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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21309 results · page 383 of 711

Negative / Null Result ReportMedicine

Down syndrome birth rate post Dobbs decision: has it changed?

Santoro SL, Alvarado C, Tseng SY et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective In 2022, the U.S. Supreme Court decision on Dobbs v. Jackson Women's Health Organization changed abortion access. We evaluated birth rates of Down syndrome (DS) before and after the Dobbs decision hypothesizing similarity to…

View details →DOI: 10.1038/s41372-026-02560-w
Negative / Null Result ReportMedicine

Impact of additional left atrial roof ablation for persistent atrial fibrillation using cryoballoon: the ICEBERG trial.

Ukita K, Egami Y, Sugino A et al. · 2026 · Clinical research in cardiology : official journal of the German Cardiac Society

Background Several studies have investigated the efficacy of additional left atrial (LA) roof ablation to pulmonary vein isolation (PVI) using cryoballoon for persistent atrial fibrillation (AF). However, the evidence from randomized…

View details →DOI: 10.1007/s00392-026-02879-6
Negative / Null Result ReportMedicine

Association of Prior Antibiotic Use With Negative Surgical Bone Biopsy Cultures and Disease Recurrence in Diabetes-related Foot Osteomyelitis.

Aragón-Sánchez J, Víquez-Molina G, Aragón-Hernández J et al. · 2026 · Advances in skin & wound care

Objective The authors hypothesized that prior antibiotic treatment does not reduce culture positivity and that empirical antibiotic therapy in culture-negative cases does not increase the risk of amputation or recurrence in…

View details →DOI: 10.1097/asw.0000000000000425
Negative / Null Result ReportOpen accessMedicine

Effects of the micronutrient Sanopal® (5-hydroxymethyl-2-furfural and α-ketoglutaric acid) on oxygen affinity of hemoglobin, oxygen saturation and exercise responses at altitude.

Woyke S, Troppmair T, Mair N et al. · 2026 · Journal of the International Society of Sports Nutrition

Background With increasing altitude, the partial pressure of oxygen and oxygen saturation (SpO 2 ) decrease, reducing physical performance. This study investigates whether the nutritional supplement Sanopal® (5-hydroxymethyl-2-furfural and…

View details →DOI: 10.1080/15502783.2026.2643684
Negative / Null Result ReportMedicine

Evaluation of the clinical reasoning of GPT-4o, a multimodal generative artificial intelligence model, in 18 public gastroenterology case studies.

García-Rudolph A, Hernández-Pena E, Del Cacho N et al. · 2026 · Revista espanola de enfermedades digestivas

Introduction and aim although generative language models have been extensively studied in the field of digestive diseases, further progress requires addressing underexplored aspects such as linguistic bias, the evaluation of clinical…

View details →DOI: 10.17235/reed.2025.11369/2025
Negative / Null Result ReportOpen accessMedicine

Effect of Tranexamic Acid on Inpatient Admission and Revision Rates in Primary Rhinoplasty: A Propensity Score-Matched Analysis.

Mehdizadeh M, Smith JE, Gill J et al. · 2026 · Plastic and reconstructive surgery. Global open

Background Tranexamic acid (TXA) is commonly used to reduce intraoperative bleeding and complications across surgical specialties. In rhinoplasty, prior studies indicate that TXA may reduce postoperative edema and ecchymosis, but its…

View details →DOI: 10.1097/gox.0000000000007659
Negative / Null Result Report

Utilizing raw rapeseed press cake in foods: A case study on sensory quality and profile of selected bitter compounds in snack bars

Thorsen JS, Bononad-Olmo A, Toft AM et al. · 2026 · Preprint

ABSTRACT Today’s canola quality rapeseed press cake (RPC) is a protein-rich co-product with potential as human food, but its application is limited due to antinutritional compounds and bitter taste. It remains, however, unknown how…

View details →DOI: 10.64898/2026.03.20.712648
Negative / Null Result ReportMedicine

Beef quality and expression of genes involved in lipid metabolism in the muscle of Nellore and Nellore × Angus steers fed whole shelled corn diets.

Teixeira PD, Casagrande DR, Rodrigues AC et al. · 2026 · Meat science

Sixteen Nellore and Sixteen Nellore × Angus steers with an initial body weight of 353 kg ±25.3 kg were randomly assigned into 2 feeding groups: whole shelled corn without forage (WSC) or WSC with sugarcane bagasse (WSCB), to evaluate…

View details →DOI: 10.1016/j.meatsci.2026.110078
Negative / Null Result ReportMedicine

Chinese Young Children Engage in Social Role-Based Sharing Behavior.

