A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 553 of 676
Freitas NM, Silva ACA, Tebaldi ND · 2025 · Preprint
Abstract Lettuce bacterial leaf spot, caused by Xanthomonas hortorum pv. vitians is one important pathogen of lettuce. The use of nanoparticles offers a new approach to controlling the disease. The objective of this work was to investigate…
Hua SV, Roberto CA, Yam E et al. · 2026 · Appetite
Large portions contribute to excess consumption. We tested whether a portion size labeling intervention influenced consumers to select smaller lunch portions. Two cafés introduced a reduced-sized main course (half the original size and…
Jariyasakoolroj T, O'Connell K, MacDonald T et al. · 2026 · Resuscitation
Aim To examine the association between tracheal intubation (TI) attempts and chest compression (CC) pauses on chest compression fraction (CCF) during pediatric CPR across a network of emergency departments. Methods Prospective…
Yang Q, Dave A, Clark RSB et al. · 2026 · Brain research
Background Short chain fatty acids (SCFAs) including acetate, produced by gut microbiota, are key signaling molecules and impact microglial maturation and metabolism. Microglia play a dual role in maintaining homeostasis and…
Rozemeijer S, Dubois EA, de Grooth HJ et al. · 2026 · Intensive care medicine
Background Besides temperature management, there is currently no effective therapy to decrease the burden of post-cardiac arrest syndrome. The pleiotropic effects of vitamin C may improve clinical outcome. Purpose This trial investigated…
Arabia A, Muñoz P, Álvarez-Real S et al. · 2026 · Plant science : an international journal of experimental plant biology
Serotonin is a widely conserved signaling molecule essential for plant development and stress responses, but its role in fruit postharvest physiology remains largely unexplored. This study aimed to evaluate the effects of 100 μM exogenous…
Ko T, Sakai A, Nakano R et al. · 2026 · Digestive diseases and sciences
Background Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is a common complication, and its prevention remains challenging. Although aggressive infusion of lactated Ringer's solution (hereafter Lactated Ringer's)…
Freeman G, Rousseau A, Brunton M et al. · 2025 · Preprint
Abstract This study presents the findings on the use of narrative when communicating complex scientific uncertainties. A growing body of evidence in narrative cognition and communication has shown promise for the use of narrative in…
Roberts ET, Schmajuk G, Fitzpatrick J et al. · 2026 · Joint Commission journal on quality and patient safety
Background Metrics with acceptable reliability are necessary to ensure that quality measures reward performance. Low metric reliability may result from a lack of differences between reporting entities or low numbers of eligible patients.…
Pundi K, Frimodt-Møller EK, Soliman EZ et al. · 2025 · Open heart
Background Previous epidemiological studies demonstrated that premature atrial contractions (PACs) and premature ventricular contractions (PVCs) detected by single 12-lead ECGs can predict incident cardiovascular disease and death. The…
Bokan J, Schmid JQ, Middelberg C et al. · 2026 · Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie
Purpose Large overjet increases the risk of traumatic dental injury (TDI). This study, part of the Münster Long-Term Study (MLS), aimed to investigate long-term changes in overjet with or without orthodontic treatment and to evaluate…
Butala AD, Nanayakkara S, Johnston R et al. · 2026 · The American journal of cardiology
Stroke is a serious complication following transcatheter aortic valve implantation, associated with increased disability and mortality. Despite this, there is a lack of patient-level data examining stroke in contemporary, lower-risk…
Zhou Y, Dai C, Wu F et al. · 2026 · Pulmonology
Background Low-dose theophylline has anti-inflammatory effects, but its efficacy in mild to moderate COPD remains controversial. Research question Is low dose theophylline effective and safe in patients with mild to moderate COPD? Methods…
Geoffrion D, Mikhail D, Rizk M et al. · 2025 · Ocular immunology and inflammation
Authors reported an 18% rate of endophthalmitis in Boston type 1 keratoprosthesis (KPro) patients, higher than previously reported rates. Most cases occurred during the COVID-19 pandemic, likely due to reduced access to care. Bandage…
Pacini GS, Manfro AG, Schuchmann RA et al. · 2026 · Clinical kidney journal
Background Percutaneous kidney allograft biopsy is essential for evaluating graft dysfunction, but post-procedural bleeding remains the most frequent complication, particularly among recipients with impaired renal function. Desmopressin…
Stelmashook EV, Genrikhs EE, Alexandrova OP et al. · 2025 · Biomeditsinskaia khimiia
Copper ions (Cu2+) at concentrations of 25-50 μM stimulate lipopolysaccharide (LPS)-induced nitric oxide (NO) production in glial cell cultures derived from rat cerebral cortex and containing both astrocytes and microglia. Addition of a…
Hamaya R, Li S, Lau J et al. · 2026 · American journal of hypertension
Background Multivitamin-multimineral (MVM) supplements have been associated with lower blood pressure (BP) in several small trials. We investigated the effects of a MVM on incident hypertension and BP in a secondary analysis of the COcoa…
Li M, Liu L, Qin Y et al. · 2025 · Preprint
Abstract Purpose The relationship between moderate physical activity (MPA) and vigorous physical activity (VPA) concerning the risk of sarcopenia in adolescents remains unclear. We aimed to investigate the association between MPA, VPA, and…
Detelich J, Martin GS · 2025 · Annals of internal medicine
Clinical impact ratings Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Critical Care: [Formula: see text].
