Negative / Null Result ReportOpen accessMedicine
Videtta G, Sasia C, Quadrino S et al. · 2026 · Molecules (Basel, Switzerland)
Activation of microglia and resulting neuroinflammation are central processes that significantly contribute to neurodegenerative disease progression. Treatments capable of attenuating neuroinflammation are therefore an urgent medical need.…
View details →DOI: 10.3390/molecules31010196 Negative / Null Result ReportOpen accessMedicine
Nguyen AP, Hadi DL, Todd DA et al. · 2026 · Clinical pharmacology and therapeutics
Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5-fold…
View details →DOI: 10.1002/cpt.70218 Negative / Null Result ReportOpen accessMedicine
Xu C, Annapureddy H, Carson L et al. · 2026 · JCI insight
Antiretroviral therapy (ART) has prolonged the life expectancy of persons living with HIV, the majority of whom are now older than 50 years. Aging people with HIV are at increased risk for cardiovascular events driven by HIV-related…
View details →DOI: 10.1172/jci.insight.202434 Negative / Null Result ReportOpen accessMedicine
Brandt RB, Lansbergen CS, Kollenburg L et al. · 2025 · Headache
Background/objective Occipital nerve stimulation (ONS) has become an established therapy for medically intractable chronic cluster headache (MICCH), but unfortunately, one third of the patients do not respond satisfactorily. Reliable…
View details →DOI: 10.1111/head.14985 Negative / Null Result ReportMedicine
Hagedoorn L, Ruiz-Rodríguez A, Leijen I et al. · 2025 · Experimental gerontology
Background Perturbation-based training improves reactive stepping responses to prevent falling following a loss-of-balance. As there is currently no safe and feasible method for home-based practice, this randomized study investigated…
View details →DOI: 10.1016/j.exger.2024.112645 Negative / Null Result ReportMedicine
Chiang Yu Y, Lu D, Rege B et al. · 2024 · Journal of pharmaceutical sciences
The addition of antioxidants to pharmaceutical products is a potential approach to inhibit nitrosamine formation, particularly in solid oral dosage forms like tablets and capsules. The objective was to assess the effect of ten antioxidants…
View details →DOI: 10.1016/j.xphs.2024.03.005 Negative / Null Result ReportOpen accessMedicine
Gootjes C, Zwaginga JJ, Nikolic T et al. · 2026 · PloS one
Iscalimab is a nondepleting anti-CD40 monoclonal antibody, expected to suppress immune responses by blocking the costimulation by antigen-presenting cells through CD40-CD40L ligation. This therapeutic antibody indeed inhibited…
View details →DOI: 10.1371/journal.pone.0351131 Negative / Null Result ReportOpen accessMedicine
Forde G, Brucker BM, Becker Ifantides K et al. · 2024 · Toxins
OnabotulinumtoxinA (onabotA) is approved in the US for 12 therapeutic indications. Real-world data on onabotA multi-indication use are limited, often leading to delayed or reduced treatment. This study provides real-world evidence on the…
View details →DOI: 10.3390/toxins16100420 Negative / Null Result ReportMedicine
Goettel M, Werner C, Honarvar N et al. · 2024 · Toxicology
The fungicide fluxapyroxad (BAS 700 F) has been shown to significantly increase the incidence of liver tumours in male Wistar rats at dietary levels of 1500 and 3000 ppm and in female rats at a dietary level of 3000 ppm via a non-genotoxic…
View details →DOI: 10.1016/j.tox.2024.153828 Negative / Null Result ReportOpen accessMedicine
Kornienko TE, Chepanova AA, Kolobenko MV et al. · 2026 · Current issues in molecular biology
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a key enzyme for the repair of stalled topoi-somerase 1 (TOP1)-DNA complexes. We have previously developed a TDP1 inhibitor, compound OL9-116, which is capable of enhancing the action of the…
