Negative / Null Result Report
Chambaro HM, Delhon G, Miraglia MC et al. · 2026 · Preprint
Foot-and-mouth disease (FMD) remains a major burden in endemic regions, where inactivated vaccines are constrained by cost, short duration of immunity, cold-chain dependence, and high-containment manufacturing. Here, we engineered a…
View details →DOI: 10.64898/2026.06.01.729332 Negative / Null Result ReportMedicine
Meisinger BD, Coufal CD, Olson EG et al. · 2026 · Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes
Reducing microbial contamination during late-stage incubation is important for hatchery sanitation and early chick microbial exposure. Formaldehyde is commonly applied in commercial hatchers to reduce airborne and eggshell-associated…
View details →DOI: 10.1080/03601234.2026.2677407 Failed Experiment ReportMedicine
Jalali F, Alami K, Hashemizadeh S et al. · 2026 · Physiology & behavior
Background and aim Adolescent morphine exposure (AME) is increasingly recognized as a risk factor for long-term alterations in pain processing, predisposing individuals to persistent pain in adulthood. Microglia are key regulators of…
View details →DOI: 10.1016/j.physbeh.2026.115414 Negative / Null Result ReportMedicine
Urbaniec J, Anagnostopoulos A, Davies P et al. · 2026 · Journal of dairy science
Bovine coronavirus (BCV) is a common calf pathogen and has been proposed as a potential contributor to bovine respiratory disease (BRD); however, little is known about its epidemiology and genetic diversity on UK farms. The aim of this…
View details →DOI: 10.3168/jds.2026-28706 Negative / Null Result Report
Adediji I, Kamra K, Kowash H et al. · 2026 · Preprint
ABSTRACT Background Maternal oxycodone (oxy) exposure can disrupt placental function and fetal neurodevelopment, but the molecular mechanisms remain unclear. We investigated whether prenatal oxy exposure activates inflammation and stress…
View details →DOI: 10.64898/2026.04.29.721662 Negative / Null Result Report
Weyer M, Hahnefeld L, Franck L et al. · 2026 · Preprint
Progranulin (PGRN) is a neurotrophic and anti-inflammatory factor produced mainly by neurons and microglia in the central nervous system. Progranulin haploinsufficiency causes frontotemporal dementia (FTD). In a previous study we showed…
View details →DOI: 10.64898/2026.04.20.719642 Negative / Null Result Report
Hadichgeni S, Shariatpanahi SP, Goliaei B et al. · 2026 · Preprint
Extremely low-frequency pulsed electromagnetic fields (ELF-PEMFs) have been proposed to modulate intracellular signaling in cancer cells, however, the primary mediators and their temporal sequence remain incompletely understood. In this…
View details →DOI: 10.64898/2026.04.15.718611 Negative / Null Result ReportMedicine
Jamnick NA, Livingston PD, Gammon CJ et al. · 2026 · Frontiers in medicine
Background Cancer cachexia is a multifactorial metabolic syndrome marked by progressive skeletal muscle loss, reduced function, and increased mortality. Mitochondrial dysfunction is a key driver of this phenotype. MOTS-c, a…
View details →DOI: 10.3389/fmed.2026.1838178 Negative / Null Result ReportMedicine
Coelho JA, Gomes KS, Cerchiaro G · 2026 · International journal of molecular sciences
Endometriosis is associated with oxidative stress and debilitating symptoms, yet its pathophysiology remains incompletely understood, and current treatments are still limited. In this study, oxidative stress responses were compared in 2D…
View details →DOI: 10.3390/ijms27094131 Negative / Null Result ReportMedicine
Pottorf TS, Lane EL, Haley-Johnson Z et al. · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience
Spinal cord ventral horn microglia proliferate after nerve injuries and migrate toward cell bodies of injured motoneurons (MNs) enwrapping them. The significance of this microglia reaction has remained unclear. Moreover, some injured MNs…
View details →DOI: 10.1523/jneurosci.0112-26.2026 Negative / Null Result ReportMedicine
