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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21350 results · page 569 of 712

Negative / Null Result ReportMedicine

HeartWare Left Ventricular Assist Device Exercise Hemodynamics With Speed Adjustment Based on Left Ventricular Filling Pressures.

Ali O, Arnold AC, Cysyk J et al. · 2024 · ASAIO journal (American Society for Artificial Internal Organs : 1992)

Functional capacity remains limited in heart failure patients with left ventricular assist devices (LVADs) due to fixed pump speed and inability to offload the left ventricle adequately. We hypothesized that manually adjusting LVAD speed…

View details →DOI: 10.1097/mat.0000000000002096
Negative / Null Result ReportOpen accessMedicine

A family history of suicide in bipolar disorders: powerful, powerless

Sagué Vilavella M, Fico G, Anmella G et al. · 2023 · European psychiatry : the journal of the Association of European Psychiatrists

Introduction When completing the medical record of a patient with bipolar disoder (BD), hardly anything is more impacting than a family history of completed suicide (FHS). In fact, FHS is a main risk factor for personal suicide attempts…

Negative / Null Result ReportMedicine

Distress tolerance, coping motives, and alcohol craving and consumption: Two experiments testing momentary responses to a mood induction.

Augur IF, Wolkowicz NR, Ham LS · 2023 · Drug and alcohol dependence

Background The current studies examined the relationship between state and trait distress tolerance (DT), drinking-related variables (alcohol craving and consumption), and the moderating role of drinking to cope with negative affect (i.e.,…

View details →DOI: 10.1016/j.drugalcdep.2023.111034
Negative / Null Result ReportOpen accessMedicine

The Role of Screentime and Family Resiliency in Overweight/Obesity in Children and Children with Developmental Disabilities Before and During COVID-19.

Mudnal PS, Chuang E, Lindly OJ et al. · 2025 · Children (Basel, Switzerland)

Background/objectives This study examines factors associated with child overweight/obesity (OW/OB), pre-COVID-19 and during the COVID-19 pandemic, among all U.S. children aged 10-17 years, with or without developmental disabilities (DD)…

View details →DOI: 10.3390/children13010066
Replication FailureMedicine

Locomotor play behavior evolves by random genetic drift but not as a correlated response to selective breeding for high voluntary wheel-running behavior.

Whitehead NN, Kelly SA, Demes JS et al. · 2023 · Behavioural processes

Locomotor play is vigorous and seemingly purposeless behavior, commonly observed in young mammals. It can be costly in terms of energy expenditure, increased injury risk, and predator exposure. The main hypothesized benefit of locomotor…

View details →DOI: 10.1016/j.beproc.2023.104973
Negative / Null Result ReportOpen accessMedicine

The independent and combined effect of price increase and price labelling on sugar-sweetened beverage vending machine sales in an Australian university: a factorial randomised controlled trial.

Blake MR, Dancey J, Cameron AJ et al. · 2026 · The international journal of behavioral nutrition and physical activity

BACKGROUND: No studies have examined how price increases on unhealthy drinks in university vending machines impact customer purchasing or vendor financial implications. Vending machines often display prices only upon product selection,…

View details →DOI: 10.1186/s12966-026-01890-4
Negative / Null Result ReportOpen accessMedicine

Variations of sex-hormones in reproductive aged females do not impact the repeated bout effect following maximal unaccustomed eccentric exercise of the elbow flexors.

Rilling A, Power GA · 2025 · Biology of sport

Neuromuscular function is impaired following unaccustomed eccentric exercise, the repeated bout effect (RBE) however, protects from damage following a subsequent bout. Muscle damage may be mitigated in females due to protective effects of…

View details →DOI: 10.5114/biolsport.2025.150041
Negative / Null Result ReportMedicine

The effect of Section 1557 of the Affordable Care Act on surgical outcomes in non-English primary language speakers.

