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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21322 results · page 455 of 711

Negative / Null Result ReportMedicine

A randomized controlled trial comparing two processes of exposure therapy: Extinction learning and habituation.

Treanor M, Zbozinek TD, Rosenberg BM et al. · 2025 · Journal of consulting and clinical psychology

Objective To investigate the role of extinction learning and habituation by comparing inhibitory retrieval to habituation-focused exposure for social anxiety and panic disorder. Method In this assessor-blinded, parallel-group, two-arm…

View details →DOI: 10.1037/ccp0000970
Negative / Null Result ReportMedicine

Prognostic and Predictive Factors in Metastatic Breast Cancer Patients Treated with CDK4/6 Inhibitors.

Demirel N, Yildiz B, Demir M · 2026 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

Objective To evaluate the safety and efficacy of CDK4/6 inhibitors in combination with hormone therapy, and to investigate potential predictive markers of treatment in metastatic breast cancer (MBC). Study design An observational study.…

View details →DOI: 10.29271/jcpsp.2026.05.614
Negative / Null Result Report

Impact of vitamin D supplementation on disease severity and visual acuity in pediatric vernal keratoconjunctivitis (VKC) Vitamin D Supplementation in Vernal Keratoconjunctivitis

K S, V KC, S AK et al. · 2026 · Preprint

Abstract Background: Vernal keratoconjunctivitis (VKC) is a chronic, recurrent allergic ocular disorder predominantly affecting children and adolescents. Vitamin D deficiency has been implicated in allergic conditions; however, its…

View details →DOI: 10.21203/rs.3.rs-9278495/v1
Negative / Null Result ReportMedicine

Feasibility assessment of integrated oral health care pathways designed for pediatric and adult patients referred to School of Dentistry.

Hashemi TM, Khami MR, Razeghi S et al. · 2026 · BMC oral health

Introduction Transitioning from a treatment-oriented model to a prevention-focused approach is essential for improving oral health outcomes. This study aimed to assess the feasibility and implementation outcomes of Integrated Oral Health…

View details →DOI: 10.1186/s12903-026-08622-x
Negative / Null Result ReportMedicine

Long-term Clinical and Radiographic Outcomes After Salto Talaris Total Ankle Arthroplasty: Long-term Follow-up of a Previously Published Cohort.

Slowinski J, Lutnick E, Frappa N et al. · 2026 · Foot & ankle international

Background This study aimed to demonstrate long term clinical follow-up and implant survivorship of Salto Talaris-type primary total ankle arthroplasty (TAA) by 1 foot and ankle-trained surgeon at a single institution. Methods Patients…

View details →DOI: 10.1177/10711007261443281
Negative / Null Result ReportMedicine

Temperature Effects on the Impact Attenuation Performance of American Football Helmets and Padding Materials.

Ghiri AA, Cavanaugh SJ, Nuñez AA et al. · 2026 · Annals of biomedical engineering

While American football games are played across a wide range of temperatures, current helmet rating protocols assess performance primarily at room temperature. This study evaluates how temperature influences impact attenuation performance…

View details →DOI: 10.1007/s10439-026-04161-2
Negative / Null Result ReportOpen accessMedicine

Evaluation of Rabeprazole for Gastrointestinal Protection in Acute Coronary Syndrome Patients Treated with Aspirin and Ticagrelor: A Pilot Study.

Hyun HK, Lee OH, Roh JW et al. · 2026 · Yonsei medical journal

Purpose Patients with acute coronary syndrome (ACS) on ticagrelor-based dual antiplatelet therapy (DAPT) have an increased risk of gastrointestinal (GI) bleeding. However, evidence supporting the protective role of proton pump inhibitors…

View details →DOI: 10.3349/ymj.2025.0232
Negative / Null Result ReportMedicine

Endoscopic three-layer graft myringoplasty without tympanomeatal flap elevation for repairing subtotal and total perforations.

Lou Z, Yang H · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

OBJECTIVE: The objective of this study was to evaluate the graft success rate, hearing outcomes, and complications associated with three-layer graft myringoplasty for repairing subtotal and total perforations. MATERIALS AND METHODS:…

View details →DOI: 10.1007/s00405-026-10223-x
Negative / Null Result ReportMedicine

Outcomes from a structured conflict management programme implemented at three paediatric healthcare sites: a mixed-methods evaluation.

Phillipson J, Menson E, Barclay S et al. · 2026 · Archives of disease in childhood

Objective Evaluation of the Medical Mediation Foundation's Conflict Management Programme (CMP)-a structured process for managing conflict. Design Mixed-methods evaluation using Kirkpatrick's framework, a four-level model for evaluating…

View details →DOI: 10.1136/archdischild-2025-329335
Negative / Null Result ReportMedicine

Daily-life posttraumatic stress symptoms, posttraumatic cognitions, and affect following the processing of positive memories technique: An open-label case-control daily diary study.

Greene T, Dicker-Oren SD, Sznitman SR et al. · 2026 · Journal of traumatic stress

The processing of positive memories technique (PPMT) is a promising new treatment for posttraumatic stress disorder (PTSD) involving the detailed narration and processing of specific positive autobiographical memories. This study used an…

View details →DOI: 10.1002/jts.70066
Negative / Null Result ReportMedicine

Intravitreal pegfilgrastim for indirect traumatic optic neuropathy: a first-in-human phase 1/2a study.

