Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Stella Aslibekyan, Marguerite R. Irvin, Bertha A. Hidalgo et al. · 2017 · Journal of Nutrition & Intermediary Metabolism
Background: Trimethylamine-N-oxide (TMAO), an atherogenic metabolite species, has emerged as a possible new risk factor for cardiovascular disease. Animal studies have shown that circulating TMAO levels are regulated by genetic and environmental factors. However, large-scale human studies have failed to replicate the observed genetic associations, and epigenetic factors such as DNA methylation have never been examined in relation to TMAO levels. Methods and results: We used data from the family-based Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) to investigate the heritable determi
View details →DOI: 10.1016/j.jnim.2017.03.002 Negative / Null Result ReportOpen accessMicrobiology
Miao Jiang, Pekka Kolehmainen, Laura Kakkola et al. · 2021 · Microbiology Spectrum
ABSTRACT The primary target organ of coronavirus disease 2019 (COVID-19) infection is the respiratory tract. Currently, there is limited information on the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to infect and regulate innate immunity in human immune cells and lung epithelial cells. Here, we compared the ability of four Finnish isolates of SARS-CoV-2 from COVID-19 patients to replicate and induce interferons (IFNs) and other cytokines in different human cells. All isolates failed to replicate in dendritic cells, macrophages, monocytes, and lymphocytes, and no in
View details →DOI: 10.1128/spectrum.00774-21 Negative / Null Result ReportOpen accessBiology (General)
Sancar Aziz, Mankinen Richard W, Lee Daekee et al. · 2006 · Journal of Circadian Rhythms
Abstract Background Recent studies have implicated the epidermal growth factor receptor (EGFR) within the subparaventricular zone as being a major mediator of locomotor and masking behaviors in mice. The results were based on small cohorts of mice homozygous for the hypomorphic Egfr wa 2 allele on a mixed, genetically uncontrolled background, and on intraventricular infusion of exogenous EGFR ligands. Subsequenlty, a larger study using the same genetically mixed background failed to replicate the original findings. Since both previous approaches were susceptible to experimental artifacts relat
View details →DOI: 10.1186/1740-3391-4-15 Negative / Null Result ReportOpen accessSocial Sciences
Christine M. Smith, Paulina Dzik, Errin Fornicola · 2019 · Social Influence
Using the lens of Deindividuation Theory, Leon Mann explored the formation of baiting crowds in a small sample of public suicides/suicide attempts. Instead of attempting to prevent the suicide, baiting crowds encourage the victim to jump. Our aim was to replicate Mann's study with a larger more diverse sample of suicide attempts and a broadened theoretical lens (Frustration-Aggression). Using ProQuest, we identified 152 public suicide attempts reported in English language newspapers and failed to replicate Mann’s findings. Rather, baiting crowd formation was associated with variables that incr
View details →DOI: 10.1080/15534510.2019.1669488 Negative / Null Result ReportOpen accessScience
Veronica Boyce, Maya Mathur, Michael C. Frank · 2023 · Royal Society Open Science
Cumulative scientific progress requires empirical results that are robust enough to support theory construction and extension. Yet in psychology, some prominent findings have failed to replicate, and large-scale studies suggest replicability issues are widespread. The identification of predictors of replication success is limited by the difficulty of conducting large samples of independent replication experiments, however: most investigations reanalyse the same set of [Formula: see text]. We introduce a new dataset of 176 replications from students in a graduate-level methods course. Replicati
View details →DOI: 10.1098/rsos.231240 Negative / Null Result ReportOpen accessTechnology
Alessandro Guarnieri, Fabiana Laurenti, Salvatore Mazzei et al. · 2025 · Applied Sciences
Table tennis (TT) is a high-speed sport requiring integrated cognitive and motor skills. However, the existing assessment tools have failed to replicate its sport-specific demands. Therefore, this study aimed to evaluate the validity and reliability of the Reactive Table Tennis test designed to assess cognitive–motor performance in TT. Sixty athletes were recruited from TT, combat sports (CS), team sports (TS), and track and field (TF). Participants were required to react to 10 visual stimuli randomly emitted from three devices placed 3 m frontally by performing 1.5 m lateral or frontal displa
