e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21720 results · page 455 of 724

Negative / Null Result ReportMedicine

Explorative investigation on effects of multi-day neurofeedback with implanted electrodes in patients with Parkinson's disease.

Rohr-Fukuma M, Stieglitz LH, Bujan B et al. · 2026 · Neuroscience

Neurofeedback, which consists of recording and visualizing neural activity in real-time, is a method currently being investigated as a supplementary treatment for Parkinson's disease (PD). By using implanted deep brain stimulation (DBS)…

View details →DOI: 10.1016/j.neuroscience.2026.06.016
Negative / Null Result ReportMedicine

Comparison of the Efficacy of Intra-Articular Polyacrylamide Hydrogel and the Cross-Linked Hyaluronic Acid/Chondroitin Sulfate Combination in Treating Advanced-Stage Knee Osteoarthritis.

Altıntaş M, Ateş O, Soy F et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Polyacrylamide hydrogel (PAAG) is still underresearched, and few human studies have validated its efficacy in knee osteoarthritis (OA), particularly in advanced stages. The aim of this study was to compare the…

View details →DOI: 10.3390/medicina62061091
Negative / Null Result ReportMedicine

Improving Operative Note Documentation in Vascular Surgery: A Two-Cycle Closed-Loop Audit Following Introduction of Standardised Procedure-Specific Templates.

Mersal M, Amin A, Embaby OM et al. · 2026 · Annals of vascular surgery

Objective To evaluate completeness of operative note documentation in a vascular surgery service and to assess whether introduction of standardised procedure-specific templates was associated with improved documentation in a repeat audit…

View details →DOI: 10.1016/j.avsg.2026.06.008
Negative / Null Result ReportMedicine

The effect of glandular frenulectomy on refractory lifelong premature ejaculation: a pilot study.

Roaiah MF, El Khayat YI, Saad El Din OA et al. · 2026 · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

Purpose Premature ejaculation (PE) is one of the most common male sexual disorders and is influenced by both psychological and biological factors. Despite available treatments, including psychosexual therapy and pharmacological…

View details →DOI: 10.4081/aiua.2026.14899
Negative / Null Result ReportMedicine

Impact of an 8-Week Targeted Potentiation Phase in the RAMP Warm-Up Protocol on Agility Performance in Female Police Officers.

Janković D, Kukić F, Radić I et al. · 2026 · Journal of strength and conditioning research

Abstract Janković, D, Kukić, F, Radić, I, Čvorović, A, Dawes, J, and Dopsaj, M. Impact of an 8-week targeted potentiation phase in the RAMP warm-up protocol on agility performance in female police officers. J Strength Cond Res XX(X):…

View details →DOI: 10.1519/jsc.0000000000005562
Negative / Null Result ReportMedicine

ST-Elevation Myocardial Infarction Complicated by Ventricular Septal Defect Is Associated With Very High Mortality Without Improvement Over Time.

Movahed MR, Rasti A, Hashemzadeh M · 2026 · Reviews in cardiovascular medicine

Background This study aimed to examine mortality trends among patients who presented with ST-elevation myocardial infarction (STEMI) complicated by ventricular septal defect (VSD) between 2016 and 2022. Methods Using the Nationwide…

View details →DOI: 10.31083/rcm49035
Negative / Null Result ReportMedicine

Tin(II) Dithiocarbamate-Derived SnS Nanoparticles for High-Performance Quantum Dot-Sensitized Solar Cells.

Vulindlela I, Paca AM, Meyer EL et al. · 2026 · Nanomaterials (Basel, Switzerland)

The increasing global demand for renewable energy has intensified the search for high-efficiency and cost-effective solar cell technologies. Quantum dot-sensitized solar cells (QDSSCs) have emerged as promising candidates due to their…

View details →DOI: 10.3390/nano16120718
Negative / Null Result ReportMedicine

Prediction of Clinically Significant Improvements During the Interdisciplinary Intensive Outpatient Program for Traumatic Brain Injury Using Machine Learning.

Srikanchana R, Samuel D, Powell J et al. · 2025 · Annals of biomedical engineering

Purpose The aim of this research was to assess the potential for machine learning to predict clinically significant patient improvement during a four-week interdisciplinary Intensive Outpatient Program (IOP) for traumatic brain injury…

View details →DOI: 10.1007/s10439-025-03853-5
Negative / Null Result ReportOpen accessMedicine

Non-Pharmacological Interventions for Symptom Cluster Management in Women with Cancer: A Scoping Review of Multicomponent and Mechanism-Based Approaches.

