Negative / Null Result ReportOpen accessHealth Professions
Girmay Tsegay Kiross, Catherine Chojenta, Daniel Barker et al. · 2020 · Health Economics Review
INTRODUCTION: Although health expenditure in sub-Saharan African countries is the lowest compared with other regions in the world, most African countries have improved their budget allocations to health care over the past 15 years. The majority of health care sources in sub-Saharan Africa are private and largely involve out-of-pocket expenditure, which may prevent healthcare access. Access to healthcare is a known predictor of infant mortality. Therefore the objective of this study is to determine the impact of health care expenditure on infant mortality in sub-Saharan Africa. METHODS: The stu
View details →DOI: 10.1186/s13561-020-00262-3Cited by 117 Negative / Null Result ReportOpen accessPsychology
Suzanna M. Zick, Benjamin D. Wright, Ananda Sen et al. · 2011 · BMC Complementary and Alternative Medicine
BACKGROUND: Despite being the most commonly used herbal for sleep disorders, chamomile's (Matricaria recutita) efficacy and safety for treating chronic primary insomnia is unknown. We examined the preliminary efficacy and safety of chamomile for improving subjective sleep and daytime symptoms in patients with chronic insomnia. METHODS: We performed a randomized, double-blind, placebo-controlled pilot trial in 34 patients aged 18-65 years with DSM-IV primary insomnia for ≥ 6-months. Patients were randomized to 270 mg of chamomile twice daily or placebo for 28-days. The primary outcomes were sle
View details →DOI: 10.1186/1472-6882-11-78Cited by 115 Negative / Null Result ReportOpen accessNursing
Simone Passarelli, Dawit Mekonnen, Elizabeth Bryan et al. · 2018 · Food Security
Interventions that aim to increase water availability for agriculture hold great potential for improving nutrition through increasing food production, generating income, enhancing water access and sanitation and hygiene conditions, and through strengthening women’s empowerment. Yet there is scarce evidence on the linkages between small-scale irrigation and the pathways through which nutrition outcomes can be achieved. Using data from a cross-sectional household survey collected in Ethiopia and Tanzania, we explored the potential for small-scale irrigation to contribute to improved diets, and i
View details →DOI: 10.1007/s12571-018-0812-5Cited by 115 Negative / Null Result ReportOpen accessDecision Sciences
Erick H. Turner, Daniel Knoepflmacher, Lee Shapley · 2012 · PLoS Medicine
BACKGROUND: Publication bias compromises the validity of evidence-based medicine, yet a growing body of research shows that this problem is widespread. Efficacy data from drug regulatory agencies, e.g., the US Food and Drug Administration (FDA), can serve as a benchmark or control against which data in journal articles can be checked. Thus one may determine whether publication bias is present and quantify the extent to which it inflates apparent drug efficacy. METHODS AND FINDINGS: FDA Drug Approval Packages for eight second-generation antipsychotics-aripiprazole, iloperidone, olanzapine, pali
View details →DOI: 10.1371/journal.pmed.1001189Cited by 109 Negative / Null Result ReportMedicine
Daniel S. Thoma, Manuel Sancho‐Puchades, Dominik A. Ettlin et al. · 2011 · Journal Of Clinical Periodontology
AIM: To test whether a collagen matrix (CM) can improve early wound healing and aesthetics, and decrease wound sensitivity compared with spontaneous healing. METHODS: In 15 volunteers, 6-mm punch biopsies were harvested at both palatal…
View details →DOI: 10.1111/j.1600-051x.2011.01823.xCited by 105 Negative / Null Result ReportOpen accessMedicine
Patrick J. Leavey, Nadia N. Laack, Mark D. Krailo et al. · 2021 · Journal of Clinical Oncology
PURPOSE The primary aim of this phase III randomized trial was to test whether the addition of vincristine, topotecan, and cyclophosphamide (VTC) to interval compressed chemotherapy improved survival outcomes for patients with previously…
View details →DOI: 10.1200/jco.21.00358Cited by 99 Negative / Null Result ReportOpen accessMedicine
Danielle S. Gruen, Joshua B. Brown, Francis X. Guyette et al. · 2020 · JCI Insight
BACKGROUNDPrehospital plasma improves survival in severely injured patients transported by air ambulance. We hypothesized that prehospital plasma would be associated with a reduction in immune imbalance and endothelial damage.METHODSWe sampled blood from 405 trauma patients enrolled in the Prehospital Air Medical Plasma (PAMPer) trial upon hospital admission (0 hours) and 24 hours post admission across 6 U.S. sites. We assayed samples for 21 inflammatory mediators and 7 markers associated with endothelial function and damage. We performed hierarchical clustering analysis (HCA) of these biomark
