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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19885 results in Negative / Null Result Report · page 527 of 663

Negative / Null Result ReportOpen accessMedicine

Associations between fat distribution and obstructive sleep apnea severity among individuals with type 2 diabetes: an MRI-based study.

Ahtola K, Ulander M, Agholme J et al. · 2026 · Scientific reports

Obstructive Sleep Apnea (OSA) affects 1 billion people globally, with a male-to-female ratio of 2:1. While obesity is a major risk factor, sex differences in fat distribution may influence OSA risk. This study examined the relationship…

View details →DOI: 10.1038/s41598-026-58058-0
Negative / Null Result ReportMedicine

Knowledge, attitudes, and practices of occupational health and safety measures among nurses at Bolgatanga Regional Hospital of Ghana.

Ti-Enkawol Nachinab G, Alem JN, Coffie GB · 2026 · BMC health services research

Introduction Occupational health and safety are major concerns for health workers worldwide. Nurses working in resource-constrained areas are at higher risk of occupational hazards. The purpose of the study was to assess the knowledge,…

View details →DOI: 10.1186/s12913-026-14956-7
Negative / Null Result ReportMedicine

Proximal femoral bionic nail is associated with lower postoperative complication risk and better early functional recovery in older patients with intertrochanteric fractures: a retrospective cohort study.

Luo X, Ma N, Yang Y et al. · 2026 · BMC surgery

Objective Proximal femoral bionic nail (PFBN) represents a novel biomechanical design for the internal fixation of intertrochanteric fractures in older adults. However, comparative real-world evidence between PFBN and the conventional…

View details →DOI: 10.1186/s12893-026-03937-6
Negative / Null Result ReportMedicine

Role of Prenatal Ultrasound and Fetal MRI in Diagnosing Congenital Anomalies of the Kidney and Urinary Tract: A Comparative Diagnostic Study.

Thompson GE, Wesemann LB, Ogundipe EA et al. · 2026 · Fetal diagnosis and therapy

Prenatal diagnoses of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) are critical for counseling families about potential postnatal outcomes. While ultrasound (US) remains the gold standard for prenatal diagnosis of CAKUT,…

View details →DOI: 10.1159/000552627
Negative / Null Result ReportMedicine

Comparative efficacy of intraoperative wound irrigation with aqueous chlorhexidine versus normal saline to prevent surgical site infections: a double-blind randomized controlled trial.

Kultanaruangnonth M, Chatrung L, Tansawet A et al. · 2026 · World journal of emergency surgery : WJES

Background Surgical site infections (SSIs) remain a major concern after abdominal surgery, with incidences of 15-22%. Intraoperative wound irrigation (IOWI) before closure is routinely performed to reduce bacterial contamination, but the…

View details →DOI: 10.1186/s13017-026-00705-y
Negative / Null Result ReportMedicine

[Comparative analysis of the efficacy between endoscopic submucosal dissection combined with low-dose radiotherapy and direct surgical resection for T1a-MM/T1b-SM stage esophageal squamous cell carcinoma].

Geng YQ, Ding Y, Fu CG et al. · 2026 · Zhonghua yi xue za zhi

Objective: To compare the efficacy between endoscopic submucosal dissection (ESD) combined with low-dose radiotherapy and direct surgical resection in patients with T1a-MM/T1b-SM stage esophageal squamous cell carcinoma. Methods: A…

View details →DOI: 10.3760/cma.j.cn112137-20251024-02757
Negative / Null Result ReportOpen accessMedicine

Resuscitative endovascular occlusion of the aorta restores cerebral metabolic markers of ischaemia induced by haemorrhagic shock.

Bader SE, Magnuson A, Brorsson C et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society

Background Resuscitative endovascular balloon occlusion of the aorta (REBOA) is used as an adjunct in haemorrhagic shock (HS) to restore proximal perfusion. Its cerebral metabolic effects during haemorrhagic shock, particularly in the…

View details →DOI: 10.1007/s00068-026-03147-y
Negative / Null Result ReportOpen accessMedicine

Plaque removal efficacy of manual versus powered toothbrushes in patients with clear aligners: a single-brushing randomized controlled trial.

