Vasopressors or Fluids in Early Septic Shock.
Peake SL; Macdonald SPJ; Howe BD; Milford E; Jones P; Arendts G; Bailey M · 2026 · The New England journal of medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background The optimal approach to early resuscitation in septic shock is unknown. Equipoise exists between the use of larger volumes of intravenous fluids to restore perfusion and the use of early vasopressor therapy along with smaller…
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Metadata source: Europe PMC · DOI 10.1056/nejmoa2516225