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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21337 results · page 514 of 712

Negative / Null Result ReportMedicine

Risk of postpartum hemorrhage according to the ultrasound measurement of the lower uterine segment before delivery of women with a prior cesarean delivery: secondary exploratory research of the Lower Uterine Segment Trial.

Jeremy B, Rozenberg P · 2026 · American journal of obstetrics & gynecology MFM

Background Women with a previous cesarean delivery have a higher risk of postpartum hemorrhage, including after successful vaginal birth after cesarean. Mechanisms underlying this excess risk remain unclear and may involve impaired…

View details →DOI: 10.1016/j.ajogmf.2026.101973
Negative / Null Result ReportMedicine

Effects of shoulder rotation and table tilt maneuvers on the lumbar and thoracic paramedian acoustic window in older adults: a quasi-experimental study.

Nunes de Souza MV, Caetano AMM, Duarte NMC et al. · 2026 · Brazilian journal of anesthesiology (Elsevier)

Background Shoulder rotation and table tilt have been reported to increase the acoustic window for spinal ultrasonography. However, evidence in older adults remains scarce. This study evaluated their anatomical effects on lumbar (L3-L4)…

View details →DOI: 10.1016/j.bjane.2026.844769
Negative / Null Result ReportMedicine

Short-term outcomes following reconstruction or direct repair of the ulnar collateral ligament.

Sribhashyam S, Talaski GM, Yazdanpanah S et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Introduction Medial ulnar collateral ligament (UCL) injuries substantially impair athletic performance due to pain, instability, and diminished throwing capabilities. While UCL reconstruction is the primary surgical treatment due to its…

View details →DOI: 10.1016/j.jisako.2026.101153
Negative / Null Result ReportMedicine

Comparison of the illness perception between age-related macular degeneration and glaucoma patients living in a middle-income country.

Germano-Morrel CS, Tomishige KS, Macchione RM et al. · 2026 · Journal of health psychology

The aim of this cross-sectional study was to compare the cognitive and emotional representations of illness in patients with primary open angle glaucoma (POAG) and age-related macular degeneration (AMD) living in a developing country. All…

View details →DOI: 10.1177/13591053261430435
Negative / Null Result ReportMedicine

Bulimia Nervosa in Adolescents: Impact of Childhood and Adolescent Sexual Abuse History and the Mediating Role of Social Media.

Alvarez-Tueros EX, Alcántara-Obando MO, Caycho-Rodríguez T et al. · 2026 · The International journal of social psychiatry

The aim of this study was to analyze whether exposure to esthetic content aligned with beauty standards on social media mediates the relationship between a history of childhood/adolescent sexual abuse and bulimic symptomatology in…

View details →DOI: 10.1177/00207640261438840
Negative / Null Result ReportMedicine

Effect of Continuous Theta-Burst Stimulation on Postoperative Delirium in Older Patients Who Undergo Cardiac Surgery.

Zhang J, Zhu Y, Yin Y et al. · 2026 · Neuromodulation : journal of the International Neuromodulation Society

Objectives Postoperative delirium (POD) is a common complication after cardiac surgery in older patients, associated with higher mortality and prolonged stays. Continuous theta-burst stimulation (cTBS), a noninvasive neuromodulation…

View details →DOI: 10.1016/j.neurom.2026.03.003
Negative / Null Result ReportMedicine

Oxidative DNA Damage as an Integrative Marker of Redox Dysfunction Associated with Doxorubicin-Induced Cardiotoxicity in Pediatric Leukemia.

Gándara-Mireles JA, Reyes Espinoza EA, Loera-Castañeda V et al. · 2026 · Current issues in molecular biology

Doxorubicin (Dox) is a cornerstone in the treatment of pediatric acute lymphoblastic leukemia (ALL), but its use is limited by dose-dependent cardiotoxicity. Oxidative stress, arising from mitochondrial dysfunction, enzymatic generation of…

View details →DOI: 10.3390/cimb48060577
Negative / Null Result ReportOpen accessMedicine

Association between shift work and insomnia in nurses: a cross-sectional study using the Athens Insomnia Scale.

Szczupak M, Kobak J, Krupa-Nurcek S · 2026 · Frontiers in public health

Introduction Shift work is a recognized occupational risk factor for sleep disturbances, particularly among healthcare professionals. Nurses are especially vulnerable due to irregular work schedules, night duties, and the high physical and…

View details →DOI: 10.3389/fpubh.2026.1848179
Negative / Null Result ReportMedicine

Mid- to long-term outcomes of different treatment strategies for chronic carotid artery occlusion: a single-center cohort study.