Irmala N, Solehati T, Sukmawati S · 2026 · International journal of women's health

Background Women with cancer frequently experience co-occurring symptoms, including cancer-related fatigue, sleep disturbance, and psychological distress, which negatively impact quality of life. Despite the increasing use of…

View details →DOI: 10.2147/ijwh.s612228
Negative / Null Result ReportMedicine

Similar performance with electrochemically deposited hydroxyapatite coating versus plasma porous spray in press-fit acetabular components for primary total hip arthroplasty: a randomised controlled study of early outcomes with DEXA.

Liu D, Turner D, Cadman J et al. · 2026 · Hip international : the journal of clinical and experimental research on hip pathology and therapy

Background Hydroxyapatite (HA) is an osteo-inductive material commonly added to the surface of components to enhance bone implant fixation; however, clinical studies have demonstrated inferior performance of HA coated acetabular cups in…

View details →DOI: 10.1177/11207000261445564
Negative / Null Result ReportMedicine

Absent Bone Marrow Edema on MRI in a Patient with Acute Vertebral Compression Fractures: Implications for Vertebral Augmentation.

Singh S, Galperin M, Waghray-Penmetcha T · 2026 · Pain medicine case reports

Background Vertebral compression fractures (VCFs) are a common and debilitating consequence of multiple myeloma (MM). Acute VCFs often benefit from percutaneous vertebral augmentation (PVA), indicated by bone marrow edema (BME) on MRI. We…

Negative / Null Result Report

Improvement in Beetroot’s ( Beta vulgaris ) Growth and Yield Parameters in Soils Fertilized with Maize ( Zea mays ) Biochar Under Drip Irrigation with Treated Wastewater

Mathapa BG, Gaba T, Mmolawa K · 2026 · Preprint

Global water scarcity due to climate change coupled with environmental pollution from artificial fertilizers threatens sustainable agricultural productivity. To address these challenges, innovative circular and sustainable agricultural…

View details →DOI: 10.20944/preprints202605.0034.v1
Negative / Null Result ReportMedicine

No clinical and functional benefit after medial congruent compared to ultra congruent total knee arthroplasty at 1 year: A prospective randomized controlled study.

Schrednitzki D, Sina J, Lamarche A et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose Various conforming bearing designs are used during total knee arthroplasty (TKA), yet their impact on clinical outcomes remains uncertain. In recent years, the use of medial congruent (MC) and ultra congruent (UC) onlays has gained…

View details →DOI: 10.1002/ksa.70482
Negative / Null Result ReportOpen accessMedicine

Clinical and Radiographic Factors Affecting the Outcomes of Decompression Surgery in Clinical and Radiographic Degenerative Spondylolisthesis (CARDS) Classification Type C Degenerative Lumbar Spondylolisthesis.

Kawano A, Tarukado K, Yokota K et al. · 2026 · Cureus

Introduction The optimal surgical strategy for Clinical and Radiographic Degenerative Spondylolisthesis (CARDS) Type C remains controversial, particularly regarding decompression alone versus fusion surgery. Evidence focusing on outcomes…

View details →DOI: 10.7759/cureus.106456
Negative / Null Result ReportMedicine

Does the ACR/EULAR Total Improvement Score reflect how individuals with autoimmune inflammatory myopathies feel and function?

Leclair V, Berger C, Bouchard-Marmen M et al. · 2026 · The Journal of rheumatology

Objective Little is known as to whether the American College of Rheumatology/European Alliance of Associations for Rheumatology Total Improvement Score (TIS) reflects how patients in the autoimmune inflammatory myopathies (AIM) spectrum…

View details →DOI: 10.3899/jrheum.2026-0046
Negative / Null Result ReportMedicine

Intraocular foreign bodies in the posterior segment: Clinical characteristics, management, and visual outcomes.

