A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19761 results in Negative / Null Result Report · page 40 of 659
Clarissa Capp, Simone Magagnin Wajner, Débora Rodrigues Siqueira et al. · 2010 · Thyroid
BACKGROUND: Vascular endothelial growth factor (VEGF-A) expression is upregulated in the majority of human tumors, where it stimulates proliferation, migration, and survival of endothelial cells. Studies have suggested that VEGF inhibitors…
Dana M. Brantley‐Sieders, Aixiang Jiang, Krishna Sarma et al. · 2011 · PLoS ONE
Pre-clinical studies provide compelling evidence that Eph family receptor tyrosine kinases (RTKs) and ligands promote cancer growth, neovascularization, invasion, and metastasis. Tumor suppressive roles have also been reported for the receptors, however, creating a potential barrier for clinical application. Determining how these observations relate to clinical outcome is a crucial step for translating the biological and mechanistic data into new molecularly targeted therapies. We investigated eph and ephrin expression in human breast cancer relative to endpoints of overall and/or recurrence-f
Alexis F. Turgeon, Dean A Fergusson, Lucy Clayton et al. · 2024 · New England Journal of Medicine
BACKGROUND: The effect of a liberal transfusion strategy as compared with a restrictive strategy on outcomes in critically ill patients with traumatic brain injury is unclear. METHODS: We randomly assigned adults with moderate or severe…
Heidi Edmonds, Julie Lovell, C. A. Knox Lovell · 2020 · Ecological Indicators
The earth’s climate is changing, with global warming attributable to anthropogenic greenhouse gas emissions driven by economic and population growth. Human systems and ecosystems vary in their exposure, mitigation and adaptive capacity,…
Leonie S. Penner, Sean P. Gavan, Darren M. Ashcroft et al. · 2022 · British Journal of Clinical Pharmacology
AIMS: To examine the risk of gastrointestinal (GI) bleeding, major bleeding, stroke and systemic embolism associated with prescribing nonsteroidal anti-inflammatory drugs (NSAIDs) to adults receiving oral anticoagulant (OAC) therapy. METHODS: We conducted a population-based cohort study in adults receiving OAC therapy using linked primary care (Clinical Practice Research Datalink GOLD) and hospital (Hospital Episodes Statistics) electronic health records. We used cause-specific Cox regression models with time-dependent NSAID treatment in a propensity score matched population to estimate the in
Jonathan Beauchamp, David Cesarini, Magnus Johannesson et al. · 2011 · The Journal of Economic Perspectives
The costs of comprehensively genotyping human subjects have fallen to the point where major funding bodies, even in the social sciences, are beginning to incorporate genetic and biological markers into major social surveys. How, if at all,…
Christopher Redding, Thomas M. Smith · 2016 · American Educational Research Journal
Alternative certification programs are now commonplace in the credentialing of new teachers. We complement the growing evidence base for these teachers by exploring their turnover patterns in four waves of the nationally representative…
Nohra Chalouhi, Robert M. Starke, Steven Yang et al. · 2013 · Stroke
BACKGROUND AND PURPOSE: Flow diverters are currently indicated for treatment of large and complex intracranial aneurysms. The purpose of this study was to determine whether the indications of flow diversion can be safely extended to…
Justin Paul, Shailja Bhakar · 2017 · Journal of Promotion Management
We examine whether image congruence (IC) of celebrities have significant effect on purchase intention (PI) and whether attitude towards brand and attitude towards advertisement mediate the relationships in a developing country, based on…
D. Rubin, G. Aldering, M. Betoule et al. · 2025 · The Astrophysical Journal
Abstract Type Ia supernovae (SNe Ia) were instrumental in establishing the acceleration of the Universe’s expansion. By virtue of their combination of distance reach, precision, and prevalence, they continue to provide key cosmological constraints, complementing other cosmological probes. Individual SN surveys cover only over about a factor of 2 in redshift, so compilations of multiple SN data sets are strongly beneficial. We assemble an up-to-date “Union” compilation of 2087 cosmologically useful SNe Ia from 24 data sets (“Union3”). We take care to put all SNe on the same distance scale and u
