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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21309 results · page 387 of 711

Failed Experiment ReportOpen accessMedicine

Loss of the distal-proximal GLP-1/Notch activation gradient in the aging <i>C. elegans</i> germline.

Janse van Vuuren R, Martel PO, Narbonne P · 2025 · microPublication biology

In C. elegans hermaphrodites, the distal tip cells (DTCs) capping the gonad arms provide a Notch ligand, the niche signal that maintains germline stem cell pools. Using fixed germlines, it was recently shown that the transcription of a…

View details →DOI: 10.17912/micropub.biology.001908
Negative / Null Result ReportMedicine

Investigating disparity in labor epidural analgesia management in black vs. white women: a retrospective case-control study (2018-2022).

Clifton J, Woodward S, Hardcastle S et al. · 2025 · International journal of obstetric anesthesia

Background Disparities in labor epidural analgesia (LEA) management could reduce maternal satisfaction and increase risk. We compared times from the first administration of breakthrough pain medication (top-up) to LEA replacement to…

View details →DOI: 10.1016/j.ijoa.2024.104327
Negative / Null Result ReportOpen accessMedicine

Skeletal muscle protein turnover and mitochondrial responses to omega-3 fatty acid supplementation: an update.

Hayden JE, Deane CS · 2026 · Current opinion in clinical nutrition and metabolic care

Purpose of review To critically review recent findings related to the effects of omega-3 fatty acid supplementation on skeletal muscle, with a particular focus on skeletal muscle protein turnover and mitochondrial function. Recent findings…

View details →DOI: 10.1097/mco.0000000000001196
Negative / Null Result ReportMedicine

Assessing the performance of chest x-ray screening in detecting early-stage lung cancer in the general population.

Chei CL, Nakamura S, Watanabe K et al. · 2025 · International journal of cancer

Chest x-ray (CXR) is widely used for lung cancer screening in Japan. We evaluated the sensitivity and specificity of CXR in detecting early lung cancer and its histological types. We cross-referenced lung cancer municipality screening data…

View details →DOI: 10.1002/ijc.35316
Negative / Null Result ReportOpen accessMedicine

Video-Assisted Thoracoscopic Left Lower Lobectomy and Bronchial Foreign Body Removal for Treating a Rare Occult Bronchial Foreign Body in an Adult.

Shi Q, Bao J, Li J et al. · 2025 · Respirology case reports

Occult bronchial foreign bodies are extremely rare in adults. Affected patients typically lack a clear history of aspiration, exhibit no characteristic clinical signs and present with unremarkable chest imaging, often leading to…

View details →DOI: 10.1002/rcr2.70262
Negative / Null Result ReportOpen accessMedicine

Identifying a Critical Blind Spot: How Commercial AI (CAD) Systems Fail to Detect Faint Ground-Glass Opacities at -730 HU on Low-Dose CT.

Liang S, Wang J, Fu W et al. · 2026 · Diagnostics (Basel, Switzerland)

Objective: The integration of artificial intelligence (AI) into computer-aided detection (CAD) is a major innovation in lung cancer diagnosis. However, its reliability in detecting the earliest radiographic sign-faint ground-glass…

View details →DOI: 10.3390/diagnostics16071014
Negative / Null Result ReportOpen accessMedicine

Sentinel Lymph Node Detection Using SPECT and Gamma Probe in Low-Risk Endometrial Cancer: Efficacy and Factors Associated With Detection Failure.

Asanoma K, Yahata H, Kodama K et al. · 2025 · Asian journal of endoscopic surgery

Introduction This study examined factors that affected sentinel lymph node (SLN) identification of patients with endometrial cancer having a preoperative estimation of low recurrent risk. Methods This study included 97 patients with…

View details →DOI: 10.1111/ases.70015
Negative / Null Result ReportMedicine

[Application of optical genome mapping technology for the detection of chromosomal structural variations].