Zhang Q, Yang T, Li L et al. · 2026 · Neurosurgical review

Chronic internal carotid artery occlusion (CICAO) is a significant cause of ischemic cerebrovascular events, with an annual stroke risk of up to 20%. Although the long-term efficacy of hybrid surgical revascularization (HSR) versus…

View details →DOI: 10.1007/s10143-026-04337-3
Negative / Null Result Report

Impact of sleep disorders and cardiovascular disease comorbidity on memory function decline in middle-aged and older adults: a 10-year trajectory analysis based on CHARLS

Peng M, Yuan Z, Lu Y et al. · 2026 · Preprint

Abstract Objective This study aims to investigate the effects of sleep disorders and cardiovascular disease comorbidity on the decade-long trajectory of memory function in middle-aged and elderly populations, thereby offering a scientific…

View details →DOI: 10.21203/rs.3.rs-9623506/v1
Negative / Null Result ReportMedicine

Predictive value of peak left atrial reservoir strain combined with left atrial appendage flow velocity for atrial fibrillation recurrence after pulsed field ablation.

Wang S, Miao J, Tang F et al. · 2026 · BMC cardiovascular disorders

Background The recurrence rate after ablation for atrial fibrillation (AF) remains high, and the predictive performance of existing predictors is limited. Left atrial dysfunction plays a key role in the occurrence and progression of AF.…

View details →DOI: 10.1186/s12872-026-06131-x
Negative / Null Result ReportMedicine

Lipid Profiles and LDL Subfractions in Patients With Symptomatic Peripheral Artery Disease: A Pilot Study.

Banerjee R, Kuruvilla C, Vega GL et al. · 2026 · The American journal of cardiology

While triglyceride-rich lipoproteins and small dense low-density lipoprotein (sdLDL) are associated with accelerated coronary atherosclerosis, their relationship with peripheral artery disease (PAD) is less clear. Fifty-five male subjects…

View details →DOI: 10.1016/j.amjcard.2026.04.040
Negative / Null Result ReportMedicine

Bidirectional risk of autoimmune disease and eosinophilic esophagitis in Sweden.

Pyne AL, Uchida AM, Carlson M et al. · 2026 · Esophagus : official journal of the Japan Esophageal Society

Background Eosinophilic esophagitis (EoE) shares several risk factors with other autoimmune diseases, but population-based studies in this field are limited. Methods Using the Swedish nationwide histopathology cohort Epidemiology…

View details →DOI: 10.1007/s10388-026-01212-4
Negative / Null Result ReportMedicine

Clinical Effects of Angulated Single-Implant Crowns With Different Retention Methods in the Aesthetic Area: A Retrospective Cohort Study With 12-24 Months Follow-Up.

Ding X, Wang Y, Choi M et al. · 2026 · Clinical oral implants research

Objective The objective of this study is to evaluate the clinical efficacy of angulated single-implant crowns using the hybrid retention versus pure screw-retained restorations in the aesthetic area. Materials and methods A retrospective…

View details →DOI: 10.1111/clr.70128
Negative / Null Result ReportMedicine

One-stage hepatectomy may be a safe and feasible alternative to ALPPS for hepatocellular carcinoma with liver fibrosis or cirrhosis and FLR/SLV ratio of 30% - 40% - A multicenter study.

Yang H, Gao J, Mo S et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Objective and background The optimal surgical strategy for patients with hepatocellular carcinoma (HCC) and liver fibrosis/cirrhosis presenting with a future liver remnant to standard liver volume (FLR/SLV) ratio of 30%-40% remains a…

View details →DOI: 10.1016/j.ejso.2026.111946
Negative / Null Result ReportOpen accessMedicine

Prognostic Utility of Albumin and the C-Reactive Protein-to-Albumin Ratio for Predicting Intravenous Steroid Response in Acute Severe Ulcerative Colitis.

Süleyman S, Emin P, Hüseyin A et al. · 2026 · Journal of clinical medicine

Background/Objectives: Acute severe ulcerative colitis (ASUC) is a high-risk condition associated with intense inflammation and a substantial risk of early colectomy. Intravenous steroids (IVS) remain the first-line therapy; however,…

View details →DOI: 10.3390/jcm15072730
Negative / Null Result ReportMedicine

Serum PTH, vitamin D, and calcium levels in patients with medication-related osteonecrosis of the jaw: A case-control study.

Leizaola-Cardesa IO, Gómez-Moreno G, Hernando J et al. · 2026 · Journal of stomatology, oral and maxillofacial surgery

Background To determine serum parathyroid hormone (PTH), vitamin D, and calcium levels in patients with medication related osteonecrosis of the jaw (MRONJ), compared with patients receiving similar medication but without MRONJ; also, to…

View details →DOI: 10.1016/j.jormas.2026.102806
Negative / Null Result ReportMedicine

The effect of empagliflozin on inflammation and oxidative stress in patients undergoing percutaneous coronary intervention, a randomized controlled trial.

