Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Sebastian Baecke, Ralf Lützkendorf, Johannes Bernarding · 2026 · Brain Sciences
Background: The efficacy of real-time fMRI neurofeedback (NFB) depends critically on how feedback is presented and perceived by the participant. Although various visual feedback designs are used in practice, there is limited evidence on the impact of modality on learning and performance. We conducted a feasibility study to compare the effectiveness of different feedback modalities, and to evaluate the technical performance of NFB across two scanner field strengths. Methods: In a single-session study, nine healthy adults (6 men, 3 women) voluntarily adapted the activation level of the primary s
View details →DOI: 10.3390/brainsci16020166 Negative / Null Result ReportOpen accessMedicine
Hannah A Edwards, Gabriela K Hajduk, Gillian Durieux et al. · 2015 · PLoS ONE
Consistency of between-individual differences in behaviour or personality is a phenomenon in populations that can have ecological consequences and evolutionary potential. One way that behaviour can evolve is to have a genetic basis. Identifying the molecular genetic basis of personality could therefore provide insight into how and why such variation is maintained, particularly in natural populations. Previously identified candidate genes for personality in birds include the dopamine receptor D4 (DRD4), and serotonin transporter (SERT). Studies of wild bird populations have shown that explorato
View details →DOI: 10.1371/journal.pone.0138439 Negative / Null Result ReportOpen accessLanguage and Literature
Matt Hunt Gardner, Xinyu Leslie Liao · 2026 · Language and Cognition
Using 3,154 tokens from American English, we test whether optionality in verb–particle placement increases speech-planning cost, measured as pre-verbal silence. Tokens were coded for object properties, idiomaticity and verb frequency. We find that pre-verbal silence does not differ between split (pick the book up) and joined (pick up the book) orders. While idiomaticity favours the joined order, it does not raise planning cost. Verb frequency shortens pauses only in fast speech, suggesting predictability acts lexically, not structurally. Choice symmetry does not lengthen pauses. We therefore f
View details →DOI: 10.1017/langcog.2026.10081 Negative / Null Result ReportOpen accessMedicine
Philipp Schoenegger, Miguel Costa-Gomes · 2022 · PLoS ONE
Charities differ, among other things, alongside the likelihood that their interventions succeed and produce the desired outcomes and alongside the extent that such likelihood can even be articulated numerically. In this paper, we investigate what best explains charitable giving behaviour regarding charities that have interventions that will succeed with a quantifiable and high probability (sure-thing charities) and charities that have interventions that only have a small and hard to quantify probability of bringing about the desired end (probabilistic charities). We study individual difference
View details →DOI: 10.1371/journal.pone.0273971 Negative / Null Result ReportOpen accessPhysics
Martin Tajmar, Lance L. Williams · 2020 · Physics
Kaluza was the first to realize that the four-dimensional gravitational field of general relativity and the classical electromagnetic field behave as if they were components of a five-dimensional gravitational field. We present a novel experimental test of the macroscopic classical interpretation of the Kaluza fifth dimension. Our experiment design probes a key feature of Kaluza unification—that electric charge is identified with motion in the fifth dimension. Therefore, we tested for a time dilation effect on an electrically charged clock. This test can also be understood as a constraint on t
View details →DOI: 10.3390/physics2040033 Negative / Null Result ReportOpen accessSocial sciences (General)
Martijn van der Meer · 2025 · Journal of Trial and Error
Expert endorsement seems a promising tool in countering vaccine hesitancy. Yet findings from an experiment in the United Kingdom, published in this journal, found that repeated expert‐backed “debunking” messages had little effect on vaccination intentions or behaviors. At the same time, a similar study in Italy had earlier observed a slight increase in the intent to vaccinate—despite actual uptake remaining unchanged. In this article, I reflect on the differences between these studies and argue for a situated public health approach: one that opens up on diversity and responds to local trust dy
