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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 527 of 676

Negative / Null Result ReportOpen accessMedicine

The association between sleep quality and postoperative pain after half-impacted mandibular third molar extraction: comparison of three statistical models.

Hu L, Zhao C, Wang T et al. · 2026 · BMC oral health

BACKGROUND: Pain is the common complication after tooth extraction, while the reasons behind it still remains. Insomnia, another prevalent issue, negatively affects physical, mental health, and quality of life. The relations between…

View details →DOI: 10.1186/s12903-026-08214-9
Negative / Null Result ReportMedicine

Network based statistics associates increased connectivity to REM sleep disorder and hallucinations in early DLB.

Carini L, Sommariva S, Famà F et al. · 2026 · NPJ Parkinson's disease

Dementia with Lewy Bodies (DLB) is a heterogeneous disease characterized by four core clinical features: visual hallucinations, REM sleep behaviour disorder (RBD), cognitive fluctuations and Parkinsonism. We study the relationship between…

View details →DOI: 10.1038/s41531-026-01412-w
Negative / Null Result ReportOpen accessMedicine

Dose and clinical impact of delineation variability in brain metastases treated with stereotactic radiotherapy.

Perrot A, Dissaux B, Roux AC et al. · 2026 · Clinical and translational radiation oncology

Introduction Accurate delineation is critical for stereotactic radiotherapy (SRT) of brain metastases. We evaluated how inter-reader delineation variability affects target dose coverage and local relapse-free survival (LRFS). Methods and…

View details →DOI: 10.1016/j.ctro.2026.101177
Negative / Null Result ReportMedicine

Impact of Scarring Disorders and Surgical Techniques on the Development of Capsular Contracture in Breast Augmentation.

Hall JA, Huttinger AL, Potturi N et al. · 2026 · Annals of plastic surgery

Background Capsular contracture is a common complication following breast augmentation and a major indication for reoperation. While pocket contamination and aberrant inflammatory processes are suspected causes, a definitive etiology has…

View details →DOI: 10.1097/sap.0000000000004706
Negative / Null Result ReportMedicine

Outcomes of a penicillin allergy de-labelling implementation intervention in a UK hospital: a prospective, single centre, type 2 hybrid effectiveness-implementation study evaluated using mixed methods.

Powell N, Hearsey D, West R et al. · 2026 · Implementation science communications

Background Non-allergy specialist healthcare workers removing low-risk penicillin allergy (penA) records, enabling patients to receive penicillin antibiotics, is safe but not common practice. We developed a behavioural change…

View details →DOI: 10.1186/s43058-026-01008-8
Negative / Null Result Report

Migration gains but not fertility change. An impact evaluation of a municipal family policy in Trentino via Synthetic Difference-in-Differences

Gorodetskaya O, Marzani P, Podesta' F · 2026 · Preprint

Abstract This study started from the assumption that family policies, although primarily implemented to improve the well-being of family members in a given territory, can exercise indirect effects on certain demographic outcomes, such as…

View details →DOI: 10.21203/rs.3.rs-8116068/v1
Negative / Null Result ReportMedicine

Comparative Analysis of Proton and Carbon-Ion Therapy for Head and Neck Cancer: LET-Dependent α/β Ratios in EQD2 and NTCP.

Wakisaka Y, Miyasaka Y, Tominaga Y et al. · 2026 · Radiation research

Proton therapy (PT) and carbon-ion therapy (CIT) differ not only in their physical dose characteristics but also in their biological effects, attributable to variations in fractionation protocols and linear energy transfer (LET). These…

View details →DOI: 10.1667/rade-25-00183.1
Negative / Null Result ReportMedicine

Threat or opportunity? Challenge vs hindrance appraisals of generative AI and self-regulated teaching among pre-service EFL teachers: A COR perspective.