View details →DOI: 10.1172/jci.insight.135350Cited by 98 Negative / Null Result ReportOpen accessNeuroscience
Benjamin M. Basile, Gabriel R. Schroeder, Emily Kathryn Brown et al. · 2014 · Journal of Experimental Psychology General
Knowing the extent to which nonhumans and humans share mechanisms for metacognition will advance our understanding of cognitive evolution and will improve selection of model systems for biomedical research. Some nonhuman species avoid…
View details →DOI: 10.1037/xge0000031Cited by 98 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Barbara C. Sorkin, Adam J. Kuszak, Gregory Bloss et al. · 2019 · The FASEB Journal
While great interest in health effects of natural product (NP) including dietary supplements and foods persists, promising preclinical NP research is not consistently translating into actionable clinical trial (CT) outcomes. Generally…
View details →DOI: 10.1096/fj.201902143rCited by 96 Negative / Null Result ReportOpen accessMedicine
Nancy Kass, Holly A. Taylor, Joseph Ali et al. · 2014 · Clinical Trials
BACKGROUND: Research suggests that participants do not always adequately understand studies. While some consent interventions increase understanding, methodologic challenges have been raised in studying consent outside of actual trial…
View details →DOI: 10.1177/1740774514560831Cited by 93 Negative / Null Result ReportOpen accessEnvironmental Science
Mingshu Wang, Neil Debbage · 2021 · Computers Environment and Urban Systems
Traffic congestion is an ever-increasing issue across urban environments in the US. One potential mitigation strategy is to improve our understanding of how the geographical patterns of urban land use influence congestion. Unfortunately, there is no consensus regarding if more sprawling or dense urban morphologies help mitigate congestion issues. To potentially clarify the conflicting findings of previous studies, we used a detailed spatial metric-based approach and panel regression to quantify the relationships between urban development patterns and congestion in 98 US urban areas from 2001 t
View details →DOI: 10.1016/j.compenvurbsys.2021.101676Cited by 93 Negative / Null Result ReportMedicine
Susanna Wiegand, Dagmar l’Allemand, Hanna Hübel et al. · 2010 · European Journal of Endocrinology
OBJECTIVE: To study whether metformin reduces obesity, homeostasis model assessment for insulin resistance index (HOMA-IR), and the metabolic syndrome (MtS) in obese European adolescents in addition to previous unsuccessful lifestyle…
View details →DOI: 10.1530/eje-10-0570Cited by 92 Negative / Null Result ReportOpen accessNursing
Muhammed A. Usman, Daniel Callo-Concha · 2021 · Agricultural and Food Economics
Abstract Market access influences the dietary diversity and food security for smallholder households in many ways. In Ethiopia, most smallholders are subsistence farmers who have poor access to markets. This study used primary data from a household survey to examine the relationship between market access and the dietary diversity and food security for 324 smallholder households in the Yayu area of southwestern Ethiopia in early 2018. Multivariate regression analysis showed that households located far from market centers consumed not only less diverse foods but also spend less on food consumpti
View details →DOI: 10.1186/s40100-021-00190-8Cited by 92 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Davide Fiore Bavaro, Alessandra Belati, Lucia Diella et al. · 2021 · Antibiotics
Cefiderocol is a new cephalosporin displaying against extensively resistant (XDR) Gram-negative bacteria. We report our experience with cefiderocol-based combination therapies as “rescue” treatments in immunocompromised or critically ill patients or in patients with post-surgical infections who had failed previous regimens. A total of 13 patients were treated from 1 September 2020 to 31 March 2021. In total, 5/13 (38%) patients were classified as critically ill, due to severe COVID-19 lung failure; 4/13 (31%) patients had post-surgical infections and 4/13 (31%) had severe infections in immunoc
View details →DOI: 10.3390/antibiotics10060652Cited by 92 Negative / Null Result ReportOpen accessMedicine
Susan M. Smith, Tom Fahey, John Smucny et al. · 2017 · Cochrane Database of Systematic Reviews