Imran Yousaf, Larisa Yarovaya · 2022 · Finance research letters
We examine the static and time-varying herding behavior in three cryptocurrency classes: ‘conventional’ cryptocurrencies, non-fungible tokens, and DeFi assets during the most recent cryptocurrency bubble of 2021. While static herding analysis failed to demonstrate any evidence of herding, the time-varying herding has been identified in conventional cryptocurrencies and DeFi assets for the short investment horizons. The herding asymmetry analysis reveals that herding is not evident in conventional cryptocurrencies and NFT during up/down market, high/low volatility days, and high/low trading day
Annika Wahl, Michel Charifzadeh, Fabian E. Diefenbach · 2020 · Business Strategy and the Environment
Abstract This study investigates how integrated reporting (IR) creates value for investors. It examines how providers of financial capital benefit from an improved firm information environment provided by IR. Specifically, this study investigates the effect of voluntary IR disclosure on analyst earnings forecast accuracy as well as on firm value. To do so, we use an international sample of 167 listed companies that voluntarily publish an integrated report. Our analysis shows no significant effect of a voluntary IR publication on analyst earnings forecast accuracy and no significant effect on f
P. M. Bombuwela, De Alwis · 2013 · Journal of Competitiveness
The study was entirely designed by centering the focal problem of the effect of Glass Ceiling on Women Career Development. The overall study was structure based on the conceptual framework built up using the information of literature survey. The study was conducted with the aim of obtaining the following objective. That is "To find out the Effect of Glass Ceiling on Women Career Development with regard to female executive level employees who are working in private sector organizations." At the same time, hypotheses are developed to find out whether there is a significant effect of Individual F
T.J. Karpanen, A.L. Casey, Peter A. Lambert et al. · 2011 · Infection Control and Hospital Epidemiology
OBJECTIVE: To determine whether copper incorporated into hospital ward furnishings and equipment can reduce their surface microbial load. DESIGN: A crossover study. SETTING: Acute care medical ward with 19 beds at a large university…
Irene H. Flønes, Erika Fernández‐Vizarra, Maria Lykouri et al. · 2017 · Acta Neuropathologica
Mitochondrial complex I deficiency occurs in the substantia nigra of individuals with Parkinson's disease. It is generally believed that this phenomenon is caused by accumulating mitochondrial DNA damage in neurons and that it contributes to the process of neurodegeneration. We hypothesized that if these theories are correct, complex I deficiency should extend beyond the substantia nigra to other affected brain regions in Parkinson's disease and correlate tightly with neuronal mitochondrial DNA damage. To test our hypothesis, we employed a combination of semiquantitative immunohistochemical an
Steven Boonen, Dennis M. Black, Cathleen Colón‐Emeric et al. · 2010 · Journal of the American Geriatrics Society
OBJECTIVES: To determine the efficacy of once-yearly intravenous zoledronic acid (ZOL) 5 mg in reducing risk of clinical vertebral, nonvertebral, and any clinical fractures in elderly osteoporotic postmenopausal women. DESIGN: A post hoc…
Kaoping Zhang, Manuel Delgado‐Baquerizo, Yong‐Guan Zhu et al. · 2020 · mSystems
Both space and time are key factors that regulate microbial community, but microbial temporal variation is often ignored at a large spatial scale. In this study, we compared spatial and seasonal effects on bacterial and fungal diversity variation across an 878-km transect and found direct evidence that space is far more important than season in regulating the soil microbial community. Partitioning the effect of season, space and environmental variables on microbial community, we further found that fast-changing environmental factors contributed to microbial temporal variation.