Arslan Çarpar K, Yılmaz T · 2026 · BMC oral health

BACKGROUND: This study aimed to compare the plaque removal efficacy of manual and powered toothbrushes around attachments in patients undergoing clear aligner therapy under standardized, single-brushing conditions. METHODS: This…

View details →DOI: 10.1186/s12903-026-08395-3
Negative / Null Result ReportMedicine

Comparison of the Impact of Different Dacryocystorhinostomy Techniques on Patient Quality of Life in Lacrimal Duct Obstruction.

Hakkani Öznay Ç, Findik H, Uzun F et al. · 2026 · Journal of clinical medicine

Objectives : To prospectively compare the outcomes of external dacryocystorhinostomy (EX-DCR), endonasal dacryocystorhinostomy (EN-DCR), and laser-assisted transcanalicular dacryocystorhinostomy (TL-DCR) in patients with nasolacrimal duct…

View details →DOI: 10.3390/jcm15124488
Negative / Null Result ReportOpen accessMedicine

Association of Driver Oncogenic Alterations with SUVmax, Preoperative Serum Calcium, and Smoking Status in Surgically Resected Non-Small-Cell Lung Cancer: A Retrospective Single-Center Study.

Korodimos N, Wojtyś ME, Kostopanagiotou K et al. · 2026 · Journal of clinical medicine

Background: Non-small-cell lung cancer (NSCLC) is driven by distinct oncogenic alterations with important therapeutic and prognostic implications. Noninvasive biomarkers that predict molecular status in surgically resectable disease may…

View details →DOI: 10.3390/jcm15114100
Negative / Null Result ReportOpen accessMedicine

Impact of oral health education program in children suffering from attention deficit hyperactivity disorder: A cross-sectional study.

Mahajan A, Haideri S, Kumar VVH et al. · 2026 · Journal of education and health promotion

Background The oral health is an integral part of general well-being in children suffering from attention deficit hyperactivity disorder (ADHD). The present study aimed to analyze the impact of oral health education program on children…

View details →DOI: 10.4103/jehp.jehp_1102_25
Negative / Null Result ReportOpen accessMedicine

Cinnarizine vs. topiramate for migraine prophylaxis in children: a randomized, double-blind, parallel-group clinical trial.

Abdi A, Abbasi E, Abazarlou A · 2026 · BMC neurology

Objectives Migraine is a common and disabling neurological disorder in children, often requiring preventive treatment. This study aimed to compare the efficacy and tolerability of cinnarizine and topiramate in the prophylaxis of migraine…

View details →DOI: 10.1186/s12883-026-04950-1
Negative / Null Result ReportMedicine

Delayed initiation of GnRH antagonist in PCOS patients undergoing IVF: a retrospective cohort study of premature ovulation and embryological outcomes.

Peker N, Yücetürk A, Tığlı E et al. · 2026 · Journal of ovarian research

Background We aimed to evaluate whether delayed initiation of gonadotropin hormone-releasing hormone (GnRH) antagonist treatment affects premature ovulation and the number of good-quality blastocysts. We retrospectively reviewed the…

View details →DOI: 10.1186/s13048-026-02161-3
Negative / Null Result ReportOpen accessMedicine

The Gut-Disc Axis: Mendelian Randomization Study Reveals Causal Effects of Gut Microbiota on Intervertebral Disc Degeneration Not Mediated by Systemic Inflammation.

Yan Z, Jiang Q, Lu Z et al. · 2026 · International journal of general medicine

Background Intervertebral disc degeneration (IVDD) is a major cause of low back pain. Observational studies suggest a link with gut microbiota (GM), possibly mediated by systemic inflammation, but causality remains unclear. Objective To…

View details →DOI: 10.2147/ijgm.s615488
Negative / Null Result ReportOpen accessMedicine

Emotional State and Pain Experience During Orthodontic Appliance Removal: Evaluation of Four Debonding Protocols.

