Tumor Debulking in Combination With Chemotherapy in Multiorgan Metastatic Colorectal Cancer: The ORCHESTRA Randomized Clinical Trial.
Gootjes EC; Bakkerus L; Adhin AA; Zonderhuis BM; Versteeg KS; Tuynman JB; Meijerink MR; Haasbeek CJA · 2026 · JAMA
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
Importance Local therapy, including surgery, radiation, and ablation, is increasingly used in patients with multiorgan metastatic colorectal cancer (mCRC). However, prospective evidence for a survival benefit of tumor debulking is lacking.…
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Metadata source: Europe PMC · DOI 10.1001/jama.2026.1929