Failed Experiment Report
Henriksen K, Jørgensen A, Kaur S et al. · 2024 · Preprint
Immune-mediated beta-cell destruction and lack of alpha-cell responsiveness to hypoglycaemia are hallmarks of type 1 diabetes pathology. The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) may hold therapeutic potential…
View details →DOI: 10.1101/2024.06.17.599254 Failed Experiment ReportMedicine
Pavicich MA, Maldonado ML, Nguyen TN et al. · 2025 · International journal of food microbiology
Apple fruit is widely consumed worldwide, but fungal contamination in the postharvest stage presents a significant food safety concern. This study evaluates the production and accumulation of Alternaria mycotoxins, including alternariol…
View details →DOI: 10.1016/j.ijfoodmicro.2025.111272 Negative / Null Result ReportOpen accessMedicine
Cifelli A, Butt Z, Cifelli E et al. · 2026 · Case reports in neurological medicine
We present the case of a lady in her early 20s who developed over a few weeks progressive appendicular and limb ataxia and dysarthria. She was found to have a high titer of voltage-gated calcium channel antibodies (VGCCAs) and was started…
View details →DOI: 10.1155/crnm/5563623 Negative / Null Result ReportMedicine
Moran MC, Tammone Santos A, Dominguez P et al. · 2025 · Veterinary immunology and immunopathology
Brucella ovis (B. ovis) is the etiological agent of ram-contagious epididymitis, the leading cause of reproductive disorders in flocks worldwide. Although the attenuated B. melitensis Rev.1 strain gives heterologous protection against this…
View details →DOI: 10.1016/j.vetimm.2025.110997 Negative / Null Result ReportOpen accessMedicine
Seco-Cervera M, Gisbert-Ferrándiz L, Macias-Ceja DC et al. · 2025 · PloS one
Epigenetics has emerged as a modulator of inflammation-related diseases and changes in miRNA expression have been associated with regional location, inflamed mucosa and disease activity in Crohn´s disease (CD). We analyse here the…
View details →DOI: 10.1371/journal.pone.0329685 Negative / Null Result ReportOpen accessMedicine
Casadevall A · 2025 · The Journal of clinical investigation
Invasive fungal infections carry high morbidity and mortality, but there are no fungal vaccines. In this issue of the JCI, Okaa et al. report that endonuclease 2 (Eng2), an antigen shared by the Blastomyces, Histoplasma, and Coccidioides…
View details →DOI: 10.1172/jci199451 Negative / Null Result ReportOpen accessMedicine
Cao L, Hu J, Mao X et al. · 2026 · Frontiers in oncology
Background Malignant phyllodes tumors (MPTs) of the breast are rare fibroepithelial neoplasms characterized by aggressive clinical behavior and limited evidence guiding systemic therapy in the metastatic setting. Immune checkpoint…
View details →DOI: 10.3389/fonc.2026.1778276 Negative / Null Result ReportOpen accessMedicine
Castro LA, Chen DE, O'Scannlain A et al. · 2026 · Journal of the mechanical behavior of biomedical materials
Elastic fibers are critical for proper mechanical function of large arteries such as the aorta. Fragmentation, degradation, or reduced amounts of elastic fibers are associated with aortic diseases such as stiffening-induced hypertension…
View details →DOI: 10.1016/j.jmbbm.2026.107340 Negative / Null Result ReportMedicine
Fage C, Loison S, Zwygart AC et al. · 2025 · Antiviral research
Influenza viruses pose a significant threat due to annual epidemics and pandemic potential. Resistance to current antivirals underscores the need for new drugs and strategies to prevent its emergence. We previously developed two novel…
View details →DOI: 10.1016/j.antiviral.2025.106174 Negative / Null Result ReportOpen accessMedicine
Jacob A, Mahmoud A, Eldweik L et al. · 2025 · BMJ neurology open
Background Neuromyelitis optica spectrum disorder (NMOSD) is a rare relapsing autoimmune disease of the central nervous system (CNS). Management during pregnancy is challenging due to limited safety data for disease-modifying therapies.…
