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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 565 of 725

Negative / Null Result ReportMedicine

Outcomes from a structured conflict management programme implemented at three paediatric healthcare sites: a mixed-methods evaluation.

Phillipson J, Menson E, Barclay S et al. · 2026 · Archives of disease in childhood

Objective Evaluation of the Medical Mediation Foundation's Conflict Management Programme (CMP)-a structured process for managing conflict. Design Mixed-methods evaluation using Kirkpatrick's framework, a four-level model for evaluating…

View details →DOI: 10.1136/archdischild-2025-329335
Negative / Null Result ReportMedicine

Daily-life posttraumatic stress symptoms, posttraumatic cognitions, and affect following the processing of positive memories technique: An open-label case-control daily diary study.

Greene T, Dicker-Oren SD, Sznitman SR et al. · 2026 · Journal of traumatic stress

The processing of positive memories technique (PPMT) is a promising new treatment for posttraumatic stress disorder (PTSD) involving the detailed narration and processing of specific positive autobiographical memories. This study used an…

View details →DOI: 10.1002/jts.70066
Negative / Null Result ReportMedicine

Intravitreal pegfilgrastim for indirect traumatic optic neuropathy: a first-in-human phase 1/2a study.

Huang CT, Wen YT, Liu PK et al. · 2026 · QJM : monthly journal of the Association of Physicians

Background Indirect traumatic optic neuropathy (TON) is associated with severe vision loss and no proven treatment. Aim To evaluate the safety and exploratory functional outcomes of intravitreal pegfilgrastim in patients with indirect TON.…

View details →DOI: 10.1093/qjmed/hcag129
Negative / Null Result ReportOpen accessMedicine

Investigation of the effects of radiotherapy and chemotherapy on brain volume in cancer patients: brain tumor study.

Deniz B, Arpaci MF, Pekmez H et al. · 2026 · Journal of neuro-oncology

Purpose Brain tumors, characterized by the uncontrolled proliferation of abnormal cells within cerebral tissue, remain clinically challenging entities. Radiotherapy and chemotherapy constitute fundamental therapeutic modalities; however,…

View details →DOI: 10.1007/s11060-025-05366-6
Negative / Null Result ReportOpen accessMedicine

The Effect of Ocrelizumab on Anti-JC Virus Antibody Index.

Virupakshaiah A, Gill AJ, Schoeps VA et al. · 2026 · Brain and behavior

Purpose/introduction The anti-JC virus (JCV) antibody index is used to stratify the risk of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS), particularly with natalizumab therapy. B-cell-depleting therapies may…

View details →DOI: 10.1002/brb3.71386
Negative / Null Result ReportMedicine

Impact of low-flow desflurane versus sevoflurane anesthesia on thiol-disulfide homeostasis in adults undergoing elective thyroidectomy: a randomized controlled trial.

Sen E, Aytekin A · 2026 · Revista da Associacao Medica Brasileira (1992)

Objective Thiol-disulfide homeostasis is a marker of oxidative stress. The aim of the study was to compare the effects of low-flow desflurane and sevoflurane anesthesia on perioperative changes in thiol-disulfide balance in patients…

View details →DOI: 10.1590/1806-9282.20250893
Negative / Null Result ReportOpen accessMedicine

Correlation of change in V4c implantable Collamer lens vaulting and pupil diameter in different light conditions.

Sinha R, Singh R, Tripathi M et al. · 2025 · Indian journal of ophthalmology

Purpose To study the change in the vault of phakic Intraocular Lens (IOL) (pIOL) with RT view anterior segment optical coherence tomography (ASOCT) in different light conditions and define its relationship with the change in pupillary…

View details →DOI: 10.4103/ijo.ijo_293_25
Negative / Null Result ReportMedicine

Impact of repeated virtual reality exposures on emotional and physical well-being in hospitalised breast cancer patients: a pilot study.

Bachelard L, Blanc N, Michel A · 2026 · BMJ supportive & palliative care

Objective Breast cancer surgery often leads to a high burden of distressing symptoms, underscoring the need for supportive care to help patients throughout the perioperative period. This pilot study aimed to evaluate the feasibility,…

View details →DOI: 10.1136/spcare-2025-005885
Negative / Null Result ReportMedicine

Long-term outcomes of patients with moderate-severe pediatric systemic lupus erythematosus treated with combination rituximab and cyclophosphamide therapy: A single center cohort experience and review of literature.

