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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21720 results · page 405 of 724

Negative / Null Result ReportMedicine

The impact of delivery models on psychomotor performance of manual procedures: a pilot study.

Borgehammar J, McClenahan B, Miller E et al. · 2026 · The Journal of manual & manipulative therapy

Objective Developing psychomotor competence in orthopedic manual physical therapy (OMPT) techniques is fundamental to post-professional physical therapy education. Concerns persist about whether online instructional models and the rise of…

View details →DOI: 10.1080/10669817.2026.2680217
Negative / Null Result ReportMedicine

Effect of Concurrent Anti-Seizure Medications on the Efficacy of the Ketogenic Diet in Children with Epilepsy.

Sharma S, Aschner A, Kabir N et al. · 2026 · The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Rationale The ketogenic diet (KD) is a well-established therapeutic option for children with non-surgical drug-resistant epilepsy (DRE). The purpose of this study was to determine whether specific anti-seizure medications (ASM) are…

View details →DOI: 10.1017/cjn.2026.10620
Failed Experiment ReportMedicine

Association of prior beta-blocker treatment and outcome in patients with out-of-hospital cardiac arrest.

Hamidi F, Muhler F, Skopp G et al. · 2026 · Clinical research in cardiology : official journal of the German Cardiac Society

Background Out-of-hospital cardiac arrest (OHCA) is associated with poor outcomes and presents a considerable treatment challenge. Here, we investigated the association of prior beta-blocker treatment with outcomes in patients with OHCA.…

View details →DOI: 10.1007/s00392-026-02968-6
Failed Experiment Report

Hormonal Dynamics around the Time of Trigger Injection Administration Predict Oocyte Yield in Planned Oocyte Cryopreservation Cycles

Kalinowska V, Hughes L, Lancki N et al. · 2026 · Preprint

Abstract Purpose To evaluate whether peri-trigger serum hormone dynamics are associated with mature oocyte yield in planned oocyte cryopreservation cycles across ovulation trigger protocols. Methods We conducted a retrospective study of…

View details →DOI: 10.21203/rs.3.rs-9202554/v1
Negative / Null Result ReportMedicine

Clinical Outcomes in Japanese Patients with Chronic Limb Threatening Ischaemia Undergoing Tibial and Pedal Bypass with a Single Segment Great Saphenous Vein Graft.

Kobayashi T, Takahara M, Kikuchi S et al. · 2026 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

Objective A single segment great saphenous vein (GSV) with a diameter ≥ 3.0 mm is widely accepted as the standard conduit for tibial and pedal bypass in chronic limb threatening ischaemia (CLTI) based on studies in European and American…

View details →DOI: 10.1016/j.ejvs.2026.06.037
Failed Experiment ReportMedicine

Infusion rate adjustment in enzyme replacement therapy with pabinafusp alfa for mucopolysaccharidosis II.

Nakamura K, Sakai N, Hirai H et al. · 2026 · British journal of clinical pharmacology

Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long-term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their…

View details →DOI: 10.1002/bcp.70612
Negative / Null Result ReportMedicine

Assessing the essential parameters of race, ethnicity and geography in endometrial cancer and the impact on presentation, treatment and outcomes.

Jamieson A, Kwon J, Gao T et al. · 2026 · Gynecologic oncology

Background Race, ethnicity, and geography can impact cancer management, genomics and outcomes. We aimed to determine the ethnic and geographic diversity of endometrial carcinoma (EC) patients in our province and their impact on molecular…

View details →DOI: 10.1016/j.ygyno.2026.05.011
Negative / Null Result ReportMedicine

Identification of chrono-nutrition behavior patterns and their associations with sociodemographic characteristics, diet quality, and obesity.

Murakami K, Shinozaki N, Livingstone MBE et al. · 2026 · The British journal of nutrition

While chrono-nutrition behaviors are inter-related, few studies examined patterns of chrono-nutrition behaviors using a comprehensive set of these behaviors. This study aimed to identify chrono-nutrition behavior patterns and examine their…

View details →DOI: 10.1017/s0007114526107090
Negative / Null Result ReportMedicine

Relationships between rest-activity rhythms, cancer-related fatigue, and quality of life: Results from a time-restricted eating randomized controlled trial.

