A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21733 results · page 472 of 725
Wade Munroe · 2023 · Episteme
Abstract Evidentialism as an account of theoretical rationality is a popular and well-defended position. However, recently, it's been argued that misleading higher-order evidence (HOE) – that is, evidence about one's evidence or about…
Peerapong Santiwong, Kantrakorn Dutsadeeviroj, Kittithad Potchanarungvakul et al. · 2023 · International Journal of Environmental Research and Public Health
Patients with a fixed orthodontic appliance may have difficulties in maintaining good oral health-related quality of life (OHRQoL), and evaluating self-perceived OHRQoL in orthodontic patients could be challenging for their orthodontists.…
Miyazaki, Ishigo, Yamada et al. · 2026 · Journal of pharmaceutical health care and sciences
Candidemia has high mortality and requires early antifungal stewardship (AFS). Management by non-infectious disease specialists has been associated with worse outcomes, particularly in small- and medium-sized hospitals where infectious…
A.M. Pyatnitskiy, V.M. Gukasov · 2025 · Medicina i vysokie tehnologii
The task of searching for clusters in sequences arises when analyzing various medical and biological data. This may be searching for clusters of events (outbreaks of events) in epidemiology, searching for areas of increased mutation…
Shauna Lucine Dworatzek, Marissa Tozer, Kathryn Austin et al. · 2025 · The Canadian Entomologist
Abstract The phenomenon of insect emergence represents a transfer of mass and energy from aquatic to terrestrial systems and is a critical part of ecosystem connectivity and functioning. Traditional methods of studying insect emergence…
Nikhil N. Verma · 2016 · Arthroscopy
Abstract Identification of symptomatic long head biceps pathology continues to be a clinical challenge. Magnetic resonance imaging may fail to identify symptomatic lesions when present. Clinicians must maintain a high index of suspicion,…
F. S. Lobyrev · 2024 · Uspehi sovremennoj biologii
The regularities that determine the preservation and/or change of statistically significant differences during the transition from comparing the average values of plastic signs of juvenile fish to comparing the average values of their…
J. Bouchez · 2000 · arXiv
We show that the unified method recently proposed by Feldman and Cousins to put confidence intervals on bounded parameters cannot avoid the possibility of getting null results. A modified bayesian approach is also proposed (although not advocated) which ensures no null results and proper coverage.
Alp Atici · 2003 · arXiv
It is an established fact that for many of the interesting problems quantum algorithms based on queries of the standard oracle bring no significant improvement in comparison to known classical algorithms. It is conceivable that there are other oracles of algorithmic importance acting in a less intuitive fashion to which such limitations do not apply. Thus motivated this article suggests a broader understanding towards what a general quantum oracle is. We propose a general definition of a quantum oracle and give a classification of quantum oracles based on the behavior of the eigenvalues and ei
Jaroslaw Kornowicz · 2024 · arXiv
This study empirically examines the "Evaluative AI" framework, which aims to enhance the decision-making process for AI users by transitioning from a recommendation-based approach to a hypothesis-driven one. Rather than offering direct recommendations, this framework presents users pro and con evidence for hypotheses to support more informed decisions. However, findings from the current behavioral experiment reveal no significant improvement in decision-making performance and limited user engagement with the evidence provided, resulting in cognitive processes similar to those observed in tradi
F. M. Brunbauer, R. Aleksan, Y. Angelis et al. · 2026 · arXiv
The combination of a Cherenkov radiator with a semi-transparent photocathode and a Micromegas based amplification stage allows PICOSEC Micromegas detectors to achieve a time resolution of better than 15ps. While tileable prototypes with 10x10 channels feature 1x1 cm^2 readout pads, finer readout granularity can be used to improve the spatial resolution. We report on the study of high readout granularity PICOSEC Micromegas prototypes which achieve around 0.5mm spatial resolution with 3.5mm large pads. No significant improvement was found when readout pad size was further reduced to 2.2mm. The t