View details →DOI: 10.36850/dfab-4bcf Negative / Null Result ReportOpen accessScience
Tianhao Liu, Katharina Rolfs, Isaac Fan et al. · 2021 · New Journal of Physics
By measuring the spin precession frequencies of polarized ^129 Xe and ^3 He, a new upper limit on the ^129 Xe atomic electric dipole moment (EDM) ${d}_{\text{A}}\left({}^{129}\mathrm{X}\mathrm{e}\right)$ was reported in Sachdev et al (2019 Phys. Rev. Lett. 123 , 143003). Here, we propose a new evaluation method based on global phase fitting (GPF) for analyzing the continuous phase development of the ^3 He– ^129 Xe comagnetometer signal. The Cramer–Rao lower bound on the ^129 Xe EDM for the GPF method is theoretically derived and shows the potential benefit of our new approach. The robustness o
View details →DOI: 10.1088/1367-2630/ac09ca Negative / Null Result ReportOpen accessMedicine
Rogier A. Kievit, Delia Fuhrmann, Gesa Sophia Borgeest et al. · 2018 · Wellcome Open Research
Background: Fluid intelligence declines with advancing age, starting in early adulthood. Within-subject declines in fluid intelligence are highly correlated with contemporaneous declines in the ability to live and function independently. To support healthy aging, the mechanisms underlying these declines need to be better understood. Methods: In this pre-registered analysis, we applied latent growth curve modelling to investigate the neural determinants of longitudinal changes in fluid intelligence across three time points in 185,317 individuals (N=9,719 two waves, N=870 three waves) from the U
View details →DOI: 10.12688/wellcomeopenres.14241.1 Negative / Null Result ReportOpen accessEducation
Nicole Shechtman, Jeremy Roschelle, Mingyu Feng et al. · 2019 · AERA Open
The Math Curriculum Impact Study was a large-scale randomized controlled trial (RCT) to test the efficacy of a digital core curriculum for Grade 5 mathematics. Reasoning Mind’s Grade 5 Common Core Curriculum was a comprehensive, adaptive, blended learning approach that schools in the treatment group implemented for an entire school year. Schools in the control group implemented their business-as-usual mathematics curriculum. The study was completed in 46 schools throughout West Virginia, resulting in achievement data from 1,919 students. It also included exploratory investigations of teacher p
View details →DOI: 10.1177/2332858419850482 Negative / Null Result ReportMedicine
Chen X, Wen W, Zheng L · 2026 · Shock (Augusta, Ga.)
Background Sepsis is a clinical syndrome marked by a dysregulated host response to infection, impairing oxygen delivery and utilization and causing organ dysfunction. Hypoxemia, which can cause significant tissue and organ damage, commonly…
View details →DOI: 10.1097/shk.0000000000002865 Negative / Null Result ReportOpen accessMedicine (General)
Hiroyuki Masaoka, Keitaro Matsuo, Isao Oze et al. · 2020 · Journal of Epidemiology
Background: The association of alcohol drinking with bladder cancer risk remains unclear in East Asian populations. Aldehyde dehydrogenase 2 (ALDH2) enzyme oxidizes alcohol-metabolized carcinogenic acetaldehyde into acetate. It is well known that the inactive ALDH2 carriers, specific to East Asian populations, have an increased risk of several cancer types because of increased exposure to acetaldehyde after alcohol consumption. The aim of this study was to examine the association between alcohol drinking and bladder cancer risk using data from ten population-based prospective cohort studies in
View details →DOI: 10.2188/jea.je20190014 Negative / Null Result ReportOpen accessMedicine
Nicholas Judd, Rogier Kievit · 2025 · eLife
Education is related to a wide variety of beneficial health, behavioral, and societal outcomes. However, whether education causes long-term structural changes in the brain remains unclear. A pressing challenge is that individuals self-select into continued education, thereby introducing a wide variety of environmental and genetic confounders. Fortunately, natural experiments allow us to isolate the causal impact of increased education from individual (and societal) characteristics. Here, we exploit a policy change in the UK (the 1972 ROSLA act) that increased the amount of mandatory schooling
