A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21337 results · page 497 of 712
Rout M, Blackett P, Sanghera DK · 2026 · Nutrients
Background: Vitamin D (25(OH)D) deficiency affects over one billion people globally and is associated with type 2 diabetes (T2D) and cardiometabolic diseases. However, causal relationships remain unclear, as vitamin D supplementation has…
İren AY, Yiğit E · 2026 · BMC oral health
BACKGROUND: The aim of this in-vitro study was to evaluate the effect of preheating on the flexural strength, flexural modulus and microhardness of several commercially available single-shade universal resin composites (SSURCs). METHODS:…
Kim SJ, Park K, Daher R et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Objective This study aimed to evaluate the impact of storage temperature and duration on the dimensional stability and mechanical properties of 3D-printed surgical guides. Materials and methods Sixty surgical guides were designed using two…
Zhong Y, Le F, Cheng J et al. · 2026 · Oncology reports
Following the publication of the above article, the authors contacted the Editorial Office to explain that they had made inadvertent errors in compiling a couple of the figures in the above paper; first, regarding the immunohistochemical…
Toczylowski K, Lewandowski D, Martonik D et al. · 2026 · Preprint
Abstract Multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) are pediatric hyperinflammatory conditions with overlapping features, but their molecular basis remains poorly defined. Matrix metalloproteinases…
Stédile EdSN, Galon L, Korchagin J et al. · 2026 · Preprint
In southern Brazil, a large proportion of farmers maintain their fields under fallow conditions during the transition period between summer and winter crops. During this interval, mechanical practices such as chiseling or the introduction…
Lazado CC, Brenne H, Olaisen D et al. · 2026 · Scientific reports
The diplomonad parasite Spironucleus salmonicida causes spironucleosis, a systemic infection characterised by internal haemorrhaging, splenomegaly, and granulomatous lesions in multiple organs. Prevention is the primary control strategy,…
Zhang S, Zheng T, Zhou M et al. · 2026 · Journal of phycology
This study investigates the chemical and morphological responses of two domoic acid (DA)-producing diatoms, Pseudo-nitzschia multiseries and P. fukuyoi, to conspecific chemical cues released from mechanically damaged cells. Cell homogenate…
Setiawan AS, Caesarini M, Musnamirwan IA et al. · 2026 · BMC public health
Background Stunting, a form of chronic malnutrition, is associated with impaired growth and potential changes in salivary function that may increase susceptibility to early childhood caries (ECC). These oral conditions may further…
Yang H, Dai T, Wolf RM · 2026 · NPJ digital medicine
Artificial intelligence (AI) is increasingly used for diagnostic screening. In diabetic retinopathy screening, autonomous AI systems can identify disease without a specialist. However, patient trust in AI remains a challenge, and it…
Roy C, Ouellet DR, Pellerin D et al. · 2026 · Journal of dairy science
The current experiment studied 2 situations proposed to lead to decreased milk protein yield (MPY). First, NRC (2001) predicts that substitution of soybean meal (SBM) by canola meal (CM) decreases MP supply, thereby negatively affecting…
Jing S, Wang J, Cheng S et al. · 2026 · Toxicon : official journal of the International Society on Toxinology
Voltage-gated sodium channels (VGSCs) are emerging therapeutic targets for cancers including neural tumors such as neuroblastomas and gliomas. BmK IT2, a neurotoxic polypeptide from the scorpion Buthus martensii Karsch, is a known…
Onu CJ, Adu M, Jabbar D et al. · 2026 · Biochimica et biophysica acta. Molecular and cell biology of lipids
Inositol is an essential metabolite required for membrane biogenesis, cell signaling and trafficking, and gene expression. Its importance is underscored by the fact that inositol depletion leads to death in eukaryotic cells ranging from…
Tiburcio MA, Cali MP, Pereira LMB et al. · 2026 · Dalton transactions (Cambridge, England : 2003)
Amyloid deposits of amyloid-β (Aβ) and hyperphosphorylated tau are pathological hallmarks of Alzheimer's disease (AD), which accounts for most dementia cases worldwide. This study investigates the effect of the complex [Ru(phen) 2 (pNDIp)]…
Gaudeul A, Krawczyk M · 2026 · Preprint
Abstract We conducted an online experiment with 3420 participants in Bulgaria, Germany and Spain to evaluate the consequences of digital access to food information via QR codes. Participants made incentivized choices between food products…
