A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19761 results in Negative / Null Result Report · page 39 of 659
Andrew Rojecki, Sharon Meraz · 2014 · New Media & Society
The World Wide Web has changed the dynamics of information transmission and agenda-setting. Facts mingle with half-truths and untruths to create factitious informational blends (FIBs) that drive speculative politics. We specify an…
Floor Bennebroek Evertsz, Pythia T. Nieuwkerk, Pieter Stokkers et al. · 2012 · Journal of Crohn s and Colitis
AIM: To develop a patient-based Simple Clinical Colitis Activity Index (P-SCCAI) of ulcerative colitis (UC) activity and to compare it with the clinician-based SCCAI, C-reactive protein (CRP) and Physician's Global Assessment (PGA) of UC…
Alexander M. Aiken, Calum Davey, James Hargreaves et al. · 2015 · International Journal of Epidemiology
BACKGROUND: Helminth (worm) infections cause morbidity among poor communities worldwide. An influential study conducted in Kenya in 1998-99 reported that a school-based drug-and-educational intervention had benefits regarding worm…
Andrew M. Ryan, Sam Krinsky, Kristin A. Maurer et al. · 2017 · New England Journal of Medicine
BACKGROUND: Starting in fiscal year 2013, the Hospital Value-Based Purchasing (HVBP) program introduced quality performance-based adjustments of up to 1% to Medicare reimbursements for acute care hospitals. METHODS: We evaluated whether…
Kenneth Younge, Tony W. Tong, Lee Fleming · 2014 · Strategic Management Journal
This study draws on strategic factor market theory and argues that acquirers' decisions regarding whether to bid for a firm reflect their expectations about employee departure from the firm post‐acquisition, suggesting a negative…
Rachel Griffith, Gareth Macartney · 2013 · The Review of Economics and Statistics
Abstract The theoretical effects of labor regulations, such as employment protection legislation (EPL), on innovation is ambiguous. EPL increases job security, and the greater enforceability of job contracts may increase worker investment…
Mark W. Becker, Nora M. Bello, Raghav Prashant Sundar et al. · 2015 · Food Policy
OBJECTIVES: 1) To assess whether Front-of-Pack (FOP) nutrition labels garner attention more readily than more complete, mandated nutrition information (the Nutrition Facts Panel (NFP), required in the US), and 2) To determine whether label…
Vincent O. Nyasembe, Peter E. A. Teal, Wolfgang R Mukabana et al. · 2012 · Parasites & Vectors
BACKGROUND: Sugar feeding is critical for survival of malaria vectors and, although discriminative plant feeding previously has been shown to occur in Anopheles gambiae s.s., little is known about the cues mediating attraction to these plants. In this study, we investigated the role of olfaction in An. gambiae discriminative feeding behaviour. METHODS: Dual choice olfactometer assays were used to study odour discrimination by An. gambiae to three suspected host plants: Parthenium hysterophorus (Asteraceae), Bidens pilosa (Asteraceae) and Ricinus communis (Euphorbiaceae). Sugar content of the t
Oisín Tansey · 2015 · Democratization
Recent scholarship has increasingly focused on the international dimensions of authoritarian rule, and the idea of autocracy promotion has gained considerable academic currency. While the literature on autocracy promotion has identified…
Floris Dammeijer, Lysanne A. Lievense, Margaretha E. Kaijen-Lambers et al. · 2017 · Cancer Immunology Research
Abstract New immunotherapeutic strategies are needed to induce effective antitumor immunity in all cancer patients. Malignant mesothelioma is characterized by a poor prognosis and resistance to conventional therapies. Infiltration of…
Daniel J. Renouf, Jonathan M. Loree, Jennifer J. Knox et al. · 2022 · Nature Communications
Immunotherapy-based monotherapy treatment in metastatic pancreatic ductal adenocarcinoma (mPDAC) has shown limited benefit outside of the mismatch repair deficiency setting, while safety and efficacy of combining dual-checkpoint inhibitor immunotherapy with chemotherapy remains uncertain. Here, we present results from the CCTG PA.7 study (NCT02879318), a randomized phase II trial comparing gemcitabine and nab-paclitaxel with and without immune checkpoint inhibitors durvalumab and tremelimumab in 180 patients with mPDAC. The primary endpoint was overall survival. Secondary endpoints included pr
David C. Wheeler, Gérard M. London, Patrick S. Parfrey et al. · 2014 · Journal of the American Heart Association
