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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19875 results in Negative / Null Result Report · page 455 of 663

Negative / Null Result ReportOpen accessAnimal culture

EFFECT OF ETHANOL EXTRACT FROM MALACCA LEAVES (Phyllanthus emblica) ON THE SPERM QUALITY OF MICE

Cut Nila Thasmi, Nuzul Asmilia, Elfi Satria Suryani et al. · 2022 · Jurnal Kedokteran Hewan

This study aims to analyze the effect of administering Malacca leaves (Phyllanthus emblica) extract on the sperm quality of mice. This leaf extract was administered orally using gavage method once daily for 21 days. There were four treatment groups: the control group (P0) received distilled water while the first (P1), second (P2), and third (P3) treatment groups received 300 mg, 600 mg, and 1200 mg of Malacca leaf ethanol extract/kg body weight, respectively. Each groups consisted of four mice and was evaluated for sperrm motility, viability, morphology, and concentration. The results showed t

View details →DOI: 10.21157/j.ked.hewan.v16i3.27246
Negative / Null Result ReportOpen accessAnimal culture

Effect of glucose oxidase combined with Lactobacillus on growth performance and immune function of broilers

Jing-ping GAO, Jia-ning SUN, Xian-hua LI et al. · 2021 · Siliao yanjiu

The experiment was to study the effect of the combination of glucose oxidase (GOD) and Lactobacillus on growth performance and immune function of broilers. A total of 1 200 one-day-old AA broilers were randomly divided into four groups: group Ⅰ (control group), group Ⅱ, group Ⅲ and group Ⅳ. The control group was free to drink water, group Ⅱ was added 0.1% GOD in the drinking water of each chicken daily, and group Ⅲ was added 1.5×10 5 CFU/g Lactobacillus preparation in the drinking water of each chicken daily. In test group Ⅳ, 0.1% GOD and 1.5×10 5 CFU/g Lactobacillus were added to each chicken

Negative / Null Result ReportOpen accessDentistry

Effect of laser etching on shear bond strength between polyether ether ketone (PEEK) and maxillofacial silicone after accelerated ageing – an in vitro study

Ganesh RamKumar Rajapandi, Ahila Singaravel Chidambaranathan, MuthuKumar Balasubramanium · 2025 · Biomaterial Investigations in Dentistry

Introduction: Debonding of silicone prostheses from metal substructures is a frequently reported complication in prosthodontics. Polyether ether ketone (PEEK) has emerged as a promising alternative framework material owing to its favourable biomechanical properties; however, its limited bond strength to silicone remains a concern. The present study aimed to evaluate the shear bond strength between PEEK and maxillofacial silicone following laser etching of PEEK and subsequent accelerated ageing. Materials and methods: According to ISO 10477:2020, 128 PEEK specimens were fabricated using Compute

View details →DOI: 10.2340/biid.v12.45066
Negative / Null Result ReportOpen accessScience

Social value orientation and attachment: a replication and extension of Van Lange et al. (1997)

Hans IJzerman, Jaap J. A. Denissen · 2019 · Royal Society Open Science

We report a replication and extension of a finding from Studies 1 and 2 of Van Lange et al.'s influential paper (Van Lange et al. 1997 J. Pers. Soc. Psychol. 73, 733–746. (doi:10.1037/0022-3514.73.4.733)), which showed an association between Social Value Orientation (SVO) and attachment security. We report a close replication but with measures of attachment that are considered superior in comparison to measures used by Van Lange et al., due to subsequent psychometric improvements. Psychometric analyses indeed showed that our attachment measures were reliable and valid, demonstrating theoretica

View details →DOI: 10.1098/rsos.181575
Negative / Null Result ReportOpen accessMedicine

The effect of Edaravone on clinical symptoms and oxidative stress factors in patients with acute ischemic stroke: A clinical trial

Mojtaba Khazaei, Fatemeh Saadati Pour, Masoud Ghiasian et al. · 2024 · مجله علوم پزشکی فیض (پیوسته)

Background and Aim: Edaravone is known for its efficacy in inhibiting free radical formation, activating microglia, and promoting neurogenesis and neuroprotection following acute ischemic stroke. This clinical trial aimed to investigate the effects of Edaravone on clinical symptoms and oxidative stress factors in patients with acute ischemic stroke. Methods: In this clinical trial, fifty-two patients diagnosed with acute ischemic stroke were randomly assigned to receive either Edaravone (120 mg daily up to 3 doses intravenously) or a placebo in addition to standard treatment. Stroke severity w