James Large, Paul Southam, Anthony Bagnall · 2018 · arXiv
tl;dr: no, it cannot, at least not on average on the standard archive problems. We assess whether using six smoothing algorithms (moving average, exponential smoothing, Gaussian filter, Savitzky-Golay filter, Fourier approximation and a recursive median sieve) could be automatically applied to time series classification problems as a preprocessing step to improve the performance of three benchmark classifiers (1-Nearest Neighbour with Euclidean and Dynamic Time Warping distances, and Rotation Forest). We found no significant improvement over unsmoothed data even when we set the smoothing param
Agnès Ferté, Kevin Hong · 2023 · arXiv
We highlight the role of weak lensing measurements from current and upcoming stage-IV imaging surveys in the search for cosmic inflation, specifically in measuring the scalar spectral index $n_s$. To do so, we combine the Dark Energy Survey 3 years of observation weak lensing and clustering data with BICEP/Keck, Planck and Sloan Digital Sky Survey data in $rΛ$CDM where $r$ is the tensor-to-scalar ratio. While there is no significant improvement in constraining power, we obtain a 1$σ$ shift on $n_s$. Additionally, we forecast a weak lensing and clustering data vector from the 10-year Legacy Sur
Dimitrios Exadaktylos, Massimo Riccaboni, Armando Rungi · 2020 · arXiv
In this paper, we test the contribution of foreign management on firms' competitiveness. We use a novel dataset on the careers of 165,084 managers employed by 13,106 companies in the United Kingdom in the period 2009-2017. We find that domestic manufacturing firms become, on average, between 7% and 12% more productive after hiring the first foreign managers, whereas foreign-owned firms register no significant improvement. In particular, we test that previous industry-specific experience is the primary driver of productivity gains in domestic firms (15.6%), in a way that allows the latter to ca
Karam Ahmed, Sherif Abuelenin, Heba Soliman et al. · 2015 · arXiv
V-BLAST detection method suffers large computational complexity due to its successive detection of symbols. In this paper, we propose a modified V-BLAST algorithm to decrease the computational complexity by reducing the number of detection iterations required in MIMO communication systems. We begin by showing the existence of a maximum number of iterations, beyond which, no significant improvement is obtained. We establish a criterion for the number of maximum effective iterations. We propose a modified algorithm that uses the measured SNR to dynamically set the number of iterations to achieve
Nuha Shawarb, Manal Badrasawi, Hassan Abu Qaoud et al. · 2023 · BMC Complementary Medicine and Therapies
Abstract Background The medicinal application of natural plant remedies is well established. These medicinal plants are still in use within the Palestinian community to treat several illnesses. This research is intended to study the use of natural plants to treat different types of respiratory tract disorders. Method This ethno botanical study focused on the medicinal plants that are used to treat respiratory diseases in the northern part of Palestine; Nablus, Tulkarm, Qalqilia, and Jenin. A questionnaire was distributed to 120 respondents. The data obtained included names of the plants used,
Liugang Xu, Yajun Wang, Hongyun Ji et al. · 2024 · PLoS ONE
Background Numerous observational studies have reported an association between frailty and atherosclerosis. However, the causal relationship between frailty and the occurrence of atherosclerosis in different anatomical sites remains unclear. we conducted a bidirectional Mendelian randomization (MR) study to evaluate the causal relationship between the frailty index (FI), and both systemic atherosclerosis and lipids. Methods We obtained summary statistics from large-scale genome-wide association studies (GWAS) of various phenotypes, including frailty (n = 175,226), coronary atherosclerosis (n =
K. Wojdak-Maksymiec, M. Kmiec, J. Ziemak · 2006 · Veterinární Medicína
