e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21733 results · page 522 of 725

Negative / Null Result ReportMedicine

Safety and Efficacy of Hypofractionated Preoperative Radiation Therapy in Retroperitoneal Sarcoma: A Comparative Study With Conventional Fractionation.

Baek JY, Yu JI, Lee KW et al. · 2026 · Practical radiation oncology

Purpose The role of preoperative radiation therapy (RT) in retroperitoneal sarcoma (RPS) remains controversial across histologic subtypes. Conventional fractionated RT (ConvRT) is the current standard, but hypofractionated RT (HypoRT) is…

View details →DOI: 10.1016/j.prro.2026.02.008
Negative / Null Result ReportMedicine

A randomized trial of iron- and zinc-biofortified pearl millet-based complementary feeding in children aged 12-18 months living in urban slums.

Mehta S, Huey SL, Ghugre PS et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)

Background and aims Biofortification of staple crops with higher concentrations of micronutrients via traditional breeding methods is a sustainable strategy and can possibly complement fortification and other interventions to target…

View details →DOI: 10.1016/j.clnu.2025.11.002
Negative / Null Result ReportMedicine

Effect of paternal resveratrol intake on mitochondria and telomere length in mouse embryos and offspring.

Teramoto N, Kobayashi N, Mitsui K et al. · 2026 · The Journal of reproduction and development

Advanced paternal age affects embryonic development and offspring phenotypes. We previously demonstrated that resveratrol prevents age-associated declines in the mitochondrial DNA copy number (mt-cn) and telomere length (TL) in embryos.…

View details →DOI: 10.1262/jrd.2026-038
Negative / Null Result ReportMedicine

Effect of white and red grape pomace on dry-cured sausages containing additives.

Carrapiso AI, Sánchez-Ordóñez M, Delgado-Adámez J et al. · 2026 · Food science and technology international = Ciencia y tecnologia de los alimentos internacional

The purpose of this study was to investigate for the first time the effect of the enrichment in white or red grape pomace stabilized by high hydrostatic pressure on the characteristics of dry-cured sausages containing additives (75 mg kg…

View details →DOI: 10.1177/10820132261461428
Negative / Null Result ReportMedicine

The Influence of Depth of Anesthesia on Motor Evoked Potentials Monitoring During Spinal Surgery in Youth: A Single-Center Prospective Study (SCOL Study).

Hudec J, Prokopova T, Hulkova M et al. · 2026 · Anesthesia and analgesia

Background Anesthetic agents or some pathophysiological conditions can affect transcranial motor evoked potentials (TcMEP) monitoring. However, the influence of depth of anesthesia on TcMEP reproducibility in youth remains unclear due to…

View details →DOI: 10.1213/ane.0000000000008158
Negative / Null Result ReportMedicine

Characterizing the V516M penicillin-binding protein 2 (PBP2) mutation causing zidebactam resistance in <i>Pseudomonas aeruginosa</i>.

Sastre-Femenia MÀ, Gomis-Font MA, Fernández-Muñoz A et al. · 2026 · Antimicrobial agents and chemotherapy

The triple action of the diazabicyclooctane (DBO) zidebactam (antibacterial activity [penicillin-binding protein 2 {PBP2} inhibitor], β-lactam enhancement [synergy with PBP3 inhibitors], and β-lactamase inhibition [classes A and C])…

View details →DOI: 10.1128/aac.00346-26
Negative / Null Result ReportMedicine

Brain Activity Changes During Bladder Filling in Women With Overactive Bladder After Percutaneous Tibial Neuromodulation.

Tam J, Wengler K, Yang J et al. · 2026 · Neurourology and urodynamics

Purpose Percutaneous tibial neuromodulation (PTNM) is a standard third line therapy for patients with overactive bladder (OAB). While the therapy has demonstrated efficacy, its exact mechanism of action is unclear. Functional neuroimaging…

View details →DOI: 10.1002/nau.70238
Negative / Null Result ReportMedicine

Redefining the role of carbon nanoparticles in colorectal cancer surgery: From lymph node yield to diagnostic paradox.

Lv Y, Wang F, Shen Y et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Background Accurate lymph node (LN) staging is critical in colorectal cancer (CRC). Carbon nanoparticles (CNPs), used as a tumor localization agent, incidentally stain LNs, creating uncertainty about their utility for improving staging and…

View details →DOI: 10.1016/j.ejso.2026.111782
Negative / Null Result ReportMedicine

The Opioid Safety Toolkit: An interactive prescription opioid safety toolkit to increase opioid safety literacy and behaviours among people prescribed opioids for pain-a randomised controlled trial.

