A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19735 results in Negative / Null Result Report · page 4 of 658
Christopher J. Soto · 2019 · Psychological Science
The Big Five personality traits have been linked to dozens of life outcomes. However, metascientific research has raised questions about the replicability of behavioral science. The Life Outcomes of Personality Replication (LOOPR) Project…
Jodie M Dodd, Deborah Turnbull, Andrew J McPhee et al. · 2014 · BMJ
OBJECTIVE: To determine the effect of antenatal dietary and lifestyle interventions on health outcomes in overweight and obese pregnant women. DESIGN: Multicentre randomised trial. We utilised a central telephone randomisation server, with…
Karen Kelly, Nasser K. Altorki, Wilfried Eberhardt et al. · 2015 · Journal of Clinical Oncology
PURPOSE: Epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitors have proven efficacy in advanced non-small-cell lung cancer (NSCLC). We hypothesized that erlotinib would be efficacious in the adjuvant setting. PATIENTS AND…
Maria Grazia Bongiorni, Charles Kennergren, Christian Butter et al. · 2017 · European Heart Journal
AIMS: The European Lead Extraction ConTRolled Registry (ELECTRa), is a prospective registry of consecutive transvenous lead extraction (TLE) procedures conducted by the European Heart Rhythm Association (EHRA) in order to identify the…
Heather C. Hazlett, Michele D. Poe, Guido Gerig et al. · 2011 · Archives of General Psychiatry
CONTEXT: Brain enlargement has been observed in 2-year-old children with autism, but the underlying mechanisms are unknown. OBJECTIVE: To investigate early growth trajectories in brain volume and cortical thickness. DESIGN: Longitudinal…
Naihui Zhou, Yuxiang Jiang, Timothy Bergquist et al. · 2019 · Genome biology
BACKGROUND: The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function. RESULTS: Here, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes. S
Michael D. Ward, Brian Greenhill, Kristin M. Bakke · 2010 · Journal of Peace Research
Abstract Large-n studies of conflict have produced a large number of statistically significant results but little accurate guidance in terms of anticipating the onset of conflict. The authors argue that too much attention has been paid to…
A. Salarian, Fay B. Horak, Cris Zampieri et al. · 2010 · IEEE Transactions on Neural Systems and Rehabilitation Engineering
Timed Up and Go (TUG) test is a widely used clinical paradigm to evaluate balance and mobility. Although TUG includes several complex subcomponents, namely: sit-to-stand, gait, 180 degree turn, and turn-to-sit; the only outcome is the…
Neil A. Smart, Mark Waldron, Hashbullah Ismail et al. · 2015 · International Journal of Evidence-Based Healthcare
INTRODUCTION: Several established tools are available to assess study quality and reporting of randomized controlled trials; however, these tools were designed with clinical intervention trials in mind. In exercise training intervention…
Sabine L. Vriezinga, Renata Auricchio, E. Bravi et al. · 2014 · New England Journal of Medicine
BACKGROUND: A window of opportunity has been suggested for reducing the risk of celiac disease by introducing gluten to infants at 4 to 6 months of age. METHODS: We performed a multicenter, randomized, double-blind, placebo-controlled…
R. Phillip Dellinger, Sean M. Bagshaw, Massimo Antonelli et al. · 2018 · JAMA
Importance: Polymyxin B hemoperfusion reduces blood endotoxin levels in sepsis. Endotoxin activity can be measured in blood with a rapid assay. Treating patients with septic shock and elevated endotoxin activity using polymyxin B…
Daniel F. McAuley, John G. Laffey, Cecilia O’Kane et al. · 2014 · New England Journal of Medicine
BACKGROUND: Studies in animals and in vitro and phase 2 studies in humans suggest that statins may be beneficial in the treatment of the acute respiratory distress syndrome (ARDS). This study tested the hypothesis that treatment with…
Devon E. Hinton, Roberto Lewis‐Fernández · 2010 · Depression and Anxiety
BACKGROUND: There is considerable debate about the cross-cultural applicability of the posttraumatic stress disorder (PTSD) category as currently specified. Concerns include the possible status of PTSD as a Western culture-bound disorder…
Falk Hildebrand, Thi Loan Anh Nguyen, Brigitta M. N. Brinkman et al. · 2013 · Genome biology
BACKGROUND: Murine models are a crucial component of gut microbiome research. Unfortunately, a multitude of genetic backgrounds and experimental setups, together with inter-individual variation, complicates cross-study comparisons and a global understanding of the mouse microbiota landscape. Here, we investigate the variability of the healthy mouse microbiota of five common lab mouse strains using 16S rDNA pyrosequencing. RESULTS: We find initial evidence for richness-driven, strain-independent murine enterotypes that show a striking resemblance to those in human, and which associate with calp
Kyohei Nishino, Atsushi Nishida, Ryo Inoüe et al. · 2017 · Journal of Gastroenterology
BACKGROUND: The mucosa-associated gut microbiota directly modulates epithelial and mucosal function. In this study, we investigated the mucosa-associated microbial community in patients with inflammatory bowel disease (IBD), using endoscopic brush samples. METHODS: A total of 174 mucus samples from 43 patients with ulcerative colitis (UC), 26 with Crohn's disease (CD) and 14 non-IBD controls were obtained by gentle brushing of mucosal surfaces using endoscopic cytology brushes. The gut microbiome was analyzed using 16S rRNA gene sequencing. RESULTS: There were no significant differences in mic
Stan B. Kaye, Jan Lubiński, Ursula A. Matulonis et al. · 2011 · Journal of Clinical Oncology
PURPOSE: Olaparib (AZD2281), an orally active poly (ADP-ribose) polymerase inhibitor that induces synthetic lethality in BRCA1- or BRCA2-deficient cells, has shown promising clinical efficacy in nonrandomized phase II trials in patients…
