A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19761 results in Negative / Null Result Report · page 42 of 659
Stefano Zauli Sajani, Rossella Miglio, Paolo Bonasoni et al. · 2010 · Occupational and Environmental Medicine
OBJECTIVE: To investigate the association between Saharan dust outbreaks and natural, cardiovascular and respiratory mortality. METHODS: A case-crossover design was adopted to assess the effects of Saharan dust days (SDD) on mortality in…
Gary Lichtenstein, Alexander C. McCormick, Sheri Sheppard et al. · 2010 · Journal of Engineering Education
B ackground The authors partnered with the National Survey of Student Engagement (NSSE) to examine how persistence within the engineering major and engagement of undergraduate students in engineering compare to other majors. P urpose (H…
Casper Nyamukondiwa, Elsje Kleynhans, John S. Terblanche · 2010 · Ecological Entomology
1. The invasion success of Ceratitis capitata probably stems from physiological, morphological, and behavioural adaptations that enable them to survive in different habitats. However, it is generally poorly understood if variation in acute…
Jennifer Ryan, Mark D. Peterson, Nicola Ryan et al. · 2019 · Developmental Medicine & Child Neurology
AIM: To compare mortality rates for cardiovascular disease, cancer, and respiratory disease between adults with cerebral palsy (CP) and the general population. METHOD: A cohort study was conducted using data from adults with CP in England,…
An Wu, Gennady Dvoryanchikov, Elizabeth Pereira et al. · 2015 · Nature Communications
Gustatory stimuli are detected by taste buds and transmitted to the hindbrain via sensory afferent neurons. Whether each taste quality (sweet, bitter and so on) is encoded by separate neurons ('labelled lines') remains controversial. We used mice expressing GCaMP3 in geniculate ganglion sensory neurons to investigate taste-evoked activity. Using confocal calcium imaging, we recorded responses to oral stimulation with prototypic taste stimuli. Up to 69% of neurons respond to multiple tastants. Moreover, neurons tuned to a single taste quality at low concentration become more broadly tuned when
Máté Rudas, Ian Seppelt, Robert Herkes et al. · 2014 · Critical Care
INTRODUCTION: Long-term ventilated intensive care patients frequently require tracheostomy. Although overall risks are low, serious immediate and late complications still arise. Real-time ultrasound guidance has been proposed to decrease complications and improve the accuracy of the tracheal puncture. We aimed to compare the procedural safety and efficacy of real-time ultrasound guidance with the traditional landmark approach during percutaneous dilatational tracheostomy (PDT). METHODS: A total of 50 patients undergoing PDT for clinical indications were randomly assigned, after obtaining infor
KJ Dodd, NF Taylor, N Shields et al. · 2011 · Multiple Sclerosis Journal
Background: Few high-quality trials have examined the effects of progressive resistance training (PRT) on people with multiple sclerosis (MS). Objective: To determine the effectiveness of PRT for people with MS, focusing on improving the…
Marina Nasri Sissini, Maria Beatriz Barbosa de Barros Barreto, Maria Teresa Menezes de Széchy et al. · 2017 · Phycologia
:This study represents the efforts of a network of researchers to characterise the large, floating Sargassum (Fucales, Phaeophyceae) biomass that had reached the Brazilian coast in 2014 and 2015. Material collected during these events was…
Kevin Kalinsky, Sandra Lee, Krista M. Rubin et al. · 2017 · Cancer
BACKGROUND KIT‐directed tyrosine kinase inhibitors such as imatinib have demonstrated benefits in KIT‐mutant (KIT+) mucosal, acral, vulvovaginal, and chronically sun‐damaged (CSD) melanoma. Dasatinib has superior preclinical activity in…
Sisay Demissew Beyene · 2023 · BMC Public Health