View details →DOI: 10.3390/cimb48040428 Negative / Null Result ReportOpen accessMedicine
Dalla Via J, Radavelli-Bagatini S, Sim M et al. · 2026 · Aging clinical and experimental research
Background Provision of vascular imaging results has been investigated to prompt changes towards healthy lifestyle behaviours, but effects on body composition and muscle health are unknown. Aim This secondary analysis of a 12-week…
View details →DOI: 10.1007/s40520-026-03335-1 Negative / Null Result ReportMedicine
Kaur J, Kaur M, Chakrapani V et al. · 2023 · Health education research
We report process evaluation findings from the 'SMART Eating' intervention trial, which significantly improved fat, sugar and salt (FSS), and fruits and vegetables (FVs) intake among adults. Intervention used information technology [short…
View details →DOI: 10.1093/her/cyad020 Negative / Null Result ReportOpen accessMedicine
Burman MA, Zuke JT · 2026 · PloS one
Early life pain and stress have lasting consequences on nervous system development that can interact with later stress or trauma to create a susceptibility to fear, anxiety, depression and chronic pain among other psychological disorders.…
View details →DOI: 10.1371/journal.pone.0326300 Negative / Null Result ReportOpen accessMedicine
Kim TE, Bae JW, Hong S et al. · 2025 · The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
Donepezil, an acetylcholinesterase inhibitor, is widely used for managing the symptoms of Alzheimer's disease (AD), yet its clinical response varies widely among individuals. This study aims to investigate the influence of CYP2D6 genetic…
View details →DOI: 10.4196/kjpp.24.239 Negative / Null Result ReportOpen accessMedicine
Hu Q, Zhong W, Hu R · 2026 · Inquiry : a journal of medical care organization, provision and financing
Research on income inequality and obesity shows inconsistent results. This study tests if this relationship depends on a country's existing inequality level. We analyzed individual-level data (N = 22 938) from the 2011 and 2021…
View details →DOI: 10.1177/00469580261444418 Negative / Null Result ReportOpen accessMedicine
Abkur T, Boogers A, Grippe T et al. · 2025 · Movement disorders clinical practice
Background The coexistence of tics with Parkinson's disease (PD) is rare, as they often emerge at different ages, follow different trajectories and involve contrasting pathophysiological mechanisms related to dopamine availability and…
View details →DOI: 10.1002/mdc3.70111 Negative / Null Result ReportMedicine
Leproult I, Lemaire B, Portrat S · 2024 · Memory & cognition
Elaboration has emerged as a potential maintenance mechanism involved in the substantial contribution of long-term memory (LTM) to working memory (WM) performance. The objective of the current study was to determine whether elaborative…
View details →DOI: 10.3758/s13421-024-01615-7 Negative / Null Result ReportOpen accessMedicine
Lee KE, Nishi M, Kim J et al. · 2024 · Frontiers in endocrinology
Rationale MG53's known function in facilitating tissue repair and anti-inflammation has broad applications to regenerative medicine. There is controversy regarding MG53's role in the development of type 2 diabetes mellitus. Objective This…
View details →DOI: 10.3389/fendo.2024.1425426 Negative / Null Result ReportOpen accessMedicine
Krakowian D, Lach M, Żemła P et al. · 2025 · Cytotechnology
The HeLa 9903 cell line is used in the in vitro endocrine disruption assay (OECD 455). After treatment with an estrogen receptor agonist, the luminescence of these cells increases. However, some autoactivation of this test system may…
View details →DOI: 10.1007/s10616-025-00817-4 Negative / Null Result ReportMedicine
Nannoni E, Martelli G, Militerno G et al. · 2024 · Animal Feed Science and Technology.