View details →DOI: 10.3390/app151810163 Negative / Null Result ReportOpen accessPsychology
Sophie Gillet, Cristina Anca Barbu, Martine Poncelet · 2020 · Frontiers in Psychology
Advantages in diverse aspects of cognitive functioning have been reported in early bilinguals (Bialystok, 2011) as well as in children frequenting an early bilingual immersion school program (Nicolay and Poncelet, 2015). However, during the last decade, some studies failed to replicate these advantages. Currently, the presence of cognitive benefits in children frequenting an immersion program remains debated. The lack of consistency between the studies could come from the fact that time spent by children within the immersion program is variable from one study to the other and that studies used
View details →DOI: 10.3389/fpsyg.2020.587574 Negative / Null Result ReportOpen accessPhysics
Javier De Miguel, Evanthia Hatziminaoglou, Frédéric Poidevin et al. · 2026 · Physics Letters B
We report a mm-wave search for axion dark matter from SGR 1745–2900, based on 4.8 h of ALMA observations. No candidate features are found between 133.99–135.78, 135.91–137.70, 145.99–147.78, and 147.99–149.78 GHz, corresponding to 0.55–0.62 meV. Interpreting this null result within a state-of-the-art stellar framework, we derive sensitivity to the axion–photon coupling at the level of gγ≳2×10−11 GeV−1 under a standard Navarro–Frenk–White profile; down to gγ≳2×10−13 GeV−1 upon accounting for a dense dark-matter spike around Sagittarius A*, probing the quantum chromodynamics axion parameter spac
View details →DOI: 10.1016/j.physletb.2026.140567 Negative / Null Result ReportOpen accessPolitical science (General)
Jeremy Ferwerda, Sascha Riaz · Political Science Research and Methods
Recent research suggests that local exposure to refugees does not increase support for far-right parties. We challenge this null result by drawing on granular data from Berlin in the wake of the Syrian refugee crisis. While prior work in the German context has generally assumed that refugee exposure is exogenous at the local level, we demonstrate that refugee housing was disproportionately concentrated in neighborhoods with young, non-citizen residents. To address this selection bias, we harmonize in-person and mail-in precinct boundaries across elections and implement a difference-in-differen
View details →DOI: 10.1017/psrm.2025.10061 Negative / Null Result ReportOpen accessAstrophysics
B. King, T. Heinzl, T. G. Blackburn · 2023 · European Physical Journal C: Particles and Fields
Abstract By combining an adiabatic approach based on a ‘locally monochromatic’ approximation with a local Hilbert transform, it is demonstrated how vacuum birefringence in the strong field regime can be calculated using a rate approach suitable for Monte Carlo simulation codes. Results for the flipping of the photon’s polarisation (helicity) are benchmarked with evaluation of exact expressions in a circularly (linearly) polarised plane wave of finite extent. For the circularly polarised case, the Heisenberg–Euler approach predicts a null result; an approximation similar to the ‘locally constan
View details →DOI: 10.1140/epjc/s10052-023-12074-w Negative / Null Result ReportMedicine
Mykolow G, Guyodo J, Cartigny MC · 2026 · Soins. Psychiatrie
The randomized SIPRéS study, conducted at Montpellier University Hospital, compares an outpatient nursing follow-up program aimed at preventing post-hospitalization suicide recurrence with standard care. Although it has no significant…
View details →DOI: 10.1016/j.spsy.2026.03.007 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Maximiliano A. Hawkes, Mauricio F. Farez, Ismael L. Calandri et al. · Arquivos de Neuro-Psiquiatria
ABSTRACT Lack of stroke awareness and slow activation of emergency medical services (EMS) are frequently reported reasons for delayed arrival to the hospital. We evaluated these variables in our population. Methods Review of hospital records and structured telephone interviews of 100 consecutive stroke patients. Forward stepwise logistic regression was used for the statistical analysis. Results Seventy patients (75%) arrived at the hospital 4.5 hours after stroke symptoms onset. The use of EMS did not improve arrival times. Most patients who recognized their symptoms did not use EMS (p < 0.02)