Achar A, Houser P, Cherian J et al. · 2026 · Lupus

ObjectiveTo determine the long-term outcomes of patients with moderate-severe pediatric systemic lupus erythematosus (pSLE) treated with systematic administration of combination rituximab (RTX) and cyclophosphamide (CYC) at our…

View details →DOI: 10.1177/09612033261441392
Negative / Null Result ReportOpen accessMedicine

Beyond the Numbers: How Clinical Performance Metrics Impact Emergency Medicine Residents.

Burger C, Pirotte M, Ray K et al. · 2026 · The western journal of emergency medicine

Introduction Emergency physicians commonly receive feedback in the form of performance metrics such as patients seen per hour. Reviewing metrics has been associated with increased stress and burnout. Although effects on efficiency have…

View details →DOI: 10.5811/westjem.50814
Negative / Null Result Report

Epidemiology of Microbial Keratitis on Uganda: A 7-year update

Arunga S, Ebong A, Orishaba F et al. · 2026 · Preprint

Purpose To provide the latest update on the epidemiology of microbial keratitis in Uganda. Methods We prospectively recruited patients presenting with microbial keratitis (MK) at three eye units in Uganda between November 2023 and June…

View details →DOI: 10.12688/wellcomeopenres.26184.1
Negative / Null Result ReportMedicine

Characterization and Evaluation of Biological Properties of Calcium Silicate Cement-based Sealers after Thermal Pretreatment.

Jang YE, Kim Y, Kim HI et al. · 2026 · Journal of endodontics

Introduction Hydraulic calcium silicate cement-based sealers (CSC sealers) are now frequently used with warm vertical compaction in root canal treatment. However, the impact of heat on the biological properties of CSC sealers remains…

View details →DOI: 10.1016/j.joen.2026.04.017
Abandoned HypothesisOpen accessMedicine

Presbyvestibulopathy: an uncommon cause of dizziness in the elderly.

Chang TP, Kuo YH, Bery AK · 2026 · Frontiers in neurology

Background Dizziness is common in older adults, and often presents a diagnostic challenge. Vestibular function declines with age, but the prevalence and diagnostic explanatory value of mild vestibular loss in isolation (i.e., the clinical…

View details →DOI: 10.3389/fneur.2026.1744462
Negative / Null Result ReportMedicine

Assessing the risk of venous thromboembolism in trans masculine persons on gender-affirming hormone therapy: A literature review.

Hugueny J, de Ricolfis A, Johnson N et al. · 2025 · Thrombosis research

Objective This review aimed to synthesize recent data on venous thromboembolism (VTE) risk in the context of masculinizing hormone therapy with testosterone. Methods An electronic search was performed in MEDLINE/PubMed without date…

View details →DOI: 10.1016/j.thromres.2025.109516
Negative / Null Result ReportMedicine

Microbiome responses to anthelmintic treatment depend on pre-treatment helminth infection status in young Ethiopian children.

Tikhonova P, Mekonnen Z, Belanger KD et al. · 2026 · Communications medicine

Background Mass deworming programs using anthelmintic drugs are a common public health strategy for controlling soil-transmitted helminth (STH) infections in high-risk, low-income countries. However, whether routine deworming induces…

View details →DOI: 10.1038/s43856-026-01625-3
Negative / Null Result ReportMedicine

Evaluating a specialty-specific objective structured clinical examination and workplace-based assessment curriculum for radiation oncology postgraduate training: a prospective educational intervention study.

Ma CY, Chen J, Fu Y et al. · 2026 · BMC medical education

Background Competence in radiation oncology is still commonly expected to emerge through apprenticeship, although essential tasks such as target delineation, treatment-plan review, and multidisciplinary reasoning are not reliably sampled…

View details →DOI: 10.1186/s12909-026-09554-4
Negative / Null Result ReportMedicine

Efficacy of Short Course Cognitive Behavioral Therapy on Stress Reduction Among First-Year Surgical Residents.

Burnet G, Vasic I, Sauaia A et al. · 2026 · Journal of surgical education

Objective To determine the efficacy of cognitive behavioral therapy (CBT) on stress, anxiety, burnout, and depression in surgical interns and to determine the optimal timing of CBT. Our hypothesis was that CBT could improve each of these…

View details →DOI: 10.1016/j.jsurg.2026.103957
Negative / Null Result ReportOpen accessMedicine

Effects of Premolar Extraction on the Dimensions of the Airway Through Cephalometric Appraisal: A Retrospective Study.

Mehraj F, Bhat MA, Mangulkar A et al. · 2025 · Journal of pharmacy & bioallied sciences

Introduction In recent years, there has been a great deal of interest in research because of the changes that the extraction of premolars has caused to the structures surrounding of the upper airway. This is because it's thought that these…

View details →DOI: 10.4103/jpbs.jpbs_1340_25