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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21346 results · page 564 of 712

Negative / Null Result ReportMedicine

The Effect of Pessary Insertion on Pelvic Anatomy: A Prospective Observational Study Using Upright MRI.

Steen AV, Simmering JA, Perik M et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology

Objective To determine the anatomical effect of pessaries in the upright position in women with pelvic organ prolapse (POP). Design Prospective observational cohort study. Setting Outpatient clinic of our gynaecology department. Population…

View details →DOI: 10.1111/1471-0528.70280
Negative / Null Result ReportMedicine

Potential usefulness of [123I]I-MIBG SPECT/CT with AC Quant protocols in diagnostics and treatment monitoring of children with neuroblastoma.

Śliwińska A, Świtaj K, Durma AD · 2026 · Nuclear medicine review. Central & Eastern Europe

Background Neuroblastoma (NB) is the most common extracranial solid tumor in children. Metaiodobenzylguanidine (MIBG) selectively accumulates in adrenergic tissue, enabling its use for diagnostic imaging of NB. The implementation of new…

View details →DOI: 10.5603/nmr.110976
Negative / Null Result ReportMedicine

Real-World Observations on the Diagnosis of Syphilis After Roll-Out of Doxycycline Postexposure Prophylaxis.

Lehman A, Layton P, Mishkulin S et al. · 2026 · Sexually transmitted diseases

Doxycycline postexposure prophylaxis (doxyPEP) may affect RPR titers. We describe syphilis diagnosis following doxyPEP roll-out. Syphilis diagnoses decreased (3.4%-1.5%) among persons prescribed doxyPEP. Diagnosis without laboratory…

View details →DOI: 10.1097/olq.0000000000002298
Negative / Null Result ReportMedicine

Driving Cerebellar Theta Oscillations Interferes With Voluntary Neck Movements in Cervical Dystonia.

Costa D, Guerra A, Birreci D et al. · 2026 · Movement disorders : official journal of the Movement Disorder Society

Background Cervical dystonia (CD) is a movement disorder with a complex pathophysiology, including cerebellar abnormalities. Transcranial alternating current stimulation (tACS), a noninvasive neuromodulation technique capable of entraining…

View details →DOI: 10.1002/mds.70394
Negative / Null Result ReportMedicine

Maxillary Advancement and Impaction Increase the Size of the Nasal Airway Anterior to the Piriform Aperture, but Not Posterior to it.

Giotakis AI, Steinbichler TB, Heppt H et al. · 2026 · The Journal of craniofacial surgery

The exact nasal changes caused by several types of maxillofacial surgery are not yet thoroughly understood. The aim of the present study was to determine the exact nasal airway changes caused by maxillary advancement and impaction. In a…

View details →DOI: 10.1097/scs.0000000000012853
Negative / Null Result ReportOpen accessMedicine

Lean Mass Gains, Cardiac Remodeling, and Muscle Oxidative Changes With High-Dose Salbutamol During Resistance Training: A Randomized Controlled Trial.

Hostrup M, Jessen S, Tischer SG et al. · 2026 · Scandinavian journal of medicine & science in sports

Misuse of beta 2 -agonists to promote leanness is increasingly reported among young men undertaking resistance training. However, preclinical models demonstrate adverse cardiac remodeling with high-dose beta 2 -agonist. We investigated…

View details →DOI: 10.1111/sms.70302
Negative / Null Result ReportMedicine

Change in modified star excursion balance test performance between 6 and 12 months after anterior cruciate ligament reconstruction.

Rostron ZPJ, Feller JA, McClelland JA et al. · 2026 · Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine

Objectives To determine the change in modified star excursion balance test scores in patients between 6 and 12 months following anterior cruciate ligament (ACL) reconstruction and the change in the proportion of patients who met…

View details →DOI: 10.1016/j.ptsp.2026.101941
Negative / Null Result ReportMedicine

Proximal Calf Muscle Cross-Sectional Area After Anterior Cruciate Ligament Reconstruction: A Longitudinal MRI Evaluation.

