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WASTE Journal
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

AllReplication FailureNegative / Null Result ReportFailed Experiment ReportAbandoned HypothesisMethods Dead-EndShort NoteNull DatasetProtocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,267Computer Science 751Biochemistry, Genetics and Molecular Biology 433Social Sciences 307Psychology 304Physics 280Neuroscience 254Economics, Econometrics and Finance 205Environmental Science 179Mathematics 159Engineering 146Agricultural and Biological Sciences 142

21322 results · page 463 of 711

Negative / Null Result ReportMedicine

Non-tobacco nicotine use and complications in single-level posterior lumbar and transforaminal lumbar interbody fusion.

Nguyen, Hall, Lebens et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Over 300,000 lumbar fusion surgeries are performed annually for various indications. Tobacco use has previously been demonstrated to increase rates of nonunion and mechanical complications, but the impact of non-tobacco nicotine (NTN)…

View details →DOI: 10.1007/s00586-026-10081-5
Negative / Null Result ReportMedicine

Utilization of indocyanine green fluorescence angiography in redo IPAA surgery.

Gulmez, Hinduja, Ajredini et al. · 2026 · International journal of colorectal disease

Redo/revisional ileal pouch-anal anastomosis (IPAA) surgery is technically challenging and more likely to require mesenteric lengthening maneuvers, largely due to mesenteric reach issues, which may affect the perfusion of the critical…

View details →DOI: 10.1007/s00384-026-05162-2
Negative / Null Result ReportMedicine

Effects of Oxidative Stress and Antioxidant Activity in Uterine Flush Fluid During Early Postpartum on Reproductive Performance of Lactating Holstein-Friesian Dairy Cows.

Hagita, Miura, Shirasuna et al. · 2026 · Animal science journal = Nihon chikusan Gakkaiho

This study examined the impact of early postpartum uterine oxidative stress and antioxidant activity on subsequent reproductive performance in lactating Holstein-Friesian dairy cows. Uterine flush fluid samples were collected at…

View details →DOI: 10.1111/asj.70200
Negative / Null Result ReportMedicine

Inhaled corticosteroids monotherapy in childhood asthma: Any differential response rate between activated and prodrugs?

Majumder, Smyrnova, Ducharme · 2026 · The Journal of asthma : official journal of the Association for the Care of Asthma

The efficacy of inhaled corticosteroids (ICS) as prodrugs (inactive at delivery) has been compared to activated ICS, in mean changes in lung function and symptoms, with limited evidence on achieving control. We aimed to compare the…

View details →DOI: 10.1080/02770903.2026.2686931
Negative / Null Result ReportMedicine

Hemodynamic-guided V-A ECMO management for cardiogenic shock: Insight from initial experience from TWEET study (to wean an ECMO trials).

Nascimbene, Tosun, Nathan et al. · 2026 · Perfusion

BackgroundVeno-arterial extracorporeal membrane oxygenation (V-A ECMO) is used for refractory cardiogenic shock, yet optimal weaning strategies and the role of left ventricular (LV) venting remain unclear. The TWEET-1 study was designed as…

View details →DOI: 10.1177/02676591261458644
Negative / Null Result ReportMedicine

Arthroscopic Repair of Anterior Labroligamentous Periosteal Sleeve Avulsion Lesions Achieves Similar Outcomes and Labral Height Compared With Typical Bankart Lesions With Adequate Capsulolabral Release.

Chang, Lee, Yoon et al. · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

To compare the serial measurements of repaired labral height in the early and late postoperative periods and clinical outcomes between patients with Bankart lesions and those with anterior labroligamentous periosteal sleeve avulsion…

View details →DOI: 10.1002/arj.70357
Negative / Null Result ReportMedicine

Amide proton transfer-weighted magnetic resonance imaging for predicting histopathology and biomarkers in rectal adenocarcinoma.