Darroudi S, Ghazaee H, Babaei N et al. · 2026 · Scientific reports

Empagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has demonstrated cardioprotective effects beyond glycemic control. Empagliflozin has anti-inflammatory and antioxidant effects in long-term administration; however, current…

View details →DOI: 10.1038/s41598-026-44492-7
Negative / Null Result ReportMedicine

Fibroblast growth factor 23 is associated with cardiac disease severity in transthyretin amyloid cardiomyopathy.

Eslami M, Ermolaev N, Kronberger C et al. · 2026 · Scientific reports

Fibroblast growth factor 23 (FGF23), a bone-derived hormone, is emerging as a potential biomarker in cardiovascular disease. However, its role in transthyretin amyloid cardiomyopathy (ATTR-CM), a progressive infiltrative cardiomyopathy,…

View details →DOI: 10.1038/s41598-026-51879-z
Negative / Null Result ReportOpen accessMedicine

Real-World Comparison of PD-1 and PD-L1 Inhibitor Monotherapy in Metastatic Non-Small Cell Lung Cancer with High PD-L1 Expression.

Marković F, Bojić Z, Stjepanović M et al. · 2026 · Cancers

Background: Immune checkpoint inhibitor monotherapy targeting the PD-1/PD-L1 axis is a standard first-line treatment option for patients with metastatic non-small cell lung cancer (NSCLC) and high PD-L1 expression. However, comparative…

View details →DOI: 10.3390/cancers18071153
Negative / Null Result ReportMedicine

Risk of Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder in Children With Hypoxic-Ischemic Encephalopathy.

Chow SCW, Wang Y, Leung OLK et al. · 2026 · Journal of autism and developmental disorders

Purpose This study investigated the risk of ASD and ADHD in children who have survived hypoxic-ischemic encephalopathy (HIE), one of the common conditions during birth resulting in neonatal brain injury. Methods A population-based cohort…

View details →DOI: 10.1007/s10803-026-07347-8
Negative / Null Result ReportMedicine

Dapagliflozin is associated with a reduction in left atrial volume index in type 2 diabetes mellitus without established cardiovascular disease.

Çakır B, Polat F, Karataş MB et al. · 2026 · Acta diabetologica

Background Diabetic cardiomyopathy (DCM) frequently begins with diastolic dysfunction (DD), which leads to increased left ventricular filling pressures and subsequent left atrial enlargement, quantified by the left atrial volume index…

View details →DOI: 10.1007/s00592-026-02707-3
Negative / Null Result ReportMedicine

Role of Tumor Volume and Prolactin Ratios in Differentiating Prolactinomas and Predicting Response to Cabergoline.

García-Sáenz MR, Castro-Murillo JI, Mercado M et al. · 2026 · Archives of medical research

Introduction Predicting resistance to cabergoline in prolactinomas remains a challenge. While prolactin (PRL)-based ratios help differentiate prolactinomas from non-functioning pituitary adenomas (NFPAs), their role in forecasting…

View details →DOI: 10.1016/j.arcmed.2026.103427
Negative / Null Result ReportMedicine

Clinical outcomes and prognostic factors in hematologic malignancy patients with probable CMV pneumonia.

Aydın Güçlü Ö, Demirdöğen E, Hunutlu FÇ et al. · 2026 · BMC infectious diseases

Background Cytomegalovirus (CMV) infection is an important cause of morbidity and mortality among immunocompromised patients, particularly those with hematologic malignancies. The present study aims to evaluate the clinical features,…

View details →DOI: 10.1186/s12879-026-13708-6
Negative / Null Result ReportMedicine

The Association Between Neonatal Jaundice and Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder: Findings From the Millennium Cohort Study.

Lee A, Higgins S, O'Driscoll D et al. · 2026 · Journal of autism and developmental disorders

OBJECTIVE: To examine the association between neonatal jaundice requiring hospital treatment and autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in offspring by age 14 years. METHODS: We used data from…

View details →DOI: 10.1007/s10803-026-07317-0
Negative / Null Result ReportMedicine

A study comparing the efficacy of R-CHOP and R-DA-EPOCH regimens in young, high-risk treatment-naïve diffuse large B-cell lymphoma patients: a multicenter retrospective analysis.

Lan H, Ding Y, Liu M · 2026 · American journal of cancer research

Background Patients with high-risk diffuse large B-cell lymphoma (DLBCL) have poor prognoses, and the comparative efficacy between R-CHOP and R-DA-EPOCH regimens remains controversial. Objective To compare the efficacy and safety of R-CHOP…

View details →DOI: 10.62347/rivm5316