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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21339 results · page 521 of 712

Negative / Null Result ReportMedicine

Bidirectional risk of autoimmune disease and eosinophilic esophagitis in Sweden.

Pyne AL, Uchida AM, Carlson M et al. · 2026 · Esophagus : official journal of the Japan Esophageal Society

Background Eosinophilic esophagitis (EoE) shares several risk factors with other autoimmune diseases, but population-based studies in this field are limited. Methods Using the Swedish nationwide histopathology cohort Epidemiology…

View details →DOI: 10.1007/s10388-026-01212-4
Negative / Null Result ReportOpen accessMedicine

Association Between Individual Functional Movement Screen™ Tasks and Sports Injury Occurrence in University Basketball Players: A Prospective Cohort Study.

Kikumoto T, Kobayashi M, Hori S et al. · 2026 · International journal of sports physical therapy

The Functional Movement Screen™ (FMS™) is widely used to evaluate movement quality and attempt to identify athletes at risk of injury. However, the predictive value of the total score is inconsistent, and it remains unclear whether…

View details →DOI: 10.26603/001c.162342
Negative / Null Result ReportMedicine

Analysis of brainstem auditory evoked potential characteristics in patients with chronic disorders of consciousness: a cross-sectional study.

Wang D, Dong X, Feng T · 2026 · Scientific reports

Brainstem auditory evoked potentials (BAEP) provide an objective assessment of brainstem functional integrity. However, their characteristic profiles and clinical significance in patients with prolonged disorders of consciousness (pDOC)…

View details →DOI: 10.1038/s41598-026-50050-y
Negative / Null Result ReportMedicine

Acute kidney injury and early mortality in extremely preterm neonates born at 22-27 weeks gestation.

Resnick E, Travers C, Griffin R et al. · 2026 · Pediatric nephrology (Berlin, Germany)

Background Extremely low gestational age neonates (ELGANs) remain at high risk for morbidity and mortality. Acute kidney injury (AKI) is increasingly recognized, but data in the most immature neonates, especially those born at 22-23 weeks,…

View details →DOI: 10.1007/s00467-026-07214-9
Negative / Null Result ReportMedicine

Multidimensional Physiologic Adaptations to a 14-Day Detraining Period in Elite Powerlifters: Neuromuscular, Morphological, and Hormonal Responses.

Yılmaz U, Buzdağlı Y, Bilgin S et al. · 2026 · Journal of strength and conditioning research

Abstract Yılmaz, U, Buzdağlı, Y, Bilgin, S, Sepil, Y, Ozan, M, Bağaçlı, UH, Şıktar, E, Baygutalp, F, and Kılıç Baygutalp, N. Multidimensional physiologic adaptations to a 14-day detraining period in elite powerlifters: Neuromuscular,…

View details →DOI: 10.1519/jsc.0000000000005487
Negative / Null Result ReportOpen accessMedicine

Accessory renal arteries in prenatal hydronephrosis as a pathophysiologic contributor or incidental vascular finding: a prospective observational study.

Avcı EA, Bülbül GA, Tsakır B et al. · 2026 · BMC pregnancy and childbirth

Background Accessory renal arteries (ARAs) are recognized as an extrinsic cause of hydronephrosis in children; however, their relationship with prenatally detected hydronephrosis remains unclear. This prospective study aimed to evaluate…

View details →DOI: 10.1186/s12884-026-09169-z
Negative / Null Result ReportMedicine

Preoperative CT-Based Pelvic Sarcopenia and Subcutaneous Adiposity Are Associated with Anaemia and Operative Time in Acetabular Fracture Surgery: A Retrospective Cohort Study.

Okur KT, Abdulaliyev F, Yalçın S et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Acetabular fracture surgery is associated with substantial perioperative blood loss and prolonged operative time. Routine preoperative pelvic computed tomography (CT) carries information about body composition…

View details →DOI: 10.3390/medicina62061036
Negative / Null Result ReportMedicine

Addition of antibiotic-impregnated bone cement discs for reduction of periprosthetic infection in implant-based breast reconstruction.

Connor CH, Katsnelson JY, Paul BJ et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS

Periprosthetic infection is a frequent complication of implant-based breast reconstruction, often resulting in implant removal, additional surgery, and increased costs. This study evaluated whether polymethyl methacrylate (PMMA) discs…

View details →DOI: 10.1016/j.bjps.2026.05.007
Negative / Null Result ReportMedicine

Hook plate versus locking plate fixation in lateral clavicle fractures: operative efficiency and cumulative surgical burden in a propensity score-matched cohort study.

Schibler D, Hinkelmann MA, Frei F et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society

INTRODUCTION: Hook plates remain controversial in the management of lateral clavicle fractures despite their biomechanical advantages. Concerns include implant-related complications, subacromial irritation, and the need for routine implant…

View details →DOI: 10.1007/s00068-026-03201-9
Negative / Null Result ReportMedicine

Clinical Effects of Angulated Single-Implant Crowns With Different Retention Methods in the Aesthetic Area: A Retrospective Cohort Study With 12-24 Months Follow-Up.