View details →DOI: 10.1590/0004-282x20160142 Negative / Null Result ReportMedicine
Suda Y, Ishida K, Shibanuma N et al. · 2026 · BMC musculoskeletal disorders
Background Previously, it was reported that preoperative medial tibial bone marrow lesions (BMLs) were not associated with worse postoperative outcomes after medial unicompartmental knee arthroplasty (UKA). However, the effect of BMLs in…
View details →DOI: 10.1186/s12891-026-10001-0 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Qirui Chen, Yan Liu, Yi Liu et al. · 2023 · Thoracic Cancer
Abstract Background To investigate the effect of continuous oral aspirin in perioperative period on bleeding in pneumonectomy. Methods A total of 170 patients who underwent pneumonectomy in our hospital from March 2021 to March 2022 were selected as the study objects. All patients took oral aspirin before surgery and did not take other antiplatelet agent or anticoagulants at the same time. The continuation group included 85 cases and continued to take aspirin 100 mg/day during the perioperative period, and the interruption group included 85 cases who stopped aspirin for 7 days before surgery a
View details →DOI: 10.1111/1759-7714.14846 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
C. Rust, D. Tonge, L. L. van denHeuvel et al. · 2025 · Brain and Behavior
ABSTRACT Introduction Recent studies have challenged the idea of sterile blood, suggesting the presence of a blood microbiome. The detection of microbial nucleic acids in blood is thought to reflect the status of distant microbial niches, including the gut. However, the origins and viability of these microbes remain debated. In this study, blood microbiome signatures in Parkinson's disease (PD), schizophrenia (SCZ), and posttraumatic stress disorder (PTSD) were evaluated by extracting RNA‐sequencing (RNA‐seq) reads that did not map to the human genome. Furthermore, we investigated the correlat
View details →DOI: 10.1002/brb3.70629 Negative / Null Result ReportOpen accessMining engineering. Metallurgy
Srija Balachandran, Kerstin Forsberg, Tom Lemaître et al. · 2021 · Metals
Selective leaching of Li from spent LIBs thermally pretreated by pyrolysis and incineration between 400 and 700 °C for 30, 60, and 90 min followed by water leaching at high temperature and high L/S ratio was examined. During the thermal pretreatment Li 2 CO 3 and LiF were leached. Along with Li salts, AlF 3 was also found to be leached with an efficiency not higher than 3.5%. The time of thermal pretreatment did not have a significant effect on Li leaching efficiency. The leaching efficiency of Li was higher with a higher L/S ratio. At a higher leaching temperature (80 °C), the leaching of Li
View details →DOI: 10.3390/met11081240 Negative / Null Result ReportMedicine
Fontaine E · 2025 · Current opinion in clinical nutrition and metabolic care
Purpose of review Many clinical trials have failed to demonstrate the superiority of one nutritional protocol over another. This raises questions about the assessment tools used. In particular, intention-to-treat data analysis can mask…
View details →DOI: 10.1097/mco.0000000000001145 Negative / Null Result ReportOpen accessMedicine
Shi-gui Yang, Bin Cao, Li-rong Liang et al. · 2012 · PLoS ONE
BACKGROUND: There is limited data on the clinical outcome of patients with pandemic H1N1 (pH1N1) pneumonia who received oseltamivir treatment, especially when the treatment was administered more than 48 hours after symptom onset. METHODS: During the pandemic in 2009, a cohort of pH1N1 influenza pneumonia was built in China, and their clinical information was collected systematically, and analyzed with Cox models. RESULTS: 920 adults and 541 children with pneumonia who didn't receive corticosteroids were analyzed. In-hospital mortality was higher in adults who did not receive antiviral therapy
View details →DOI: 10.1371/journal.pone.0029652 Negative / Null Result ReportOpen accessMicrobiology
Amanda Louise White, Gregory Jaye Bix · 2023 · Biomolecules