BACKGROUND: Food insecurity adversely affects human health, which means food security and nutrition are crucial to improving people's health outcomes. Both food insecurity and health outcomes are the policy and agenda of the 2030 Sustainable Development Goals (SDGs). However, there is a lack of macro-level empirical studies (Macro-level study means studies at the broadest level using variables that represent a given country or the whole population of a country or economy as a whole. For example, if the urban population (% of the total population) of XYZ country is 30%, it is used as a proxy va
Marian E. Berryhill · 2014 · Frontiers in Psychology
The popularity of non-invasive brain stimulation techniques in basic, commercial, and applied settings grew tremendously over the last decade. Here, we focus on one popular neurostimulation method: transcranial direct current stimulation (tDCS). Many assumptions regarding the outcomes of tDCS are based on the results of stimulating motor cortex. For instance, the primary motor cortex is predictably suppressed by cathodal tDCS or made more excitable by anodal tDCS. However, wide-ranging studies testing cognition provide more complex and sometimes paradoxical results that challenge this heuristi
Nishitha Thumallapally, Ahmed Meshref, Mohammed Mousa et al. · 2017 · BMC Cancer
BACKGROUND: Solitary plasmacytoma (SP) is a localized neoplastic plasma cell disorder with an annual incidence of less than 450 cases. Given the rarity of this disorder, it is difficult to conduct large-scale population studies. Consequently, very limited information on the disorder is available, making it difficult to estimate the incidence and survival rates. Furthermore, limited information is available on the efficacy of various treatment modalities in relation to primary tumor sites. METHODS: The data for this retrospective study were drawn from the Surveillance, Epidemiology and End Resu
Christopher G. Salib, Nicolas Reina, Kevin I. Perry et al. · 2019 · The Bone & Joint Journal
AIMS: Concurrent hip and spine pathologies can alter the biomechanics of spinopelvic mobility in primary total hip arthroplasty (THA). This study examines how differences in pelvic orientation of patients with spine fusions can increase…
Joon‐Tae Kim, Reza Jahan, Jeffrey L. Saver et al. · 2015 · Stroke
BACKGROUND AND PURPOSE: Sparse data are available regarding the association between hyperglycemia and outcomes in acute ischemic stroke patients receiving mechanical thrombectomy (MT). We investigated whether hyperglycemia affected the…
Hidekazu Suzuki, Juntaro Matsuzaki, Yasushi Fukushima et al. · 2014 · Neurogastroenterology & Motility
BACKGROUND: Rikkunshito, a standardized Japanese herbal medicine, is thought to accelerate gastric emptying and relieve dyspepsia, although no large-scale, randomized, placebo-controlled trials of rikkunshito have been conducted. This…
Kai Barron · 2020 · Experimental Economics
Abstract Bayes’ statistical rule remains the status quo for modeling belief updating in both normative and descriptive models of behavior under uncertainty. Some recent research has questioned the use of Bayes’ rule in descriptive models of behavior, presenting evidence that people overweight ‘good news’ relative to ‘bad news’ when updating ego-relevant beliefs. In this paper, we present experimental evidence testing whether this ‘good-news, bad-news’ effect is present in a financial decision making context (i.e. a domain that is important for understanding much economic decision making). We f
Dana A. Opulente, Abigail L. LaBella, Marie‐Claire Harrison et al. · 2024 · Science
Organisms exhibit extensive variation in ecological niche breadth, from very narrow (specialists) to very broad (generalists). Two general paradigms have been proposed to explain this variation: (i) trade-offs between performance efficiency and breadth and (ii) the joint influence of extrinsic (environmental) and intrinsic (genomic) factors. We assembled genomic, metabolic, and ecological data from nearly all known species of the ancient fungal subphylum Saccharomycotina (1154 yeast strains from 1051 species), grown in 24 different environmental conditions, to examine niche breadth evolution.