Ding X, Wang Y, Choi M et al. · 2026 · Clinical oral implants research

Objective The objective of this study is to evaluate the clinical efficacy of angulated single-implant crowns using the hybrid retention versus pure screw-retained restorations in the aesthetic area. Materials and methods A retrospective…

View details →DOI: 10.1111/clr.70128
Negative / Null Result ReportMedicine

One-stage hepatectomy may be a safe and feasible alternative to ALPPS for hepatocellular carcinoma with liver fibrosis or cirrhosis and FLR/SLV ratio of 30% - 40% - A multicenter study.

Yang H, Gao J, Mo S et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Objective and background The optimal surgical strategy for patients with hepatocellular carcinoma (HCC) and liver fibrosis/cirrhosis presenting with a future liver remnant to standard liver volume (FLR/SLV) ratio of 30%-40% remains a…

View details →DOI: 10.1016/j.ejso.2026.111946
Negative / Null Result ReportOpen accessMedicine

Prognostic Utility of Albumin and the C-Reactive Protein-to-Albumin Ratio for Predicting Intravenous Steroid Response in Acute Severe Ulcerative Colitis.

Süleyman S, Emin P, Hüseyin A et al. · 2026 · Journal of clinical medicine

Background/Objectives: Acute severe ulcerative colitis (ASUC) is a high-risk condition associated with intense inflammation and a substantial risk of early colectomy. Intravenous steroids (IVS) remain the first-line therapy; however,…

View details →DOI: 10.3390/jcm15072730
Negative / Null Result ReportMedicine

Serum PTH, vitamin D, and calcium levels in patients with medication-related osteonecrosis of the jaw: A case-control study.

Leizaola-Cardesa IO, Gómez-Moreno G, Hernando J et al. · 2026 · Journal of stomatology, oral and maxillofacial surgery

Background To determine serum parathyroid hormone (PTH), vitamin D, and calcium levels in patients with medication related osteonecrosis of the jaw (MRONJ), compared with patients receiving similar medication but without MRONJ; also, to…

View details →DOI: 10.1016/j.jormas.2026.102806
Negative / Null Result ReportMedicine

The effect of empagliflozin on inflammation and oxidative stress in patients undergoing percutaneous coronary intervention, a randomized controlled trial.

Darroudi S, Ghazaee H, Babaei N et al. · 2026 · Scientific reports

Empagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has demonstrated cardioprotective effects beyond glycemic control. Empagliflozin has anti-inflammatory and antioxidant effects in long-term administration; however, current…

View details →DOI: 10.1038/s41598-026-44492-7
Negative / Null Result ReportMedicine

Fibroblast growth factor 23 is associated with cardiac disease severity in transthyretin amyloid cardiomyopathy.

Eslami M, Ermolaev N, Kronberger C et al. · 2026 · Scientific reports

Fibroblast growth factor 23 (FGF23), a bone-derived hormone, is emerging as a potential biomarker in cardiovascular disease. However, its role in transthyretin amyloid cardiomyopathy (ATTR-CM), a progressive infiltrative cardiomyopathy,…

View details →DOI: 10.1038/s41598-026-51879-z
Negative / Null Result ReportOpen accessMedicine

Real-World Comparison of PD-1 and PD-L1 Inhibitor Monotherapy in Metastatic Non-Small Cell Lung Cancer with High PD-L1 Expression.

Marković F, Bojić Z, Stjepanović M et al. · 2026 · Cancers

Background: Immune checkpoint inhibitor monotherapy targeting the PD-1/PD-L1 axis is a standard first-line treatment option for patients with metastatic non-small cell lung cancer (NSCLC) and high PD-L1 expression. However, comparative…

View details →DOI: 10.3390/cancers18071153
Negative / Null Result ReportMedicine

Risk of Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder in Children With Hypoxic-Ischemic Encephalopathy.

Chow SCW, Wang Y, Leung OLK et al. · 2026 · Journal of autism and developmental disorders

Purpose This study investigated the risk of ASD and ADHD in children who have survived hypoxic-ischemic encephalopathy (HIE), one of the common conditions during birth resulting in neonatal brain injury. Methods A population-based cohort…

View details →DOI: 10.1007/s10803-026-07347-8
Negative / Null Result ReportMedicine

Dapagliflozin is associated with a reduction in left atrial volume index in type 2 diabetes mellitus without established cardiovascular disease.

Çakır B, Polat F, Karataş MB et al. · 2026 · Acta diabetologica

Background Diabetic cardiomyopathy (DCM) frequently begins with diastolic dysfunction (DD), which leads to increased left ventricular filling pressures and subsequent left atrial enlargement, quantified by the left atrial volume index…

View details →DOI: 10.1007/s00592-026-02707-3
Negative / Null Result ReportMedicine

Effects of multistrain probiotics on metabolic biomarkers, inflammation, and antioxidant system in patients with type 2 diabetes mellitus: a prospective controlled trial in Türkiye.