Hart HF, Patterson BE, Atkinson HF et al. · 2026 · Journal of sport rehabilitation

Context Weakness of the quadriceps and hamstrings often persists following rehabilitation after anterior cruciate ligament reconstruction (ACLR). Yet, recovery of the gastrocnemius muscle following ACLR remains unclear. Thus, we aimed to…

View details →DOI: 10.1123/jsr.2026-0023
Negative / Null Result ReportOpen accessMedicine

Acid-base balance and respiratory mechanics during robotic-assisted surgery: an observational study.

Pitimada M, Chiumello D, Monte A et al. · 2026 · Journal of robotic surgery

To evaluate changes in acid-base equilibrium in plasma and urine according to the Stewart’s approach, in gas exchange and in respiratory mechanics during robotic-assisted surgery. Prospective observational study on patients undergoing…

View details →DOI: 10.1007/s11701-026-03392-8
Negative / Null Result ReportMedicine

Serial Dried Blood Spot C-Peptide Sampling, but Not Urine C-Peptide-to-Creatinine Ratio, Detects Early Preservation of β-Cell Function in New-Onset Type 1 Diabetes: Experience From the USTEKID Trial.

Dunseath GJ, Cheung WY, Luzio SD et al. · 2026 · Diabetes care

Objective To determine whether less invasive C-peptide tests, urine C-peptide-to-creatinine ratio (UCPCR) and dried blood spot (DBS), could replace the mixed-meal tolerance test (MMTT) in the context of an interventional clinical trial…

View details →DOI: 10.2337/dc25-2896
Negative / Null Result ReportMedicine

More graminoids in community breaks the trade-off between forage production and quality to improve forage quality storage in alpine grasslands

Wu S, Liu Q, Li L et al. · 2025 · Agriculture, Ecosystems and Environment.

Forage production and quality, two crucial ecosystem functions of grasslands, often demonstrate a trade-off and are significantly affected by both grassland community characteristics and environmental factors. However, whether and how…

Negative / Null Result ReportMedicine

Behavioral Adaptation to Neck Radio-Collars and Its Relations with Temperament in Two Neotropical Psittacid Species.

de Almeida GN, de Jesus LG, Branco MEC et al. · 2026 · Journal of applied animal welfare science : JAAWS

Track devices can cause behavioral, physical, and physiological adverse effects, with individuals varying in how quickly they adapt to them. We examined behavioral effects of replica radio-collars on two captive psittacid species,…

View details →DOI: 10.1080/10888705.2026.2681557
Negative / Null Result ReportMedicine

Impact of tighter glycaemic targets on pregnancy outcomes in a multi-ethnic cohort with gestational diabetes: A retrospective, single centre observational study.

Huda MS, Margari N, Islam N et al. · 2026 · Obstetric medicine

Aims To determine the impact of tighter glycaemic targets for gestational diabetes. Methods Retrospective data analysis before and after introducing tighter glucose targets. Results In 2265 pregnancies there was no change in…

View details →DOI: 10.1177/1753495x261445509
Negative / Null Result ReportMedicine

An evaluation of anatomical and functional outcomes in patients undergoing retinectomy for proliferative vitreoretinopathy.

Uzlu D, Erdöl H, Bulanık ÖB et al. · 2026 · BMC ophthalmology

Background The objective of this study was to evaluate the anatomical and functional outcomes of patients who underwent relaxing retinotomy or retinectomy for retinal detachment complicated by proliferative vitreoretinopathy. Methods The…

View details →DOI: 10.1186/s12886-026-04904-8
Negative / Null Result ReportMedicine

Mental rotation performance after acute stress.

Richardson AE, VanderKaay Tomasulo MM · 2026 · BMC psychology

Background The need to mentally rotate objects is common in everyday activities (e.g., driving, loading suitcases in a car, playing 3D video games) and in specific professions (e.g., air traffic controllers, mechanics, pilots, surgeons).…

View details →DOI: 10.1186/s40359-026-04818-6
Negative / Null Result ReportMedicine

The Importance of Objective Functional and Balance Testing in Pediatric Anterior Cruciate Ligament Reconstruction for a Safe Return-To-Sport: A Two-Year Prospective Study.

