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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21339 results · page 541 of 712

Failed Experiment ReportMedicine

Does Adherence Modify Low-Dose Aspirin Effects in Pregnancy? Post Hoc Analysis From a Multi-Centre Trial.

Mwenechanya M, Tembo AM, Chomba E et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology

Objective To evaluate if the effect of low-dose aspirin (LDA) commenced between 6 and 13 weeks of gestational age (GA) on preterm delivery (PTD) is modified by total exposure. Design Post hoc analysis of a randomized controlled trial.…

View details →DOI: 10.1111/1471-0528.70244
Negative / Null Result ReportMedicine

Crystalline Lens Shape During Accommodation in Children.

Pradhan A, Hughes RPJ, Woodman-Pieterse EC et al. · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Purpose To determine how accommodation affects lens shape in myopic and non-myopic children. Methods Participants included 76 non-myopic (spherical equivalent refraction (SER): 0.00 to +1.75 D) and 18 myopic children (SER = -3.50 to -0.75…

View details →DOI: 10.1007/s44402-026-00069-5
Negative / Null Result Report

Changes in species composition of sessile communities on subtidal rock walls in the southern Gulf of Maine during four decades of warming

McCollum BA, Byrnes JEK, Sebens KP · 2026 · Preprint

Climate change is driving species range shifts and population change in density and location globally. Two theories behind these shifts, that species in the ocean are largely tracking climate velocities, and the concept of long-term…

View details →DOI: 10.64898/2026.03.01.708879
Negative / Null Result ReportMedicine

Evolution of the rate, molecular spectrum, and fitness effects of mutation under minimal selection in Caenorhabditis elegans.

Saber S, Rifat MMI, Rahimi F et al. · 2026 · Genetics

The rate, molecular spectrum, and fitness effects of mutations vary at all levels of the biological hierarchy, from within individual genomes to among taxonomic domains. Understanding the evolutionary factors underpinning that variation is…

View details →DOI: 10.1093/genetics/iyag085
Negative / Null Result ReportOpen accessMedicine

Short communication: performance of beef cows fed Kernza intermediate wheatgrass straw mixed with alfalfa haylage.

Pizarro DM, Crooks A, Wattiaux MA et al. · 2026 · Translational animal science

Kernza intermediate wheatgrass ( Thinopyrum intermedium [Host] Barkworth & D.R. Dewey) is a novel dual-use perennial grain and forage crop with environmental and economic benefits for farmers. Perennial crop byproducts, such as Kernza…

View details →DOI: 10.1093/tas/txaf131
Negative / Null Result ReportMedicine

Attentional lapses and mind wandering during the maintenance of visual attention over varying durations.

Zanesco AP, Spivey DJ, Horn LF et al. · 2026 · Attention, perception & psychophysics

Sustaining the focus of our attention is effortful and cannot be maintained indefinitely. Our minds naturally wander, necessitating effortful control of attention to maintain focus and resist distraction from external events or internally…

View details →DOI: 10.3758/s13414-026-03229-4
Negative / Null Result ReportMedicine

How lability impacts the biological activity of polynuclear μ-oxo bridged ruthenium acetates.

Nazar PHO, Reis FCC, Barbosa HE et al. · 2026 · Journal of inorganic biochemistry

Complexes of the μ-oxo-bis(μ-acetate)diruthenium class exhibit ligand lability at the positions trans to the μ-oxo bridge. Lability is an important property for numerous drugs, such as cis-[Pt(NH 3 ) 2 Cl 2 ], given that its biological…

View details →DOI: 10.1016/j.jinorgbio.2026.113390
Negative / Null Result ReportMedicine

Position of Swing-Phase Foot Relative to Stance-Phase Foot at Minimum Toe Clearance: The Effect of Walking Speed.