A. A. de Graaff, Thomas D’Hooghe, G.A.J. Dunselman et al. · 2013 · Human Reproduction
STUDY QUESTION: To what extent do the management of endometriosis and the symptoms that remain after treatment affect the quality of life in women with the disease? SUMMARY ANSWER: Many women with endometriosis had impaired quality of life…
Angela K. Davis, David A. Guenther, Linda K. Krull et al. · 2015 · The Accounting Review
ABSTRACT We investigate the relation between corporate tax payments and corporate social responsibility. Because existing theory and empirical studies find inconsistent evidence on the relation between these constructs, we investigate…
Nazlı Dizman, Luís Meza, Paulo Gustavo Bergerot et al. · 2022 · Nature Medicine
Previous studies have suggested that the gut microbiome influences the response to checkpoint inhibitors (CPIs) in patients with cancer. CBM588 is a bifidogenic live bacterial product that we postulated could augment CPI response through modulation of the gut microbiome. In this open-label, single-center study (NCT03829111), 30 treatment-naive patients with metastatic renal cell carcinoma with clear cell and/or sarcomatoid histology and intermediate- or poor-risk disease were randomized 2:1 to receive nivolumab and ipilimumab with or without daily oral CBM588, respectively. Stool metagenomic s
Tiantian Ren, Stan Boutin, Murray M. Humphries et al. · 2017 · Microbiome
BACKGROUND: Our understanding of gut microbiota has been limited primarily to findings from human and laboratory animals, but what shapes the gut microbiota in nature remains largely unknown. To fill this gap, we conducted a comprehensive study of gut microbiota of a well-studied North American red squirrel (Tamiasciurus hudsonicus) population. Red squirrels are territorial, solitary, and live in a highly seasonal environment and therefore represent a very attractive system to study factors that drive the temporal and spatial dynamics of gut microbiota. RESULT: For the first time, this study r
Siliang Tong, Nan Jia, Xueming Luo et al. · 2021 · Strategic Management Journal
Abstract Companies are increasingly using artificial intelligence (AI) to provide performance feedback to employees, by tracking employee behavior at work, automating performance evaluations, and recommending job improvements. However,…
Zoltán Dörnyei, Letty Chan · 2013 · Language Learning
Recent theorizing on second language (L2) motivation has proposed viewing motivation as a function of the language learners’ vision of their desired future language selves. This would suggest that the intensity of motivation is partly…
Christiane Maria Prado Jerônimo, Maria Eduarda Leão de Farias, Fernando Val et al. · 2020 · Clinical Infectious Diseases
BACKGROUND: Steroid use for coronavirus disease 2019 (COVID-19) is based on the possible role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by severe acute respiratory syndrome coronavirus 2…
Mehmet Mehmetoglu, Marit Engen · 2011 · Journal of Quality Assurance in Hospitality & Tourism
The growing attention placed on experiences can be regarded as a mega-trend, and has given currency to the proposition that experiences function as a personal source of information for the stories people tell about their lives and are…
Virginia Rauh, Frederica P. Perera, Megan K. Horton et al. · 2012 · Proceedings of the National Academy of Sciences
Prenatal exposure to chlorpyrifos (CPF), an organophosphate insecticide, is associated with neurobehavioral deficits in humans and animal models. We investigated associations between CPF exposure and brain morphology using magnetic…
Jacob D. Estes, Levelle D. Harris, Nichole R. Klatt et al. · 2010 · PLoS Pathogens
The chronic phase of HIV infection is marked by pathological activation of the immune system, the extent of which better predicts disease progression than either plasma viral load or CD4(+) T cell count. Recently, translocation of microbial products from the gastrointestinal tract has been proposed as an underlying cause of this immune activation, based on indirect evidence including the detection of microbial products and specific immune responses in the plasma of chronically HIV-infected humans or SIV-infected Asian macaques. We analyzed tissues from SIV-infected rhesus macaques (RMs) to pro
Janine Giese‐Davis, Kate Collie, Kate M. Rancourt et al. · 2010 · Journal of Clinical Oncology
PURPOSE: Numerous studies have examined the comorbidity of depression with cancer, and some have indicated that depression may be associated with cancer progression or survival. However, few studies have assessed whether changes in…
Daniel J. Wilson · 2019 · Proceedings of the National Academy of Sciences
-value (HMP), which controls the FWER while greatly improving statistical power by combining dependent tests using generalized central limit theorem. I show that the HMP effortlessly combines information to detect statistically significant signals among groups of individually nonsignificant hypotheses in examples of a human GWAS for neuroticism and a joint human-pathogen GWAS for hepatitis C viral load. The HMP simultaneously tests all ways to group hypotheses, allowing the smallest groups of hypotheses that retain significance to be sought. The power of the HMP to detect significant hypothesi
Mary E. Tinetti, Ling Han, David S. H. Lee et al. · 2014 · JAMA Internal Medicine
IMPORTANCE The effect of serious injuries, such as hip fracture and head injury, on mortality and function is comparable to that of cardiovascular events. Concerns have been raised about the risk of fall injuries in older adults taking…
Suharno Pawirosumarto, Purwanto Katijan Sarjana, Rachmad Gunawan · 2017 · International Journal of Law and Management
Purpose The purpose of this paper is to determine the effect of the work environment, leadership style and organizational culture on job satisfaction and its implication toward the performance of the employees. Design/methodology/approach…