Negative / Null Result ReportOpen accessMedicine (General)

Clinical Outcomes in Maximum Tolerated Medical Therapy in Penetrating Keratoplasty for Bullous Keratopathy

Seoyoung Wy, Seoyoung Wy, Young Kook Kim et al. · 2022 · Frontiers in Medicine

PurposeTo compare the clinical outcomes of maximum tolerated medical therapy (MTMT) in patients with penetrating keratoplasty (PKP) with those of Ahmed glaucoma valve (AGV) implantation.MethodsThe medical records were retrospectively reviewed in patients who had undergone PKP for bullous keratopathy and were treated with MTMT or AGV implantation for the management of glaucoma. A total of 18 bullous keratopathic patients were investigated between January 2010 and February 2017: 9 patients treated with MTMT and 9 patients treated with AGV implantation. Non-corrected visual acuity (NCVA), intraoc

View details →DOI: 10.3389/fmed.2022.810848
Negative / Null Result ReportOpen accessVeterinary medicine

Evaluation of Rectal and Skin Temperature Variations of Anesthetised Dogs Undergoing Magnetic Resonance Imaging Diagnosis

Andra DEGAN, Ruxandra TUDOR, Ruxandra COSTEA et al. · 2019 · Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Veterinary Medicine

General anesthesia produces different degrees of central nervous depression and changes in the peripheral circulation, therefore affecting the patient’s thermoregulatory mechanism. Moreover, the lack of proper, specially designed equipment for magnetic resonance imaging (MRI) environment monitoring can represent a challenge for the anesthetist. We examined the temperature variations correlated with different anesthetic protocols in dogs that underwent general anesthesia in order to evaluate changes in rectal and distal extremities temperature, before and after anesthesia. This study was conduc

View details →DOI: 10.15835/buasvmcn-vm:2019.0024
Negative / Null Result ReportOpen accessMedicine (General)

Pregabalin to improve postoperative recovery in bariatric surgery: a parallel, randomized, doubleblinded, placebo-controlled study

Martins MJ, Martins CPMO, Castro-Alves LJ et al. · 2018 · Journal of Pain Research

Marcelo J Martins,1 Caroline Paiva Matos Oliveira Martins,2 Lucas J Castro-Alves,3 Gabriel Nascimento Jesus,4 Guilherme Oliveira Campos,5 Breno Barbosa Cerqueira Sacramento,4 Leonardo Ferrari Borges,6 Carlos Augusto Bastos Mello,6 Rodrigo Leal Alves,5 Norma Sueli Pinheiro Módolo7 1Department of Anesthesiology, São Paulo State University (UNESP), São Paulo, Brazil; 2Department of Anesthesiology at Federal University of Bahia, Bahia, Brazil; 3Department of Anesthesiology, Santo Antonio Hospital, Salvador, Bahia, Brazil; 4Department of Anesthesia, Bahia University of Medicine

Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system

Application of ultrasound in avoiding radial nerve injury during elbow arthroscopy: a retrospective follow-up study

Xingtao Ge, Xinghua Ge, Chen Wang et al. · 2022 · BMC Musculoskeletal Disorders

Abstract Background A safe and effective technique for anterolateral portal placement in elbow arthroscopy is significant. We compared the outcomes of patients who underwent elbow arthroscopy using different ultrasound-assisted techniques. Methods From May 2016 to June 2021 a retrospective analysis on all patients who underwent elbow arthroscopy in our department was performed. Patients were separated into three groups: non-ultrasound; preoperative ultrasound; and intraoperative ultrasound. The minimum follow-up period was 1 year. Nerve injuries, visual analog scale (VAS), Mayo elbow-performan

View details →DOI: 10.1186/s12891-022-06109-8
Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry

Comparing the synaptic potentiation in schaffer collateral-CA1 synapses in dorsal and intermediate regions of the hippocampus in normal and kindled rats

Maryam Sharifi, Shahrbanoo Oryan, Alireza Komaki et al. · 2023 · IBRO Neuroscience Reports

There is growing evidence that the hippocampus comprises diverse neural circuits that exhibit longitudinal variation in their properties, however, the intermediate region of the hippocampus has received comparatively little attention. Therefore, this study was designed to compared short- and long-term synaptic plasticity between the dorsal and intermediate regions of the hippocampus in normal and PTZ-kindled rats. Short-term plasticity was assessed by measuring the ratio of field excitatory postsynaptic potentials’ (fEPSPs) slope in response to paired-pulse stimulation at three different inter