Gomez NG, Gomez MA, MacWilliams BA et al. · 2026 · Journal of applied biomechanics

Minimum toe clearance (MTC) location relative to the stance-phase foot, as well as how this location changes with walking speed, helps in better understanding the circumstances when MTC is most relevant. This study helps define where MTC…

View details →DOI: 10.1123/jab.2025-0327
Negative / Null Result Report

Very short-term monitoring of Romosozumab longitudinal effects in a cohort of postmenopausal women by means of Radiofrequency Echographic Multi-Spectrometry (REMS) technology

Semeraro A, Chialà A, Carafa A et al. · 2026 · Preprint

Abstract Background Romosozumab/AMG785 (Evenity®, Amgen and UCB pharma, RMZ) is a sclerostin-neutralizing antibody that rapidly increases BMD, but very short-term monitoring in clinical routine is limited by specific issues of available…

View details →DOI: 10.21203/rs.3.rs-9116907/v1
Failed Experiment ReportMedicine

A Dual Cell-Line Molecular Platform to Assess Sub-Threshold Biocompatibility: Application to Processed Orthodontic Clears Aligners.

Barbaro K, Candida E, Biavati FS et al. · 2026 · Orthodontics & craniofacial research

Objective Traditional biocompatibility assessments primarily address cytotoxicity and bulk material properties but often overlook molecular responses that occur below toxicity thresholds. Detecting these subtle effects is crucial for…

View details →DOI: 10.1111/ocr.70119
Negative / Null Result ReportMedicine

Minimally invasive evacuation for intracerebral hemorrhage: current practice and perspectives after ENRICH.

Incontri D, Kellner CP, Polymeris A et al. · 2026 · Journal of neurointerventional surgery

Background The results of the Early Minimally Invasive Removal of Intracerebral Hemorrhage (ENRICH) trial have renewed interest in minimally invasive hematoma evacuation (MIE) as a treatment option for intracerebral hemorrhage (ICH).…

View details →DOI: 10.1136/jnis-2025-023804
Negative / Null Result ReportOpen accessMedicine

Postoperative Reduction in Postvoid Residual Urine Volume May Be Associated With Bladder Capacity Decrease Rather Than an Increase in Tidal Voided Urine Volume in Patients With Pelvic Organ Prolapse.

Kuroda K, Miyoshi H, Hamamoto K et al. · 2026 · The journal of obstetrics and gynaecology research

Aim More than half of patients with pelvic organ prolapse (POP) complain of lower urinary tract symptoms (LUTS), especially voiding difficulty. Surgical approaches such as laparoscopic sacrocolpopexy (LSC) and transvaginal mesh surgery…

View details →DOI: 10.1111/jog.70358
Negative / Null Result ReportMedicine

A wound dressing with copper and silver nanoparticles versus ionic silver hydrofibre dressing for the treatment of diabetic foot ulcers: a randomised clinical trial.

Roosimaa M, Ilumets H, Kaha T et al. · 2026 · Journal of wound care

Objective The objective of this trial was to compare the clinical performance and safety of a novel wound dressing containing silver and copper nanoparticles (Nanordica; Nanordica Medical OÜ, Estonia) (Ag/Cu) with the ionic silver-based…

View details →DOI: 10.12968/jowc.2025.0002
Negative / Null Result ReportMedicine

Loss of type III collagen has limited effect on tendon healing in young adult mice.

Tamburro MK, Carlson JA, Yen WK et al. · 2026 · Matrix biology : journal of the International Society for Matrix Biology

Tendon injuries account for considerable and escalating clinical burden. After injury, tendons heal poorly with persistent fibrovascular scar. Unlike healthy tendon which is type I collagen (COL1)-rich and highly-aligned, fibrovascular…

View details →DOI: 10.1016/j.matbio.2026.102012
Negative / Null Result ReportMedicine

Bacterial dysbiosis, cervicovaginal human papillomaviruses and inflammation persist in women living with HIV-1 after a year of antiretroviral treatment.

Lisco A, Borgognone A, Vanpouille C et al. · 2026 · The Journal of infectious diseases

Background The cervicovaginal microbiome may affect HIV-1 susceptibility and can in turn influence the prevalence and clinical course of HIV-1 and other sexually transmitted diseases. As the determinants, immunological correlates and…

View details →DOI: 10.1093/infdis/jiag211
Negative / Null Result ReportMedicine

Low-frequency transient-evoked otoacoustic emission characteristics as potential indicators of hearing improvement in acute Ménière's disease: an exploratory analysis.