Liu F, Wu H · 2026 · Acta psychologica

This study investigates how Chinese pre-service teachers of English as a foreign language (EFL) develop self-regulated teaching competencies in the face of disruptions posed by generative artificial intelligence (GenAI) and structural…

View details →DOI: 10.1016/j.actpsy.2026.106747
Negative / Null Result ReportMedicine

Structural reconfiguration of gluten-starch matrices driven by yeast fermentation and its effects on quality of fermented dried noodles.

Zhang G, Zhao P, Zhu L et al. · 2026 · Food chemistry

This study aimed to systemically investigate the effects of yeast fermentation (0-2% yeast, flour basis; 0.5-2 h) on gluten and starch structures, and cooking and textural properties of fermented dried noodles (FDN). Yeast fermentation…

View details →DOI: 10.1016/j.foodchem.2026.149417
Negative / Null Result ReportMedicine

Dysregulation of HIF-1α-regulated and thromboinflammatory genes may contribute to thrombotic risk in patients with BCR::ABL1-negative myeloproliferative neoplasms.

Morath O, Wolfrum T, Crodel C et al. · 2026 · Journal of thrombosis and haemostasis : JTH

Background Hypoxia-inducible factor-1α (HIF-1α) regulates multiple pathways involved in metabolism, inflammation, and coagulation and may contribute to thrombotic complications in patients with BCR::ABL1-negative myeloproliferative…

View details →DOI: 10.1016/j.jtha.2026.04.013
Negative / Null Result ReportMedicine

Persistent Chemotherapy-Induced Alopecia: Updates in Diagnosis and Treatment Persistent Chemotherapy Induced Alopecia: An Updated Approach.

Garza-Rodríguez V, Imbernon-Moya A, Hermosa-Gelbard A et al. · 2026 · Actas dermo-sifiliograficas

Chemotherapy-induced alopecia (CIA) is characterized by absent or incomplete hair regrowth after completion of chemotherapy. Alopecia that persists beyond 6 months after completing chemotherapy is defined as persistent chemotherapy-induced…

View details →DOI: 10.1016/j.ad.2026.104660
Negative / Null Result ReportMedicine

Autopolyploidy exacerbates dominance masking under negative frequency-dependent selection: evidence from sporophytic self-incompatibility in Arabidopsis arenosa and Arabidopsis lyrata.

Vekemans X, Kolesnikova U, Vlček J et al. · 2026 · Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Polyploidy is widespread within flowering plants, with 35% of extant species being recent polyploids. Whether and how polyploidy modulates the action of natural selection remains debated, and the particular case of balancing selection has…

View details →DOI: 10.1098/rstb.2025.0182
Negative / Null Result ReportMedicine

Asthma in Active Military Aircrew: Long-term Health and Flight Performance.

Angel O, Rittblat M, Freund O et al. · 2026 · The Israel Medical Association journal : IMAJ

Background Asthma poses unique challenges in aviation medicine. While strict criteria typically dictate waiver approvals in military aviators with asthma, the Israeli Air Force (IAF) applies a more individualized approach. Still, evidence…

Negative / Null Result ReportMedicine

Examining the relationship between organizational health, happiness and employee performance: The case of hospital employees.

Kalender S, Kişi M, Özkan O · 2026 · Work (Reading, Mass.)

BackgroundHealthcare workers face challenges such as intense work tempo, irregular working hours and high patient expectations. This situation may affect the happiness and performance of employees, as well as the quality of health…

View details →DOI: 10.1177/10519815261449929
Negative / Null Result ReportMedicine

Effects of Ayres sensory integration therapy versus conservative treatment in autism spectrum disorder.