Wu X, Chai Q, He J · 2026 · Developmental science

Role ethics suggests that moral obligations arise from the duties associated with one's social roles. Yet, the influence of social roles on children's moral behavior remains unclear. This research addressed this gap by testing whether…

View details →DOI: 10.1111/desc.70140
Negative / Null Result ReportMedicine

Intraoperative 3D Fluoroscopy Reduces Revision Rates and Improves Reduction Quality in Acetabular Fracture Fixation.

Le Baron M, David G, Ward BA et al. · 2026 · Journal of orthopaedic trauma

Objectives To evaluate whether the use of intraoperative 3D fluoroscopy during acetabular fracture fixation reduces the rate of unplanned returns to the operating room and improves radiographic quality of reduction without increasing…

View details →DOI: 10.1097/bot.0000000000003100
Negative / Null Result ReportMedicine

Poplar CLE peptides promoting ectomycorrhizal symbiosis identified through genome-wide analysis of responsive small secreted peptides.

Bonnot C, Morin E, Da Silva Machado E et al. · 2026 · Plant physiology

Plant small secreted peptides (SSPs) are involved in numerous developmental processes and adaptive plant responses. These include root development, immunity, and symbiotic relationships in herbaceous plants; three processes crucial for…

View details →DOI: 10.1093/plphys/kiag071
Negative / Null Result ReportMedicine

18-Crown-6 ether increases molecular weight of poly(3-hydroxybutyrate) synthesized in Escherichia coli.

Tanaka S, Kikukawa H, Nakai H et al. · 2026 · Journal of bioscience and bioengineering

Molecular weight of polyhydroxyalkanoate (PHA) is a critical factor governing their physical properties, particularly mechanical strength. It is empirically known that molecular weight of PHA varies depending on factors such as the…

View details →DOI: 10.1016/j.jbiosc.2026.01.008
Negative / Null Result ReportMedicine

Safety and Efficacy of Hypofractionated Preoperative Radiation Therapy in Retroperitoneal Sarcoma: A Comparative Study With Conventional Fractionation.

Baek JY, Yu JI, Lee KW et al. · 2026 · Practical radiation oncology

Purpose The role of preoperative radiation therapy (RT) in retroperitoneal sarcoma (RPS) remains controversial across histologic subtypes. Conventional fractionated RT (ConvRT) is the current standard, but hypofractionated RT (HypoRT) is…

View details →DOI: 10.1016/j.prro.2026.02.008
Negative / Null Result ReportMedicine

A randomized trial of iron- and zinc-biofortified pearl millet-based complementary feeding in children aged 12-18 months living in urban slums.

Mehta S, Huey SL, Ghugre PS et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)

Background and aims Biofortification of staple crops with higher concentrations of micronutrients via traditional breeding methods is a sustainable strategy and can possibly complement fortification and other interventions to target…

View details →DOI: 10.1016/j.clnu.2025.11.002
Negative / Null Result ReportMedicine

Effect of paternal resveratrol intake on mitochondria and telomere length in mouse embryos and offspring.

Teramoto N, Kobayashi N, Mitsui K et al. · 2026 · The Journal of reproduction and development

Advanced paternal age affects embryonic development and offspring phenotypes. We previously demonstrated that resveratrol prevents age-associated declines in the mitochondrial DNA copy number (mt-cn) and telomere length (TL) in embryos.…

View details →DOI: 10.1262/jrd.2026-038
Negative / Null Result ReportMedicine

Effect of white and red grape pomace on dry-cured sausages containing additives.

Carrapiso AI, Sánchez-Ordóñez M, Delgado-Adámez J et al. · 2026 · Food science and technology international = Ciencia y tecnologia de los alimentos internacional

The purpose of this study was to investigate for the first time the effect of the enrichment in white or red grape pomace stabilized by high hydrostatic pressure on the characteristics of dry-cured sausages containing additives (75 mg kg…

View details →DOI: 10.1177/10820132261461428
Negative / Null Result ReportMedicine

The Influence of Depth of Anesthesia on Motor Evoked Potentials Monitoring During Spinal Surgery in Youth: A Single-Center Prospective Study (SCOL Study).

Hudec J, Prokopova T, Hulkova M et al. · 2026 · Anesthesia and analgesia

Background Anesthetic agents or some pathophysiological conditions can affect transcranial motor evoked potentials (TcMEP) monitoring. However, the influence of depth of anesthesia on TcMEP reproducibility in youth remains unclear due to…

View details →DOI: 10.1213/ane.0000000000008158
Negative / Null Result ReportMedicine

Characterizing the V516M penicillin-binding protein 2 (PBP2) mutation causing zidebactam resistance in <i>Pseudomonas aeruginosa</i>.

