A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19885 results in Negative / Null Result Report · page 535 of 663
López-Moraga A, De Ceuninck M, Van der Heyden Y et al. · 2025 · Preprint
Although avoidance can serve an adaptive function in daily life, excessive or persistent avoidance can form a debilitating symptom of anxiety-related disorders. The transition from adaptive to maladaptive avoidance remains poorly…
Maier LE, Vanden Berg ER, Simpson L et al. · 2026 · Physiological reports
This study examined how sex influences blood flow during exercise at altitude and relative contributions of adrenergic mechanisms. Thirteen participants (8 M/5F) were tested at low and high altitude (days 3-11). Participants performed…
Rikken RM, Yaqub M, Coomans EM et al. · 2025 · Alzheimer's research & therapy
Background Neuroinflammation plays a key role in Alzheimer's disease (AD) pathophysiology, but it is not clear how neuroinflammation contributes to disease progression. We aim to investigate the role of neuroinflammation on longitudinal…
Chamoux M, Rakobowchuk M, Gaston AF et al. · 2025 · Journal of sport and health science
Background Interest in clothing that reflects far infrared (FIR) radiation naturally emitted by the body during and after exercise has increased based on the assumption that this can increase arterial and venous blood flow. Indeed, in…
DiSilvestro AN, Wesolowski LT, Williams BD et al. · 2025 · Journal of equine veterinary science
In humans, intestinal microbiota are recognized to play key regulatory roles in inflammation. In horses, addition of dietary starch is known to alter the intestinal microbiome, but the relationship between diet and inflammation in horses…
Nelson TB, Stutts KJ, Nair SS et al. · 2025 · Journal of equine veterinary science
Repetitive concussive forces on joints during exercise may lead to increased inflammation and gait asymmetry. While used to reduce inflammation and symptoms related to joint disease, intra-articular corticosteroids have not been…
Liu Z, Chitoran I, Turco G · 2025 · Language and speech
The present study examines the perceptual salience of tonal speech errors compared with segmental errors (consonant and vowel). Tonal errors are observed less often than segmental errors. We thus hypothesize that tone errors are more…
Munroe S, O'Mara K, Kenyon R et al. · 2025 · Marine environmental research
Wet season freshwater flows deliver catchment nutrients (terrestrial and freshwater) to tropical estuaries that stimulate productivity and support consumers. However, the impact of flows on species in the adjacent nearshore is unclear. We…
Skau S, Karlsson J, Åsberg Johnels J et al. · 2026 · Frontiers in psychology
This study investigates whether visual aids increase or decrease cognitive load during arithmetic tasks in 9-year-old children, using behavioral measures and functional near-infrared spectroscopy (fNIRS). Previous research suggests mixed…
Goodwin I, Larsen KM, Sangchooli A et al. · 2025 · Preprint
Structural deficits in white matter fibre have been linked to psychosis. However, it remains unclear whether these aberrations are present in individuals that experience non-clinical psychotic-like experiences, predating illness onset.…
Moore TM, Walker K, Tung E et al. · 2025 · Journal of affective disorders
Depression and PTSD are prevalent psychiatric conditions that often co-occur and significantly impact quality of life. Ketamine has emerged as a promising rapid-acting treatment for both conditions, while traditional treatments like…
Sencan A, Dundar N, Gunel B et al. · 2025 · Medeniyet medical journal
Objective To compare mechanical power (MP) levels among flow-controlled ventilation (FCV), volume-controlled ventilation (VCV), and pressure-controlled volume-guaranteed ventilation (PCV-VG) during laparoscopic surgery and to test the…
Wesolowski LT, DiSilvestro AN, Williams BD et al. · 2025 · Journal of equine veterinary science
Disruption of circadian rhythms contributes to a myriad of health issues. Rhythms can be strengthened using artificial light but whether optimal light patterns support health parameters in horses is unknown. To test the hypothesis that…
Rau J, Joseph R, Weise L et al. · 2025 · Journal of neurotrauma
Previous studies have shown that administration of high doses of morphine in the acute phase of spinal cord injury (SCI) significantly undermines locomotor recovery and increases symptoms of chronic pain in a rat spinal contusion model.…
Pleau J, Tanguay N, Courtemanche Y et al. · 2025 · Maternal and child health journal
