Negative / Null Result ReportOpen accessMedicine
Wang J, Liu LL, Huang L et al. · 2026 · BMC nephrology
Background The European STOP study showed that glucocorticoids (with/without immunosuppressants) did not delay disease progression in adults with IgA nephropathy (IgAN). However, pediatric IgAN is characterized by more severe acute…
View details →DOI: 10.1186/s12882-026-05101-x Negative / Null Result ReportOpen accessMedicine
Park HJ, Park S, Heo S et al. · 2026 · Journal of microbiology and biotechnology
Leuconostoc lactis DMLL10 is a novel strain isolated from kimchi. The strain did not exhibit toxicity in genetic tests. This study aims to conduct a preclinical safety assessment by performing repeated-dose toxicity studies in animals. In…
View details →DOI: 10.4014/jmb.2601.01021 Negative / Null Result ReportOpen accessMedicine
Said C, Hayward C, Stevens M et al. · 2026 · Bioengineering (Basel, Switzerland)
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has failed to demonstrate mortality benefit in randomised controlled trials of cardiogenic shock. We aimed to determine whether a novel 'Hemi-ECMO' configuration, involving aortic…
View details →DOI: 10.3390/bioengineering13050499 Negative / Null Result ReportMedicine
Endo S, Tanaka R, Yamaguchi T et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Background Large type 3 (≥ 8 cm) and type 4 gastric cancers are associated with extremely poor prognoses. The phase III JCOG0501 trial, which evaluated neoadjuvant S-1 plus cisplatin, failed to demonstrate any survival benefits. Docetaxel,…
View details →DOI: 10.1007/s10120-025-01705-8 Negative / Null Result Report
Chaudhari A, Rosenstein ZM, Kamal R et al. · 2025 · Preprint
Background Intracranial atherosclerotic disease (ICAD) is associated with up to 10% of ischemic strokes and a high risk of recurrence. Endovascular treatments including percutaneous transluminal angioplasty and stenting have failed to…
View details →DOI: 10.1101/2025.09.17.25336036 Negative / Null Result ReportMedicine
Schreiner M, Thien H, Braasch T et al. · 2025 · Abdominal radiology (New York)
Background Many patients are instructed to fast before abdominal ultrasound examinations in order to obtain better image quality. However, the few available studies on this topic have so far failed to demonstrate an advantage of several…
View details →DOI: 10.1007/s00261-025-04947-3 Negative / Null Result ReportMedicine
Thery G, Noly PE, Cavayas YA et al. · 2025 · Seminars in thoracic and cardiovascular surgery
ECLS-SHOCK is the largest randomized control trial on Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) in Acute Myocardial Infarction-related Cardiogenic Shock (AMI-CS). Unfortunately, ECLS-SHOCK failed to demonstrate a…
View details →DOI: 10.1053/j.semtcvs.2025.01.004 Negative / Null Result ReportOpen accessMedicine
Liu S, Chen B, Zhu Y et al. · 2025 · The oncologist
Background Previous results of our trial demonstrated that the addition of induction chemotherapy (IC) prior to definitive chemoradiotherapy (CRT) failed to significantly improve the response rate or 3-year survival in patients with…
View details →DOI: 10.1093/oncolo/oyae295 Negative / Null Result ReportMedicine
Emborg C, Kothari SF, Finnerup NB et al. · 2025 · Handbook of clinical neurology
Over the past decades, a growing number of clinical trials in neurologic conditions have failed to demonstrate superiority of active treatments over placebo. A key question in this context is whether an increase in placebo response can…
View details →DOI: 10.1016/b978-0-443-29884-4.00018-2 Negative / Null Result ReportOpen accessMedicine
Hattori Y, Abe S, Kakino Y et al. · 2026 · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Interventional trials with high-density lipoprotein cholesterol (HDL-C)-raising drugs have generally failed to demonstrate a beneficial effect on cardiovascular outcomes, although low HDL-C levels confer the risk of cerebrocardiovascular…
View details →DOI: 10.1016/j.neurot.2026.e00849 Negative / Null Result ReportOpen accessMedicine
Murillo-Olaizola A, Rodrigo-Gisbert M, Requena M et al. · 2026 · Stroke (Hoboken, N.J.)