Crippa M, Turati M, Flumian C et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Introduction/objectives Pediatric anterior cruciate ligament reconstruction (ACLR) outcomes, particularly long-term functional recovery and return-to-sport (RTS), remain debated and have not been well characterized in skeletally immature…

View details →DOI: 10.1016/j.jisako.2026.101149
Negative / Null Result ReportMedicine

Antifungal susceptibility of genital yeast isolates, Auckland, 2016-2025.

Morris AJ, McKinney WP, Roberts SA · 2026 · The New Zealand medical journal

Aim Our aim was to record current susceptibility results of genital yeast isolates and to compare the results to the previous report covering the period 2001-2015. Methods Genital yeast isolates had their antifungal susceptibility…

View details →DOI: 10.26635/6965.7444
Negative / Null Result ReportMedicine

Sono-anatomy of the supraclavicular region for ultrasound-guided subclavian vein catheterization: revaluation of a former method.

Berk AZ, Balaban O, Eman A et al. · 2026 · BMC anesthesiology

BACKGROUND/OBJECTIVE: Ultrasound-guided subclavian vein (SCV) catheterization offers an alternative approach to the classical jugular vein catheterization for central venous catheter placement. The objective of this study was to evaluate…

View details →DOI: 10.1186/s12871-026-03857-1
Negative / Null Result ReportOpen accessMedicine

Changes in macular structure after removal of epiretinal membrane in combined hamartomas of the retina and retinal pigment epithelium.

Lee CH, Kim KH, Choi YJ et al. · 2026 · Scientific reports

This study investigates the effect of epiretinal membrane (ERM) removal in the combined hamartomas of the retina and retinal pigment epithelium (CHRRPE) patients. In this retrospective, comparative case series, 15 CHRRPE patients were…

View details →DOI: 10.1038/s41598-026-39124-z
Negative / Null Result ReportMedicine

The impact of hormonal contraceptives containing estradiol, estradiol valerate, and estetrol on liver proteins, lipids, glucose, blood pressure, and bone. A literature review.

Cagnacci A, Xholli A, Gabbi L et al. · 2026 · The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

Objective We investigated the metabolic profile induced by contraceptives containing body-identical oestrogens. Methods A literature search was made for articles on contraceptives with oestradiol/nomegestrol acetate (E2/NOMAc), oestradiol…

View details →DOI: 10.1080/13625187.2025.2596612
Negative / Null Result ReportMedicine

Quantification of Changes in Bifidobacteria and Lactobacilli Colony-forming Units During Rifaximin Treatment and Synbiotic Gel in Healthy Volunteers.

Cassís-Nosthas ML, Vorácková FV, Dzib FT et al. · 2026 · Journal of visualized experiments : JoVE

Although the gut microbiota is generally stable, it can be influenced by antibiotic treatment. Rifaximin, which is used to treat gastrointestinal disorders, is frequently administered with probiotics to reduce the risk of dysbiosis.…

View details →DOI: 10.3791/70201
Negative / Null Result ReportMedicine

Cerebral physiology following general anaesthesia with sevoflurane or propofol in healthy volunteers - a randomised, single-blind cross-over trial.

Madsen SS, Asghar MS, Lindberg U et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

Although general anaesthesia is a very common medical procedure, knowledge of how the brain physiologically recovers remains limited. In this randomized cross-over trial, we investigated brain physiology during recovery from general…

View details →DOI: 10.1152/japplphysiol.01169.2025
Negative / Null Result ReportMedicine

Diurnal Rhythm in Blood Pressure Is Preserved in Hypertensive Mice Despite Therapy With Mineralocorticoid Receptor Antagonists.

Usai DS, Kudryavtseva O, Thomsen MB · 2026 · Journal of cardiovascular pharmacology

Abstract Human arterial blood pressure follows a circadian rhythm, where pressure is highest during the day and lowest during the night. Patients with hypertension can have either a preserved rhythm or a dampened rhythm with a lower…

View details →DOI: 10.1097/fjc.0000000000001812