Objectives The objectives of this study are to describe cannabis use during pregnancy, identify associated factors, examine the associations between prenatal cannabis use and the cognitive, motor and language development of 2-year-old…
Quaedflieg CWEM, Ashton SM, Beckers T et al. · 2025 · Journal of behavior therapy and experimental psychiatry
Fear is a universal experience and fuels our response to cope with threat. Persistent fear, after the threat is no longer present, is a central symptom seen in a number of clinical conditions. Exposure therapy, the most common treatment to…
van Berlo E · 2024 · Preprint
In this study, we investigated how spatial, temporal, and effort dimensions collectively influence reward discounting across different age groups. Using a 3D simulated environment, participants aged 7 to 77 chose between a nearby tree with…
Lazar R, Fazlali F, Dourte M et al. · 2024 · Preprint
Whether light exposure during the day reduces non-visual light effects later in the evening has not been studied in adolescents. We investigate whether afternoon-early evening (AEE) light interventions (130 lx, 2500 lx, 4.5 hours, compared…
Vidal V, Pretel MR, Capurro L et al. · 2024 · Preprint
Abstract The application of neuroscience findings in educational settings offers promising opportunities to enhance academic performance. Adolescents, particularly affected by delayed sleep patterns due to early school start times, often…
Molloy M, McLennan E, Fox S et al. · 2024 · Preprint
The gut microbiome is an important component of host health and function and is influenced by internal and external factors such as host phylogeny, age, diet, and environment. Monitoring the gut microbiome has become an increasingly…
Hidding M, van der Stouwe E, Rosema BS et al. · 2025 · Psychological medicine
Background Low self-esteem is an important and potentially modifiable risk factor for the development and outcome of psychotic disorders. The factors involved in low self-esteem in psychotic disorders are not yet fully understood. The…
Pascual LMM, Vusirikala A, Nemenman IM et al. · 2024 · Preprint
The changes in neural activity that underlie motor skill acquisition during development are unknown. Juvenile songbirds learn their songs by an imitative process, and after learning adults use a millisecond-precise spike timing code to…
Tao Z, Fowler K, Trenga-Schein N et al. · 2025 · Journal of palliative medicine
Background: Historically, there have been perceptions that engagement with palliative care (PC) services may preclude potentially curative but high-risk operations. As such, we sought to investigate the relationship between specialty PC…
Harada S, Teraoka R, Kuroda N et al. · 2026 · Experimental brain research
This study investigated audiovisual integration in visual motion perception among both younger and older adults. Participants were asked to discriminate the visual motion direction of a random dot kinematogram in two experiments. The…
Chung YH, Williams L, Brady TF et al. · 2024 · Preprint
Across many studies, verbal labels have been shown to significantly affect perceptual and cognitive processes. Here we ask whether verbal labels can also improve visual working memory performance by making objects more recognizable. In a…
Moore TM, Walker K, Tung E et al. · 2024 · Preprint
Depression and PTSD are prevalent psychiatric conditions that often co-occur and significantly impact quality of life. Ketamine has emerged as a promising rapid-acting treatment for both conditions, while traditional treatments like…
Andreassen M, Larsen EO, Mølmen KS et al. · 2024 · Preprint
Abstract Introduction: A positive relationship between physical exercise training and cognitive function in humans is well-established. However, knowledge of how resistance exercise training affects patients with chronic obstructive…
Midilli B, Nurten A, Gürtekin B et al. · 2025 · Behavioural brain research
Antimuscarinic administration and food intake cause convulsions in mice and rats after fasting for 48 h or less. Increased M 1 and M 2 muscarinic receptor expression in brain regions during fasting, and reversal of changes by refeeding may…
Rothe J, Thiel T, Roessner V et al. · 2025 · BMC psychiatry
Background Autistic individuals often experience significant difficulties adapting to even slight changes in their routines. The COVID-19 pandemic created an uncertain situation marked by frequent changes in daily life, though some…
Honkanen J, Molnár K, Karhumaa T et al. · 2025 · Journal of endocrinological investigation
Purpose Thyroid surgery is performed for various indications, including goiter, suspected or diagnosed malignancy, and hyperthyroidism. While previous studies have focused on postoperative quality of life (QoL) improvements, limited data…