View details →DOI: 10.1016/j.ibneur.2023.09.010
Negative / Null Result ReportOpen accessComputer applications to medicine. Medical informatics

The Impact of Digital Technology–Based Exercise Combined With Dietary Intervention on Body Composition in College Students With Obesity: Prospective Study

Chengyuan Hu, Zixin Lv, Jieping Zhu et al. · 2025 · Journal of Medical Internet Research

BackgroundLifestyle interventions are a critical component of weight loss programs, yet digital, personalized, and theory- and evidence-based lifestyle interventions remain limited. ObjectiveThis study aimed to investigate the effects of a combination of various dietary approaches and digital technology–based exercise on the body composition of college students with obesity. MethodsA total of 129 college students with obesity (mean age 18.3, SD 0.7 years; mean weight 89.9, SD 13.6 kg; mean BMI 30.6, SD 3.3 kg/m2) were initially recruited for this study. After excluding 2 participants, 127 stud

View details →DOI: 10.2196/65868
Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry

Surgical outcomes following encephaloduroarteriosynangiosis in moyamoya disease associated with hyperhomocysteinemia

Gan Gao, Fang‐bin Hao, Qian‐Nan Wang et al. · 2023 · Brain and Behavior

Abstract Introduction This study investigated the effect of indirect revascularization surgery in adult patients with moyamoya disease (MMD) complicated with hyperhomocysteinemia (HHcy), and the effect of HHcy on the progression of adult MMD. Methods A retrospective case‐control study was conducted in patients with MMD, with or without HHcy (n = 123). Postoperative collateral angiogenesis was evaluated using the Matsushima grading system and disease progression using the Suzuki staging system. Cerebral blood flow was evaluated before and after surgery using dynamic susceptibility contrast magn

View details →DOI: 10.1002/brb3.3093
Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology

Efficacy of Anticholinergics for Chronic Prostatitis/Chronic Pelvic Pain Syndrome in Young and Middle-Aged Patients: A Single-Blinded, Prospective, Multi-Center Study

Doo Sang Kim, Yoon Soo Kyung, Seung Hyo Woo et al. · 2011 · International Neurourology Journal

Purpose Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) exhibits variable lower urinary tract symptoms (LUTS). The aim of this study was to evaluate the incidence of LUTS and the efficacy of an anticholinergic agent in young and middle-aged CP/CPPS patients. Methods Ninety-six men with CP/CPPS were randomly assigned in a single-blind fashion and received either ciprofloxacin (group 1, 49 patients) or ciprofloxacin and solifenacin (5 mg/day; group 2, 47 patients) for 8 weeks. The National Institutes of Health chronic prostatitis symptom index (NIH-CPSI), the International Prostate Sy

View details →DOI: 10.5213/inj.2011.15.3.172
Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system

The effect of repetitive bilateral arm training with rhythmic auditory cueing on motor performance and central motor changes in patients with chronic stroke

Enas M Shahine, Tarek S Shafshak · 2014 · Egyptian Rheumatology and Rehabilitation

Objective The aim of this study was to compare the effects of bilateral arm training with auditory cueing (BATRAC) versus control intervention on motor performance of the upper extremity (UE) and to explore the central neurophysiological mechanism underlying this effect in moderately impaired chronic stroke patients. Design This was a randomized-controlled clinical trial. Materials and Methods Overall, 76 chronic stroke patients (mean age = 50.2 ± 6.2 years), 6-67 months after the onset of the first stroke were enrolled. They received either BATRAC (with both UE trained simultaneously in symme

View details →DOI: 10.4103/1110-161x.128128
Negative / Null Result ReportOpen accessMedicine

Digestive tolerability and acceptability of Fibersol-2 in healthy and diarrheal children 1-3 years old at a rural facility, Bangladesh: Results from a four arm exploratory study.