Nielsen S, Fox F, Lam T et al. · 2026 · Addiction (Abingdon, England)

Background and aims Prescription opioid-related harm remains a significant public health concern. This study aimed to evaluate the efficacy of the Opioid Safety Toolkit, a co-designed, interactive online resource, in increasing naloxone…

View details →DOI: 10.1111/add.70412
Negative / Null Result ReportMedicine

Epidemiologic and Clinical Trends of Pediatric Human Rhinovirus Infections: A 2-year Comparative Analysis From a Single Center.

Yildirim Arslan S, Turanli E, Dinc F · 2026 · The Pediatric infectious disease journal

Background Human rhinovirus is one of the leading causes of pediatric respiratory infections worldwide. Its circulation patterns have shown notable changes in recent years. This study aimed to compare the epidemiologic, clinical and…

View details →DOI: 10.1097/inf.0000000000005171
Negative / Null Result ReportMedicine

Glucocorticoid dose at discharge and the risk of infectious complications and rehospitalization in renal diseases.

Yahata K, Seta K, Osaki K et al. · 2026 · Clinical and experimental nephrology

Background Glucocorticoids have diverse adverse effects, particularly infections that may be severe or opportunistic. Therefore, glucocorticoids are often initiated during hospitalization; however, the optimal glucocorticoid dose at…

View details →DOI: 10.1007/s10157-026-02868-z
Negative / Null Result ReportMedicine

Disinfection by-products in ballast water treated with oxidants - effects of treatment type, filter pre-treatment, test location, and salinity.

Sverdrup LE, Pollestad BM, Sigvaldsen I et al. · 2026 · Chemosphere

Ballast water is essential for ship stability during cargo operations and voyage, but its discharge can introduce invasive aquatic species to new environments. To mitigate this risk, ballast water is commonly treated with oxidants such as…

View details →DOI: 10.1016/j.chemosphere.2026.144899
Negative / Null Result ReportMedicine

Evaluation of a Clinical Practice Algorithm for Pediatric Complicated Pneumonia: A Retrospective, Observational, Single-Center Study.

Ostertag-Hill CA, Cummings OW, Renaud EJ · 2026 · Rhode Island medical journal (2013)

Objective The diagnostic evaluation, antibiotic treatment, and type and timing of surgical intervention for pediatric patients with complicated pneumonia is not standardized and may lead to increased length of stay, more radiation…

Negative / Null Result ReportMedicine

Comparison of Different Lighting Protocols on Female Cat Reproduction.

Lantermino A, Lapuente C, Blanco PG et al. · 2026 · Reproduction in domestic animals = Zuchthygiene

The aim of this study was to describe and compare the effect of different lighting protocols on sexual cyclicity and serum melatonin in domestic female cats. Additionally, anti-Müllerian hormone (AMH) concentrations and ultrasound or…

View details →DOI: 10.1111/rda.70177
Negative / Null Result ReportMedicine

Comparison of the somatic mutations in breast carcinomas in sporadic and BRCA1 carrier patients through targeted next generation sequencing.

Barron CR, Ramineni M, Finkelman BS et al. · 2026 · Human pathology

Objectives Women who carry a germline mutation in BRCA1 have an increased lifetime risk of developing breast cancer (BC). Prior Next-Generation Sequencing (NGS) studies on BCs from patients with germline BRCA1 mutations (gBRCA1) were…

View details →DOI: 10.1016/j.humpath.2026.106144
Failed Experiment ReportMedicine

Phillyrin improves pulmonary epithelial barrier dysfunction in LPS-induced acute lung injury through the RhoA/ROCK signaling pathway.

Wang Y, Wu Q, Li L et al. · 2026 · The Journal of pharmacy and pharmacology

Objective Forsythiae Fructus, the fruit of Forsythia suspensa (Thunb.) Vahl, is a traditional Chinese medicine widely used for clearing heat and detoxifying and for treating inflammatory conditions such as fever and respiratory infection.…

View details →DOI: 10.1093/jpp/rgaf115
Negative / Null Result ReportMedicine

Long-term increase in Mediterranean diet adherence combined with decrease in ultra-processed food consumption is associated with reduction in depressive symptoms: Results from the Moli-sani study.

Bracone F, Di Castelnuovo A, Costanzo S et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)

Background and aims Mediterranean diet (MD) has been associated with a reduced risk of depressive symptoms, while high intake of ultra-processed foods (UPFs) has been linked to poorer mental health. However, the long-term combined effects…

View details →DOI: 10.1016/j.clnu.2026.106627
Negative / Null Result ReportMedicine

Single-Leg Balance: Bias for the Non-Preferred Leg in Complex Tasks, But no Association with Footedness.