Huang CT, Wen YT, Liu PK et al. · 2026 · QJM : monthly journal of the Association of Physicians

Background Indirect traumatic optic neuropathy (TON) is associated with severe vision loss and no proven treatment. Aim To evaluate the safety and exploratory functional outcomes of intravitreal pegfilgrastim in patients with indirect TON.…

View details →DOI: 10.1093/qjmed/hcag129
Negative / Null Result ReportOpen accessMedicine

Investigation of the effects of radiotherapy and chemotherapy on brain volume in cancer patients: brain tumor study.

Deniz B, Arpaci MF, Pekmez H et al. · 2026 · Journal of neuro-oncology

Purpose Brain tumors, characterized by the uncontrolled proliferation of abnormal cells within cerebral tissue, remain clinically challenging entities. Radiotherapy and chemotherapy constitute fundamental therapeutic modalities; however,…

View details →DOI: 10.1007/s11060-025-05366-6
Negative / Null Result ReportOpen accessMedicine

The Effect of Ocrelizumab on Anti-JC Virus Antibody Index.

Virupakshaiah A, Gill AJ, Schoeps VA et al. · 2026 · Brain and behavior

Purpose/introduction The anti-JC virus (JCV) antibody index is used to stratify the risk of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS), particularly with natalizumab therapy. B-cell-depleting therapies may…

View details →DOI: 10.1002/brb3.71386
Negative / Null Result ReportMedicine

Impact of low-flow desflurane versus sevoflurane anesthesia on thiol-disulfide homeostasis in adults undergoing elective thyroidectomy: a randomized controlled trial.

Sen E, Aytekin A · 2026 · Revista da Associacao Medica Brasileira (1992)

Objective Thiol-disulfide homeostasis is a marker of oxidative stress. The aim of the study was to compare the effects of low-flow desflurane and sevoflurane anesthesia on perioperative changes in thiol-disulfide balance in patients…

View details →DOI: 10.1590/1806-9282.20250893
Negative / Null Result ReportOpen accessMedicine

Correlation of change in V4c implantable Collamer lens vaulting and pupil diameter in different light conditions.

Sinha R, Singh R, Tripathi M et al. · 2025 · Indian journal of ophthalmology

Purpose To study the change in the vault of phakic Intraocular Lens (IOL) (pIOL) with RT view anterior segment optical coherence tomography (ASOCT) in different light conditions and define its relationship with the change in pupillary…

View details →DOI: 10.4103/ijo.ijo_293_25
Negative / Null Result ReportMedicine

Impact of repeated virtual reality exposures on emotional and physical well-being in hospitalised breast cancer patients: a pilot study.

Bachelard L, Blanc N, Michel A · 2026 · BMJ supportive & palliative care

Objective Breast cancer surgery often leads to a high burden of distressing symptoms, underscoring the need for supportive care to help patients throughout the perioperative period. This pilot study aimed to evaluate the feasibility,…

View details →DOI: 10.1136/spcare-2025-005885
Negative / Null Result ReportMedicine

Long-term outcomes of patients with moderate-severe pediatric systemic lupus erythematosus treated with combination rituximab and cyclophosphamide therapy: A single center cohort experience and review of literature.

Achar A, Houser P, Cherian J et al. · 2026 · Lupus

ObjectiveTo determine the long-term outcomes of patients with moderate-severe pediatric systemic lupus erythematosus (pSLE) treated with systematic administration of combination rituximab (RTX) and cyclophosphamide (CYC) at our…

View details →DOI: 10.1177/09612033261441392
Negative / Null Result ReportOpen accessMedicine

Beyond the Numbers: How Clinical Performance Metrics Impact Emergency Medicine Residents.

Burger C, Pirotte M, Ray K et al. · 2026 · The western journal of emergency medicine

Introduction Emergency physicians commonly receive feedback in the form of performance metrics such as patients seen per hour. Reviewing metrics has been associated with increased stress and burnout. Although effects on efficiency have…

View details →DOI: 10.5811/westjem.50814
Negative / Null Result Report

Epidemiology of Microbial Keratitis on Uganda: A 7-year update

Arunga S, Ebong A, Orishaba F et al. · 2026 · Preprint

Purpose To provide the latest update on the epidemiology of microbial keratitis in Uganda. Methods We prospectively recruited patients presenting with microbial keratitis (MK) at three eye units in Uganda between November 2023 and June…

View details →DOI: 10.12688/wellcomeopenres.26184.1
Negative / Null Result ReportMedicine

Characterization and Evaluation of Biological Properties of Calcium Silicate Cement-based Sealers after Thermal Pretreatment.

Jang YE, Kim Y, Kim HI et al. · 2026 · Journal of endodontics

Introduction Hydraulic calcium silicate cement-based sealers (CSC sealers) are now frequently used with warm vertical compaction in root canal treatment. However, the impact of heat on the biological properties of CSC sealers remains…

View details →DOI: 10.1016/j.joen.2026.04.017