Phogat J, Prabha C, Nada M et al. · 2026 · Chinese journal of traumatology = Zhonghua chuang shang za zhi

Purpose To analyze the clinical characteristics, management, and visual outcomes of patients with retained posterior segment intraocular foreign bodies (IOFBs). Methods This was a retrospective, non-comparative, single-institutional case…

View details →DOI: 10.1016/j.cjtee.2026.03.005
Failed Experiment ReportMedicine

[External vs. endonasal dacryocystorhinostomy: Comparison of patient-reported functional impact and quality of life].

Galuscan TM, Marty PA, Saguet P et al. · 2026 · Journal francais d'ophtalmologie

Introduction The goal of this study is to compare the functional outcomes and impact on quality of life of external and endonasal dacryocystorhinostomies using the Lac-Q questionnaire. Material and methods This was an observational,…

View details →DOI: 10.1016/j.jfo.2026.104902
Negative / Null Result ReportMedicine

Use of Expected Utility to Evaluate Artificial Intelligence-Enabled Rule-out Devices for Mammography Screening.

Fan KL, Thompson YLE, Chen W et al. · 2026 · Medical decision making : an international journal of the Society for Medical Decision Making

BackgroundAn artificial intelligence (AI)-enabled rule-out device may autonomously remove patient images unlikely to have cancer from radiologist review. Many published studies evaluate this type of device by retrospectively applying the…

View details →DOI: 10.1177/0272989x251388665
Negative / Null Result ReportMedicine

Evaluation of text- and image-based generative artificial intelligence for simulating impacted third molar extraction.

Hamada M, Nishiyama K, Ichiyama S et al. · 2026 · Journal of stomatology, oral and maxillofacial surgery

Background Recent advances in generative artificial intelligence (AI) have opened new opportunities in procedural simulation. However, its clinical accuracy for simulating impacted mandibular third molar extraction remains unclear.…

View details →DOI: 10.1016/j.jormas.2026.102863
Negative / Null Result ReportMedicine

The effects of hyperbaric oxygen dosing on the delayed neuropsychiatric sequalae of carbon monoxide poisoning.

Gur I, Safrai A, Nov Y · 2026 · Clinical toxicology (Philadelphia, Pa.)

Introduction A paucity of evidence exists as to the comparative effectiveness of various hyperbaric oxygen regimens in preventing delayed neuropsychiatric sequelae. We aimed to compare the effect of four such treatment regimens: (1) P O 2…

View details →DOI: 10.1080/15563650.2026.2666318
Negative / Null Result ReportMedicine

A critical analysis of the Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) and the European Carotid Surgery Trial (ECST)-2.

Paraskevas KI, Zeebregts CJ, Blecha M et al. · 2026 · Seminars in vascular surgery

The Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) concluded that addition of transfemoral carotid artery stenting to intensive medical therapy (IMT) among patients with high-grade…

View details →DOI: 10.1053/j.semvascsurg.2026.03.008
Negative / Null Result ReportMedicine

Percutaneous thoracolumbar burst-fracture fixation - does additional anterior support offer significant benefit?

Urbaneja A, Martin Laez R, López Gomez P · 2026 · British journal of neurosurgery

Purpose Percutaneous pedicle screw fixation has become a widely adopted technique for treating thoracolumbar burst fractures without neurological deficit, though optimal strategies - particularly regarding anterior support - remain…

View details →DOI: 10.1080/02688697.2026.2643667
Negative / Null Result ReportMedicine

Chitosan-fibrinogen-thrombin matrix accelerates re-epithelialization and cornification in a rat wound healing model.

Lerhcha H, Chevrier A, Lavertu M · 2026 · NPJ Regenerative medicine

This study evaluated a chitosan-fibrinogen-thrombin (CFT) matrix enriched with autologous skin cells and a fatty acid sodium salt (FASS) to enhance wound closure and regeneration. A rat excisional wound model compared six treatments: CFT…

View details →DOI: 10.1038/s41536-026-00486-7
Negative / Null Result ReportMedicine

Exploring the Gut Microbiome's Association in Psoriasis and Psoriatic Arthritis: A Scoping Review.

Kent J, Chao J, Liao W et al. · 2026 · Journal of psoriasis and psoriatic arthritis

Introduction Psoriasis (PsO) and psoriatic arthritis (PsA) are chronic inflammatory conditions treated with primarily immune-modulating medication. However, interest is growing in gut microbiome therapies. Studies have reported altered gut…

View details →DOI: 10.1177/24755303261464171