Therapeutic angiogenesis has long been considered a viable treatment for vasculature disruptions, including cerebral vasculature diseases. One widely-discussed treatment method to increase angiogenesis is vascular endothelial growth factor (VEGF) A. In animal models, treatment with VEGFA proved beneficial, resulting in increased angiogenesis, increased neuronal density, and improved outcome. However, VEGFA administration in clinical trials has thus far failed to replicate the promising results seen in animal models. The lack of beneficial effects in humans and the difficulty in medicinal trans
View details →DOI: 10.3390/biom13040702 Negative / Null Result ReportOpen accessMedicine
Emma T L Cheng, Mohammad Cheik-Hussein, Noelle Lin et al. · 2023 · PLoS ONE
Background Pregabalin is a drug used to treat neuropathic pain, and its use has increased substantially since 2007. Early trials found a strong treatment effect on pain for post-herpetic neuralgia and diabetic neuropathy. However more recent studies have failed to replicate these results. Methods This meta-epidemiological study aimed to assess change in the reported effectiveness of pregabalin in neuropathic pain trials over time, and if a change is present, determine any associated factors. Data sources We performed electronic searches for published trials in Medline, Embase and Cochrane Cent
View details →DOI: 10.1371/journal.pone.0280593 Negative / Null Result ReportOpen accessAstrophysics
Yuta Hamada, Masatoshi Yamada · 2017 · European Physical Journal C: Particles and Fields
Abstract The null result in the LHC may indicate that the standard model is not drastically modified up to very high scales, such as the GUT/string scale. Having this in the mind, we suggest a novel leptogenesis scenario realized in the false vacuum of the Higgs field. If the Higgs field develops a large vacuum expectation value in the early universe, a lepton number violating process is enhanced, which we use for baryogenesis. To demonstrate the scenario, several models are discussed. For example, we show that the observed baryon asymmetry is successfully generated in the standard model with
View details →DOI: 10.1140/epjc/s10052-017-5215-9 Negative / Null Result ReportOpen accessOptics. Light
Alex Midasala · 2024 · Results in Optics
A viable solution to detect the one-way speed of light anisotropy in linear motion is by using an Isosceles triangle-shaped design for the experimental setup, from which two light pulses from both ends of one of the triangle’s sides are sent to the same clock upon the detection of the incident and the reflected pulse, thereby evading the need for synchronization. The relativistic effects are taken into account in the timing measurements by incorporating the Lorentz transformation equations of length contraction and time dilation, which produces a non-null result for the time difference of the
View details →DOI: 10.1016/j.rio.2024.100710 Negative / Null Result ReportOpen accessScience
Milton Gering, Tayla Johnson, Colin Tredoux · 2023 · South African Journal of Science
The effect of stress on face identification is not yet clear, with recent experiments finding positive, negative and null results. Here we report the results of two experiments examining the effect of stress on eyewitness performance in line-up face recognition tasks. Both experiments use a stress manipulation and live mock crime paradigm to examine the relationship between stress at encoding and subsequent line-up performance. Experiment 1 replicated an experiment by Sauerland et al. (Behav Sci Law. 2016;34(4):580–594) which induced stress using the Maastricht Acute Stress Test. The replicati
View details →DOI: 10.17159/sajs.2023/12102 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Tom A. de Graaf, Tom A. de Graaf, Alexander T. Sack et al. · 2018 · Frontiers in Neuroscience
Experiments often challenge the null hypothesis that an intervention, for instance application of non-invasive brain stimulation (NIBS), has no effect on an outcome measure. In conventional statistics, a positive result rejects that hypothesis, but a null result is meaningless. Informally, however, researchers often do find null results meaningful to a greater or lesser extent. We present a model to guide interpretation of null results in NIBS research. Along a “gradient of surprise,” from Replication nulls through Exploration nulls to Hypothesized nulls, null results can be less or more surpr
View details →DOI: 10.3389/fnins.2018.00915 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
H. Tanji, H. Nagasawa, T. Hayashi et al. · 1996 · Behavioural Neurology