Lu X, Ferraz GA, Sivakumar S et al. · 2026 · Preprint
ABSTRACT Aging is associated with a gradual and progressive decline in skeletal muscle mass and strength known as sarcopenia, which has been attributed to chronic low-grade inflammation. Dietary long-chain polyunsaturated fatty acids…
Cherkasova M, Assi A, Craw M et al. · 2026 · Preprint
Objective: A prominent feature of land-based and online slot machines is audiovisual feedback that accompanies winning outcomes. Prior laboratory work suggests that this design feature may influence game experience, facilitate immersion,…
Sevim B · 2026 · Tropical animal health and production
This study investigated the effects of dietary supplementation with fermented black garlic powder on performance, carcass characteristics, serum parameters, immunological responses and antioxidant status in male Japanese quail. A total of…
Silva ACD, Varela Junior AS, França RT et al. · 2026 · Cell biochemistry and function
Lectins are carbohydrate-binding proteins that recognize specific glycan patterns on cell surfaces and have been increasingly explored as analytical tools in reproductive biology. This study characterized the interaction of a lectin…
Wang NN, Luo CJ, Liu LG et al. · 2026 · Ying yong sheng tai xue bao = The journal of applied ecology
Litter decomposition is a core process regulating the formation and stability of soil organic carbon. Under the background of climate warming, the intrinsic mechanisms by which the expansion of alpine shrubs affects carbon balance of…
Sanei A, Asgarian FS, Ebrahiminezhad M · 2026 · Preprint
Abstract Background The lack of studies and sometimes conflicting results in this field, has required that this study be conducted with the aim of improving treatment results in dental health care system. Methods The present study was…
Suarez-Baquero DE, Boido D, Assali A et al. · 2026 · Preprint
Abstract In brain gray matter, neurovascular coupling (NVC) maintains brain metabolism homeostasis by modulating blood flow according to neuronal activity. In white matter, the energy cost of information transmission along myelinated axons…
Tan X, Ding Z · 2026 · Preprint
Astrocytes are the most abundant glial cells in the brain and an integrative component of the neural network. Studies have shown that ethanol altered expression of an astrocyte marker, i.e., glial fibrillary acidic protein (GFAP), in two…
Gokdemir MT, Gokdemir GS · 2026 · BMC infectious diseases
Background Studies have reported that the Coronavirus Disease 2019 (COVID-19) vaccine causes other serious health problems, including myocarditis, pericarditis, neurological problems, and problems resulting from the reactivation of chronic…
Shehata MA, Khirallah MG, Al Nafesa A et al. · 2026 · Pediatric surgery international
Purpose To evaluate whether routine omentectomy improves outcomes during laparoscopic placement of peritoneal dialysis (PD) catheters in children. Methods This multicenter retrospective study included children ≤ 5 years who underwent…
Matsuoka C, Takatama N, Muraoka T et al. · 2026 · Genes and environment : the official journal of the Japanese Environmental Mutagen Society
Background Previous research using the Ames assay showed that licoricidin (LCD) and isoliquiritigenin (ILTG) can block mutations caused by N-methyl-N-nitrosourea (MNU) in Salmonella typhimurium (S. typhimurium) TA1535. With the aim to…
Loayza J, Taylor CJL, Renstrom JG et al. · 2026 · eNeuro
Tourette syndrome (TS) has been linked to reduced GABAergic inhibition, the so-called neural disinhibition, in the dorsal striatum. Dorsal striatal neural disinhibition in animal models, caused by local microinfusion of GABA-A receptor…
Caenepeel C, Deleu S, Vazquez Castellanos JF et al. · 2025 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Background & aims Rigorous donor preselection on microbiota level, strict anaerobic processing, and repeated fecal microbiota transplantation (FMT) administration were hypothesized to improve FMT induction of remission in ulcerative…
Chihara Y, Takeda T, Goto Y et al. · 2022 · The oncologist
Background Osimertinib is one of the standard first-line treatments for advanced non-small cell lung cancer in patients with epidermal growth factor receptor (EGFR) mutations, because it achieves significantly longer progression-free…
Tsimafeyeu I, Goutnik V, Shrainer I et al. · 2023 · American journal of cancer research
About 40% of patients with non-small cell lung cancer (NSCLC) developed pleural effusions at some time during the course of their disease. Preliminary results from our Phase 2 multicentre clinical trial (Cohort 1) demonstrated the safety…