Liu, Cui, Sun et al. · 2026 · Quantitative imaging in medicine and surgery

Preoperative evaluation of histopathological features and biomarkers is critical for personalized treatment of rectal adenocarcinoma. Amide proton transfer-weighted (APTw) magnetic resonance imaging (MRI) is a promising noninvasive…

View details →DOI: 10.21037/qims-2025-1-2596
Negative / Null Result ReportMedicine

Comparative evaluation of interdental papilla fills around bone level and tissue level implants: A randomised controlled trial.

Mulay, Bhansali, Indurkar et al. · 2026 · Bioinformation

Early achievement of optimal interdental papilla fill around dental implants remains a clinical challenge affecting aesthetic outcomes in single-tooth replacement. Therefore, it is of interest to compare interdental papilla fill around…

View details →DOI: 10.6026/973206300222332
Negative / Null Result ReportMedicine

Primary High-Grade Spinal Sarcomas: A Retrospective Review of 10 Cases.

Fukushi, Emori, Tsuchie et al. · 2026 · Cureus

Aggressive surgical resection with adequate margins is associated with improved local control and survival in selected patients with primary spinal sarcomas. However, anatomical constraints often preclude complete resection, and outcomes…

View details →DOI: 10.7759/cureus.108569
Negative / Null Result ReportMedicine

Oral Health Status and Utilization of Dental Services Among Adults With Disability Compared to Those Without Disabilities in Nevada, United States.

Benson, Gomez, DerAshodian et al. · 2026 · Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

This study examines disability-related disparities in tooth loss and dental visits, and Medicaid dental service utilization across Nevada counties in 2022. A cross-sectional analysis of the 2022 Behavioral Risk Factor Surveillance System…

View details →DOI: 10.1111/scd.70195
Negative / Null Result ReportMedicine

Meal Replacement Therapy for Metabolic Dysfunction-Associated Steatotic Liver Disease in Adolescents with Severe Obesity.

Rode, Wolf, Bolan et al. · 2026 · Childhood obesity (Print)

This clinical trial evaluated hepatic fat content and weight loss in adolescents with severe obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) following short-term meal replacement therapy (MRT). Adolescents aged…

View details →DOI: 10.1177/21532176261457202
Negative / Null Result ReportMedicine

Effect of Irreversible Compression on the Pulmonary Nodule Detection Rate in Chest Radiographs Using AI Software.

Kohzai, Yamamoto, Matsushita et al. · 2026 · Diagnostics (Basel, Switzerland)

Objectives : Whereas irreversible compression of Digital Imaging and Communications in Medicine (DICOM) files can reduce data size, research on its impact on diagnostic ability when using artificial intelligence (AI) software is limited.…

View details →DOI: 10.3390/diagnostics16111637
Negative / Null Result ReportMedicine

Consensus-Level and Cluster-Adjusted Evaluation of a Large Language Model for Diagnostic Extraction from Musculoskeletal Radiology Reports.

Bosbach, Montazeri, Senge et al. · 2026 · Diagnostics (Basel, Switzerland)

Purpose: Large language models (LLMs) may reduce administrative workload in radiology by automating structured diagnostic extraction from text reports. This study evaluates the accuracy of ChatGPT-4.0 when extracting correct diagnoses from…

View details →DOI: 10.3390/diagnostics16111590
Negative / Null Result ReportMedicine

Impact of Body Mass Index on Clinical Outcomes of LLETZ.

Paternostro, Joura, Postl et al. · 2026 · Journal of clinical medicine

Background/Objectives: Large loop excision of the transformation zone (LLETZ) is used as a standard treatment for cervical dysplasia. Although obesity is associated with reduced cervical screening participation and may complicate…

View details →DOI: 10.3390/jcm15114307
Negative / Null Result ReportMedicine

Outcomes of Indication-Based Reconstruction Strategies in a Retrospective Observational Cohort of Patients with Paprosky Type IIC Acetabular Defects.