Background Recent randomized controlled trials of endovascular treatment (EVT) for distal and medium vessel occlusion (DMVO) stroke did not demonstrate clinical benefit over best medical therapy and suggested potential safety concerns. We…
View details →DOI: 10.1161/svin.125.002137 Negative / Null Result ReportMedicine
Peker Y, Saygin M, Celik Y et al. · 2026 · Annals of the American Thoracic Society
Rationale Recent randomized controlled trials failed to show cardiovascular benefits of treating obstructive sleep apnea (OSA) in intention-to-treat analyses which has been a matter of debate since publication of the results. Objectives To…
View details →DOI: 10.1093/annalsats/aaoag072 Negative / Null Result ReportMedicine
Gaub M, Shaffer KV, Patel P et al. · 2026 · Clinical neurology and neurosurgery
Objective EC-IC bypass for symptomatic atherosclerotic internal carotid and middle cerebral artery chronic occlusion (AIMCAO) failed to show benefit over medical management in previous randomized controlled trials. We explored how a…
View details →DOI: 10.1016/j.clineuro.2026.109417 Negative / Null Result ReportMedicine
Hajime T, Shiota M, Fukuchi G et al. · 2026 · Annals of surgical oncology
Background Although lymph node involvement (LNI) is a critical prognostic factor guiding adjuvant therapy, randomized trials have failed to show a survival advantage of extended versus standard pelvic lymph node dissection (PLND) but have…
View details →DOI: 10.1245/s10434-026-19088-0 Negative / Null Result ReportMedicine
Dintakurti A, Parikh MA, Silver RJ et al. · 2025 · Cardiology in review
Large-scale clinical trials of intensive glycemic control have failed to show cardiovascular benefit, with hypoglycemia implicated as a key factor. Increasing evidence suggests hypoglycemia is not merely a complication of diabetes therapy…
View details →DOI: 10.1097/crd.0000000000001114 Replication FailureMedicine
Pieracci FM, Doben A, Eriksson E et al. · 2026 · The journal of trauma and acute care surgery
Abstract The use of surgical stabilization of rib fractures (SSRF) for non-flail fracture patterns continues to rise. However, multiple, recent randomized controlled trials in this patient population have failed to show a clear benefit to…
View details →DOI: 10.1097/ta.0000000000004723 Negative / Null Result ReportMedicine
Bhardwaj A, Saili A, Yadav DK et al. · 2025 · Journal of neonatal-perinatal medicine
BackgroundThe prolonged ductal patency in preterm newborns despite being associated with short- and long-term morbidities has failed to show significant improvement in the long-term outcome with routine ductal treatment. Echocardiography…
View details →DOI: 10.1177/19345798251343494 Negative / Null Result ReportMedicine
Van Gent JM, Clements TW, Gurney JM et al. · 2025 · The journal of trauma and acute care surgery
Background Empiric cryoprecipitate administration has recently failed to show survival benefit in hemorrhaging trauma patients. However, a recent Trauma Quality Improvement Program query suggested a survival benefit in massive transfusions…
View details →DOI: 10.1097/ta.0000000000004643 Negative / Null Result ReportMedicine
Sant VR, Zhou H, Zhou MM et al. · 2025 · The Journal of clinical endocrinology and metabolism
Context Primary hyperparathyroidism (PHPT) has initially been implicated in adverse maternal and neonatal outcomes, while subsequent population studies have failed to show an association. Objective This work aimed to compare maternal,…
View details →DOI: 10.1210/clinem/dgae409 Negative / Null Result ReportMedicine
Wan H, Myerson J, Green L et al. · 2025 · The journals of gerontology. Series B, Psychological sciences and social sciences
Objectives Previous studies failed to find age-related differences in the discounting of delayed, monetary losses, potentially due to their failure to examine the effects of income and their use of relatively small loss amounts.…
