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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19866 results in Negative / Null Result Report · page 400 of 663

Negative / Null Result ReportMedicine

The effect of video assisted instruction on central venous catheter application skills, anxiety and satisfaction in nursing students: a randomised controlled study.

Koç G, Yüce Başaran HD, Yavuz B et al. · 2026 · BMC medical education

Objective This study aimed to evaluate the effect of video-assisted instruction on central venous catheter (CVC)-related psychomotor skills (blood collection, drug administration, and dressing care), anxiety levels, and student…

View details →DOI: 10.1186/s12909-026-09532-w
Negative / Null Result ReportMedicine

Impact of different treatment approaches on long-term refractive and visual outcomes in retinopathy of prematurity.

Kizilay O, Kunbaz A, Akarsu Acar OP et al. · 2026 · International journal of ophthalmology

Aim To evaluate the long-term refractive and visual outcomes in infants with retinopathy of prematurity (ROP) treated with intravitreal bevacizumab (IVB), laser photocoagulation (LPC), or combined IVB+LPC therapy, and to assess disease…

View details →DOI: 10.18240/ijo.2026.06.11
Negative / Null Result ReportOpen accessMedicine

Effects of different personal protective equipment on the cardiovascular system in a 6-minute walk test.

Masilamani PK, Muhammad NB, Sankaran RS et al. · 2026 · Clinics (Sao Paulo, Brazil)

Introduction During the Coronavirus Disease (COVID-19) pandemic, public and healthcare workers were recommended to use Personal Protective Equipment (PPE) to prevent the spread of infection. With the increased use of different types of…

View details →DOI: 10.1016/j.clinsp.2026.100994
Negative / Null Result ReportOpen accessMedicine

Midterm Quadriceps Strength Outcomes of Revision ACL Reconstructions Comparing Ipsilateral Extensor Mechanism Autografts and Hamstring Tendon Autografts.

Zavala P, Eggleston GG, Greufe NA et al. · 2026 · Orthopaedic journal of sports medicine

Background Primary anterior cruciate ligament reconstructions (ACLRs) with extensor mechanism autografts (bone-patellar tendon-bone [BTB] or quadriceps tendon [QT]) have been reported to have lower quadriceps strength symmetry outcomes 6…

View details →DOI: 10.1177/23259671261451830
Negative / Null Result ReportOpen accessMedicine

Evaluation of occlusion and disocclusion time in immediately loaded implant overdentures retained by two splinted versus non-splinted interforaminal implants: A randomized clinical trial.

Refai OM, Abdelfattah Mohamed AM, Ali El-Fiky AM · 2026 · BMC oral health

Background Mandibular complete dentures often lack stability, leading to prolonged occlusion and disocclusion times. Immediate-loading implant overdentures can improve functional control, but evidence comparing splinted and non-splinted…

View details →DOI: 10.1186/s12903-026-08855-w
Negative / Null Result Report

Analysis of Characteristics of 115 Cases with Unexpected Antibodies and Exploration of Transfusion Strategies: A Retrospective Study

Wen¹ C, Tang¹ Y, Zhu¹ L et al. · 2026 · Preprint

Abstract Objective: To investigate the incidence and distribution characteristics of unexpected antibodies through a retrospective analysis of 115 positive cases and explore transfusion strategies for patients with unexpected antibodies.…

View details →DOI: 10.21203/rs.3.rs-9562251/v1
Negative / Null Result ReportOpen accessMedicine

Patellofemoral Pain After Knee Trauma: Exploring Clinical, Biomechanical, and Muscle Strength Variables.

Dos Santos Lopes H, Waiteman MC, Serrão FV et al. · 2026 · Scandinavian journal of medicine & science in sports

It remains unclear whether people with traumatic-onset patellofemoral pain (PFP_T) present with the same physical and non-physical changes as people with gradual-onset patellofemoral pain (PFP_A). In this cross-sectional study, we aimed to…

View details →DOI: 10.1111/sms.70274
Negative / Null Result ReportMedicine

A study on the role of palliative care in the physical and psychological well-being of people with life-limiting illnesses in Kashmir, India.

Wani SQ, Matia M, Jayaprakasan AK et al. · 2026 · BMC palliative care

Background Living with life-limiting illnesses (LLIs) is psychologically distressing, even more so in areas with a complicated terrain and which are conflict-prone, where insecurity, displacement, and limited healthcare access adds to the…

View details →DOI: 10.1186/s12904-026-02142-9
Negative / Null Result ReportOpen accessMedicine

Mental health strain due to COVID-19: Psychological distress and somatic symptoms among health care workers and the general population in Kashmir, India.

Manzoor M, Banday MS, Para BA et al. · 2026 · Virus research

Background/objectives The COVID-19 pandemic precipitated a global rise in psychological morbidities, markedly increasing depression, anxiety, and stress. This study provides early region-specific evidence from Kashmir on the post-pandemic…

View details →DOI: 10.1016/j.virusres.2026.199753
Negative / Null Result ReportOpen accessMedicine

Ferroptosis inhibits biological behaviors of glioma cells by downregulating Galectin-9 transcriptional level via extracellular Acetyl-HMGB1.