Sastre-Femenia MÀ, Gomis-Font MA, Fernández-Muñoz A et al. · 2026 · Antimicrobial agents and chemotherapy

The triple action of the diazabicyclooctane (DBO) zidebactam (antibacterial activity [penicillin-binding protein 2 {PBP2} inhibitor], β-lactam enhancement [synergy with PBP3 inhibitors], and β-lactamase inhibition [classes A and C])…

View details →DOI: 10.1128/aac.00346-26
Negative / Null Result ReportMedicine

Nocturnal Sleep Breathing Patterns in Healthy Adolescents Residing at Very High Altitudes in Bolivia.

Patterson K, Rodríguez SU, Arancibia-Levit EN et al. · 2026 · Journal of sleep research

Data on sleep and respiratory patterns among adolescents residing at very high altitude (> 3500 m) remain scarce, and altitude-related physiological differences may influence these parameters. Studying adolescents at different very high…

View details →DOI: 10.1111/jsr.70326
Negative / Null Result ReportMedicine

Incidence of Gastrointestinal Adverse Events Following Left Hepatic Lobe Radiation Segmentectomy for the Treatment of Hepatocellular Carcinoma.

De La Garza-Ramos C, Silver C, Islam F et al. · 2026 · Cardiovascular and interventional radiology

Purpose Describe the incidence and severity of gastrointestinal tract-related adverse events (GIAE) following radiation segmentectomy (RS) for hepatocellular carcinoma (HCC) in the left hepatic lobe. Materials and methods A single-center…

View details →DOI: 10.1007/s00270-026-04376-9
Negative / Null Result ReportMedicine

Evaluation of squid shiokara products marketed in Japan using sensory tests, amino acid and organic acid profiles, and analysis of bacterial communities

Mizusawa N, Nishimura K, Ouchi D et al. · 2026 · Fish Sci

Shiokara is a traditional Japanese salted and fermented seafood product. The aim of this study was to compare various commercially available squid shiokara products in Japan by examining their NaCl content, free amino acid content (all…

Negative / Null Result ReportMedicine

Preliminary evaluation of a developmentally centred approach to optimise comfort in neonates following cardiac surgery.

Jones MB, Caprarola SD, Gordish H et al. · 2026 · Cardiology in the young

Introduction Children with CHD are at risk for neurodevelopmental impairments, and though these are often mild, some children face severe developmental challenges. Both unalleviated pain and exposure to opioids in the neonatal period have…

View details →DOI: 10.1017/s1047951125110949
Negative / Null Result ReportMedicine

Dung beetles do not profit from enhanced spatial heterogeneity in temperate production forests: A forest manipulation experiment

Asch J, Scherer‐Lorenzen M, Pierick K et al. · 2026 · Journal of Applied Ecology.

Central European forest management strategies promoting structurally homogeneous closed‐canopy forests have led to landscape‐level declines in biodiversity and ecosystem multifunctionality. Conservation‐targeted management programs aim at…

Negative / Null Result ReportMedicine

Exopolysaccharide biosynthesis and regulation in Leuconostoc mesenteroides influences water holding capacity of fermented plant-based milks.

Sukarno AS, Dong A, Gumulya Y et al. · 2026 · International journal of food microbiology

Physical instability remains a major challenge in fermented plant-based yoghurts in the absence of added texturizing agents. Cultures can improve water holding capacity (WHC) through production of exopolysaccharide (EPS). This study…

View details →DOI: 10.1016/j.ijfoodmicro.2026.111797
Negative / Null Result ReportMedicine

The influence of adolescent idiopathic scoliosis on hip joint development: a two-year longitudinal evaluation of the hip center-edge angle.

Matsumoto T, Yokoe T, Takahashi T et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

PURPOSE: Several studies have reported an association between adolescent idiopathic scoliosis (AIS) and hip decentration (HD). However, these previous studies evaluated the hip center-edge (CE) angle at only a single time point. This study…

View details →DOI: 10.1007/s00586-026-09787-3
Negative / Null Result ReportMedicine

Non-modifiable cardiovascular risk factors and coronary plaque characteristics in patients with acute coronary syndromes.

Scalamera R, Covani M, Andreaggi S et al. · 2026 · European heart journal. Cardiovascular Imaging

Aims Cardiovascular risk factors predict adverse clinical outcomes, including acute coronary syndromes (ACS). A recent study showed a close correlation between the number of modifiable risk factors and plaque vulnerability. However, the…

View details →DOI: 10.1093/ehjci/jeag023
Negative / Null Result ReportMedicine

Bark beetles as ecosystem engineers: triggered tree mortality rearranges the assemblage of Tree-related Microhabitats in old-growth coniferous forest

Przepióra F, Ciach M · 2025 · Forest Ecology and Management.

Although species with ecosystem engineering capabilities like woodpeckers, ungulates or saproxylic insects may initiate the formation of Tree-related Microhabitats (TreMs), their overall impact on TreM assemblages remains unexplored. Bark…