Rogier M. Thurlings, Marie Boumans, Janneke Tekstra et al. · 2010 · Arthritis & Rheumatism
OBJECTIVE: To analyze the relationship between the type I interferon (IFN) signature and clinical response to rituximab in rheumatoid arthritis (RA) patients. METHODS: Twenty RA patients were treated with rituximab (cohort 1). Clinical…
Pauline Stanton, Richard Gough, Ruth Ballardie et al. · 2014 · The International Journal of Human Resource Management
This article analyses a process improvement project based on Lean Six Sigma (LSS) techniques in the emergency department (ED) of a large Australian hospital. We consider perspectives of the clinical and managerial staff involved in the…
Hans Kirschner, Willem Kuyken, Kim Wright et al. · 2019 · Clinical Psychological Science
Self-compassion and its cultivation in psychological interventions are associated with improved mental health and well-being. However, the underlying processes for this are not well understood. We randomly assigned 135 participants to study the effect of two short-term self-compassion exercises on self-reported-state mood and psychophysiological responses compared to three control conditions of negative (rumination), neutral, and positive (excitement) valence. Increased self-reported-state self-compassion, affiliative affect, and decreased self-criticism were found after both self-compassion e
Kamalesh Mishra, Mary J. Metilda · 2015 · IIMB Management Review
This paper aims at studying the impact of investment experience, gender, and level of education on two specific biases—overconfidence and self-attribution, and exploring the relationship between the two biases. Data collected from a sample…
Jochen Klucken, Anne-Maria Poehler, Darius Ebrahimi‐Fakhari et al. · 2012 · Autophagy
Synucleinopathies like Parkinson disease and dementia with Lewy bodies (DLB) are characterized by α-synuclein aggregates within neurons (Lewy bodies) and their processes (Lewy neurites). Whereas α-synuclein has been genetically linked to…
Daantje Derks, Lieke L. ten Brummelhuis, Dino Zecic et al. · 2012 · European Journal of Work and Organizational Psychology
This study examines the impact of work-related smartphone use on daily recovery from work-related efforts. The literature shows that work–home interference (WHI) is an important inhibitor of the recovery process. We propose that the…
Brendan McMullan, Catriona Halliday, Tania C. Sorrell et al. · 2012 · PLoS ONE
BACKGROUND: Cryptococcus neoformans causes life-threatening meningitis. A recently introduced lateral flow immunoassay (LFA) to detect cryptococcal antigen (CRAG) is reportedly more rapid and convenient than standard latex agglutination (LA), but has not yet been evaluated in a diagnostic laboratory setting. METHODS: One hundred and six serum, 42 cerebrospinal fluid (CSF), and 20 urine samples from 92 patients with known or suspected cryptococcosis were tested by LA and LFA, and titres were compared. Results were correlated with laboratory-confirmed cryptococcosis. Serial samples were tested i
Jordan Spatz, E. E. Fields, Elaine W Yu et al. · 2012 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Animal models and human studies suggest that osteocytes regulate the skeleton's response to mechanical unloading in part by an increase in sclerostin. However, few studies have reported changes in serum sclerostin in humans…
Mark Umbricht, Frank Fernandez, Justin C. Ortagus · 2015 · Educational Policy
Previous studies have shown that state performance funding policies do not increase baccalaureate degree production, but higher education scholarship lacks a rigorous, quantitative analysis of the unintended consequences of performance…
Man‐Fung Yuen, Ingolf Schiefke, Jung‐Hwan Yoon et al. · 2019 · Hepatology
BACKGROUND AND AIMS: ARC-520, the first an RNA interference (RNAi) therapeutic, was designed to reduce all RNA transcripts derived from covalently closed circular DNA, leading to a reduction in viral antigens and hepatitis B virus (HBV)…
Catalina Medina, Sı́món Barquera, Ian Janssen · 2013 · PubMed
OBJECTIVE: To determine the test-retest reliability and validity of the Spanish version of the short-form International Physical Activity Questionnaire (IPAQ) among adults in Mexico. METHODS: This was a cross-sectional study of a…
Jaap Brand, Stef van Buuren, Saskia le Cessie et al. · 2018 · Statistics in Medicine
In healthcare cost-effectiveness analysis, probability distributions are typically skewed and missing data are frequent. Bootstrap and multiple imputation are well-established resampling methods for handling skewed and missing data.…
Patrick N. Osakwe, Amelia U. Santos‐Paulino, Berna Doğan · 2018 · Journal of African Trade
This paper explores the relationship between trade, trade liberalization, and exports diversification in developing and Sub-Saharan African (SSA) countries. The non-parametric analyses indicate that developing countries that are more open…