Abu Sadat Mohammad Sayeem Bin Shahid, Shahnawaz Ahmed, Tanzina Tazul Renesa et al. · 2022 · PLoS ONE

Background Fibersol-2 has some beneficial effects on human health. We aimed to evaluate the digestive tolerability and acceptability of Fibersol-2 in healthy and diarrheal children, as well as improvement in stool consistencies in young diarrheal children. Methods Sixty children of either sex, aged 1-3 years having four groups (healthy children/low dose, healthy children/high dose, children with diarrhea/low dose and children with diarrhea/high dose) were enrolled into this exploratory study between 1st August to 23rd October 2017. Two presumptive doses, low (2.5g) and high (5g), twice daily w

View details →DOI: 10.1371/journal.pone.0274302
Negative / Null Result ReportOpen accessBiology (General)

The Ability of Different Imputation Methods to Preserve the Significant Genes and Pathways in Cancer

Rosa Aghdam, Taban Baghfalaki, Pegah Khosravi et al. · 2017 · Genomics, Proteomics & Bioinformatics

Deciphering important genes and pathways from incomplete gene expression data could facilitate a better understanding of cancer. Different imputation methods can be applied to estimate the missing values. In our study, we evaluated various imputation methods for their performance in preserving significant genes and pathways. In the first step, 5% genes are considered in random for two types of ignorable and non-ignorable missingness mechanisms with various missing rates. Next, 10 well-known imputation methods were applied to the complete datasets. The significance analysis of microarrays (SAM)

View details →DOI: 10.1016/j.gpb.2017.08.003
Negative / Null Result ReportOpen accessOrthopedic surgery

A biomechanics study on ligamentous injury in anterior-posterior compression type II pelvic injury

Jianzhong Kong, Yupeng Chu, Chengwei Zhou et al. · 2021 · Journal of Orthopaedic Surgery and Research

Abstract Background Anterior-posterior compression (APC) type II pelvis fracture is caused by the destruction of pelvic ligaments. This study aims to explore ligaments injury in APC type II pelvic injury. Method Fourteen human cadaveric pelvis samples with sacrospinous ligament (SPL), sacrotuberous ligament (SBL), anterior sacroiliac ligament (ASL), and partial bone retaining unilaterally were acquired for this study. They were randomly divided into hemipelvis restricted and unrestricted groups. We recorded the separation distance of the pubic symphysis and anterior sacroiliac joint, external

View details →DOI: 10.1186/s13018-020-02156-w
Negative / Null Result ReportOpen accessVeterinary medicine

A quantitative evaluation of different regions of skin in adult Iranian native sheep

B. Mobini · 2013 · Veterinární Medicína

The present investigation aimed to evaluate the histomorphometric features of the skin of the Iranian native sheep (Bakhtiari breed). A total of 24 apparently healthy Iranian Bakhtiari sheep, aged 1-2 years were analysed and categorised on the basis of sex (12 females and 12 males). Samples were taken as small pieces from different regions of the skin, fixed and stained with H&E. The quantitative evaluations of different regions of skin were carried out using lattice line graticule (5 × 5) and light microscopy. The Student t-test and one-way ANOVA were used to analyse the data and detect signi

View details →DOI: 10.17221/6807-vetmed
Negative / Null Result ReportOpen accessAnimal culture

Effect of treated waste water intake on physiological, growth and hematological parameters in Karan-Fries, Tharparkar and Murrah female calves

ANKITA RAUTELA, ASHUTOSH, ANIL KUMAR et al. · 2023 · Indian Journal of Animal Sciences

The present study was conducted to study the effect of treated effluent waste water over fresh water supply served for drinking purpose to calves on dry matter intake, water intake, growth, physiological and hematological parameters. For the study, 6-8 months old female calves (Karan-Fries (n=12), Tharparkar (n=12) and Murrah (n=12)) were selected from Livestock Research Center of ICAR-National Dairy Research Institute, Karnal. These experimental calves of each breed were distributed equally into two groups. The control group was offered fresh water and treatment group was offered effluent tre

View details →DOI: 10.56093/ijans.v93i8.120166
Negative / Null Result ReportOpen accessDentistry

Comparison of the occlusal contact area of virtual models and actual models: a comparative in vitro study on Class I and Class II malocclusion models

Hyemin Lee, Jooly Cha, Youn-Sic Chun et al. · 2018 · BMC Oral Health

Abstract Backgrounds The occlusal registration of virtual models taken by intraoral scanners sometimes shows patterns which seem much different from the patients’ occlusion. Therefore, this study aims to evaluate the accuracy of virtual occlusion by comparing virtual occlusal contact area with actual occlusal contact area using a plaster model in vitro. Methods Plaster dental models, 24 sets of Class I models and 20 sets of Class II models, were divided into a Molar, Premolar, and Anterior group. The occlusal contact areas calculated by the Prescale method and the virtual occlusion by scanning

View details →DOI: 10.1186/s12903-018-0566-7
Negative / Null Result ReportOpen accessSports

Does Performance of Speed-Accuracy Movements Depend on Gender and the Left or the Right Hand?