View details →DOI: 10.1136/bmjno-2025-001286 Negative / Null Result ReportOpen accessMedicine
Tekin-Taş Z, Özger HS, Sultanova F et al. · 2025 · Infectious diseases & clinical microbiology
Objective Real-time multiplex polymerase chain reaction (PCR) test increases the detection of viral respiratory tract infections. This study aimed to evaluate the effect of real-time multiplex PCR on antibiotic use in viral respiratory…
View details →DOI: 10.36519/idcm.2025.729 Negative / Null Result ReportMedicine
Cajado AG, Lopes MH, Rangel GFP et al. · 2025 · European journal of pharmacology
Irinotecan-based anticancer therapy induces intestinal mucositis, increasing the risk of sepsis and patient death. The phosphoinositide 3-kinases (PI3K) are involved in cancer and inflammatory diseases, but their role in intestinal…
View details →DOI: 10.1016/j.ejphar.2025.178165 Negative / Null Result ReportOpen accessMedicine
Etemadi R, Mansouri A, Salehidoost R et al. · 2025 · International journal of endocrinology
Objective Hungry bone syndrome (HBS), marked by severe and persistent hypocalcemia, frequently occurs after parathyroidectomy for primary hyperparathyroidism (PHPT). Despite its prevalence, there is limited research on this complication.…
View details →DOI: 10.1155/ije/8285521 Negative / Null Result ReportMedicine
Mütze U, Stengel J, Gleich F et al. · 2025 · Pediatrics
Objective Although newborn screening (NBS) programs were expanded with the implementation of tandem mass spectrometry in the late 1990s, the impact on long-term clinical and cognitive outcomes of adolescents and young adults with inherited…
View details →DOI: 10.1542/peds.2024-068293 Negative / Null Result ReportMedicine
Watanabe S, Furuya N, Nakamura A et al. · 2024 · European journal of cancer (Oxford, England : 1990)
Introduction Treatment options for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) after EGFR-tyrosine kinase inhibitor (TKI) treatment failure are limited. An exploratory analysis of 26…
View details →DOI: 10.1016/j.ejca.2023.113469 Negative / Null Result ReportMedicine
Boess FG, Scelsi MA, Grimmer T et al. · 2024 · The journal of prevention of Alzheimer's disease
Background Monoclonal antibodies that target amyloid-beta and remove amyloid plaques can slow cognitive and functional decline in early Alzheimer's disease. Gantenerumab is a subcutaneously administered fully-human anti-amyloid-beta…
View details →DOI: 10.14283/jpad.2024.60 Negative / Null Result ReportMedicine
Del Rivero J, Donahue RN, Marte JL et al. · 2026 · The oncologist
Background Medullary thyroid cancer (MTC) accounts for approximately 4% of thyroid carcinomas. Patients with unresectable, metastatic disease are candidates for approved agent-targeted therapies such as vandetanib, cabozantinib, or…
View details →DOI: 10.1093/oncolo/oyaf429 Negative / Null Result ReportOpen accessMedicine
Hanna GJ, Scarfo N, Shin KY et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Glycogen synthase kinase 3β (GSK-3β) is a known therapeutic target in cancer. Aberrant nuclear GSK-3β (nGSK-3β) expression has been shown in some salivary gland cancers. Elraglusib is a small-molecule GSK-3β inhibitor with…
View details →DOI: 10.1158/1078-0432.ccr-25-2731 Negative / Null Result ReportMedicine
Finch L, Andres S, Iasonos A et al. · 2025 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Objective We sought to determine the safety and efficacy of the oral progesterone antagonist onapristone in combination with anastrozole in patients with recurrent progesterone receptor-positive adult-type granulosa cell tumor of the…
View details →DOI: 10.1016/j.ijgc.2024.100005 Negative / Null Result ReportOpen accessMedicine
Kim EH, Carr WW, Assa'ad AH et al. · 2025 · The journal of allergy and clinical immunology. Global
Background Oral immunotherapy is an established approach to desensitize the immune system in the context of allergic disease; however, the only currently approved product is for peanut allergy. ADP101 is a novel, pharmaceutical-grade,…