Background The benefits and risks of antibiotics for acute bronchitis remain unclear despite it being one of the most common illnesses seen in primary care. Objectives To assess the effects of antibiotics in improving outcomes and to…
View details →DOI: 10.1002/14651858.cd000245.pub4Cited by 90 Negative / Null Result ReportMedicine
Mark A. Hyde, Michael L. Hadley, Payam Tristani‐Firouzi et al. · 2012 · Archives of Dermatology
OBJECTIVE: To determine if the complete response rates of lentigo maligna (LM) to imiquimod, 5%, cream can be improved by the addition of a topical retinoid. DESIGN: Prospective randomized study of patients treated with imiquimod alone vs…
View details →DOI: 10.1001/archdermatol.2012.270Cited by 89 Negative / Null Result ReportOpen accessMedicine
Raffaele Garofalo, Brody A. Flanagin, Alessandro Castagna et al. · 2015 · Journal of Orthopaedic Surgery and Research
BACKGROUND: Complex proximal humeral fractures are very difficult to treat particularly in patients older than 65 years with an osteoporotic bone and tuberosities compromised. The goal of this paper is to evaluate radiological outcomes at mid-term follow-up of proximal humerus fractures treated with reverse shoulder arthroplasty using a dedicated fracture stem. MATERIALS AND METHODS: The study population included 98 patients who underwent reverse shoulder with a dedicated fracture stem for an acute proximal humerus fracture; 87/98 patients were available for analysis. There were 62 female and
View details →DOI: 10.1186/s13018-015-0261-1Cited by 87 Negative / Null Result ReportOpen accessMedicine
Christopher W. Lewis, Jamiluddin Qazi, Daniel S. Hippe et al. · 2019 · Cancer Medicine
Approximately one-third of Merkel cell carcinoma (MCC) patients eventually develop distant metastatic disease. Little is known about whether the location of the primary lesion is predictive of initial distant metastatic site, or if survival likelihood differs depending on the metastatic site. Such data could inform imaging/surveillance practices and improve prognostic accuracy. Multivariate and competing-risk analyses were performed on a cohort of 215 MCC patients with distant metastases, 31% of whom had two or more initial sites of distant metastasis. At time of initial distant metastasis in
View details →DOI: 10.1002/cam4.2781Cited by 84 Negative / Null Result ReportOpen accessMedicine
Katherine D. LaClair, Kebreten F. Manaye, Dexter L. Lee et al. · 2013 · Molecular Neurodegeneration
BACKGROUND: Though the precise cause(s) of Alzheimer's disease (AD) remain unknown, there is strong evidence that decreased clearance of β-amyloid (Aβ) from the brain can contribute to the disease. Therapeutic strategies to promote natural Aβ clearance mechanisms, such as the protein apolipoprotein-E (APOE), hold promise for the treatment of AD. The amount of APOE in the brain is regulated by nuclear receptors including retinoid X receptors (RXRs). Drugs that activate RXRs, including bexarotene, can increase APOE and ABCA1 production, and have been shown to decrease the Aβ burden and improve c
View details →DOI: 10.1186/1750-1326-8-18Cited by 84 Negative / Null Result ReportOpen accessEnvironmental Science
Michael A. Litzow, Mary E. Hunsicker · 2016 · Ecosphere
Abstract Early warning signals ( EWS ) might dramatically improve our ability to manage nonlinear ecological change. However, the degree to which theoretical EWS predictions are supported in empirical systems remains unclear. The goal of this study is to make recommendations for identifying the types of ecological transitions that are expected to show EWS . We conducted a review and meta‐analysis of published studies and comparative analysis of eight northeast Pacific Ocean time series to illustrate the importance of testing for nonlinearity in empirical EWS studies. We found that published st
View details →DOI: 10.1002/ecs2.1614Cited by 82 Negative / Null Result Report
Christina Brock, Christian Stevns Hansen, Jesper Karmisholt et al. · 2019 · British Journal of Clinical Pharmacology
Aims Type 1 diabetes can be complicated with neuropathy that involves immune‐mediated and inflammatory pathways. Glucagon‐like peptide‐1 receptor agonists such as liraglutide, have shown anti‐inflammatory properties, and thus we…
View details →DOI: 10.1111/bcp.14063Cited by 81 Negative / Null Result ReportOpen accessMedicine
Konstantinos A. Toulis, Brian H Willis, Tom Marshall et al. · 2017 · The Journal of Clinical Endocrinology & Metabolism
Context: Empagliflozin was found to decrease mortality in patients with type 2 diabetes mellitus (T2DM) and a prior cardiovascular disease (CVD) event. Objectives: To establish whether these benefits can be replicated in a real-world…