Kilavuz A, Zorbozan O, Yildirim Simsir I et al. · 2026 · BMC nutrition

Background Recent evidence suggests that the gut microbiota plays a crucial role in the development and progression type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of multi-strain probiotic supplementation on…

View details →DOI: 10.1186/s40795-026-01354-9
Negative / Null Result ReportMedicine

Periprocedural Outcomes of Carotid Artery Stenting According to Embolic Protection Strategy: A 20-Year Single-Center Experience.

Tajima Y, Kubota M, Yoshida Y et al. · 2026 · World neurosurgery

Objective This study aimed to evaluate the impact of embolic protection strategies on outcomes in asymptomatic patients undergoing carotid artery stenting (CAS). Methods We retrospectively analyzed 312 consecutive asymptomatic patients…

View details →DOI: 10.1016/j.wneu.2026.124997
Negative / Null Result ReportMedicine

The weekend effect in internal medicine admissions: A limited impact at a large tertiary-care center.

Feigin L, Feigin E, Bronstein Y · 2026 · The American journal of medicine

Background This study was conducted to examine whether a "weekend effect" exists in internal medicine departments of a large tertiary medical center in Israel. Methods We conducted a retrospective cohort study of patients > 18 admitted to…

View details →DOI: 10.1016/j.amjmed.2026.03.005
Negative / Null Result ReportMedicine

NEUTROPHIL-TO-LYMPHOCYTE RATIO AS A POTENTIAL PREDICTOR OF IN-HOSPITAL MORTALITY AMONG ISCHEMIC STROKE PATIENTS: A PROSPECTIVE COHORT STUDY.

Urasheva Z, Khamidulla A, Yermagambetova A et al. · 2026 · Georgian medical news

Background Ischemic stroke is a major cause of death and disability worldwide. Recent evidence highlights the role of systemic inflammation in stroke pathophysiology and prognosis. The neutrophil-to-lymphocyte ratio (NLR), an accessible…

Negative / Null Result ReportMedicine

The Immediate Impact of Hemodialysis on Gait Metrics.

Cernes R, Hershkovich O, Tsehovsky T et al. · 2026 · The Israel Medical Association journal : IMAJ

Background Gait disturbances are common in patients undergoing hemodialysis and are associated with increased fall risk, mobility decline, and adverse health outcomes. Prior research suggests that hemodialysis may impact gait parameters…

Negative / Null Result ReportMedicine

Right Ventricular Functional Changes in Patients Undergoing Bone Marrow Transplantation: An Advanced Echocardiographic Analysis.

Ugurluoglu G, Ulutas Z, Yigit Y et al. · 2026 · Echocardiography (Mount Kisco, N.Y.)

Objective This study aimed to evaluate right ventricular (RV) function pre and post bone marrow transplantation (BMT) using transthoracic echocardiography (TTE), in order to detect subclinical or clinical RV dysfunction that may occur in…

View details →DOI: 10.1111/echo.70437
Negative / Null Result ReportMedicine

Relaxing Environment Lowers Anxiety During Chemodenervation: a Randomized Trial.

Franks E, Rigdon J, Kennelly M et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Importance Intradetrusor chemodenervation with onabotulinumtoxinA (BOTOX) injections, a common office-based procedure for overactive bladder (OAB), is associated with patient anxiety and discomfort. Aromatherapy and music have been shown…

View details →DOI: 10.1097/spv.0000000000001809
Negative / Null Result ReportOpen accessMedicine

Periodontal Status of Patients with Celiac Disease and Non-Celiac Gluten Sensitivity: A Literature Review.

Angelopoulou T, Bobetsis YA · 2026 · Journal of clinical medicine

Background/Objectives : Celiac disease (CD) is a chronic, immune-mediated enteropathy induced by dietary gluten exposure in genetically predisposed individuals. Along with non-celiac gluten sensitivity (NCGS), these disorders present with…

View details →DOI: 10.3390/jcm15082828
Negative / Null Result ReportMedicine

Endoscopic-Assisted Osteotomy with Absorbable Plate as Internal Attachment Point for External Spring Distraction Osteogenesis in the Treatment of Sagittal Synostosis in Infants.

Shen W, Cui J, Ji Y et al. · 2026 · World neurosurgery

Background Sagittal synostosis (SS) is the premature closure of sagittal sutures. To investigate the use of absorbable plates as internal attachment points for external spring (ES) traction in the treatment of sagittal craniosynostosis in…

View details →DOI: 10.1016/j.wneu.2026.124977
Negative / Null Result ReportOpen accessMedicine

Postoperative Outcomes After Rectal Cancer Surgery With or Without Primary Anastomosis: A Propensity Score-Weighted Study.

Sanda NA, Filip PV, Bobirca FT et al. · 2026 · Diagnostics (Basel, Switzerland)

Background: The role of primary anastomosis in rectal cancer surgery remains debated, particularly due to concerns regarding postoperative morbidity. Evidence from randomized trials is limited, and observational studies are frequently…

View details →DOI: 10.3390/diagnostics16101533