Zhang Z, He S, Li X et al. · 2024 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Objective To assess the value of optical genome mapping (OGM) for the detection of chromosomal structural abnormalities including ring chromosomes, balanced translocations, and insertional translocations. Methods Clinical data of four…

View details →DOI: 10.3760/cma.j.cn511374-20230107-00013
Negative / Null Result ReportOpen accessMedicine

Pipeline evaluation of a state-of-the-art AI algorithm for detection of focal cortical dysplasia: insights into potential failure sources.

Esmeraldo MA, Chambers S, Kravutske Y et al. · 2026 · Brain informatics

Purpose MELD Graph is a state-of-the-art artificial intelligence (AI) model for automated detection of focal cortical dysplasia (FCD), but its performance remains limited, highlighting the need to investigate which aspects of the pipeline…

View details →DOI: 10.1186/s40708-026-00299-w
Negative / Null Result ReportMedicine

Evaluation of the AMP rapid test ROTA/ADENOVIRUS for simultaneous detection of rotavirus and adenovirus in stool samples.

Allahham M, Rennert W, Miller KM et al. · 2025 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Background Rotavirus (RV) and Adenovirus (AdV) gastroenteritis affect children worldwide. The sensitivity and specificity of the AMP Rapid Test ROTA/ADENOVIRUS [AMP-RA] for the detection of RV and AdV were compared against qPCR Allplex™…

View details →DOI: 10.1007/s10096-025-05042-7
Negative / Null Result ReportMedicine

Twenty-one days of bed rest alter motor unit properties and neuromuscular junction transmission in young adults.

Sarto F, Kalc M, Motanova ES et al. · 2025 · Journal of applied physiology (Bethesda, Md. : 1985)

Previous studies showed that properties of higher-threshold motor units (MUs) and neuromuscular junction (NMJ) function are preserved during short-term disuse. This study aimed to test how a longer disuse period affects MU properties, NMJ…

View details →DOI: 10.1152/japplphysiol.00178.2025
Negative / Null Result ReportOpen accessMedicine

Diagnostic Performance of Cardiac CT and Transthoracic Echocardiography in Congenital Heart Disease: A Surgical Correlation Study.

Bakhshaliyev S, Arslanoğlu E, Huseynov H et al. · 2026 · Diagnostics (Basel, Switzerland)

Background : This study evaluated the diagnostic efficacy of transthoracic echocardiography (TTE) and 128-slice multislice computed tomography (MSCT) angiography in congenital heart disease (CHD). Methods : Between January 2018 and August…

View details →DOI: 10.3390/diagnostics16020259
Negative / Null Result ReportMedicine

Significance of Variants of Uncertain Significance: The Human Cost of Genetic Uncertainty.

Gonullu-Rotman D · 2024 · American journal of medical genetics. Part C, Seminars in medical genetics

This piece narrates the journey of Maria (name of the mother has been altered to protect the family's privacy), a new mother confronting her newborn's unexpected diagnosis of very long chain acyl-CoA dehydrogenase (VLCAD) deficiency,…

View details →DOI: 10.1002/ajmg.c.32109
Negative / Null Result ReportOpen accessMedicine

Reevaluating the senolytic activity of a GLS1 inhibitor and an anti-PD-1 antibody: toward greater reproducibility and methodological rigor.

Kawamoto S, Horiguchi H, Torigoe D et al. · 2026 · EMBO reports

The discovery of the senescence-associated secretory phenotype (SASP) has reshaped our understanding of cellular senescence, shifting its role from a solely tumor-suppressive mechanism to a potential driver of chronic inflammation and…

View details →DOI: 10.1038/s44319-026-00740-5
Negative / Null Result ReportOpen accessMedicine

Double pyramidal lobe of the thyroid gland: report of two consecutive cases with surgical and oncologic implications.

Ağar ET, Yüksel C · 2026 · Journal of surgical case reports

The pyramidal lobe (PL) of the thyroid gland is a common embryological remnant; however, the presence of double PLs is an exceptionally rare anatomical variation. Failure to recognize this anomaly may result in incomplete thyroidectomy,…

View details →DOI: 10.1093/jscr/rjag049
Negative / Null Result ReportMedicine

Post-hoc out-of-distribution detection for cardiac MRI segmentation.