View details →DOI: 10.7554/elife.101526 Negative / Null Result ReportOpen accessSpecial aspects of education
علي عبدالله علي مسافر · 2016 · مجلة التربیة الخاصة والتأهیل
تهدف الدراسة الحالية إلى استقصاء الضغوط المهنية لمعلمي التربية الخاصة في کل من البيئة الثقافية السعودية والمصرية، ومعرفة الفروق في نوعية تلک الضغوط في هاتين البيئتين تبعاً لمتغيرات فئة الإعاقة التي يعمل معها المعلم (عقلية وتوحد/ بصرية/ سمعية)، وجنس المعلم (ذکر/ أنثى)، وسنوات خبرة المعلم (أقل من 5 سنوات/ 5 سنوات فأکثر). وأجريت الدراسة على عينة قوامها (224) معلماً ومعلمةً من معلمي التربية الخاصة بجمهورية مصر العربية والمملکة العربية السعودية، واستخدمت الدراسة مقياس الضغوط المهنية لمعلمي التربية الخاصة (إعداد الباحث)، ولتحليل البيانات تم تطبيق اختبار "ت"، وتحليل التباين المتعدد MANOVA، واختبار شي
View details →DOI: 10.21608/sero.2016.92111 Negative / Null Result ReportOpen accessMedicine
Seyyed Abolfazl Tabatabaie-Zadeh, Nazanin Mahdavi, Behnaz Mahdaviani et al. · 2024 · PLoS ONE
Purpose Oral cancers are the 6th most common malignancy worldwide and oral squamous cell carcinoma, comprises over 90% of oral cancers. This study investigates the relationship between physical activity level during the lifetime and oral squamous cell carcinoma risk. Methods 100 oral squamous cell carcinoma patients and 200 healthy individuals participated in this case-control study. Physical activity level was evaluated via the Lifetime Physical Activity Questionnaire. The occupational, household, and sports domains of lifetime physical activity were determined. Case and control groups' parti
View details →DOI: 10.1371/journal.pone.0303929 Negative / Null Result ReportOpen accessMedicine (General)
Lisa Argnani, Anna Zanetti, Anna Zanetti et al. · 2021 · Frontiers in Medicine
Background: Rheumatoid arthritis (RA) is associated with an increase in cardiovascular (CV) risk. This issue maybe not only explained by a genetic component, as well as by the traditional CV risk factors, but also by an underestimation and undertreatment of concomitant CV comorbidities.Method: This was a retrospective matched-cohort analysis in the Italian RA real-world population based on the healthcare-administrative databases to assess the CV risk factors and incidence of CV events in comparison with the general population. Persistence and adherence to the CV therapy were also evaluated in
View details →DOI: 10.3389/fmed.2021.745601 Negative / Null Result Report
Grynchuk F, Horditsa V · 2026 · Preprint
Abstract Objective Early detection of bowel necrosis and peritonitis is crucial for choosing a treatment strategy in patients with acute small bowel obstruction (ASBO). The aim of this study was to evaluate the effect of comorbidity on the…
View details →DOI: 10.21203/rs.3.rs-8804686/v1 Negative / Null Result ReportOpen accessMedicine
Renata Jabłońska, Marta Gralik, Agnieszka Królikowska et al. · 2016 · Pielęgniarstwo Neurologiczne i Neurochirurgiczne
Introduction. In the occupational medicine back pain is treated as a paraoccupational disease, mainly related to specific professional groups. They include those employed in the sector of health care, who are at the highest risk of developing back pain, nurses in particular. Aim. Assessment of back pain occurrence among nurses and determining the factors affecting this condition. Material and Methods. The study group consisted of 76 nurses working in neurology and neurosurgery wards/clinics. The research methodology applied consisted of diagnostic survey method, and as the technique, a survey
View details →DOI: 10.15225/pnn.2016.5.3.1 Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology
Kinga Mate, Pedro de Pablos-Rodríguez, Marta Burbano Herraiz et al. · 2026 · International Brazilian Journal of Urology
ABSTRACT Purpose: Focal cryotherapy is a minimally invasive treatment for localized prostate cancer (PCa), but its oncological outcomes, particularly in relation to baseline Gleason Grade Group (GG), remain understudied. This study evaluates its efficacy and the impact while radical of baseline Gleason score on recurrence-free survival. Materials and Methods: A retrospective analysis included 111 patients with localized PCa treated with focal cryotherapy between 2014 and January 2024. Patients with prior treatments or follow-up 1. Results: Median follow-up was 35 months (IQR 24–49). Confirmato