Scioli MV, Sosa E, Barale J et al. · 2026 · Veterinary immunology and immunopathology
Bovine genital campylobacteriosis (BGC) remains a major cause of reproductive failure in beef cattle systems. This study evaluated the persistence of Campylobacter fetus subsp. venerealis (Cfv) and associated lesions in the reproductive…
View details →DOI: 10.1016/j.vetimm.2026.111131 Negative / Null Result ReportMedicine
Ormes JA, Smrcka AV, Jutkiewicz EM · 2026 · Molecular pharmacology
The clinical utility of μ-opioid receptor (MOR) agonists is limited by side effects and tolerance. G protein βγ subunits (Gβγ) are critical mediators of MOR signaling that not only drive anticonception but also regulate phospholipase C and…
View details →DOI: 10.1016/j.molpha.2026.100123 Negative / Null Result ReportMedicine
Sigaard JVA, Spindler H, Joensen EDR et al. · 2026 · Journal of palliative medicine
Background An estimated 4.4 million people in Europe require palliative care annually, a number expected to rise with population aging. Telepalliative care (TPC) has been practiced in various settings over the past two decades. The Telepal…
View details →DOI: 10.1177/10966218261444643 Negative / Null Result ReportMedicine
AhmadQaderi F, Pazouki A, Pishgahroudsari M et al. · 2026 · Obesity surgery
BACKGROUND: Metabolic-bariatric surgery (MBS) is recognized as the most effective long-term intervention for obesity and its associated conditions, including type 2 diabetes mellitus (T2DM) One-anastomosis gastric bypass (OAGB), the third…
View details →DOI: 10.1007/s11695-026-08632-2 Negative / Null Result ReportMedicine
Del-Ángel-Monroy S, Rodríguez-Márquez A, Orozco-Suárez S et al. · 2026 · Basic & clinical pharmacology & toxicology
Vascular relaxation induced by 5-HT 2B receptor is thought to be mediated by stimulation of endothelial nitric oxide synthase (eNOS), but this assumption still requires investigation. To investigate potential mechanisms, BW723C86 (5-HT 2B…
View details →DOI: 10.1111/bcpt.70236 Negative / Null Result ReportMedicine
Torres-Huerta A, Ruley-Haase K, Boger-May A et al. · 2026 · Journal of immunology (Baltimore, Md. : 1950)
The cause of inflammatory bowel disease (IBD) is not known, but both innate and adaptive immunity contribute to IBD pathogenesis. To better understand the contributions of innate immunity to IBD, we have generated a mouse model of IBD that…
View details →DOI: 10.1093/jimmun/vkag111 Negative / Null Result ReportOpen accessMedicine
Aragone L, Burbano P, Cameron A et al. · 2026 · Annals of surgical treatment and research
Purpose A Suffocating Neck Hematoma (Snh) Is A Rare But Potentially Fatal Surgical Complication Of Thyroidectomy. In An Effort To Reduce Its Incidence, Many Surgeons Opt For The Selective Use Of Drains. However, There Are No Studies…
View details →DOI: 10.4174/astr.2026.110.3.144 Negative / Null Result ReportMedicine
Szlufik S, Duszyńska-Wąs K, Koźmińska A et al. · 2026 · Neurologia i neurochirurgia polska
Introduction Bilateral subthalamic nucleus deep brain stimulation (DBS STN) is a very effective surgical method of treating motor symptoms in Parkinson's disease (PD) patients. The long-term cognitive outcome after the surgery is still…
View details →DOI: 10.5603/pjnns.107017 Negative / Null Result ReportMedicine
Piślewska-Bednarek M, Czerniawski P, Kuczewska S et al. · 2026 · Phytochemistry
Glucosinolates (GLs) are sulfur-containing specialized metabolites from plants representing the Brassicales order. They can be derived from several amino acids through a complex biosynthetic pathway. The majority of steps on this pathway…
View details →DOI: 10.1016/j.phytochem.2026.114872 Negative / Null Result ReportMedicine
Wang X, Xi Q, Zhuang Q et al. · 2026 · Clinical nutrition ESPEN
Background & aims Malnutrition complicates recovery in gastrectomy patients, worsened by adjuvant chemotherapy and linked to poorer outcomes. However, evidence regarding the influence of Oral Nutritional Supplements (ONS) on skeletal…