Astan, Balta, Zengin et al. · 2026 · Journal of clinical medicine

Background/Objectives: Paprosky Type IIC acetabular defects encountered during revision total hip arthroplasty (rTHA) present substantial challenges in terms of surgical planning and implant stability. This study evaluates the outcomes of…

View details →DOI: 10.3390/jcm15114220
Negative / Null Result ReportMedicine

Prophylactic Effects of Combined Bosentan and Nintedanib on Early Post-Traumatic Joint Contracture Formation in a Rat Model.

Wegner, Warnke, Buschmann et al. · 2026 · Journal of clinical medicine

Background/Objectives : Post-traumatic joint contracture (PTJC) is a common complication in orthopedic surgery characterized by fibrosis and restricted joint mobility. Previous work by our multi-arm study demonstrated that nintedanib…

View details →DOI: 10.3390/jcm15114116
Negative / Null Result ReportMedicine

Effectiveness of the Anatomage Table Vet Prior to Cadaveric Dissection of Dog's Thoracic Limb Muscles: A Preliminary Assessment and Student Learning Outcomes.

Merluzzi, Lepri, Lidano et al. · 2026 · Animals : an open access journal from MDPI

The Anatomage Table Vet (ATV) is a digital tool that may facilitate the understanding of complex structures and improve visuospatial skills. This study evaluated the effectiveness of the ATV as a review method prior to cadaveric dissection…

View details →DOI: 10.3390/ani16111695
Negative / Null Result ReportMedicine

The internal fit and fracture resistance of stainless-steel crowns and porcelain fused to metal crowns in intact and severely damaged permanent molars: an in vitro study.

Moosavi, Khorakian, Sedaghati et al. · 2026 · BMC oral health

Severe caries in mixed dentition frequently affects mandibular first permanent molars, often necessitating full-coverage restorations. Stainless steel crowns (SSCs) and porcelain-fused-to-metal (PFM) crowns are among the most commonly used…

View details →DOI: 10.1186/s12903-026-08831-4
Negative / Null Result ReportMedicine

Impact of time to ablation on survival outcomes in patients with colorectal liver metastases: an inverse probability-weighted cohort study.

Yue, Kong, Huang et al. · 2026 · BMC cancer

The optimal timing for thermal ablation (TA) in patients with colorectal liver metastases (CRLM) eligible for local curative therapy remains undefined. This study aimed to evaluate the impact of time to ablation (TTA) on long-term survival…

View details →DOI: 10.1186/s12885-026-16333-3
Negative / Null Result ReportMedicine

1-year patient-reported outcomes in patients with a documented GLP-1 agonist prescription history prior to total hip arthroplasty: a retrospective cohort study.

Benyamini, Khan, Elmenawi et al. · 2026 · Hip international : the journal of clinical and experimental research on hip pathology and therapy

Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly utilised for metabolic optimisation in surgical patients. Their effect on postoperative patient-reported outcomes (PROMs) and satisfaction following primary total hip…

View details →DOI: 10.1177/11207000261450078
Negative / Null Result ReportMedicine

Efficacy of High Flow Nasal Cannula in Reducing Hypoxemia in Children Undergoing Elective Flexible Fibreoptic Bronchoscopy as Compared to Conventional Low Flow Nasal Cannula: A Randomized Controlled Trial.

Rajvanshi, Kumar, Goyal et al. · 2026 · Pediatric pulmonology

Flexible fibreoptic bronchoscopy (FFB) is widely used in pediatric pulmonology, though hypoxemia remains a primary concern during the procedure. High-flow nasal cannula (HFNC) has shown potential in reducing hypoxemia in adults undergoing…

View details →DOI: 10.1002/ppul.71683
Negative / Null Result ReportMedicine

Prospective observational comparative study of radiotherapy induced toxicities (xerostomia, skin reaction, and mucositis) between three-dimensional conformal radiotherapy and intensity modulated radiotherapy technique to oral cavity cancer of head and neck.

Dhakar, Ghori, Parihar et al. · 2026 · The Gulf journal of oncology

Oral cavity cancers often require radiotherapy (RT), leading to toxicities such as xerostomia, skin reactions, and mucositis. This study aims to compare these toxicities between three-dimensional conformal radiotherapy (3D-CRT) and…

View details →