Yin TK, Sengar N, Fang TY et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

PURPOSE: Fluctuating hearing loss in Ménière’s disease (MD) presents a key clinical challenge due to lack of reliable prognostic markers. The clinical value of transient-evoked otoacoustic emissions (TEOAEs) low-frequency components…

View details →DOI: 10.1007/s00405-026-10152-9
Negative / Null Result ReportMedicine

Congestive heart failure in patients with acute respiratory distress syndrome: a secondary analysis of large randomized controlled trials.

Gkirgkiris K, Charalampaki E, Margioula E et al. · 2026 · Anaesthesia, critical care & pain medicine

Background stive heart failure may coexist and aggravate the non-cardiogenic pulmonary edema of acute respiratory distress syndrome (ARDS). Yet, patients with congestive heart failure are likely under-represented in ARDS trials. We aimed…

View details →DOI: 10.1016/j.accpm.2026.101818
Negative / Null Result Report

Short-term changes in body composition and the development of sarcopenia following acute pancreatitis: An observational study

Bhattarai S, Baral S, Bhowmick M et al. · 2026 · Preprint

Abstract Objective: Malnutrition is a common complication of acute pancreatitis (AP), and it may adversely affect outcomes. This study aimed to evaluate short-term changes in body composition and the development of sarcopenia in patients…

View details →DOI: 10.21203/rs.3.rs-8842854/v1
Negative / Null Result ReportMedicine

Generating structure in soft solids: heat stable milk chocolate

Holian JA, Bolton MD, Wilson DI · 2025 · Current Research in Food Science

Addition of small amounts of glycerol to milk chocolate during the tempering stage can yield a product which exhibits enhanced mechanical strength and retards motion of the continuous phase (cocoa butter, a mixture of fats) of this dense…

Null DatasetMedicine

Integrating systemic toxicity and toxicokinetic data to inform the need for subchronic dog studies in human health safety assessments of agrochemicals.

Murphy L, Mingoia R, Bianchi E et al. · 2026 · Regulatory toxicology and pharmacology : RTP

Regulatory testing for agrochemicals has traditionally included a 90-day toxicity study in a non-rodent species, usually the dog. With growing emphasis on the 3Rs-replacement, reduction, and refinement of animal use-and increased adoption…

View details →DOI: 10.1016/j.yrtph.2026.106081
Negative / Null Result ReportMedicine

A Video Analysis Study Examining Neuromuscular Training Warm-Up Practices in Youth Soccer.

Lutz D, van den Berg C, Neill MG et al. · 2026 · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

Objectives To investigate time spent completing neuromuscular training (NMT) exercises in youth soccer team warm-up across a season considering sex, level of play, session type, and coach exposure and awareness of NMT. Design…

View details →DOI: 10.1097/jsm.0000000000001423
Negative / Null Result ReportMedicine

Heroines: Limited Effects of an Educational Program With Counter-Stereotypical Female Role Models on Gender Schemas in Middle Childhood.

Endendijk JJ · 2025 · Psychological reports

Interventions in which people are exposed to counter-stereotypical role models are often used for breaking gender stereotypes. Most gender role-model interventions focus on adolescents and emerging adults. Yet, middle childhood might be a…

View details →DOI: 10.1177/00332941251409153
Negative / Null Result ReportMedicine

Effect of Vitamin B12 Supplementation on Hematological and Athropometric Parameters in Children With Severe Acute Malnutrition, Aged 1 to 60 Months in Nutritional Rehabilitation Center (RCT).

Pathak BK, Maurya M, Mishra N et al. · 2026 · Clinical pediatrics

Microcytic hypochromic anemia is common in severe acute malnutrition (SAM) children, but macrocytic anemia (vitamin B12/folate deficiency) is not uncommon. Vitamin B12 deficiency leads to anemia and developmental slowing. We looked for the…

View details →DOI: 10.1177/00099228251415045