Marcori AJ, Gamberini MG, Silva Freitas MFD et al. · 2026 · Journal of motor behavior

In unchallenging single-leg balance (SLB) tasks, the lower limbs demonstrate symmetrical control and stability. Balance asymmetries between the legs are expected to increase with task demands, being evident in complex motor tasks. In this…

View details →DOI: 10.1080/00222895.2026.2637973
Negative / Null Result ReportMedicine

Radiation dose for common pediatric computed tomography examinations and evaluation of clinical image quality in pediatric chest CT scans.

Findikli I, Yalcin A, Kasapgil O et al. · 2026 · Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

The increasing use of computed tomography (CT) in pediatric patients has prompted researchers to investigate the radiation dose associated with pediatric CT scans. Studies optimizing image quality and minimizing radiation dose in pediatric…

View details →DOI: 10.1016/j.apradiso.2026.112569
Negative / Null Result ReportMedicine

Psychological Resilience Moderates Autonomous Motivation After Mild Traumatic Brain Injury: A Randomized Controlled Trial of a Remote Walking Program.

Chang YC, Tsai HF, Shi RS et al. · 2026 · The Journal of head trauma rehabilitation

Objective The aim of this study was to evaluate whether a 12-week remotely delivered walking program based on self-determination theory (SDT) improves autonomous exercise motivation in adults with mild traumatic brain injury (mTBI) versus…

View details →DOI: 10.1097/htr.0000000000001153
Negative / Null Result ReportMedicine

Increasing Buprenorphine and Naloxone Access in Texas Community Pharmacies Through an Academic Detailing Intervention.

Torrez SB, Evoy KE, Reveles KR et al. · 2026 · Substance use & addiction journal

Background Patients with opioid use disorder need prompt buprenorphine/naloxone (BUP/NX) and naloxone nasal spray (NNS) access from pharmacies, but audit studies report substantial availability deficits. No specific intervention has…

View details →DOI: 10.1177/29767342261422061
Negative / Null Result ReportMedicine

Marine heatwaves have no impact on fertilization, early development and sensitivity to metal toxicity in the sea urchin Paracentrotus lividus.

Gambardella C, Soro P, Miroglio R et al. · 2026 · Marine environmental research

Marine Heatwaves (MHWs) have become more severe and frequent worldwide under global warming. They are projected to intensify under different climate scenarios, with unknown consequences for the marine biota. In this study we assess the…

View details →DOI: 10.1016/j.marenvres.2026.107983
Negative / Null Result ReportMedicine

Nocturnal Sleep Breathing Patterns in Healthy Adolescents Residing at Very High Altitudes in Bolivia.

Patterson K, Rodríguez SU, Arancibia-Levit EN et al. · 2026 · Journal of sleep research

Data on sleep and respiratory patterns among adolescents residing at very high altitude (> 3500 m) remain scarce, and altitude-related physiological differences may influence these parameters. Studying adolescents at different very high…

View details →DOI: 10.1111/jsr.70326
Negative / Null Result ReportMedicine

Incidence of Gastrointestinal Adverse Events Following Left Hepatic Lobe Radiation Segmentectomy for the Treatment of Hepatocellular Carcinoma.

De La Garza-Ramos C, Silver C, Islam F et al. · 2026 · Cardiovascular and interventional radiology

Purpose Describe the incidence and severity of gastrointestinal tract-related adverse events (GIAE) following radiation segmentectomy (RS) for hepatocellular carcinoma (HCC) in the left hepatic lobe. Materials and methods A single-center…

View details →DOI: 10.1007/s00270-026-04376-9
Negative / Null Result ReportMedicine

Evaluation of squid shiokara products marketed in Japan using sensory tests, amino acid and organic acid profiles, and analysis of bacterial communities

Mizusawa N, Nishimura K, Ouchi D et al. · 2026 · Fish Sci

Shiokara is a traditional Japanese salted and fermented seafood product. The aim of this study was to compare various commercially available squid shiokara products in Japan by examining their NaCl content, free amino acid content (all…

Negative / Null Result ReportMedicine

Preliminary evaluation of a developmentally centred approach to optimise comfort in neonates following cardiac surgery.

Jones MB, Caprarola SD, Gordish H et al. · 2026 · Cardiology in the young

Introduction Children with CHD are at risk for neurodevelopmental impairments, and though these are often mild, some children face severe developmental challenges. Both unalleviated pain and exposure to opioids in the neonatal period have…

View details →DOI: 10.1017/s1047951125110949