Inam R, Shah S, Ullah MS et al. · 2026 · JPMA. The Journal of the Pakistan Medical Association

The study was conducted to evaluate the effects of Ayres sensory integration therapy versus conservative treatment in autism spectrum disorder. In a prospective randomised controlled trial, we assessed pre- and post-intervention scores of…

View details →DOI: 10.47391/jpma.21549
Negative / Null Result ReportOpen accessMedicine

Footwear effect on the orthopedic injury profile in ankle and foot trauma caused by motorcycle accidents.

de Lima HLN, Soares MJNL, Macedo SMMPC et al. · 2026 · Acta ortopedica brasileira

Motorcycle accidents represent a significant cause of trauma in developing countries such as Brazil. Within the possible lesions, lower limb injuries are among the most prevalent, with ankle and foot injuries causing a high incidence of…

View details →DOI: 10.1590/1413-785220263403e292429
Negative / Null Result ReportOpen accessMedicine

Evaluating the Serum Levels of CD73 in Patients with Head and Neck Squamous Cell Carcinoma.

Zare R, Ranjbar MA, Ebrahimi A et al. · 2026 · Journal of dentistry (Shiraz, Iran)

Background The expression of CD73 antigen is associated with different prognoses in different carcinomas. However, few studies have assessed the level of this marker in squamous cell carcinoma (SCC) as the most common malignancy of the…

View details →DOI: 10.30476/dentjods.2025.102855.2403
Negative / Null Result ReportMedicine

[Survey on the establishment of smoking areas in city halls in National Association of Directors of Health Departments of Designated Cities, West Block Conference].

Hamada M, Miyamura K, Kasamatsu M et al. · 2026 · [Nihon koshu eisei zasshi] Japanese journal of public health

Objectives In Tokyo, preventing passive smoking progressed during the 32nd Olympic Games. However, smoking areas remain in many local city halls, and tobacco product companies donate smoking areas in front of stations and near parks. A…

View details →DOI: 10.11236/jph.25-131
Negative / Null Result ReportOpen accessMedicine

Relationships Among Cognitive Distortions, Forgiveness of Others, and Self-Forgiveness in Psychiatric Outpatients with Depressive Disorders: A Cross-Sectional Study.

Saklamaz S, Akpınar H · 2026 · Healthcare (Basel, Switzerland)

Background : Depression is associated with cognitive, emotional, and interpersonal difficulties that may influence forgiveness-related processes. This study aimed to examine the relationships among cognitive distortions, forgiveness of…

View details →DOI: 10.3390/healthcare14111478
Negative / Null Result ReportMedicine

An examination of core beliefs in generalized anxiety disorder.

Doust AE, Trenoska Basile V, McDonald S et al. · 2026 · The British journal of clinical psychology

Objective Generalised anxiety disorder (GAD) is characterised by uncontrollable worries. Cognitive behaviour therapy (CBT) is an effective treatment for GAD; however, manualised treatments rarely include interventions to target core…

View details →DOI: 10.1111/bjc.70047
Negative / Null Result ReportOpen accessMedicine

Effect of ambient light level on scanning accuracy and duration of intraoral scanners: a clinical evaluation.

Turgut M, Kaplan MH, Eroglu Z et al. · 2026 · BMC oral health

BACKGROUND: This study aimed to evaluate the effects of natural light conditions and ambient lighting levels changing at different times of the day on the accuracy and duration of digital scans made with intraoral scanners in a clinical…

View details →DOI: 10.1186/s12903-026-08075-2
Negative / Null Result ReportMedicine

Longitudinal Relationship Between Helicopter Parenting and Depressive Symptoms in Chinese Middle Adolescents: An Examination of Gender Differences.

Wu Y, Yuan Y, Wang Z · 2026 · Journal of adolescence

Introduction Although substantial evidence has established an association between helicopter parenting and depressive symptoms, the causal direction between the two remains unclear. In particular, the dynamic interplay between the…

View details →DOI: 10.1002/jad.70202
Negative / Null Result ReportMedicine

A 10-Year Retrospective Cohort Study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis at the Royal Brisbane and Women's Hospital.

Pagliaro T, Butler G, Godbolt A et al. · 2026 · The Australasian journal of dermatology

Background/objectives The Royal Brisbane & Women's Hospital (RBWH) in Queensland, Australia provides definitive care for all diagnosed adult patients with SJS/TEN within its catchment. In this retrospective cohort study, we identified all…

View details →DOI: 10.1111/ajd.70076