A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21328 results · page 472 of 711
Mano T · 2025 · Clinical medicine insights. Case reports
Cervical traction therapy is commonly used for cervical spondylosis; however, complications, such as subdural hematomas can occur. Possible mechanisms include cerebrospinal fluid (CSF) leakage and bridging vein damage. A 51-year-old…
Serour MH, Mohammad H, Aziza O et al. · 2026 · Journal of surgical case reports
Chronic diabetic foot ulcers remain a major clinical challenge, particularly when complicated by tendon exposure and failure to respond to standard care. We report a 47-year-old male with Type II diabetes mellitus with a history of smoking…
Gootjes EC, Bakkerus L, Adhin AA et al. · 2026 · JAMA
Importance Local therapy, including surgery, radiation, and ablation, is increasingly used in patients with multiorgan metastatic colorectal cancer (mCRC). However, prospective evidence for a survival benefit of tumor debulking is lacking.…
Yano K, Ishida T, Yokosuka K et al. · 2026 · Internal medicine (Tokyo, Japan)
Tumor management is the cornerstone of treatment for anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis that is refractory to immunosuppressive therapy. However, little is known about the effectiveness of chemotherapy for…
Kankotia S, Park S, Thomas J · 2025 · Current opinion in oncology
Purpose of review Relapsed or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is a deadly disease that historically was treated with palliative chemotherapy-based regimens. Since 2019, immunotherapy-based regimens have become…
Glauser G, Kvint S, Ramayya AG et al. · 2025 · Neurosurgery practice
Background and objectives The purpose of the present work was to review our series of patients with far lateral disk herniations treated by the intertransverse approach. Methods Patients undergoing intertransverse approach to treat…
Tian F, Hu C, Liu W et al. · 2025 · The American journal of cardiology
Myocardial work (MW) by noninvasive pressure-strain loop (PSL) is a novel echocardiographic tool that provides a more precise estimation of right ventricular (RV) performance by accounting for the RV loading conditions. The study sought to…
Childs H, Zhou P, Donald BR · 2025 · Preprint
Due to their favorable therapeutic properties, including improved stability, bioavailability, and membrane permeability, D-peptides that bind biological L-proteins represent an important class of systems in computational drug design. A…
Simeonova L, Leseva M, Stoyanov K et al. · 2025 · Biochimica et biophysica acta. Molecular basis of disease
Sirtuin 1 (Sirt1), a class III histone deacetylase, is a key regulator of gene expression in various immune cell types, including neutrophils, during infection and acute inflammation. Herein, we studied the effect of the Sirt1 activator…
Jackson CB, Xue W, Gupta AA et al. · 2025 · International journal of radiation oncology, biology, physics
Purpose To evaluate local failure (LF) rates for patients with intermediate-risk rhabdomyosarcoma treated on the Children's Oncology Group ARST1431 clinical trial, the first and largest international, phase 3 randomized study to use FOXO1…
Chow WD, Spinner RJ, Amrami KK et al. · 2026 · Journal of neurosurgery. Case lessons
Background Bertolotti syndrome is an underrecognized cause of chronic low back pain. Back pain generated from Bertolotti syndrome is believed to result from altered weight dissipation mechanics and/or instability of the pseudoarticulation,…
Boda A, Bandey IN, Chowdhury S et al. · 2025 · Preprint
Pancreatic ductal adenocarcinoma (PDAC) has a poor survival rate and limited treatments. Agonistic CD40 antibodies are promising, but clinical trials have shown only modest efficacy and significant hepatotoxicity. We previously reported…
Vicenti C, Cercone M, Nieman G et al. · 2025 · Veterinary anaesthesia and analgesia
Objective To compare early versus late time-controlled adaptive ventilation (TCAV) for setting airway pressure release ventilation (APRV) on arterial oxygenation in dorsally recumbent anesthetized horses. Study design A crossover,…
Jacob A, He J, Peck A et al. · 2025 · Heliyon
Sjögren's (SS) involves salivary and lacrimal gland dysfunction. These studies examined metabolic profiles in the B6. Il14α transgene mouse model of SS and a cohort of human SS patients at different stages of disease. In B6. Il14α mice,…
Döhner H, Späth D, Saadati M et al. · 2026 · Blood
Abstract Core-binding factor acute myeloid leukemia (CBF-AML) is associated with KIT mutations and deregulated expression of KIT. We report results from the randomized, open-label, phase 3 trial of intensive chemotherapy with or without…
