Negative / Null Result ReportMedicine
Vaidie J, Demiselle J, Gabriel A et al. · 2025 · Intensive care medicine
Purpose Decision-making for management of immunosuppressive drugs in solid organ transplant patients admitted to the ICU remains controversial. This study aimed to evaluate the impact of a temporary suspension strategy (interruption of…
View details →DOI: 10.1007/s00134-025-08024-7 Negative / Null Result ReportMedicine
Gröning M, Smerup MH, Nissen H et al. · 2026 · Pediatric cardiology
To assess temporal changes in the timing of pulmonary valve replacement (PVR) among patients with tetralogy of Fallot and to determine whether temporal shifts toward earlier PVR were accompanied by differences in ventricular volumes,…
View details →DOI: 10.1007/s00246-026-04294-0 Negative / Null Result ReportMedicine
Pascoe B, Cocks K, Clarke N et al. · 2026 · Schizophrenia research
Cognitive impairment associated with schizophrenia (CIAS) is a fundamental symptom of the disorder, which significantly affects individuals' daily functioning and overall quality of life. Currently available antipsychotic drugs have little…
View details →DOI: 10.1016/j.schres.2026.03.028 Negative / Null Result ReportMedicine
Thimmesch M, Cheping Simo C, Boulay M et al. · 2026 · Revue medicale de Liege
Cystic fibrosis, the most common genetic disorder in Caucasian populations, is caused by mutations in the CFTR gene (Cystic Fibrosis Transmembrane Conductance Regulator), which disrupts chloride ion transport and leads to the production of…
Negative / Null Result ReportMedicine
Kloura C, Jensen MM, Ekblond TS et al. · 2026 · Diabetes research and clinical practice
Aim The aim of this exploratory analysis was to investigate effects of time-restricted eating (TRE) on glycemic control and variability in adults with prediabetes. Methods This study utilized data from the Restricted Eating Time (RESET)…
View details →DOI: 10.1016/j.diabres.2026.113276 Negative / Null Result ReportOpen accessMedicine
Mommers I, Mubarik S, van Boven JFM et al. · 2025 · BMJ open respiratory research
Background Antibiotics are widely used to manage acute asthma exacerbations, despite little evidence for their effectiveness. This study assesses the added value of antibiotics alongside oral corticosteroids (OCSs) in treating asthma…
View details →DOI: 10.1136/bmjresp-2025-003506 Negative / Null Result Report
Lee BJ, Kim R · 2026 · Preprint
Background: There is a growing interest in the effects of coffee consumption on the human health. This study was conducted to identify a causal relationship between the coffee consumption and the risk of metabolic syndrome (MetS). Methods:…
View details →DOI: 10.20944/preprints202601.0373.v1 Negative / Null Result ReportMedicine
Toraño P, Balmaseda A, Bordons A et al. · 2025 · Food Microbiology.
Oenococcus oeni is the main species of lactic acid bacteria (LAB) responsible for malolactic fermentation (MLF) in winemaking. MLF development can present difficulties because of the harsh, stressful conditions of wine. Yeast mannoproteins…
Negative / Null Result ReportMedicine
Holzhauer CG, Bickar L · 2026 · Alcohol, clinical & experimental research
Background The associations of stress and negative emotion with alcohol use are well established. These associations are mediated by cognitive and psychological mechanisms that may be sex-dependent. This pilot study examined sex…
View details →DOI: 10.1111/acer.70268 Negative / Null Result ReportMedicine
Kobayashi Y, Hosoda C, Kohda M et al. · 2026 · Journal of ethology
Parental care has a direct and beneficial effect on parental fitness. An important question regarding the evolution of parental care is why parental roles and the amount of care invested are characterized by sexual bias. In species that…
Negative / Null Result ReportMedicine
Bourgeois J, Domange C, Celie B · 2026 · International journal of environmental research and public health
Sleep is a fundamental aspect of physiological and psychological functioning, and the beneficial effect of exercise on sleep quality and quantity, depending on training modality, remains underexplored. This study compared the effects of…
View details →DOI: 10.3390/ijerph23020202 Replication Failure
Lan T, Ming J, Liu J et al. · 2026 · Preprint
Objective: Evidence on the stress–fecundability relationship is mixed, and both the population heterogeneity and the effects of moderate stress remain understudied. We aimed to investigate the association of stress with fecundability in…
View details →DOI: 10.22541/au.177095736.68250416/v1 Failed Experiment ReportOpen accessMedicine
Okon-Rocha E, Taylor D · 2026 · Therapeutic advances in psychopharmacology
Cariprazine is effective in a number of conditions and has shown efficacy in the treatment of negative symptoms. Data on its use as an adjunct to other antipsychotics is growing. To evaluate the effectiveness of add-on cariprazine in…
View details →DOI: 10.1177/20451253261456389 Negative / Null Result ReportMedicine
Kolli RD, Kasireddy B, Iuspa MA et al. · 2026 · British poultry science
1. This 42 d study further examined the physiological mechanisms underlying responses to a precision biotic (PB) on growth performance and ileal amino acid digestibility. It focussed on fermentation profile, caecal soluble protein levels,…
View details →DOI: 10.1080/00071668.2026.2630726 Negative / Null Result ReportOpen accessMedicine
Fransisca S, Sitepu BRE, Delfi · 2026 · Frontiers in medicine
Background Visual disturbances are a common and often debilitating complication following stroke, significantly impairing patients' functional independence and quality of life. Among various neuroprotective agents, Citicoline…
View details →DOI: 10.3389/fmed.2026.1769632 Negative / Null Result ReportMedicine