View details →DOI: 10.1590/s1677-5538.ibju.2025.0289 Negative / Null Result ReportOpen accessSurgery
Sebastian Holm, MD, Mario Zambrana, MD, Juan E. Berner, MD, PhD et al. · 2025 · Plastic and Reconstructive Surgery, Global Open
Summary:. Generative artificial intelligence (AI) large language models are an emerging technology, with ChatGPT and Gemini being 2 well-known examples. The current literature discusses clinical applications and limitations of AI, but its role in research has not yet been extensively evaluated. This study aimed to assess the role of ChatGPT and Gemini in developing novel and clinically relevant research ideas (RIs) for systematic reviews (SRs) in head and neck reconstruction. ChatGPT and Gemini were prompted to provide 10 novel and clinically relevant RIs for SRs in the following domains: head
View details →DOI: 10.1097/gox.0000000000007057 Negative / Null Result ReportOpen accessDentistry
Thayanne Monteiro Ramos Oliveira, Thaysa Monteiro Ramos, Bruna Uglik Garbui et al. · 2014 · Brazilian Dental Science
Objective: This in vitro study measured the microshear bond strength (µSBS) of a composite resin to sound and artificially eroded dentin, submitted to surface treatment with diamond bur (DB) or Er,Cr:YSGG laser (L). Material and Methods: Bovine dentin samples were randomly divided into six groups (n=11): G1-sound dentin, G2-eroded dentin, G3-eroded dentin treated with Er,Cr:YSGG laser at 1.5W, G4-eroded dentin treated with Er,Cr:YSGG laser at 2.0W, G5-eroded dentin treated with Er,Cr:YSGG laser at 2.5W and G6-eroded dentin treated with diamond bur. Erosive cycling was performed by immersion in
View details →DOI: 10.14295/bds.2014.v17i4.1029 Negative / Null Result ReportOpen accessDermatology
Gi-Wook Lee, Keunyoung Kim, Seong-Jang Kim et al. · 2023 · Acta Dermato-Venereologica
Atopic dermatitis (AD) is an inflammatory skin disease associated with increased systemic and vascular inflammation. Although dupilumab has been proven to be effective against severe AD, imaging studies analysing its inflammation-reducing effect have rarely been reported. The aim of this study was to evaluate the effect of dupilumab on systemic and vascular inflammation in adult patients with severe AD, using 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT). A total of 33 adult patients with severe AD and 25 healthy controls underwent 18F-FDG PET/CT at b
View details →DOI: 10.2340/actadv.v103.5320 Negative / Null Result ReportOpen accessMedicine
Kataruka M, Sannyashi P, Bhattacharjee S et al. · 2026 · Cureus
Introduction Neuropathic ulcers occur mainly at the plantar aspect and correspond to areas with peak plantar pressure, usually seen in a sensory-deficient foot. Trophic ulcers are seen in diabetic neuropathy, post-leprosy, and any other…
View details →DOI: 10.7759/cureus.109479 Negative / Null Result ReportOpen accessDentistry
Fabiana Soares Grecca, Roberto Brandão Garcia, Clóvis Monteiro Bramante et al. · 2007 · Journal of Applied Oral Science
OBJECTIVE: The efficiency of rotary, manual and ultrasonic root canal instrumentation techniques was investigated in proximally flattened root canals. MATERIAL AND METHODS: Forty human mandibular left and right central incisors, lateral incisors and premolars were used. The pulp tissue was removed and the root canals were filled with red die. Teeth were instrumented using three techniques: (i) K3 and ProTaper rotary systems; (ii) ultrasonic crown-down technique; and (iii) progressive manual technique. Roots were bisected longitudinally in a buccolingual direction. The instrumented canal walls
View details →DOI: 10.1590/s1678-77572007000200003 Negative / Null Result ReportOpen accessMedicine (General)
Ana Marija Hosnjak, Martina Smrekar, Sanja Ledinski-Ficko et al. · 2023 · Journal of Health Sciences
Introduction: In times when the term inclusion, rights of patients, and the patient as a subject in health care are used more often, the limited availability of written material or sign language interpreters at health services is still a key barrier to health services for people who are hearing-impaired. The aim of this study is to examine nurses’ knowledge of communication skills with hearing-impaired patients, their preferred methods, and the possibility of using translation services. Methods: The study was cross-sectional, and data were collected in September–October 2019. The study include
Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Phyllis Waruguru, Dasel Mulwa, Michael Okoth et al. · 2025 · Journal of Food Innovation, Nutrition, and Environmental Sciences
Background: Antiretroviral therapy (ART) effectively suppresses HIV viral load. However, people living with HIV (PLWH) fail to achieve optimal viral suppression and especially in resource limited settings. Nutritional supplements such as Moringa oleifera have been traditionally used to improve health outcomes in PLWH, yet their effects on viral load remain under researched. Objective: To evaluate the effect of dietary supplementation with Moringa oleifera seed flour on HIV viral load among adult women receiving ART in a resource-limited setting. Methods: This was a crossover clinical trial inv
View details →DOI: 10.70851/ynxgrq90 Negative / Null Result ReportOpen accessMedicine
Michele L Ybarra, Sheana S Bull, Tonya L Prescott et al. · 2013 · PLoS ONE
Cost-effective, scalable programs are urgently needed in countries deeply affected by HIV.This parallel-group RCT was conducted in four secondary schools in Mbarara, Uganda. Participants were 12 years and older, reported past-year computer or Internet use, and provided informed caregiver permission and youth assent. The intervention, CyberSenga, was a five-hour online healthy sexuality program. Half of the intervention group was further randomized to receive a booster at four-months post-intervention. The control arm received 'treatment as usual' (i.e., school-delivered sexuality programming).
View details →DOI: 10.1371/journal.pone.0070083 Negative / Null Result ReportOpen accessSurgery
Ahmet Murat Bayraktar, Muhammet İrfan Dönmez · 2019 · Journal of Urological Surgery
Objective:The aim of this study was to determine if anti-platelet treatment would have any effect on the rate and duration of resolution in penile Mondor’s disease.Materials and Methods:A retrospective review of patients diagnosed with Mondor’s disease between 2014 and 2018 was conducted. The patients were divided into two groups with regard to anti-platelet treatment. Age, initial symptom, medications [short-term fluoroquinolone antibiotics (Ab) ± low-dose acetyl salicylic acid (ASA)], and erectile function scores were evaluated. Moreover, ultrasonographic findings (location and length of thr
View details →DOI: 10.4274/jus.galenos.2018.2341 Negative / Null Result ReportOpen accessOphthalmology
Anika Amritanand, Danica Lyngwa, Nimmy Thomas et al. · 2021 · TNOA Journal of Ophthalmic Science and Research
Purpose: The purpose of the study was to compare the efficacy of two vertically integrated teaching–learning methods, a peer-led ocular basic science workshop (OBSW) versus lecture by ophthalmology faculty, in enhancing the underlying basic science knowledge and examination skills of ophthalmic clinical tests among second clinical year medical students. Design: This was a prospective, interventional comparative study. Students were randomly assigned to peer-led OBSW and interactive lecture-based method of teaching by a faculty. Change in knowledge was assessed using pre and post multiple-choic
View details →DOI: 10.4103/tjosr.tjosr_14_21 Negative / Null Result ReportOpen accessMedicine
Patil VE, Barick D, Degloorkar P et al. · 2026 · Hip & pelvis
Purpose There is ongoing debate on the haemoglobin level at which red cell transfusion should be administered following surgery. This study aimed to evaluate the benefits of a restrictive blood transfusion strategy and assess potential…
View details →DOI: 10.5371/hp.2026.38.2.187 Negative / Null Result ReportOpen accessMedicine
Elham Tabesh, Farzad Yadmehr, Awat Feizi et al. · 2024 · Health Science Reports
Abstract Backgrounds and Aims This controlled randomized clinical trial was designed to compare effectiveness, side effects, and severity of symptoms before and after therapy between quadruple (QT) and sequential regimens (SQ) for Helicobacter Pylori (H. pylori). Methods Patients were randomly allocated into two groups. Group A received a 14‐day QT including pantoprazole 40 mg q12 h, bismuth subcitrate 240 mg q12 h, clarithromycin 500 mg q12 h, and amoxicillin 1000 mg q12 h and group B received ST including pantoprazole 40 mg q12 h and amoxicillin 1000 mg q12 h for the initial 5 days followed
View details →DOI: 10.1002/hsr2.1842 