and rely on…

View details →DOI: 10.64898/2026.03.24.714072
Negative / Null Result Report

Geomagnetic Excursions as CO₂-Null Climate Forcing Events: The Laschamps/Adams Event in Proxy Context and a Comparative Analysis of Brunhes Chron Excursions Against the EPICA Dome C Record

Gray JH · 2026 · Preprint

The Laschamps geomagnetic excursion (~41-42 ka BP) represents the largest geomagnetic field collapse in the past 800,000 years, driving documented megafaunal extinctions, Neanderthal extinction, Northern Hemisphere ice sheet expansion, and…

View details →DOI: 10.22541/au.177499034.42719500/v1