Dubrovsky L, Pushkarsky T, Brichacek B et al. · 2026 · Microorganisms
Trained immunity (TRIM) enhances innate immune responses through epigenetic and metabolic reprogramming but may become maladaptive, contributing to chronic inflammation. In people living with HIV (PLWH), maladaptive TRIM has been proposed…
Tamoto M, Kai S, Yoshida H et al. · 2026 · Journal of cardiothoracic and vascular anesthesia
Objectives To compare the real-world effectiveness of combined propofol and dexmedetomidine (PRODEX) sedation with propofol monotherapy on survival and postoperative delirium (POD) in a large nationwide cohort of patients undergoing…
Sielski W, Osęka T, Antolak A et al. · 2026 · Frontiers in endocrinology
Background Parathyroid preservation during total thyroidectomy with central neck dissection in papillary thyroid carcinoma remains challenging due to the glands' delicate vascular anatomy and risk of inadvertent devascularization or…
Palmier M, Ghorayeb G, Arhant G et al. · 2026 · Annals of vascular surgery
Background Supraceliac aortic cross-clamping can induce remote organ injury, particularly affecting the lungs through ischemia-reperfusion mechanisms. Pulmonary endothelial dysfunction plays a central role in acute lung injury, potentially…
García-García M, Mosqueda J, Escobar Cabrera JE et al. · 2025 · Toxicon
A recent clinical case involving a Poecilotheria regalis bite was treated with Mexican L. mactans antivenom (Aracmyn Plus, Silanes, Mexico), resulting in the improvement of some of the symptoms. This could be attributed to cross-reactivity…
Hooshiar MH · 2026 · The Journal of prosthetic dentistry
Statement of problem Artificial intelligence (AI) language models have been increasingly used for clinical decision-making in implant dentistry and for scholarly writing. Yet, their reliability, fabrication rates, and comparative…
Tsakmaki PV, Tasoulis S, Georgakopoulos SV et al. · 2025 · International journal of neural systems
This research looks at the use of long-short-term memory (LSTM) networks to predict psychosis, in patients within the schizophrenia spectrum, based on Heart Rate Variability (HRV) data acquired from wearable devices. Our primary objective…
Szabó D, Tóth A, Nagy CB et al. · 2025 · Orvosi hetilap
Introduction The glomus caroticum, located at the carotid bifurcation, contains chemoreceptors and is essential for the rapid physiological adaptation to changes in blood oxygen, carbon dioxide, and pH levels. Paragangliomas of the glomus…
Sanak F, Iselin K, Kaufmann C et al. · 2026 · Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Purpose To analyze the effect of fasting on volume, growth factor, and lipid concentration in eye drops derived from autologous serum (AS) and leukocyte-poor platelet-rich plasma (LP-PRP). To assess changes in protein and growth factor…
Hughes C, Myers MA, Tickell-Painter M et al. · 2026 · Clinical biochemistry
Introduction The climate crisis is a health crisis, and healthcare contributes to this via consumption of resources, the release of greenhouse gases, and the generation of waste. Pathology testing underpins most healthcare, and the vast…
Regev-Yochay G, Barda N, Shusterman Y et al. · 2026 · NEJM evidence
Background In 2024, Israel faced a major West Nile virus (WNV) disease outbreak. We aimed to evaluate the efficacy and safety of WNV-neutralizing plasma for hospitalized patients with WNV disease. Methods We conducted a randomized,…