View details →DOI: 10.1016/j.clnesp.2026.103263 Negative / Null Result ReportMedicine
Barney DE Jr, Panik KN, Michalak J et al. · 2026 · The Journal of nutrition
Background When glucose (GLU) is consumed during endurance exercise in an energy deficit state (DEF), exogenous carbohydrate oxidation is lower than in energy balance (BAL). Whether consuming multiple transportable carbohydrates, such as…
View details →DOI: 10.1016/j.tjnut.2026.101593 Negative / Null Result Report
Strnadová A, Ericsson M, Nyrén R et al. · 2026 · Preprint
Hypertrophic cardiomyopathy (HCM) is a genetic heart disease characterized by left ventricular hypertrophy. Mutations in genes for sarcomere proteins, e.g. in cardiac myosin-binding protein C (cMyBPC), cause symptoms like heart failure and…
View details →DOI: 10.64898/2026.01.30.702716 Negative / Null Result ReportMedicine
Agarwal A, Iqbal MZ, Bhalla S · 2026 · Journal of clinical orthopaedics and trauma
Background Prophylactic trochanteric epiphyseodesis is commonly performed with proximal femoral varus osteotomy in Perthes disease to reduce relative trochanteric overgrowth. However, its effectiveness, particularly in children at the…
View details →DOI: 10.1016/j.jcot.2026.103379 Negative / Null Result ReportMedicine
Thomou Z, Dovas CI, Poutahidis T et al. · 2026 · Viral immunology
Maternal antibodies protect mink kits early in life, but their duration and impact on subsequent SARS-CoV-2 exposure remain unclear. We longitudinally characterized passive immunity in kits born to mothers previously infected with lineage…
View details →DOI: 10.1177/08828245261444539 Negative / Null Result Report
Baghdadi MA, Las Casas PHFdC, Mbemba E et al. · 2026 · Preprint
Background: /Objectives: Tissue factor (TF)-expressing cancer cells and their extracellular vesicles (CaCe-dEVs) are key drivers of cancer-associated hypercoagulability and vascular dysfunction. While low-molecular-weight heparins (LMWHs)…
View details →DOI: 10.20944/preprints202603.1869.v1 Negative / Null Result ReportMedicine
Suárez F, Couso-Queiruga E, Osorio J et al. · 2026 · Clinical implant dentistry and related research
Objectives The objective of this ex vivo investigation was to study the significance of barrier membrane application on graft stability across different peri-implantitis-related bone defect configurations. Materials and methods Fresh pig…
View details →DOI: 10.1111/cid.70140 Negative / Null Result ReportMedicine
Zhu C, Zhu Y, Gao H et al. · 2026 · Current microbiology
This study evaluates the long-term conservation of humid earthen archaeological sites using protective shelters and plant essential oil treatments at the Laohuling Dam (Liangzhu, China), a UNESCO World Heritage site. Over seven years…
View details →DOI: 10.1007/s00284-026-04816-2 Negative / Null Result ReportMedicine
Ott A, Gül AZ, Löber U et al. · 2026 · Brain research bulletin
High-fat diet (HFD) consumption contributes to obesity, yet its impact on females of (pre)reproductive age and the effects of dietary modification after adolescence remain underexplored. This study examined how continuous HFD exposure or…
View details →DOI: 10.1016/j.brainresbull.2026.111883 Negative / Null Result ReportMedicine
Lagacé JC, St-Martin P, Avino M et al. · 2026 · Experimental physiology
Prolonged bed rest and immobilization have deleterious effects on skeletal muscle mass and function, especially in older adults. These can lead to reduced physical capacity and quality of life. Previous experiments in younger individuals…
View details →DOI: 10.1113/ep093524 Negative / Null Result ReportMedicine
Stadie N, Heinzer R, Marques-Vidal P · 2026 · European journal of nutrition
PURPOSE: Many individuals turn to supplements like magnesium, believing them to offer a natural way to improve sleep quality. Yet, research on magnesium’s effects has produced inconsistent results. We assessed the relationships between…
View details →DOI: 10.1007/s00394-026-03910-2 