View details →DOI: 10.1093/geronb/gbaf162 Negative / Null Result ReportOpen accessMedicine
Gibb RD, Brum JM, Sloan KJ et al. · 2025 · Journal of travel medicine
What can be concluded from a clinical trial that spanned 5 years yet failed to achieve target enrollment, generated flat results that contradict the existing body of knowledge and has a primary efficacy endpoint confounded by a…
View details →DOI: 10.1093/jtm/taaf076 Negative / Null Result ReportMedicine
Chevalley S, Wängberg V, Åhlén M et al. · 2024 · The Journal of hand surgery
Purpose There is no consensus on the optimal postoperative rehabilitation program following flexor tendon repair. Some studies suggest a faster recovery after active mobilization, whereas other studies have failed to find any differences…
View details →DOI: 10.1016/j.jhsa.2024.08.011 Negative / Null Result Report
Cassario A, Brandt MJ · 2024 · Preprint
Recent attempts to establish the veracity of the conservative shift hypothesis have failed to find supportive evidence. Instead, this work yields inconsistent results and reveals considerable individual differences in ideological responses…
View details →DOI: 10.31234/osf.io/bjrhd Negative / Null Result ReportMedicine
Madill-Thomsen KS, Gauthier PT, Abouljoud M et al. · 2025 · Transplantation
Background Initial analysis of liver transplant biopsies in the INTERLIVER study ( ClinicalTrials.gov ; unique identifier NCT03193151) using rejection-associated transcripts failed to find an antibody-mediated rejection state (ie, rich in…
View details →DOI: 10.1097/tp.0000000000005269 Negative / Null Result ReportMedicine
Stone BM, Hammersley JJ, Rabinovich NE et al. · 2024 · Experimental and clinical psychopharmacology
In contrast to overnight deprivation versus satiety studies, a small number of placebo-controlled studies have failed to find that nicotine administration reduces attentional bias (AB) to smoking cues. To assess the reliability of this…
View details →DOI: 10.1037/pha0000707 Negative / Null Result Report
Liu R, Cheng W · 2023 · Preprint
Background Previous observational studies in patients with diabetes have examined the relationship between insulin resistance (IR) and cognitive outcomes and failed to find that IR is associated with cognitive function. And the…
View details →DOI: 10.1101/2023.11.06.23298189 Negative / Null Result ReportOpen accessMedicine
Catling FJR, Nagendran M, Festor P et al. · 2024 · Critical care explorations
Large randomized trials in sepsis have generally failed to find effective novel treatments. This is increasingly attributed to patient heterogeneity, including heterogeneous cardiovascular changes in septic shock. We discuss the potential…
View details →DOI: 10.1097/cce.0000000000001087 Negative / Null Result ReportOpen accessMedicine
Saki F, Shams M, Dastghaib S et al. · 2023 · BioMed research international
Background Recent researches have failed to uncover a clear explanation for proton pump inhibitors' bone-loss effects. In light of pantoprazole's effects on gastrin secretion, the goal of this study was to see if it caused bone loss…
View details →DOI: 10.1155/2023/2594664 Failed Experiment Report
Diel A, Lewis M · 2023 · Preprint
The uncanny valley describes the negative evaluation of near humanlike artificial entities. Previous research with synthetic and real voices failed to find an uncanny valley of voices. This may have been due to the selection of stimuli. In…
View details →DOI: 10.21203/rs.3.rs-2784067/v1 Negative / Null Result ReportMedicine
Legendre M, Sabourin S, Bégin C · 2022 · Eating and weight disorders : EWD
Purpose A higher risk of food addiction (FA) in individuals reporting childhood sexual abuse (CSA) has been well demonstrated with community samples, but studies including clinical samples failed to replicate this relation. This study…
View details →DOI: 10.1007/s40519-022-01441-3 