Kristina Motiejūnaitė, Dalia Mickevičienė, Albertas Skurvydas et al. · 2018 · Baltic Journal of Sport and Health Sciences

The aim of the study was to establish the differences in men and women’s performance of speed-accuracy movements with their left (LH) and right (RH) hands. The research participants were 24 healthy right-handed subjects: 12 males (aged 20.8 ± 1.1 years) and 12 females (aged 21.4 ± 1.0 years). The research was carried out in the Laboratory of Human Motor Control at the Lithuanian Academy of Physical Education (LAPE) applying the analyzer of dynamic parameters of human leg and arm movement (DPA-1; Patent No. 5251; 2005 08 25), which is used for the qualitative estimation of the dynamic parameter

View details →DOI: 10.33607/bjshs.v2i77.381
Negative / Null Result ReportOpen accessMedicine

Repair of microdamage in osteonal cortical bone adjacent to bone screw.

Lei Wang, Tingjun Ye, Lianfu Deng et al. · 2014 · PLoS ONE

Up to date, little is known about the repair mode of microdamage in osteonal cortical bone resulting from bone screw implantation. In this study, self-tapping titanium cortical bone screws were inserted into the tibial diaphyses of 24 adult male rabbits. The animals were sacrificed at 1 day, 2 weeks, 1 month and 2 months after surgery. Histomorphometric measurement and confocal microscopy were performed on basic fuchsin stained bone sections to examine the morphological characteristics of microdamage, bone resorption activity and spatial relationship between microdamage and bone resorption. Di

View details →DOI: 10.1371/journal.pone.0089343
Negative / Null Result ReportOpen accessOils, fats, and waxes

粒径对平底筒仓中心卸料的流态 及仓壁压力分布的影响Influence of particle size on the flow pattern and wall pressure distribution of central discharge in flat-bottom silo

杨世明1,刘克瑾2,姚辉江2,黄硕硕2,杜春来1,章敬波1 YANG Shiming1, LIU Kejin2, YAO Huijiang2, HUANG Shuoshuo2, DU Chunlai1, ZHANG Jingbo1 · 2025 · Zhongguo youzhi

旨在为筒仓的设计和优化提供参考,基于自主设计的半圆柱形有机玻璃平底筒仓模型,进行了平均粒径分别为15、3.5 mm和5.5 mm陶球颗粒的室内筒仓中心卸料试验和离散元数值模拟。采用流态观察、速度分析、颗粒位移追踪3种方法探究了3组粒径颗粒的流态演变过程,分析了仓壁压力分布及变化规律,通过PFC 2D得到孔隙率、力链等细观变量分布并联合宏观层次的物理试验探讨了粒径大小对流态及仓壁压力的影响。结果表明:粒径对颗粒流态的整体演化过程无显著影响,不同粒径颗粒的流态均由整体流经漏斗流过渡为管状流;大粒径颗粒完成卸料过程耗时更久,卸料速率更慢;粒径对颗粒的流动轨迹无显著影响;边界区并不是一成不变的,在卸料过程中随着粒径的增大而逐渐上移;不同粒径颗粒组的峰值卸料压力最大值均位于距离仓底约1/3的位置;粒径越大,仓壁的压力波动越剧烈,峰值卸料压力也越大。综上,粒径对平底筒仓中心卸料的流态无显著影响,不同粒径的颗粒流态演化过程和颗粒流动轨迹具有相似性,粒径越大产生的仓壁卸料压力也越大。在实际工程中,需考虑粒径对筒仓结构安全性的影响。 To provide a reference for the design and optimization of silos, based on a self-designed semi-cylindrical plexiglass flat-bottom silo

View details →DOI: 10.19902/j.cnki.zgyz.1003-7969.240387
Negative / Null Result ReportOpen accessBusiness

KEBIJAKAN DIVIDEN DAN BI RATE SEBAGAI PEMODERASI LIKUIDITAS, PROFITABILITAS, DAN LEVERAGE TERHADAP NILAI PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BEI TAHUN 2011-2017

Ananto Dwi Antoro, Sri Hermuningsih · 2018 · Upajiwa Dewantara: Jurnal Ekonomi, Bisnis dan Manajemen Daulat Rakyat