Xu Y, Tan G, Zhu R · 2026 · Scientific reports

Ferroptosis, the most common programmed cell death process, and immune checkpoints play increasingly prominent roles in glioma. However, the effects of ferroptosis on immune checkpoints on glioma remain unclear. The intracellular ROS…

View details →DOI: 10.1038/s41598-026-45969-1
Negative / Null Result ReportMedicine

Sirolimus-based treatment regimens for antinuclear antibody (ANA)-positive immune thrombocytopenia: a retrospective single-center cohort study.

Tan A, Liu J, Chen X et al. · 2026 · Hematology (Amsterdam, Netherlands)

Objectives To evaluate the efficacy and safety of sirolimus-based treatment regimens in patients with antinuclear antibody (ANA)-positive immune thrombocytopenia (ITP). Methods This retrospective single-center study enrolled patients with…

View details →DOI: 10.1080/16078454.2026.2678626
Negative / Null Result ReportOpen accessMedicine

The Effects of Heated Tobacco Products on Oral Health and Quality of Life: An Observational Cross-Sectional Study.

Glavina A, Gravić A, Demo J et al. · 2026 · Healthcare (Basel, Switzerland)

Background/objectives Over the past decade, the popularity of smokeless tobacco products, particularly heated tobacco products (HTPs), has increased among adolescents and young adults. This study aimed to determine the effects of HTPs and…

View details →DOI: 10.3390/healthcare14101297
Negative / Null Result ReportMedicine

A new clinical examination finding in obstructive sleep apnea; diagonal auricular fold (Frank sign).

Dogan R, Kulaksiz Y, Yeni̇gun A et al. · 2026 · Sleep & breathing = Schlaf & Atmung

Objective Diagonal ear lobule fold (DELF)(Frank sign); It is a diagonal fold in the earlobe at an angle of about 45°, running diagonally from the tragus to the edge of the auricle at varying depths. In our study, the relationship between…

View details →DOI: 10.1007/s11325-026-03700-4
Negative / Null Result ReportOpen accessMedicine

Melody vs. message: Effects of traditional song and concise social media communications on iodine knowledge, attitudes, behaviors, and biomarkers in pregnant women-A randomized controlled trial.

Ruengsiriphakakul S, Bumrerraj S, Thaenkham T · 2026 · Journal of education and health promotion

Background Iodine deficiency remains a global public health problem. Urinary iodine concentration (UIC) in pregnant women is a key indicator of iodine status in the population. Knowledge (K), attitude (A), and practice (P) levels of…

View details →DOI: 10.4103/jehp.jehp_815_25
Negative / Null Result ReportOpen accessMedicine

Novel Taiwan-I-type infectious bronchitis virus: First evidence of testicular atrophy and efficacious protection with strain-matched oil-emulsified inactivated vaccine.

Zhang T, Xie Y, Yang C et al. · 2026 · Virulence

The Taiwan-I-type infectious bronchitis virus (IBV) has become one of the most dominant and threatening genotypes circulating in China poultry farms. In this study, we characterized the Taiwan-I-type IBV strain GX-NN200723 and evaluated…

View details →DOI: 10.1080/21505594.2026.2664950
Negative / Null Result ReportOpen accessMedicine

A comparative evaluation of apical sealing ability of NeoPutty, Biodentine, and Bio-c repair using a radioactive isotope method - An <i>in vitro</i> study.

Rathore S, Bhushan J, Uppal AS et al. · 2026 · Journal of conservative dentistry and endodontics

Background Treatment of teeth with immature apices is difficult to manage by conventional endodontics. Apical barrier formation using bioceramic materials offers a biologically favorable solution, providing a hermetic seal that supports…

View details →DOI: 10.4103/jcde.jcde_97_26
Negative / Null Result ReportMedicine

Comparison of Dexamethasone versus Ondansetron for Postoperative Nausea and Vomiting in Laparoscopic Cholecystectomy.

Loomba P, Nayak M, Podder S et al. · 2026 · Annals of African medicine

Background Postoperative nausea and vomiting (PONV) are a prevalent complication after laparoscopic surgeries, with an incidence reaching up to 63% without antiemetic prophylaxis. Objectives To evaluate the efficacy of dexamethasone and…

View details →DOI: 10.4103/aam.aam_60_26
Negative / Null Result ReportMedicine

The Effect of Virtual Simulation of Parenteral Medication Administration on Nursing Students' Knowledge and Skills: A Randomized Controlled Experimental Study.

Biyik Bayram S, Gülnar E, Çalişkan N et al. · 2026 · Computers, informatics, nursing : CIN

This study investigated the effect of virtual simulation of parenteral medication administrations on nursing students' knowledge and skills. This randomized controlled experimental study adopted a pretest-posttest research design. The…

View details →DOI: 10.1097/cin.0000000000001581
Negative / Null Result ReportOpen accessMedicine

Evaluation of Time-Dependent Chemical Alterations in Sodium Hypochlorite Solution Kept on the Unit Tray During an Average Root Canal Treatment Period.