Kleckner AS, Zhou Y, Diaz-Mercado Y et al. · 2026 · Chronobiology international

Circadian rest-activity rhythms, or a person's consistency in their daily activity and rest patterns, can be quantified using various parametric and non-parametric methods. However, these methods are seldom applied to understand symptoms…

View details →DOI: 10.1080/07420528.2026.2669594
Negative / Null Result ReportMedicine

IL-6 and TNFα are associated with depressive symptoms among men in a community-based cohort, with a tentative trend for IL-17A: Findings from the Shika Study in Japan.

Tsuboi H, Sakakibara H, Minamida-Urata Y et al. · 2026 · Neuro endocrinology letters

Objective Emerging evidence suggests that low-grade systemic inflammation contributes to depressive symptoms; however, population-based longitudinal evidence, particularly from community samples, remains limited. This study examined the…

Negative / Null Result ReportMedicine

Outcomes of extremely preterm infants with neonatal hyperglycemia and hypernatremia: a retrospective cohort study.

Fursule A, Athalye-Jape G, Deepak D et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective To assess whether early hypernatremia (HN) and/or hyperglycemia (HG) in the first postnatal week are associated with adverse neurodevelopmental outcomes in extremely preterm (EP; Study design This was a single-center…

View details →DOI: 10.1038/s41372-026-02683-0
Negative / Null Result ReportMedicine

Association between platelet indices and next-day bleeding and clotting in children and adults on extracorporeal membrane oxygenation: A retrospective study.

Chegondi M, Jawahar A, Badheka A et al. · 2026 · Perfusion

IntroductionBleeding and clotting phenotypes are common in patients supported with Extracorporeal Membrane Oxygenation (ECMO) and are associated with increased mortality. However, tools to distinguish bleeding from clotting phenotypes…

View details →DOI: 10.1177/02676591261445354
Negative / Null Result ReportMedicine

Subclinical malaria in sickle cell disease in Northern Uganda: prevalence, predictors, and hematologic impact.

Matejak NJ, Ngolobe H, O'Connell CT et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Sickle Cell Disease (SCD), characterized by persistently low hemoglobin (Hb) and hematocrit levels, is among the leading causes of under-five mortality in high prevalence countries. Sub-Saharan Africa bears the highest burden of…

View details →DOI: 10.1016/j.ijid.2026.108823
Negative / Null Result ReportMedicine

The relationships between proprioceptive awareness, balance, and spasticity in patients post-stroke with varying levels of trunk impairment.

Ada G, Duray M · 2026 · Physiotherapy theory and practice

Background Cervical and trunk proprioceptive deficits resulting from impaired sensorimotor integration post-stroke may contribute to deficiencies in balance reactions and tone regulation. Purpose: To examine relationships between cervical…

View details →DOI: 10.1080/09593985.2026.2656807
Negative / Null Result ReportMedicine

Associations between attitudes and beliefs about the role of nutrition and diet quality with pain interference and physical function.

Fredhoff B, Bernstetter A, Fotiou H et al. · 2026 · Complementary therapies in clinical practice

Background and purpose Nutrition likely influences pain, but the role of patient beliefs remains understudied in musculoskeletal conditions. This study examined whether beliefs about the role of nutrition in pain, diet quality, and eating…

View details →DOI: 10.1016/j.ctcp.2026.102057
Negative / Null Result ReportMedicine

Other-Oriented Perfectionism and Romantic Relationship Stress: The Role of Social Media Use Among Italians.

Amodeo AL, Giaquinto V, Reginelli F et al. · 2026 · Psychological reports

The present study examines the associations between other-oriented perfectionism and individual stress within romantic relationships, focusing on the intervening role of social media use as a relational context. Data were collected through…

View details →DOI: 10.1177/00332941261423478
Failed Experiment ReportMedicine

Effectiveness of chlorhexidine gluconate-impregnated dressings in preventing central line-associated bloodstream infection in a paediatric intensive care unit: A randomised controlled trial.