BACKGROUND: Premature cardiovascular disease limits the duration and quality of life on long-term hemodialysis. The objective of this study was to define the frequency of fatal and nonfatal cardiovascular events attributable to…
Philip T. Yanos, David Roe, Michelle L. West et al. · 2012 · Psychological Services
Elevated internalized stigma is common and is linked to subjective and objective outcomes for severe mental illness. The authors developed a manualized group-based intervention (Narrative Enhancement/Cognitive Therapy; NECT) to address…
Céline Grégoire, Caroline Ritacco, Muriel Hannon et al. · 2019 · Frontiers in Immunology
Mesenchymal stromal cells (MSCs) have potent immunomodulatory properties that make them an attractive tool against graft-versus-host disease (GVHD). However, despite promising results in phase I/II studies, bone marrow (BM-) derived MSCs failed to demonstrate their superiority over placebo in the sole phase III trial reported thus far. MSCs from different tissue origins display different characteristics, but their therapeutic benefits have never been directly compared in GVHD. Here, we compared the impact of BM-, umbilical cord (UC-), and adipose-tissue (AT-) derived MSCs on T-cell function in
Emily C. LaVoy, Christopher P. Fagundes, Robert Dantzer · 2026 · PubMed
Cancer-related fatigue significantly disrupts normal functioning and quality of life for a substantial portion of cancer survivors, and may persist for years following cancer treatment. While the causes of persistent fatigue among cancer…
Donna R. Rivera, Solange Peters, Orestis A. Panagiotou et al. · 2020 · Cancer Discovery
Abstract Among 2,186 U.S. adults with invasive cancer and laboratory-confirmed SARS-CoV-2 infection, we examined the association of COVID-19 treatments with 30-day all-cause mortality and factors associated with treatment. Logistic…
Lee S. Katz, Aaron Petkau, John Beaulaurier et al. · 2013 · mBio
UNLABELLED: Prior to the epidemic that emerged in Haiti in October of 2010, cholera had not been documented in this country. After its introduction, a strain of Vibrio cholerae O1 spread rapidly throughout Haiti, where it caused over 600,000 cases of disease and >7,500 deaths in the first two years of the epidemic. We applied whole-genome sequencing to a temporal series of V. cholerae isolates from Haiti to gain insight into the mode and tempo of evolution in this isolated population of V. cholerae O1. Phylogenetic and Bayesian analyses supported the hypothesis that all isolates in the sample
Priyanka Sharma, William E. Barlow, Andrew K. Godwin et al. · 2017 · Annals of Oncology
Background: Homologous recombination deficiency (HRD)-causing alterations have been reported in triple-negative breast cancer (TNBC). We hypothesized that TNBCs with HRD alterations might be more sensitive to anthracycline plus…
Celso Brunetti, Bahattin Büyükşahin, Jeffrey H. Harris · 2016 · Journal of Financial and Quantitative Analysis
We use data from 2005–2009 that uniquely identify categories of traders to test how speculators such as hedge funds and swap dealers relate to volatility and price changes. In examining various subperiods where price trends are strong, we…
Kevin J. Gaston, Daniel T. C. Cox, Sonia B. Canavelli et al. · 2018 · BioScience
Although there is a diversity of concerns about recent persistent declines in the abundances of many species, the implications for the associated delivery of ecosystem services to people are surprisingly poorly understood. In principle, there are a broad range of potential functional relationships between the abundance of a species or group of species and the magnitude of ecosystem-service provision. Here, we identify the forms these relationships are most likely to take. Focusing on the case of birds, we review the empirical evidence for these functional relationships, with examples of suppor
Alessandro Gavazza, Mattia Nardotto, Tommaso Valletti · 2018 · The Review of Economic Studies
Abstract We empirically study the effects of broadband internet diffusion on local election outcomes and on local government policies using rich data from the U.K. Our analysis shows that the internet has displaced other media with greater…
Nia Plamenova Djourova, Isabel Rodríguez, Núria Tordera et al. · 2019 · Journal of Leadership & Organizational Studies