The purpose of this study is dividend payout ratio and BI Rate as moderation of liquidity, profitability, and leverage on financial firm value in Indonesia Stock Exchange within period 2011-2017. Research using purposive sampling method for taking sample, as many as 10 banks based on criteria. The research used secondary data from company’s annual report. The data were analyzed by using SPSS and SmastPls 3.2.7. The result showed that :1) the Liquidity and BI Rate have negative effect on company’s value but the effect were not significant, 2) profitability has a positive significant effect on f

View details →DOI: 10.26460/mmud.v2i1.3070
Negative / Null Result ReportOpen accessSports medicine

Safety and Effectiveness of a Perturbation-based Neuromuscular Training Program on Dynamic Balance in Adolescent Females: A Randomized Controlled Trial

Alison Bulow, Judith E Anderson, Jeff R S Leiter et al. · 2021 · International Journal of Sports Physical Therapy

# Background Adolescent females are at much greater risk for ACL injury than their male counterparts when participating in the same sports. Preventative and pre-operative rehabilitation neuromuscular (NM) exercise programs are often recommended to improve knee function and reduce injury rates. The effectiveness of perturbation-based NM training program has been established in an adult population but has yet to be investigated in the at-risk adolescent female population. # Purpose To determine the effectiveness of a perturbation-based NM exercise program in a group of physically active adolesce

View details →DOI: 10.26603/001c.25685
Negative / Null Result ReportOpen accessGeography (General)

An Analysis on the Urban Identity Element of Sabzevar with Emphasis on the Views of Citizens

Fatemeh Hajari, Yaghoob Zanganeh, Alireza Hamidian · 2018 · تحقيقات جغرافيايی

Introduction and Background: The issue of identity in general and urban identity in particular has a great importance because of the role that play in recognizing individuals, objects, communities and places. In spite of the importance of this issue, urban identity crisis is alarming in recent times. Natural elements, physical and socio-cultural components are three main elements identifying that conditions and characteristics of each of them determining their role in the identity of the city. Aims: The main purpose of this study is investigate and identify the urban identity component of Sabz

Negative / Null Result ReportOpen accessSurgery

A compara tive analysis of short-term patient outcomes after laparoscop ic versus robotic rectal surgery

Chi Zhaocheng · 2022 · 结直肠肛门外科

[Background] The popularity of robot-assisted colorectal surgery has risen over recent years; however, patient-related advantages over laparoscopic surgery remain uncertain. [Objective] The goal of this study was to compare short-term patient outcomes following robotic and laparoscopic partial or complete rectal resections. [Design] This was a retrospective cohort study. [Settings] The study was conducted at 5 large tertiary care Kaiser Permanente medical centers across Southern California. [Patients] There were 863 consecutive robotic and laparoscopic pelvic rectal surgeries, including low an

View details →DOI: 10.19668/j.cnki.issn1674-0491.2022.02.019
Negative / Null Result ReportOpen accessMedicine (General)

Association of Apolipoprotein E Polymorphism with Ischemic Stroke Subtypes in Taiwan

Chiou-Lian Lai, Ching-Kuan Liu, Ruey-Tay Lin et al. · 2007 · Kaohsiung Journal of Medical Sciences

The aim of this study was to clarify whether the apolipoprotein E gene (APOE) is related to ischemic stroke subtypes in Taiwan's Chinese population. Using the classification of Cerebrovascular Diseases III, 143 patients with lacunar infarction, 114 patients with atherothrombotic infarction, and 112 healthy controls were enrolled. APOE genotype was determined using polymerase chain reaction. Regarding the distribution of APOE genotypes, the frequency of ϵ3/ϵ4 genotypes in lacunar patients was significantly different from that in control subjects, by logistic regression, using ϵ3/ϵ3 as a referen

View details →DOI: 10.1016/s1607-551x(08)70006-8
Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system

Risk of Ischemic Heart Disease in Patients With Postpancreatectomy Diabetes and Pancreatic Cancer: A Population‐Based Study

Daegwang Yoo, Minsun Kang, Jaehun Jung · 2023 · Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background Postpancreatectomy diabetes can be caused by resection of functioning pancreatic tissue and is associated with postoperative pancreatic islet cell mass loss and subsequent endocrine dysfunction. Diabetes is a well‐known risk factor for ischemic heart disease. However, no previous studies have investigated ischemic heart disease in patients with postpancreatectomy diabetes and pancreatic cancer. Methods and Results Rates of patients with diabetes diagnosed with pancreatic cancer who underwent pancreatectomy between 2002 and 2019 in South Korea were obtained from the Korean National H

View details →DOI: 10.1161/jaha.123.031321