A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20253 results in Negative / Null Result Report · page 455 of 676
Madrigano J, Yan D, Liu T et al. · 2024 · GeoHealth
Indonesia faces significant air quality issues due to multiple emissions sources, including rapid urbanization and peatland fires associated with agricultural land management. Limited prior research has estimated the episodic shock of…
Wachowicz A, Galbarczyk A, Marcinkowska UM et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council
Objectives Duration and quality of sleep are influenced by many factors, including hormonal changes. The aim of this study was to investigate the differences between the phases of the menstrual cycle in total sleep duration and sleep stage…
Jennings EA, Roberts-Toler C, Harriman NW et al. · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences
Objectives Social isolation is a concern among aging populations, and household composition may play an important role in its impact on mental health. We use data from an aging cohort in rural South Africa to investigate the moderating…
Abdul Jafar NK, Tham EKH, Fok D et al. · 2026 · Nutrients
Background: Maternal chronotype, maternal sleep, and breastfeeding practices are separately associated with maternal mood. However, it is not known if maternal mood mediates the associations between maternal chronotype or maternal sleep…
Barendse MEA, Bilder RM, Snijders AL et al. · 2026 · Biological psychiatry global open science
Background Function of the striatal reward system has been implicated in both psychotic and bipolar disorders. We aimed to test whether ventral striatum (VS) activation during reward anticipation meets criteria of an endophenotype of these…
Mifune N · 2021 · Preprint
Whether intergroup conflict is a necessary condition for the evolution of human prosociality has been a matter of debate. At the center of the debate is the coevolutionary model of parochial altruism—that human cooperation with in-group…
Enouy S, Desrochers J, Bossom I et al. · 2022 · Preprint
Objective: A recent meta-review of attentional bias research in eating disorders suggests that meta-analyses and systematic reviews include many low-quality and underpowered studies (Stott et al., 2021). As such, we examined whether…
Martineau AR · 2023 · The Proceedings of the Nutrition Society
This review summarises evidence relating to a potential role for vitamin D supplementation in the prevention or treatment of coronavirus disease 2019 (COVID-19). Laboratory studies show that the active vitamin D metabolite…
Palepu K, Sadeghi K, Kleinschmidt DF et al. · 2023 · BMC neurology
Background Sleep spindle activity is commonly estimated by measuring sigma power during stage 2 non-rapid eye movement (NREM2) sleep. However, spindles account for little of the total NREM2 interval and therefore sigma power over the…
Trombetta AB, Hanney WJ, Anderson AW et al. · 2026 · Muscles (Basel, Switzerland)
Background Tensiomyography (TMG) offers a noninvasive means of evaluating skeletal muscle contractile properties, including muscle displacement (Dm), delay time (Td), contraction time (Tc), half-relaxation time (Tr), and sustain time (Ts).…
Errington TM, Mathur M, Soderberg CK et al. · 2021 · eLife
Replicability is an important feature of scientific research, but aspects of contemporary research culture, such as an emphasis on novelty, can make replicability seem less important than it should be. The Reproducibility Project: Cancer…
Giesen CG, Eder AB · 2022 · Cognition & emotion
The adaptation-by-binding account and the arousal-biased competition model suggest that emotional arousal increases binding effects for transient links between stimuli and responses. Two highly-powered, pre-registered experiments tested…
Ianni KM, Chernew ME, McWilliams JM · 2026 · Health services research
Objective To examine the effects of offering non-emergency medical transportation (NEMT) on care utilization among low-income and disabled beneficiaries in Medicare Advantage (MA). Study setting and design We leveraged the 2019 expansion…
Jaeger B, Jones AL, Satchell L et al. · 2026 · International review of social psychology
The role of perceiver differences in impression formation remains relatively poorly understood. One line of research has tried to understand these differences by exploring the role of perceivers' needs and motivations, reasoning that…
Rafiee Y, Jones BC, Shiramizu VKM · 2022 · Preprint
The Compensatory Prophylaxis Hypothesis proposes that women will show increased pathogen disgust at points in the menstrual cycle when progesterone is high, compensating for the immunosuppressive effects of progesterone. However, evidence…