The objective of this article is to test the roles of self-efficacy and resilience as consecutive mediators in the relationship between the four dimensions of transformational leadership and well-being (operationalized as psychosomatic complaints and psychological distress). The sample consists of 225 social services employees in Spain. Data were gathered at two time points with a time-lag of 6 months. We used path analysis to test the hypothesized model and Monte Carlo confidence intervals to check the significance of the indirect effects. Our results showed that only two of the four transfor
Sherief Abd‐Elsalam, Eslam Saber Esmail, Mai Khalaf et al. · 2020 · American Journal of Tropical Medicine and Hygiene
The COVID-19 pandemic is showing an exponential growth, mandating an urgent need to develop an effective treatment. Indeed, to date, a well-established therapy is still lacking. We aimed to evaluate the safety and efficacy of…
Colin Steer, George Davey Smith, Pauline Emmett et al. · 2010 · PLoS ONE
BACKGROUND: Breastfeeding is important for child cognitive development. A study by Caspi et al has suggested that rs174575 within the FADS2 gene moderates this effect so that children homozygous in the minor allele (GG genotype) have similar IQs irrespective of feeding method. METHODS AND PRINCIPAL FINDINGS: In our study of 5934 children aged 8 years, no genetic main effect with IQ was found for rs174575. However, an interaction with this polymorphism was observed such that breastfed GG children performed better than their formula fed counterparts by an additional 5.8 points [1.4, 10.1] (inter
Julia Depa, Juan Ramón Barrada, María Roncero · 2019 · Nutrients
Recent research points to the bidimensional nature of orthorexia, with one dimension related to interest in healthy eating (healthy orthorexia) and another dimension related to a pathological preoccupation with eating healthily (orthorexia nervosa). Research was needed to provide further support for this differentiation. We examined the food-choice motives related to both aspects of orthorexia. Participants were 460 students from a Spanish university who completed the Teruel Orthorexia Scale and the Food Choice Questionnaire. By means of structural equation modeling, we analyzed the relationsh
Stijn van Roessel, Eran van Veldhuisen, Sjors Klompmaker et al. · 2020 · JAMA Oncology
IMPORTANCE: The benefit of adjuvant chemotherapy after resection of pancreatic cancer following neoadjuvant combination treatment with folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) is unclear. OBJECTIVE: To assess…
Amy J. Schuh, Melissa J. Ward, Andrew Brown et al. · 2013 · PLoS neglected tropical diseases
The circulation of vector-borne zoonotic viruses is largely determined by the overlap in the geographical distributions of virus-competent vectors and reservoir hosts. What is less clear are the factors influencing the distribution of virus-specific lineages. Japanese encephalitis virus (JEV) is the most important etiologic agent of epidemic encephalitis worldwide, and is primarily maintained between vertebrate reservoir hosts (avian and swine) and culicine mosquitoes. There are five genotypes of JEV: GI-V. In recent years, GI has displaced GIII as the dominant JEV genotype and GV has re-emerg
Weijun Xuan, Fatma Vatansever, Liyi Huang et al. · 2013 · PLoS ONE
Low-level laser (light) therapy (LLLT) has been clinically applied around the world for a spectrum of disorders requiring healing, regeneration and prevention of tissue death. One area that is attracting growing interest in this scope is the use of transcranial LLLT to treat stroke and traumatic brain injury (TBI). We developed a mouse model of severe TBI induced by controlled cortical impact and explored the effect of different treatment schedules. Adult male BALB/c mice were divided into 3 broad groups (a) sham-TBI sham-treatment, (b) real-TBI sham-treatment, and (c) real-TBI active-treatmen
Kabir Peay, Sabrina E. Russo, Krista L. McGuire et al. · 2015 · Ecology Letters
Plants interact with a diversity of microorganisms, and there is often concordance in their community structures. Because most community-level studies are observational, it is unclear if such concordance arises because of host specificity,…
David A. Tandberg, Nicholas Hillman · 2014 · Journal of education finance
As states explore strategies for increasing educational attainment levels, attention is being paid to performance funding. This study asks, “Does the introduction of performance funding programs affect degree completion among participating…