Pae Y, Park H, Lee H et al. · 2024 · Preprint
Abstract Background Hyperhidrosis is the secretion of excess sweat beyond what the body needs for homeostatic regulation. Secondary hyperhidrosis is usually related to an underlying cause, mostly a medical condition, or extrinsic factors…
Bertsias A, Flouri I, Emmanouilidou E et al. · 2026 · Arthritis research & therapy
Background Difficult to manage (D2M) axial spondyloarthritis (axSpA) is an evolving clinical concept. We aimed to assess the prevalence, predictors and long-term outcomes of D2M axSpA. Methods Prospective single center cohort study of…
Bošnjak K, Vengust R · 2025 · Journal of clinical medicine
Background : We aimed to analyze radiographic sagittal balance parameters in patients who underwent a TLIF procedure for single-level degenerative spondylolisthesis with a mean follow-up of 8.6 years and to determine whether lumbar…
Ribic A, McCoy E, Pendala V et al. · 2024 · Preprint
Abstract Preterm birth is a leading risk factor for atypicalities in cognitive and sensory processing, but it is unclear how prematurity impacts circuits that support these functions. To address this, we trained adult mice born a day early…
Ikegishi Y, Abe R, Maehata A et al. · 2026 · Internal medicine (Tokyo, Japan)
Copper deficiency is a rare but critical cause of anemia and neurological impairment. We herein report a hemodialysis patient who developed acute-onset copper deficiency after spinal surgery with zinc supplementation, despite no…
Umer A, Nafis S, Karimi M · 2026 · Cureus
Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare inherited bone marrow failure disorder characterized by severe thrombocytopenia due to absent or markedly decreased megakaryocytes. It typically presents in infancy and may…
Fina A, Àvila Cabré S, Vázquez Pereira E et al. · 2024 · Preprint
The introduction of heterologous pathways into microbial cell compartments offers several potential advantages, including increasing enzyme concentrations and reducing competition with native pathways, making this approach attractive to…
Artal JM, Randall L, Rubeck S et al. · 2025 · American journal of medical genetics. Part A
Parents of children with Down syndrome have historically reported poor experiences receiving a prenatal diagnosis. In a 2003 survey, mothers reported that their physicians pitied them, emphasized negative aspects of Down syndrome, and…
Grant Owens R, Lockwood G, Storm D · 2025 · Urology
Prenatal diagnosis of left multicystic dysplastic kidney (MCDK) and ureterocele was made in a male fetus at 24-week gestation. The initial postnatal course was uneventful. At 4 weeks of age, he developed urosepsis and respiratory distress.…
Pisljar Z, Markelc B, Brezar SK et al. · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Radiotherapy is a standard therapy for oral squamous cell carcinoma (OSCC) with immunomodulatory potential. Due to high lymphocyte radiosensitivity, partial tumor-volume irradiation (pIR), targeting only part of the tumor, is being…
Davis MP, Ulrich A, Segal R et al. · 2024 · Cancers
Background: Chemotherapy-induced peripheral neuropathy (CIPN) from oxaliplatin and taxane drugs is a bothersome toxicity. Palmitoylethanolamide (PEA) has been reported to improve myelinated nerve fiber function in patients experiencing…
Paul N, Weiss B · 2025 · Die Anaesthesiologie
With a decrease in mortality of critically ill patients in recent years, intensive care medicine research has shifted its focus on functional impairments of intensive care units (ICU) survivors. ICU survivorship is characterized by…
Aguila L, Castillo R, Pérez-García F et al. · 2026 · Animals : an open access journal from MDPI
Haploid embryos constitute a valuable model for genetic and epigenetic studies; however, their developmental competence is reduced compared with diploid counterparts. This study evaluated whether supplementation of the culture medium with…
Bi X, Yu Y, Zhou S et al. · 2024 · Nephron
Introduction The renoprotective benefits of adding immunosuppressant therapy to corticosteroid (CS) treatment for immunoglobulin A nephropathy (IgAN) patients with less than 25% crescent formation (C1) remain uncertain, warranting further…
Vicenti C, Cercone M, Nieman G et al. · 2025 · Veterinary Anaesthesia and Analgesia
To compare early versus late time-controlled adaptive ventilation (TCAV) for setting airway pressure release ventilation (APRV) on arterial oxygenation in dorsally recumbent anesthetized horses. A crossover, nonrandomized, experimental…