Øyvind Stiansen, Erik Voeten · 2020 · International Studies Quarterly
Abstract How does backlash from consolidated democracies affect the behavior of liberal international institutions? We argue that liberal international institutions have incentives to appease their democratic critics. Liberal institutions…
Caitlin Martin, Thuy M. Pham, Wei Sun · 2010 · European Journal of Cardio-Thoracic Surgery
OBJECTIVE: Currently, percutaneous aortic valve (PAV) replacement devices are being investigated to treat aortic stenosis in patients deemed to be of too high a risk for conventional open-chest surgery. Successful PAV deployment and…
Nga M. Lau, Peter H.R. Green, Annette K. Taylor et al. · 2013 · PLoS ONE
OBJECTIVE: Gastrointestinal symptoms are a common feature in children with autism, drawing attention to a potential association with celiac disease or gluten sensitivity. However, studies to date regarding the immune response to gluten in autism and its association with celiac disease have been inconsistent. The aim of this study was to assess immune reactivity to gluten in pediatric patients diagnosed with autism according to strict criteria and to evaluate the potential link between autism and celiac disease. METHODS: Study participants included children (with or without gastrointestinal sym
Adrienne Lucas, Isaac Mbiti · 2014 · American Economic Journal Applied Economics
The most desirable Kenyan secondary schools are elite government schools that admit the best students from across the country. We exploit the random variation generated by the centralized school admissions process in a regression…
N. J. Schweitzer, Michael J. Saks, Emily R. Murphy et al. · 2011 · Psychology Public Policy and Law
Recent developments in the neuropsychology of criminal behavior have given rise to concerns that neuroimaging evidence (such as MRI and functional MRI [fMRI] images) could unduly influence jurors. Across four experiments, a nationally…
M. Lukasiewicz, Stéphanie Gerard, Adeline Besnard et al. · 2013 · International Journal of Methods in Psychiatric Research
The aim of this analysis was to identify Young Mania Rating Scale (YMRS) meaningful benchmarks for clinicians (severity threshold, minimal clinically significant difference [MCSD]) using the Clinical Global Impressions Bipolar (CGI-BP)…
Mary Wang · 2016 · PubMed
Anemia, defined as a hemoglobin level two standard deviations below the mean for age, is prevalent in infants and children worldwide. The evaluation of a child with anemia should begin with a thorough history and risk assessment.…
Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami et al. · 2021 · Nature Communications
IL11 is important for fibrosis in non-alcoholic steatohepatitis (NASH) but its role beyond the stroma in liver disease is unclear. Here, we investigate the role of IL11 in hepatocyte lipotoxicity. Hepatocytes highly express IL11RA and secrete IL11 in response to lipid loading. Autocrine IL11 activity causes hepatocyte death through NOX4-derived ROS, activation of ERK, JNK and caspase-3, impaired mitochondrial function and reduced fatty acid oxidation. Paracrine IL11 activity stimulates hepatic stellate cells and causes fibrosis. In mouse models of NASH, hepatocyte-specific deletion of Il11ra1
Lotte A van de Stadt, Wouter H Bos, Marlies Meursinge Reynders et al. · 2010 · Arthritis Research & Therapy
INTRODUCTION: Ultrasonography (US) has better sensitivity than clinical evaluation for the detection of synovitis in early rheumatoid arthritis (RA). Patients presenting with arthralgia and a positive anti-citrullinated protein antibodies (ACPA) and/or Rheumatoid Factor (IgM-RF) status are at risk for developing RA. In the present study, US utility and predictive properties in arthralgia patients at risk for the development of arthritis were studied. METHODS: 192 arthralgia patients with ACPA and/or IgM-RF were included. Absence of clinical arthritis was confirmed by two physicians. US was per
Laura J. Wozniak, Michelle J. Hickey, Robert S. Venick et al. · 2015 · Transplantation
BACKGROUND: The role of donor-specific HLA antibodies (DSA) after pediatric liver transplantation (LTx) is not clearly established. We completed a cross-sectional study to characterize DSA in long-term survivors of pediatric LTx and assess…
Daniel A. Shoskes, Hannah Wang, A. Scott Polackwich et al. · 2016 · The Journal of Urology
PURPOSE: Chronic prostatitis/chronic pelvic pain syndrome is a common disorder with heterogeneous etiologies and clinical features. The gut microbiome is a metabolically active ecosystem linked to systemic conditions (gut-brain axis). We…
Sydney Ch’ng, Roman J. Skoracki, Jesse C. Selber et al. · 2014 · Head & Neck
BACKGROUND: Dental restoration is an integral part of head and neck cancer reconstruction. METHODS: We evaluated the success rate of osseointegrated implants in patients with head and neck cancer, comparing outcomes between implants placed…
Jill E. Moore, Henry Pratt, Michael Purcaro et al. · 2020 · Genome biology
BACKGROUND: Many genome-wide collections of candidate cis-regulatory elements (cCREs) have been defined using genomic and epigenomic data, but it remains a major challenge to connect these elements to their target genes. RESULTS: To facilitate the development of computational methods for predicting target genes, we develop a Benchmark of candidate Enhancer-Gene Interactions (BENGI) by integrating the recently developed Registry of cCREs with experimentally derived genomic interactions. We use BENGI to test several published computational methods for linking enhancers with genes, including sign