The study included 124 Polish Black-and-White dairy cows of various share of the Holstein-Friesian (HF) breed. Lactoferrin (LTF) gene polymorphism was obtained with PCR-RFLP method using EcoRI enzyme. Two alleles of LTF, A and B, were found in the studied population. Their frequencies were 67.74% and 32.56%, respectively. The alleles controlled the occurrence of three genotypes: AA, BB and AB, of frequencies equal to 37.90%, 2.42% and 59.68%, respectively. It was established that statistically significant associations exist between the somatic cell count (SCC) and LTF genotype, lactation month
Sofya Ilmer, Rubab Sohail, Sharon Hyman · 2026 · Frontiers in Endocrinology
IntroductionThis retrospective chart review investigated the relationship between 25-hydroxyvitamin D levels and the initial clinical and biochemical presentation of type 1 diabetes mellitus (T1DM) in children under 18 years of age, specifically: (1) presence or absence of diabetic ketoacidosis and the severity of diabetic ketoacidosis (DKA) - among those with DKA, and (2) beta-cell function.MethodsThis study included 99 children with new-onset Type 1 Diabetes Mellitus (T1DM). Patients were diagnosed at our pediatric endocrinology practice at Northwell Health between June 2023 and February 202
S Bakhti, S Latifi-Navid, S Zahri et al. · 2015 · Journal of Ardabil University of Medical Sciences
Background & objectives: Several studies have described VacA and CagA as the two important virulence determinants of Helicobacter pylori, which are associated with gastric ulcer (GU) and duodenal ulcer (DU). The aim of present study was to determine the associations of the i and d regions genotypes of H. pylori vacA gene and cagA status with GU and DU risk. Methods: A total of 177 isolates were cultured from the biopsies of Iranian patients with different geographic origins and genotyped. Data were collected and analyzed. Results: Frequency of the vacA i1, i2, i1i2, d1, and d2 alleles and cagA
Erik Artur Cortinhas-Alves, Victor Henrique Botelho Lourenço, Andreza Juliana Moreira da Costa et al. · 2025 · Genetics and Molecular Biology
ABSTRACT The literature shows a correlation between ethnicity and pathogenic variants of the thyroid stimulating hormone receptor (TSHR) gene. Some of these polymorphisms may be risk factors for the development of primary congenital hypothyroidism (PCH). In this study, we investigated the relationship between the frequency of TSHR gene polymorphisms and the genetic influence of African, Amerindian, and European ancestry-informative markers in patients from an Amazonian population in Brazil who were diagnosed with PCH. The study was conducted on samples from 106 patients who were diagnosed with
Yijia Wang, Songting Gao, Qiang Xu et al. · 2025 · Diabetology & Metabolic Syndrome
Abstract Background Type 2 diabetes mellitus (T2DM) and sarcopenia have emerged as significant public health challenges that disproportionately affect middle-aged adults. However, the relationship between T2DM and muscle parameters in this critical age remains inadequately elucidated. Methods We conducted a comprehensive analysis of cross-sectional data derived from 2,446 middle-aged participants (aged 40–59 years; 1,230 men and 1,216 women) enrolled in the National Health and Nutrition Examination Survey (NHANES) 2011–2014. T2DM was defined by physician-confirmed diagnosis and/or glycohemoglo
Bintang Y.M. Sinaga, Muhammad Amin, Yahwardiah Siregar et al. · 2014 · Acta Medica Indonesiana
Aim: to explore the role of FokI and BsmI polymorphisms the VDR gene in the susceptibility to pulmonary tuberculosis (PTB) in an Indonesian Batak ethnic population. Methods: matched case-control study was conducted on 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D Receptor (VDR) gene were analysed using PCR-RFLP. Results: the frequencies of FokI genotypes were FF 35.5%, Ff 55.3%, ff 9.2% for PTB patients and FF 39.5%, Ff 44.7.% and ff 15.8% for normal control. The BsmI genotypes frequencies were BB 0%, Bb 68.4%, bb 31.6% for TB patients and BB 2.6%, Bb 23.7%
Mahdieh Hosseinzadeh, Niloufar Saber, Sakineh Shab Bidar et al. · 2024 · BMC Endocrine Disorders
Abstract Background Type 2 diabetes mellitus (T2DM) is often linked to chronic inflammation, which can be influenced by both lifestyle and dietary choices. However, the relationship between the inflammatory potential of diet and lifestyle factors and the risk of developing T2DM remains unclear. The present study aimed to investigate the associations of the empirical dietary inflammatory index (EDII), dietary inflammatory score (DIS), and lifestyle inflammatory score (LIS) with the risk of T2DM among Iranian adults. Methods The current study was conducted on 5714 individuals from Yazd Health St