Portero-Prados FJ, Pabón-Carrasco M, Ponce-Blandón JA · 2026 · Intensive & critical care nursing

Objectives To compare the effectiveness and dermatological safety of chlorhexidine gluconate (CHG)-impregnated dressings versus conventional transparent dressings in preventing central line-associated bloodstream infection (CLABSI) in…

View details →DOI: 10.1016/j.iccn.2026.104441
Negative / Null Result Report

Predictive Value of Clinical and Trauma Scores for Life-Saving Interventions in Pediatric Trauma Patients: A Retrospecti̇ve Cohort Study

Güngör E, Birbilen AZ, Yildiz LA et al. · 2026 · Preprint

Abstract Purpose Early identification of pediatric trauma patients requiring life-saving interventions (LSIs) is fundamental for optimizing emergency triage and allocation planning. This study aimed to evaluate and compare the predictive…

View details →DOI: 10.21203/rs.3.rs-9271487/v1
Negative / Null Result ReportMedicine

Factors Contributing to the Depressive Symptoms among Patients Receiving Hemodialysis: A Cross-Sectional Analysis Using the PHQ-9.

Jeremias Macedo M, Beirão B, Rodrigues R et al. · 2026 · Blood purification

Introduction Depression is the most prevalent psychiatric disorder among patients with end-stage renal disease receiving hemodialysis (HD), associated with reduced quality of life, poor treatment adherence, higher hospitalization rates,…

View details →DOI: 10.1159/000551823
Negative / Null Result ReportMedicine

Associations of preoperative patient mental health status, sociodemographic and clinical characteristics with baseline pain, function and satisfaction in patients undergoing revision rotator cuff repairs.

Streubel PN, Sahoo S, Zhang C et al. · 2026 · Journal of shoulder and elbow surgery

Background This study aimed to investigate the associations of general patient and disease-specific factors with baseline patient reported outcome measures (PROMs) in patients undergoing revision rotator cuff repair (RCR). Baseline…

View details →DOI: 10.1016/j.jse.2026.05.007
Negative / Null Result ReportMedicine

Individuals with posttraumatic stress disorder have increased beat-to-beat blood pressure variability.

McGranahan MJ, Sabino-Carvalho JL, Zanuzzi MG et al. · 2026 · American journal of physiology. Regulatory, integrative and comparative physiology

Individuals with posttraumatic stress disorder (PTSD) are at elevated risk for cardiovascular disease (CVD). Emerging research suggests that increased blood pressure variability (BPV) reflects abnormalities in autonomic regulation and may…

View details →DOI: 10.1152/ajpregu.00322.2025
Negative / Null Result ReportOpen accessMedicine

Sexual and bowel function in women with obstetric anal sphincter injuries after perineoplasty and sphincterorrhaphy.

Imantika E, Praharsini RK, Sasotya RM et al. · 2026 · Narra J

Obstetric anal sphincter injury (OASIS) may lead to persistent sexual and bowel dysfunction, even after surgical repair. Evidence on the functional outcomes after sphincterorrhaphy and perineoplasty remains limited, particularly in…

View details →DOI: 10.52225/narra.v6i1.3038
Negative / Null Result ReportMedicine

Risk Factors for Recurrence and Complications Following Cytoreductive Surgery in Platinum-Resistant Ovarian Cancer: A Retrospective Cohort Study.

Wang L, Yao L, Wan J et al. · 2026 · Annali italiani di chirurgia

Aim This study aims to identify independent risk factors for tumor recurrence and postoperative complications in platinum-resistant ovarian cancer patients undergoing cytoreductive surgery. Methods This study retrospectively included 96…

View details →DOI: 10.62713/aic.4351
Negative / Null Result ReportOpen accessMedicine

Associations of circulating resistin with Alzheimer's disease biomarkers and cognitive function in the preclinical stage of Alzheimer's disease.

Eruysal E, Ravdin L, Iadecola C et al. · 2026 · Journal of Alzheimer's disease : JAD

BackgroundResistin is a circulating protein linked to systemic metabolic disorders and inflammation, both of which can contribute to the pathogenesis of Alzheimer's disease (AD). However, the role of resistin during the preclinical stage…

View details →DOI: 10.1177/13872877261442230