View details →DOI: 10.1210/jc.2016-3446Cited by 80 Negative / Null Result ReportOpen accessMedicine
Boulos Nassar, Mary Vaughan‐Sarrazin, Lan Jiang et al. · 2014 · JAMA Internal Medicine
IMPORTANCE: Intensive care unit (ICU) telemedicine (TM) programs have been promoted as improving access to intensive care specialists and ultimately improving patient outcomes, but data on effectiveness are limited and conflicting.…
View details →DOI: 10.1001/jamainternmed.2014.1503Cited by 79 Negative / Null Result ReportOpen accessPsychology
Adam Oei, Michael D. Patterson · 2015 · Frontiers in Psychology
Despite increasing evidence that shows action video game play improves perceptual and cognitive skills, the mechanisms of transfer are not well-understood. In line with previous work, we suggest that transfer is dependent upon common demands between the game and transfer task. In the current study, participants played one of four action games with varying speed, visual, and attentional demands for 20 h. We examined whether training enhanced performance for attentional blink, selective attention, attending to multiple items, visual search and auditory detection. Non-gamers who played the game (
View details →DOI: 10.3389/fpsyg.2015.00113Cited by 77 Negative / Null Result ReportBusiness, Management and Accounting
Maria Steinmeier, Michael Stich · 2017 · European Accounting Review
This study analyzes the effect of sustainability assurance (SA) on managerial investment decisions in terms of sustainability investment (SI) efficiency. We hypothesize that SA improves the set of information available for managerial…
View details →DOI: 10.1080/09638180.2017.1412337Cited by 75 Negative / Null Result ReportMedicine
Cynthia Braden, Lenore Hawley, Jody Newman et al. · 2010 · Brain Injury
OBJECTIVES: To evaluate the feasibility of improving impaired social communication skills in persons with traumatic brain injury (TBI) and concomitant neurological or psychiatric conditions, using an intervention with evidence of efficacy…
View details →DOI: 10.3109/02699052.2010.506859Cited by 74 Negative / Null Result ReportOpen accessMedicine
Raanan Marants, Elena Qirjazi, Claire Grant et al. · 2019 · Journal of the American Society of Nephrology
Significance Statement Residual renal function (RRF) characteristically declines after patients with ESRD initiate dialysis. Although RRF preservation correlates with improved outcomes, poor understanding of the pathophysiology underlying…
View details →DOI: 10.1681/asn.2018121194Cited by 74 Negative / Null Result ReportOpen accessPsychology
Sabina Eggert, Frauke Ostermeyer, Marcus Hasselhorn et al. · 2013 · Education Research International
The purpose of the present study was to examine the effects of cooperative training strategies to enhance students' socioscientific decision making as well as their metacognitive skills in the science classroom. Socioscientific decision making refers to both “describing socioscientific issues” as well as “developing and evaluating solutions” to socioscientific issues. We investigated two cooperative training strategies which differed with respect to embedded metacognitive instructions that were developed on the basis of the IMPROVE method. Participants were 360 senior high school students who
View details →DOI: 10.1155/2013/309894Cited by 73 Negative / Null Result ReportOpen accessMedicine
Robert S. Schwartz, Stacia Merkel Kraus, Jonathan Schwartz et al. · 2014 · PubMed
BACKGROUND: Long-term marathon running improves many cardiovascular risk factors, and is presumed to protect against coronary artery plaque formation. This hypothesis, that long-term marathon running is protective against coronary…
Negative / Null Result ReportOpen accessImmunology and Microbiology
Lavinia Rech, Mahmoud Abdellatif, Maria Pöttler et al. · 2021 · Life Sciences
AIMS: Myocardial infarction (MI) is a major global cause of death. Massive cell death leads to inflammation, which is necessary for ensuing wound healing. Extensive inflammation, however, promotes infarct expansion and adverse remodeling. The DNA sensing receptor cyclic GMP-AMP synthase and its downstream signaling effector stimulator of interferon genes (cGAS-STING) is central in innate immune reactions in infections or autoimmunity. Cytosolic double-strand DNA activates the pathway and down-stream inflammatory responses. Recent papers demonstrated that this pathway is also active following M
View details →DOI: 10.1016/j.lfs.2021.120263Cited by 70 