View details →DOI: 10.1016/j.jacig.2024.100382 Negative / Null Result ReportMedicine
Ozer BH, Cohen AL, Colman H et al. · 2026 · Neuro-oncology advances
Background Glioblastoma (GBM) has limited effective salvage therapy options. The combination of the Type 1B topoisomerase/HIF1α inhibitor topotecan and the tyrosine kinase inhibitor pazopanib has shown promise in solid tumors and may be…
View details →DOI: 10.1093/noajnl/vdaf261 Negative / Null Result ReportOpen accessMedicine
Roberts G, Just J, Nolte H et al. · 2025 · Allergy
Background In children, house dust mite (HDM) sensitisation is a contributing factor for developing allergic asthma. HDM allergen immunotherapy has demonstrated efficacy and safety in adults with allergic asthma; however, evidence for its…
View details →DOI: 10.1111/all.70073 Negative / Null Result ReportMedicine
Delibasi IB, Gumusburun N, Bulut S et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)
Citalopram is a selective serotonin reuptake inhibitor (SSRI) and has been associated with reproductive dysfunction in women. In this study, the effects of citalopram on reproductive health in female rats were investigated. Albino Wistar…
View details →DOI: 10.1016/j.reprotox.2025.108859 Negative / Null Result ReportOpen accessMedicine
Lodefalk M, Nilsson O · 2025 · Hormone research in paediatrics
Introduction Vitamin D-dependent rickets type 2A (VDDR2A) is a rare, autosomal recessive disorder caused by pathogenic variants of the VDR gene encoding the vitamin D receptor. It has been proposed to be a form of parathyroid hormone…
View details →DOI: 10.1159/000546444 Failed Experiment ReportOpen accessMedicine
Konold T, Spiropoulos J, Bellerby P et al. · 2025 · BMC research notes
Objective Prions, the causative agent of scrapie in sheep, are extremely resistant to disinfection and can remain biologically active for years, which makes it challenging to prevent re-infection of susceptible animals on farms after a…
View details →DOI: 10.1186/s13104-025-07188-1 Negative / Null Result ReportOpen accessMedicine
Mann K, Potluri P, Paul EE et al. · 2026 · Journal of cosmetic dermatology
Introduction Chemotherapy-induced alopecia (CIA) is known to have a significant psychological and quality of life impact. Although cold caps have been shown to prevent CIA, expense and extension of treatment durations are barriers for…
View details →DOI: 10.1111/jocd.70797 Negative / Null Result Report
Shakhidzhanov S, Filippova A, Bovt E et al. · 2025 · Preprint
Introduction: Critically ill COVID-19 patients receiving prophylactic-dose antico-agulation exhibit high rates of thrombosis and mortality. Escalation of anticoagu-lation also does not reduce mortality and has an uncertain impact on the…
View details →DOI: 10.20944/preprints202502.1172.v1 Negative / Null Result ReportOpen accessMedicine
Pereira GF, Sanches MC, De-Paula OC et al. · 2025 · Scientific reports
Classifying seed dormancy is an essential task for plant propagation; however, several plant species lack information about the kind of dormancy the seeds have or inaccurate reports are passed on without an in-depth investigation. We…
View details →DOI: 10.1038/s41598-025-27823-y Negative / Null Result ReportMedicine
He Y, Ding Y, Gong C et al. · 2024 · Behavioural brain research
The tail plays important roles in locomotion control in many animals. But in animals with multiple body segments, the roles of the hind body segments and corresponding innervating neurons in locomotion control are not clear. Here, using…
View details →DOI: 10.1016/j.bbr.2024.115074 Negative / Null Result ReportMedicine
Bosnali E, Mutlu N, Cakmak K et al. · 2025 · Journal of pediatric surgery
Background Pediatric urolithiasis remains a significant health problem in certain regions worldwide. Extracorporeal shock wave lithotripsy (ESWL) is the preferred treatment for upper urinary tract stones smaller than 20 mm in children due…
View details →DOI: 10.1016/j.jpedsurg.2025.162274 