We studied the chronic effect of thyrotropin releasing hormone (TRH) in a patient with spinocerebellar degeneration by measuring cerebral metabolic rate for glucose (CMRG1c) using 2-[18F]fluoro-2-deoxy-D-glucose (18FDG) and positron emission tomography (PET). A 56-year-old female, who had suffered from progressive ataxia for 2 years, was treated by intravenous administration of 2 mg TRH for 3 weeks, and CMRG1c of the brain was measured before and after treatment. CMRG1c was markedly decreased in the cerebellum and there was no significant difference before and after the treatment, i.e. mean CM
View details →DOI: 10.3233/ben-1996-93-409 Negative / Null Result ReportOpen accessScience
NATALIA C. SILVA, KAREN M. LEÃO, JOÃO T. PÁDUA et al. · 2021 · Anais da Academia Brasileira de Ciências
Abstract To evaluate the addition of antioxidants in extenders on post-thaw bovine semen quality and in vitro embryo production efficiency. Six semen samples were collected from five Holstein bulls. In the experiment I, the samples were diluted with AndroMed® and Bovimix® and added antioxidants glutathione (1.5 and 2.5 mM) and melatonin (0.5 and 1.0 mM). In the experiment II, the best treatments obtained in experiment I were used for in vitro fecundation. Glutathione did not improve sperm viability. Melatonin had a negative effect on semen characteristics. Andromed® showed better results in sp
View details →DOI: 10.1590/0001-3765202120191229 Negative / Null Result ReportOpen accessMedicine
M.Ghasemi, Z. Hajheidari, M. Golpour · 2007 · Journal of Mazandaran University of Medical Sciences
AbstractPemphigus Erythematosus specially its localized form is a rare autoimmune blistering disease combining features of Pemphigus Foliaceus and Lupus Erythematosus. We reported a 60 years old woman with skin lesion which presented Erythemato squamo plaque with oozing in the right cheek. The chief compliant was burning and pruritus. Skin biopsy was obtained and discoid Lupus Erythemato was reported. She was prescribed with topical steroid but did not improve. All of the lab tests such as Anti DNA, ESR, RF, CRP, CH50, C3, C4, ANA were normal. The biopsy repeated and Pemphigus Erythematosus wa
Negative / Null Result ReportOpen accessAgriculture
Marjatta Uosukainen, Mauritz Vestberg · 1994 · Agricultural and Food Science
The importance of different rooting methods and the effects of arbuscular mycorrhizal (AMF) inoculation on the rooting rate, weaning survival and subsequent growth of microcuttings of Malus rootstock YP and the Finnish crab apple cultivars Hanna and Marjatta were studied in four experiments conducted at the Laukaa Research and Elite Plant Unit, Finland. Sucrose in the in vitro rooting medium gave the best support to weaning survival in comparision with glucose and fructose. Directly rooted microcuttings had a higher survival rate than in vitro rooted microcuttings. AMF inoculation did not impr
Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
Daniel A. Ermann, Victoria A. Vardell, Lindsey Fitzgerald et al. · 2026 · eJHaem
ABSTRACT Introduction B‐cell prolymphocytic leukemia (B‐PLL) is a rare, aggressive leukemic B‐cell malignancy historically associated with poor outcomes and recently reclassified in the WHO Fifth Edition but retained as a distinct entity in the ICC. Methods We analyzed 950 patients labeled as B‐PLL in the National Cancer Database (2004–2019), identified using ICD‐O‐3 morphology code 9833/3. Results Median age was 72 years, and 72% received systemic therapy at diagnosis. Median overall survival (OS) was poor (2.8 years) and did not improve over time. Patients initially managed with active surve
View details →DOI: 10.1002/jha2.70299 Negative / Null Result ReportOpen accessMedicine
Xavier Jannot, Alpha Oumar Diallo, Judicaelle Didierjean et al. · 2025 · European Journal of Case Reports in Internal Medicine
We report the case of a 75-year-old woman admitted to the emergency department for confusion, gait disturbances and mutism associated with an inflammatory syndrome occurring 3 weeks after acute carbon monoxide intoxication. The main hypothesis upon arrival was infectious meningoencephalitis, and the patient was put on acyclovir and antibiotics in meningeal doses. After a short stay in intensive care, the patient’s condition did not improve, and the revaluation of her case history and imaging studies led to the diagnosis of post-interval syndrome secondary to carbon monoxide intoxication after
View details →DOI: 10.12890/2025_005235 