Bastug Guven E, Genc Sen O · 2026 · Medical science monitor : international medical journal of experimental and clinical research

BACKGROUND Sodium hypochlorite (NaOCl) is the most commonly used irrigant in root canal treatment because of its antimicrobial activity and tissue-dissolving capacity. Since these properties are related to its physicochemical…

View details →DOI: 10.12659/msm.952416
Negative / Null Result ReportOpen accessMedicine

A Comparison of Monoaxial Pedicle Screws Versus Polyaxial Pedicle Screws in Posterior Fusion Surgery for Adolescent Idiopathic Scoliosis (Lenke Type 1).

Hammad A, Saleh ME, Shehab AA · 2026 · Cureus

Background Adolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity in adolescents, characterized by a three-dimensional curvature of the spine with unknown etiology. Surgical intervention is indicated in…

View details →DOI: 10.7759/cureus.107673
Negative / Null Result ReportOpen accessMedicine

Effects of music during endoscopy on pain, anxiety and vital signs: a randomized controlled study.

Bozkurt SN, Kocasli S · 2026 · BMC complementary medicine and therapies

AIMS: The aim of this study was to the effects of music during the endoscopy procedure on anxiety, pain and vital signs. METHODS: This study was conducted as a randomized, controlled, double-blind trial. The study population consisted of…

View details →DOI: 10.1186/s12906-026-05381-8
Negative / Null Result ReportOpen accessMedicine

Quantifying glenoid bone loss in the setting of primary reverse shoulder arthroplasty.

MacFarlane AJ, Larson JH, Kucharik MP et al. · 2026 · Journal of shoulder and elbow arthroplasty

Background Presently, there is no quantifiable and objective criteria for defining severe glenoid bone loss (GBL) for primary reverse total shoulder arthroplasty (rTSA). In this study, we sought to establish quantifiable thresholds of…

View details →DOI: 10.1016/j.jsea.2026.100015
Negative / Null Result ReportOpen accessMedicine

Prognostic Value of Combined Neutrophil-to-Lymphocyte Ratio and Prognostic Nutritional Index in Advanced Ovarian Cancer Treated With Neoadjuvant Chemotherapy.

Ishida H, Egashira H, Asano N et al. · 2026 · Cureus

Background Inflammation- and nutrition-related biomarkers such as the neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) have been reported as prognostic factors for ovarian cancer. However, their clinical…

View details →DOI: 10.7759/cureus.108250
Negative / Null Result ReportMedicine

Effect of remazolam combined with hydromorphone postoperative analgesia on cognitive function in elderly patients undergoing hip replacement.

Zheng X, Fu X, Shao Y et al. · 2026 · American journal of translational research

Objective To investigate the effect of remazolam combined with hydromorphone on postoperative cognitive function in elderly patients undergoing hip replacement. Methods 184 elderly patients who underwent hip replacement in Sir Run Run Shaw…

View details →DOI: 10.62347/tfej7525
Negative / Null Result Report

Under-correction is not advisable in valgus knee and lateral approach is more feasible than medial approach to achieve this: A 5-year follow-up study

Li S, Chai H, Bao W et al. · 2026 · Preprint

Abstract Background: It is commonly recommended to restore the mechanical axis to within –0° ± 3° in valgus knee. However, the situation is quite different when the alignment is –3° or 3° in the presence of a compromised MCL in Ranawat…

View details →DOI: 10.21203/rs.3.rs-9715753/v1
Negative / Null Result ReportOpen accessMedicine

Effects of ultrasound-assisted tumbling on physicochemical properties, myofibrillar protein structure, and protein oxidation during beef curing.

Jin L, Zhang J, Zhang R et al. · 2026 · Ultrasonics sonochemistry

The aim of this study was to investigate the effects of ultrasound-assisted tumbling (100, 300, 500, and 700 W) with different treatment times (30, 60, 90, 120, 150, and 180 min) on the quality, myofibrillar protein structure, and protein…

View details →DOI: 10.1016/j.ultsonch.2026.107919
Negative / Null Result ReportOpen accessMedicine

Effectiveness of Acupressure on Anxiety, Fatigue, and Sleep Quality Among Operating Room Personnel: A Randomized Controlled Trial.

Abjar R, NasiriFormi E, Kazemi AH et al. · 2026 · Health science reports

Background and aims High-quality sleep, calmness, and lack of fatigue are vital for the health of critical hospital staff. Operating room personnel experience significant mental and physical stress, including anxiety and sleep…

View details →DOI: 10.1002/hsr2.72680
Negative / Null Result Report

Association of Primary Nocturnal Enuresis with Renal Parenchymal Thickness: Insights from a Study on Enuresis Prevalence and Related Factors

Merikhi A, Gheisari A, Kasiri P et al. · 2026 · Preprint

Abstract Background: Nocturnal Enuresis (NE), characterized by the inability to control nighttime voiding in children above five years, is one of the common problems faced by the young generation today and can result in some psychological…

View details →DOI: 10.21203/rs.3.rs-9818630/v1