The experiment aimed to obtain information on the water requirements, drinking behavior and drinking motivation of liquid-fed pigs and was conducted during the hot season. Eighty castrated male pigs (initial body weight: 36 kg) fed a…
View details →DOI: 10.1016/j.anifeedsci.2024.116004 Negative / Null Result ReportMedicine
Schumacher JD, van Holstein M, Zhou P et al. · 2025 · The Journal of neuroscience : the official journal of the Society for Neuroscience
Converging evidence suggests that orbitofrontal cortex (OFC) subregions subserve distinct roles in decision-making across a variety of tasks. Cost/benefit decisions can require an organism to choose between options based on information…
View details →DOI: 10.1523/jneurosci.1989-24.2025 Negative / Null Result Report
Furnival-Adams J, Houana A, Nicolas P et al. · 2024 · Preprint
Abstract Background Headlice are prevalent worldwide, with a higher burden in rural, lower-middle income settings. They can cause intense itchiness, discomfort, and secondary bacterial infections with potentially serious consequences.…
View details →DOI: 10.21203/rs.3.rs-5198695/v1 Negative / Null Result ReportOpen accessMedicine
Dekhne MS, Kunze KN, Chiu YF et al. · 2025 · Arthroplasty today
Background Patient-reported outcome measures (PROMs) assess quality of care after total joint arthroplasty (TJA) and will be mandatory for reporting by 2027 under the Center for Medicare and Medicare Services. This study evaluated the…
View details →DOI: 10.1016/j.artd.2025.101767 Negative / Null Result ReportMedicine
Robinson HL, Banks ML · 2026 · ASPET discovery
Rationale Mesocorticolimbic dopamine neurotransmission is hypothesized to play a central role in both cocaine reinforcement and amphetamine maintenance-induced decreases in cocaine self-administration. One method to selectively modulate…
View details →DOI: 10.1016/j.aspetd.2026.100020 Negative / Null Result ReportOpen accessMedicine
Rahimi A, Fatehi F, Rafiee H et al. · 2026 · Veterinary medicine and science
Background Beet vinasse (VIN), a by-product of sugar beet processing, is rich in non-protein nitrogen (NPN), potassium, and prebiotic compounds, offering potential as a feed additive to enhance dairy cow performance while reducing…
View details →DOI: 10.1002/vms3.70990 Negative / Null Result ReportOpen accessMedicine
Cuezva JM, Domínguez-Zorita S · 2024 · Cancers
The relevant role played by the ATPase Inhibitory Factor 1 (IF1) as a physiological in vivo inhibitor of mitochondrial ATP synthase in cancer and non-cancer cells, and in the mitochondria of different mouse tissues, as assessed in…
View details →DOI: 10.3390/cancers16051014 Negative / Null Result ReportOpen accessMedicine
Djuric N, Rochman CM, Riskin SH · 2026 · PloS one
Agroecosystems are increasingly recognized as major basins for terrestrial microplastics. Many agricultural practices have led to high loading of plastic mulch films, synthetic microfibers, and other microplastics onto fields. There is…
View details →DOI: 10.1371/journal.pone.0336191 Negative / Null Result ReportMedicine
Abbasi A, Ahmad K, Ferguson C et al. · 2024 · European journal of applied physiology
Purpose Pathogen transmission during cardio-pulmonary exercise testing (CPET) is caused by carrier aerosols generated during respiration. Methods Ten healthy volunteers (age range: 34 ± 15; 4 females) were recruited to see if the…
View details →DOI: 10.1007/s00421-023-05327-9 Negative / Null Result ReportOpen accessMedicine
Gerhart BJ, Pellerin D, Danzi MC et al. · 2024 · Neurology. Genetics
Background and objectives The number of GAA repeats in the FXN gene is a major but not sole determinant of the clinical presentation of Friedreich ataxia (FRDA). The objective of this study was to establish whether the length of the GAA…
View details →DOI: 10.1212/nxg.0000000000200210 Negative / Null Result ReportOpen accessMedicine
Rodríguez Rondón AV, Prins K, Volker F et al. · 2026 · Human molecular genetics
Melanocortin-2 receptor accessory protein-2 (MRAP2) modulates the activity of hypothalamic melanocortin-4 (MC4R) and growth hormone-secretagogue (GHSR) receptors, which suppress and promote appetite, respectively. We investigate whether…
View details →DOI: 10.1093/hmg/ddag010 