Kumar AR, Sanford NN · 2025 · Seminars in radiation oncology
Based on available Level 1 evidence, standard dose conventional chemoradiation does not improve survival in patients with locally advanced pancreas cancer (LAPC), thus chemotherapy remains the only widely accepted therapy. Yet prognosis…
Tebib N, Liaudet L, Ltaief Z · 2026 · Journal of intensive care
Background In patients with refractory cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (ECMO) provides temporary circulatory support, but optimal strategies to promote myocardial recovery and facilitate ECMO weaning…
Xu H, Yan Y, Niu J et al. · 2026 · BMC cancer
BACKGROUND: Metastatic colorectal cancer (mCRC) patients who progress following the standard chemotherapy have maintained a favourable performance status. Nevertheless, there are limited effective treatment options, particularly for a…
Koonrungsesomboon N, Teeyakasem P, Dukaew N et al. · 2025 · International journal of clinical oncology
Background Osteosarcoma is a prevalent and aggressive bone malignancy primarily affecting young adults. Despite advances in standard treatment, the 5-year survival rate remains low, highlighting the need for new chemotherapy options.…
Liu J, Moura DS, Jones RL et al. · 2024 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose This exploratory analysis evaluated the tumor samples of the patients treated with doxorubicin (with or without olaratumab) in a negative phase III ANNOUNCE trial to better understand the complexity of advanced soft tissue sarcomas…
Bendetowicz D, Fabbri M, Sirna F et al. · 2024 · Current neurology and neuroscience reports
Purpose of review This review summarizes previous and ongoing neuroprotection trials in multiple system atrophy (MSA), a rare and fatal neurodegenerative disease characterized by parkinsonism, cerebellar, and autonomic dysfunction. It also…
Van der Helm-van Mil AHM · 2023 · Joint bone spine
During the last decade, the outlook for patients with rheumatoid arthritis (RA) has improved greatly, especially for patients with autoantibody-positive RA. To further improve long-term disease outcomes, the field has turned to…
Ghimouz A, Dureau S, Carton M et al. · 2026 · Scientific reports
The value of music (MUS) and virtual reality (VR) in reducing pain or anxiety during central venous port implantation (CVPI) is controversial. We conducted a randomised multicenter controlled trial in 127 patients who received either MUS…
Janeway KA, Chou AJ, Buxton A et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Mouse models demonstrate a role for RANK and its ligand, RANKL, in osteosarcoma. The primary objective of this single-arm, open-label phase 2 trial was to determine whether denosumab, a RANKL mAb, improved disease control in…
Savsani PK, Khan SH, Perkins AJ et al. · 2025 · Critical care medicine
Objectives To describe the performance of the Healthy Aging Brain Care Monitor Self Report (HABC-M SR) in assessment of post-intensive care syndrome (PICS) among Acute Respiratory Failure ICU survivors. Design Secondary data analysis of a…
Chaudhari A, Almajali M, Khan N et al. · 2026 · Stroke (Hoboken, N.J.)
Background Endovascular thrombectomy (EVT) has transformed the management of acute ischemic stroke, but remains inaccessible to many patients due to anatomic, clinical, or logistical limitations. Treatment strategies for patients with…
Andersson Y, Løvstakken E, Herud TM et al. · 2025 · Annals of surgical oncology
Background Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery is a potentially curative treatment for patients with peritoneal metastases. Currently, there is no standardized protocol for performing HIPEC and…
Dubbelman MA, Vromen EM, Tijms BM et al. · 2024 · Alzheimer's & dementia (New York, N. Y.)
With the advent of the first generation of disease-modifying treatments for Alzheimer's disease, it is clearer now more than ever that the field needs to move toward personalized medicine. Pooling data from past trials may help identify…
Scahill L, Shillingsburg MA, Ousley O et al. · 2022 · Journal of the American Academy of Child and Adolescent Psychiatry
Objective To compare Direct Instruction Language for Learning (DI) plus treatment as usual (TAU) with TAU alone in children with autism spectrum disorder and moderate language delay. Method In this study, 83 children (age range, 4 years to…
Bremhorst A, Mills DS, Würbel H et al. · 2022 · Animal cognition
Facial expressions potentially serve as indicators of animal emotions if they are consistently present across situations that (likely) elicit the same emotional state. In a previous study, we used the Dog Facial Action Coding System…