Omae K, Luo Y, Sahker E et al. · 2026 · World journal of urology
PURPOSE: The smallest worthwhile difference (SWD) represents the minimal beneficial effect of an intervention that patients consider valuable when weighed against its burdens, including potential harms, costs, and inconveniences. We aimed…
View details →DOI: 10.1007/s00345-026-06274-8 Negative / Null Result ReportMedicine
Zhiping N, Yuanyuan Y, Qichun Z et al. · 2025 · Journal of applied gerontology : the official journal of the Southern Gerontological Society
With the acceleration of China's aging society, how to enhance the subjective well-being of older adults has become a core issue of concern. This study aims to explore the influence mechanisms of socioeconomic status, health, recreation,…
View details →DOI: 10.1177/07334648251409958 Methods Dead-EndMedicine
Khatib M, Robinson D, Lavon E et al. · 2026 · Journal of clinical medicine
Background/Objectives : Chronic lower limb ulcers represent a significant clinical challenge, with conventional therapies achieving healing in only 30-40% of complex cases. This study evaluated the comparative effectiveness of autologous…
View details →DOI: 10.3390/jcm15051902 Negative / Null Result Report
Cohen L, Laferrère A · 2025 · Preprint
Palliative care (PC) is a multidimensional approach to end-of-life care aimed at alleviating suffering and enhancing the quality of life for individuals and their families. A key aspect of PC is managing symptoms such as pain, dyspnea, and…
View details →DOI: 10.20944/preprints202510.1534.v1 Negative / Null Result ReportOpen accessMedicine
Lamb CJ, Biedermann BM, Lin EH et al. · 2025 · JSES international
Background Spin in scientific literature is defined as bias that overstates efficacy and/or underestimates harms of an experimental treatment. Glenoid augmentation is a technique used to correct glenoid bone deficiency during shoulder…
View details →DOI: 10.1016/j.jseint.2025.02.021 Negative / Null Result ReportMedicine
Bkaily G, Jazzar A, Jacques D · 2026 · Canadian journal of physiology and pharmacology
Generation of reactive oxygen species (ROS) is a physiological product of cell activity that is mainly generated by the mitochondria as well as by transmembrane NADPH oxidases (NOX1-5) present at the plasma and nuclear envelope membranes.…
View details →DOI: 10.1139/cjpp-2025-0240 Negative / Null Result ReportMedicine
Zhou HY, Xin ZM, Lu YY · 2026 · Journal of clinical psychology
Objective Theory of mind (ToM), the ability of mental state attribution, is an important aspect of social cognition. The autism-psychosis diametrical model suggests that there is an opposite impact of autistic traits and psychotic-like…
View details →DOI: 10.1002/jclp.70100 Negative / Null Result ReportOpen accessMedicine
Feola M, Landra F, Greco CA et al. · 2026 · Journal of clinical medicine
Cardiac arrest is a way of demise of patients who are affected by heart failure (HF), being more frequent in those with HF with a reduced left ventricular ejection fraction (HFrEF), and is, as such, responsible for 30-50% of cardiac death.…
View details →DOI: 10.3390/jcm15083041 Negative / Null Result ReportMedicine
Noël A, Picard L · 2025 · Emotion (Washington, D.C.)
Numerous studies have highlighted the beneficial effect of humor on memory in younger adults. While older adults are known to preferentially process positive information and appreciate humor, no study has investigated whether the effect of…
View details →DOI: 10.1037/emo0001519 Negative / Null Result Report
Kolb B, Witt-Lajeunesse A, Cioe J · 2025 · Preprint
This experiment compared the effects of a structured rehabilitation regime (skilled reaching for 5 mo) and more varied training (complex environment for 5 mo) with and without postlesion infusion of FGF-2 for 7 days in rats having…
View details →DOI: 10.1101/2025.10.02.680152 Negative / Null Result ReportMedicine
Wei Y, Meade ML, Soderstrom NC · 2025 · Memory (Hove, England)
The present study replicated and extended prior research by comparing the effects of reviewing notes in groups vs. reviewing notes individually on individual final test performance. We also examined the potential interaction between…
View details →DOI: 10.1080/09658211.2025.2573272 Negative / Null Result ReportMedicine
Silva AT, Ferreira NM, Vaz F et al. · 2025 · Journal of biomechanical engineering
Pelvic organ prolapse (POP) is a common pelvic floor disorder resulting from weakened supportive muscles and ligaments. Although the demand for surgeries involving surgical meshes is expected to increase, current options remain limited. In…
View details →DOI: 10.1115/1.4069708 Negative / Null Result ReportMedicine
Wang C, Ren J, Cui Y et al. · 2025 · Journal of Applied Ecology.
Grassland carbon storage depends on microbial‐mediated interactions between grazing and nitrogen (N) addition, which regulates the balance between soil organic carbon (SOC) retention and priming effects. However, uncertainties regarding…
Negative / Null Result ReportOpen accessMedicine
Panopoulos S, Poulia V, Vlachogiannis N et al. · 2026 · Rheumatology international
Randomized trials have demonstrated that nintedanib is beneficial for Systemic Sclerosis-associated interstitial lung disease (SSc-ILD) with an acceptable safety profile. We evaluated the long-term safety and efficacy of nintedanib in a…
View details →DOI: 10.1007/s00296-026-06173-6 Negative / Null Result ReportMedicine
Cai Y, Ren X, Ding C · 2026 · Intensive & critical care nursing
Objectives To assess the effects of various non-pharmacological interventions on long-term outcomes associated with Post-Intensive Care Syndrome (PICS) in intensive care unit (ICU) survivors, based on existing systematic reviews and…
View details →DOI: 10.1016/j.iccn.2025.104326 