Arega TW, Bricq S, Meriaudeau F · 2025 · Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society

In real-world scenarios, medical image segmentation models encounter input images that may deviate from the training images in various ways. These differences can arise from changes in image scanners and acquisition protocols, or even the…

View details →DOI: 10.1016/j.compmedimag.2024.102476
Negative / Null Result ReportMedicine

Reliability of brain localization using task-based fMRI for late-life depression with suicidal risk.

Hsu AL, Wu CW, Huang CM et al. · 2025 · Journal of psychiatric research

Late-life depression (LLD) is a heterogeneous mental disorder with a high risk of suicide, often linked to abnormalities in brain networks, particularly the prefrontal cortex. While transcranial magnetic stimulation targeting the dorsal…

View details →DOI: 10.1016/j.jpsychires.2025.04.053
Negative / Null Result ReportOpen accessMedicine

False negativity for trisomy 18 in non-invasive prenatal testing: A case report.

Andová N, Repiská V, Priščáková P et al. · 2026 · Case reports in women's health

False-negative results in non-invasive prenatal testing are rare but clinically significant, particularly in the presence of biological factors such as feto-placental mosaicism. This report describes a pregnancy affected by fetal trisomy…

View details →DOI: 10.1016/j.crwh.2026.e00813
Negative / Null Result ReportOpen accessMedicine

The addition of sweetness reduces aversion to high salt concentrations in patients with chronic kidney disease.

Okuno-Ozeki N, Kohama Y, Taguchi H et al. · 2025 · Scientific reports

Reducing salt intake is crucial for managing hypertension. While efforts to reduce salt intake are based on the assumption that people have a preference for salt, it is also important to acknowledge that there is an aversion to high levels…

View details →DOI: 10.1038/s41598-025-09602-x
Negative / Null Result ReportOpen accessMedicine

Establishing population-specific gestational weight gain ranges for twin pregnancies and comparing their performance with IOM recommendations: a retrospective cohort study from central China.

Yang R, Wang Y, Fu Q et al. · 2026 · BMJ open

Objectives To establish optimal pre-pregnancy body mass index (BMI)-specific gestational weight gain (GWG) ranges for twin pregnancies and compare their association with maternal and neonatal adverse outcomes against Institute of Medicine…

View details →DOI: 10.1136/bmjopen-2025-112189
Negative / Null Result ReportOpen accessMedicine

Clinical utility of the Oncomine Dx Target Test multi-CDx system and the possibility of utilizing those original sequence data.

Saito A, Terai H, Kim TJ et al. · 2024 · Cancer medicine

Background Companion diagnostic tests play a crucial role in guiding treatment decisions for patients with non-small cell lung cancer (NSCLC). The Oncomine Dx Target Test (ODxTT) Multi-CDx System has emerged as a prominent companion…

View details →DOI: 10.1002/cam4.7077
Negative / Null Result ReportOpen accessMedicine

Case Report: Novel likely pathogenic <i>MEN1</i> mosaic mutation in the family with MEN-1 syndrome.

Salimkhanov R, Utkina M, Bagirova H et al. · 2025 · Frontiers in endocrinology

Multiple endocrine neoplasia type 1 (MEN-1; OMIM 131100) is a rare, autosomal dominant syndrome caused by heterozygous inactivating mutations in the MEN1 tumor suppressor gene (11q13; OMIM 613733). MEN-1 is characterized by polyglandular…

View details →DOI: 10.3389/fendo.2025.1662871
Negative / Null Result ReportOpen accessMedicine

Measured and Estimated Glomerular Filtration Rate to Evaluate Rapid Progression and Changes over Time in Autosomal Polycystic Kidney Disease: Potential Impact on Therapeutic Decision-Making.

Miquel-Rodríguez R, González-Toledo B, Pérez-Gómez MV et al. · 2024 · International journal of molecular sciences

Autosomal polycystic kidney disease (ADPKD) is the most common genetic form of kidney failure, reflecting unmet needs in management. Prescription of the only approved treatment (tolvaptan) is limited to persons with rapidly progressing…

View details →DOI: 10.3390/ijms25095036