Conde-Disla E, González-Olmo MJ, Olmos-Valverde M et al. · 2026 · Dentistry journal

Background: Pain during orthodontic debonding is a common clinical concern. Although previous studies have mainly focused on mechanical approaches to reduce discomfort, the influence of emotional characteristics of patients on pain…

View details →DOI: 10.3390/dj14060386
Negative / Null Result ReportOpen accessMedicine

Comparison of Clinical Outcomes of INBONE II Total Ankle Arthroplasty in Patients Under 50 and Over 65 Years: A 4-Year Retrospective Study.

Xu X, Zhang B, Wang X et al. · 2026 · Orthopaedic surgery

Objective There is no consensus on the age restriction for total ankle arthroplasty (TAA) patients. The aim of our study was to analyze the clinical function, radiographic outcomes, patient satisfaction, and complications between patients…

View details →DOI: 10.1111/os.70326
Negative / Null Result ReportOpen accessMedicine

Evaluation of Postoperative Pain and Apical Outcomes Following Three Distinct Obturation Techniques: A Randomized Controlled Trial.

Agarwal P, Kumar P, Chugh VK et al. · 2026 · Cureus

Background and aim Postoperative pain following root canal treatment (RCT) can be influenced by the obturation technique, as variations in apical sealing and material extrusion may affect periapical tissue response. The aim of this study…

View details →DOI: 10.7759/cureus.107873
Negative / Null Result ReportOpen accessMedicine

An examination into the safety and efficacy of Khapregesic®, a Khaya senegalensis preparation, on physical and psychological wellbeing in women experiencing menopausal symptoms: a randomised, double-blind, placebo-controlled trial.

Lopresti AL, Smith SJ, Ferdinands FR · 2026 · Frontiers in reproductive health

Background Khaya senegalensis is a tree species that has traditional use for the alleviation of menstrual and hormonal symptoms in women. Moreover, supplementation with a Khaya senegalensis preparation (Khapregesic®) was associated with…

View details →DOI: 10.3389/frph.2026.1824321
Negative / Null Result ReportOpen accessMedicine

Short-Term Gingival Microcirculatory Responses to Non-Invasive Physical Stimulation: Implications for Accelerated Orthodontic Research.

Atsuta S, Koizumi S, Takahashi SS et al. · 2026 · Dentistry journal

Background/Objectives : Acceleration of orthodontic tooth movement remains a major challenge in clinical orthodontics. Evidence suggests that increased local blood flow around the alveolar bone is key to bone remodeling and potentially…

View details →DOI: 10.3390/dj14060353
Negative / Null Result ReportOpen accessMedicine

Digestive Tract Cancer: A Retrospective Study of the Epidemiological Profile of Populations Exposed and Not Exposed to Uranium Contamination in North Kazakhstan (2014-2023).

Ilbekova K, Ibrayeva D, Saifulina E et al. · 2026 · Journal of clinical medicine

Background/Objectives : Cancer incidence and mortality are key epidemiological indicators for evaluating the long-term biological effects of chronic low-dose radiation exposure. The aim of this study was to assess the incidence, structure,…

View details →DOI: 10.3390/jcm15114330
Negative / Null Result Report

Pseudoperplexity Probes Memorization in Protein Language Models

Plaikner A, Ploner M, Sewald Z et al. · 2026 · Preprint

Protein Language Models (pLMs) have significantly advanced computational biology. Yet their scale and reliance on redundant training data raise a fundamental question: do pLMs generalize the statistical grammar of proteins, or do they…

View details →DOI: 10.64898/2026.06.08.730685
Negative / Null Result ReportMedicine

Impact of chemotherapy dose reduction during concurrent chemoradiotherapy on survival outcomes in limited-stage small-cell lung cancer.

Shan J, Yu J, Zhao L et al. · 2026 · BMC cancer

Background Dose reduction during concurrent chemoradiotherapy (cCRT) is frequently required in patients with limited-stage small-cell lung cancer (LS-SCLC) because of treatment-related toxicities or poor tolerance. However, the impact of…

View details →DOI: 10.1186/s12885-026-16150-8