Hajibagheri K, Abaszade A, Afrasiabian Sh et al. · 2018 · مجله علمی دانشگاه علوم پزشکی کردستان
Background and Aim: Genital wart is the most common sexually transmitted infection and its role in cervical cancer has been confirmed. The aim of this study was to determine the presence of human papillomavirus (HPV) and the frequency of its genotypes in the patients with genital lesions referring to the clinics in Sanandaj, Iran. Material and Method: This descriptive analytical study included 50 women with genital lesions referring to the clinics in Sanandaj City from February 2016 to February 2017. Biopsy samples were examined for four genotypes (HPV 16, 18 (high risk) and HPV 11, 6 (Low ris
Leena Verma, Ravi Sharma, Sidhi Passi et al. · 2023 · Journal of South Asian Association of Pediatric Dentistry
Aim: To evaluate the correlation between dental caries and obesity in 8–10 years school children of Chandigarh, India. Materials and methods: Around 100 children of the age range of 8–10 years who attended the Pediatrics OPD of Dr Harvansh Singh Judge Institute of Dental Sciences & Hospital, Chandigarh, India were selected. Four groups were made group I—25 healthy teeth and nonobese (HNO) children, group II—25 carious teeth and nonobese (CNO) children, group III—25 healthy teeth and obese (HO) children, and group IV—carious teeth and obese (CO) children. Caries score was recorded after careful
Daniela Cristina Batista Pieroni, Naylla do Carmo Carlins, Pamela Polato et al. · 2017 · O Mundo da Saúde
Aging is associated with a decline in sensory acuity that may lead to impaired nutritional status. Thus, the study aimed to evaluate gustatory sensitivity in relation to the nutritional status of elderly women participating in an Activity Center for the Elderly (ACE). For that, an observational, analytical cross-sectional study was performed with elderly participants of an ACE, in Curitiba, PR. An anamnesis was applied to know and characterize the evaluated population, then an evaluation of the nutritional status was made through anthropometry. The taste sensitivity evaluation was carried out
El Sobky, Abeer, F, El Bokhary, M, AwadAllah, Hala, I et al. · 2018 · Journal of Environmental Science
This study was conducted to highlight the significant environmental factors that may have impacts on breast benign and malignant diseases. This study was carried out on one hundred females who came to radiology department to perform mammographic examination. A complete personal and family history of patients was taken, clinical examination was done, all cases were asked to fill a questionnaire about how often they deal with each item of the environmental factors including (alcohol, caffeine, smoking, use of some material that are commonly used in daily life and known to have estrogenic effect
Dirk Hays, Steve Hague, Seth C. Murray et al. · 2013 · Agronomy
To identify and develop drought tolerant maize (Zea mays L.), high-throughput and cost-effective screening methods are needed. In dicot crops, measuring survival and recovery of seedlings has been successful in predicting drought tolerance but has not been reported in C4 grasses such as maize. Seedlings of sixty-two diverse maize inbred lines and their hybrid testcross progeny were evaluated for germination, survival and recovery after a series of drought cycles. Genotypic differences among inbred lines and hybrid testcrosses were best explained approximately 13 and 18 days after planting, res
Suming Dai, Ping Wang, Sijia Wang et al. · 2025 · Frontiers in Nutrition
BackgroundExisting epidemiological studies investigated the association between a single vitamin and hypertension. However, the potential relationship between the level of circulating multivitamins and blood pressure has not been explored. We aimed to investigate the association between multiple fat-soluble vitamin levels and blood pressure.MethodsA total of 2052 participants with essential hypertension were sampled nationwide. The plasma concentrations of fat-soluble vitamins (A, E, D, and K) were assessed using liquid chromatography coupled with the mass spectrometry method. Participants wer