Bakillah E, Finn CB, Sharpe J et al. · 2024 · American journal of surgery

Background In 2016, Section 1557 mandated use of qualified language interpreter services. We examined the effect of Section 1557 on surgical outcomes. Methods Utilizing the Healthcare Cost and Utilization Project State Inpatient Database…

View details →DOI: 10.1016/j.amjsurg.2023.10.018
Negative / Null Result ReportMedicine

Interaction between cold ischemia time and Kidney Donor Profile Index on postrenal transplant outcomes.

Cashion WT, Zhang X, Puttarajappa C et al. · 2024 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

We analyzed whether there is an interaction between the Kidney Donor Profile Index (KDPI) and cold ischemia time (CIT) in recipients of deceased donor kidney transplant (KTs). Adults who underwent KTs in the United States between 2014 and…

View details →DOI: 10.1016/j.ajt.2024.01.026
Negative / Null Result ReportMedicine

Patients with chronic bipolar disorder show impairments in interpreting literary fiction - A preliminary explorative study with the short story task.

Herold M, Kovács GX, Herold R et al. · 2024 · Journal of psychiatric research

Introduction Theory of mind (ToM) is a crucial skill in navigating and functioning in the social world. Significant ToM impairment was consistently found in bipolar disorder; it can be both a state and trait marker of the disorder.…

View details →DOI: 10.1016/j.jpsychires.2024.01.022
Negative / Null Result ReportOpen accessMedicine

Impact of a brief series of soccer matches on vascular conditions in youth women.

Sugawara J, Ogoh N, Watanabe H et al. · 2024 · Frontiers in physiology

Background Accumulative excessive physical load elevates central arterial stiffness and smooth muscular tone of peripheral vascular beds in endurance athletes. The aim of this study was to test the hypothesis that a brief series of soccer…

View details →DOI: 10.3389/fphys.2024.1476627
Negative / Null Result ReportOpen accessMedicine

Correlation of Physical Activity Level with Muscle Strength and Size During One Week of Knee Joint Immobilization.

Harmon KK, Pourhatami Z, Malinowski D et al. · 2025 · Journal of functional morphology and kinesiology

Background : Knee joint immobilization is common after surgery or injury. Whether remaining physically active during immobilization preserves muscle strength and size has not been studied. Objectives : This observational study examined…

View details →DOI: 10.3390/jfmk10020192
Negative / Null Result ReportOpen accessMedicine

Age-dependent increase in peripheral neuropeptide Y with no cross-sectional link to depression.

Dahlaki M, Alam MDZ, Nyholm Nielsen M et al. · 2026 · Acta neuropsychiatrica

Background Neuropeptide Y (NPY) has been implicated in stress resilience and depression, yet findings on circulating levels in major depressive disorder (MDD) remain inconsistent, possibly due to confounders such as age, sex, and body mass…

View details →DOI: 10.1017/neu.2026.10084
Negative / Null Result ReportMedicine

The impact of co-occurring mental health problems on referral to and initiation of treatment among youth under probation supervision: Findings from a cluster randomized trial.

Stanley JN, DeLucca SC, Perron L et al. · 2024 · Journal of substance use and addiction treatment

Introduction Many youth under community supervision have substance use and co-occurring mental health issues. Yet, access to treatment is limited, and many programs cannot address co-occurring disorders. This study examines how…

View details →DOI: 10.1016/j.josat.2023.209279
Negative / Null Result ReportOpen accessMedicine

The impact of cognitive behavioral therapy for insomnia on cognitive performance and amyloid beta in older adults: A randomized controlled trial.

Siengsukon CF, Hand LK, Nelson E et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association

Introduction Insomnia is associated with increased risk for Alzheimer's disease (AD). It is unknown how cognitive behavioral therapy for insomnia (CBT-I) impacts two hallmarks of AD progression, cognitive performance and beta-amyloid (Aβ)…

View details →DOI: 10.1002/alz.71591
Negative / Null Result ReportMedicine

Posttraumatic growth and health-related quality of life in cancer survivors: Does fatigue moderate the link?

Onyedibe MC, Blickle P, Schmidt ME et al. · 2024 · Stress and health : journal of the International Society for the Investigation of Stress

Interest in post-traumatic growth (PTG) as a predictor of health-related quality of life (HRQoL) is currently gaining attention. However, current evidence is still inconclusive on the nature of this relationship. The first objective of…

View details →DOI: 10.1002/smi.3299
Negative / Null Result ReportOpen accessMedicine

Exploring the impact of virtual reality anatomy training on preparing biomedical illustrators for drawing anatomical structures.

Cheung HCK, Zhong LS, Wall SL et al. · 2026 · Anatomical sciences education

Three-dimensional visualization technologies (3DVTs) in anatomy education are popular as they offer a cost-effective and accessible alternative to cadaveric specimens. However, the literature presents conflicting results regarding the…

View details →DOI: 10.1002/ase.70150
Negative / Null Result ReportOpen accessMedicine

Instructing participants about the random assignment of patients to treated and non-treated conditions does not diminish causal illusions.

Barreiro A, Rodríguez-Ferreiro J, Barberia I · 2025 · Royal Society open science

People sometimes perceive causal relationships between non-contingent events. When having to assess the contingency between a putative cause and an outcome, it is vital to ensure that all other causal forces are held constant whether the…

View details →DOI: 10.1098/rsos.251004
Negative / Null Result ReportOpen accessMedicine

Risk Factors for Endoscopic Gastric Mucosal Lesions: Analysis of Lifestyle, Dietary, and Clinical Determinants in 361 Patients.

Chiciudean PL, Filip AM, Munteanu SN et al. · 2025 · Life (Basel, Switzerland)

Background/objectives Gastric mucosal lesions represent a significant health burden, with Helicobacter pylori infection being the primary cause of chronic gastritis worldwide. However, the role of modifiable lifestyle factors in modulating…

View details →DOI: 10.3390/life15091474
Negative / Null Result ReportOpen accessMedicine

Tipping the scale: Effects of physical activity and body composition on cardiac parameters in postmenopausal females.

Fischer M, Tamariz-Ellemann A, Egelund J et al. · 2024 · Physiological reports

The risk of cardiovascular disease increases significantly after menopause. We sought to assess the impact of different activity levels on cardiac structure and function in postmenopausal women. We grouped age-similar, postmenopausal women…

View details →DOI: 10.14814/phy2.70144
Negative / Null Result ReportMedicine

The emergence of inflammatory microglia during gut inflammation is not affected by FFAR2 expression in intestinal epithelial cells or peripheral myeloid cells.

Caetano-Silva ME, Rund L, Vailati-Riboni M et al. · 2024 · Brain, behavior, and immunity

Gut inflammation can trigger neuroinflammation and is linked to mood disorders. Microbiota-derived short-chain fatty acids (SCFAs) can modulate microglia, yet the mechanism remains elusive. Since microglia do not express free-fatty acid…

View details →DOI: 10.1016/j.bbi.2024.03.016
Negative / Null Result ReportMedicine

Chronic estrogen supplementation in the aging castrated male rat is not associated with renal injury or activation of the renin angiotensin system.

Mallette JH, Crudup BF, Oudomrath Speyrer A et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

The biological effects of chronic estrogen supplementation on renal function and injury with aging in men are unknown. Using an experimental model of feminizing hormone therapy (FHT) induced by 17β-estradiol (E2) (5 mg/kg sc)…

View details →DOI: 10.1152/japplphysiol.00052.2026
Negative / Null Result ReportMedicine

Light exposure impact on cardiac autonomic control before and following exercise.

Marin TC, Oliveira GF, Azevêdo LM et al. · 2025 · Chronobiology international

We aimed to investigate whether bright light (BL) exposure affects sympathovagal activity in controlling heart rate (HR) before and after exercise. Eighteen healthy men (28 ± 4 years) underwent two experimental conditions: one under BL…

View details →DOI: 10.1080/07420528.2025.2556841