A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19761 results in Negative / Null Result Report · page 38 of 659
Mitchel Seruya, Mark Fisher, Eduardo D. Rodriguez · 2013 · Plastic & Reconstructive Surgery
BACKGROUND: There has been rising interest in computer-aided design/computer-aided manufacturing for preoperative planning and execution of osseous free flap reconstruction. The purpose of this study was to compare outcomes between…
Sri Rahayu Natasia, Yuyun Tri Wiranti, Anggi Parastika · 2022 · Procedia Computer Science
The sudden change in the learning process during the Covid-19 pandemic has brought schools at all levels to adopt e-learning. In this study, we analyze user acceptance of NUADU platform in private schools in Balikpapan, Indonesia. The…
Haoxuan Liu, Yanxiao Jia, Xiaoguang Sun et al. · 2016 · Molecular Biology and Evolution
Accurate knowledge of the mutation rate provides a base line for inferring expected rates of evolution, for testing evolutionary hypotheses and for estimation of key parameters. Advances in sequencing technology now permit direct estimates…
Matthew C. Freeman, Thomas Clasen, Simon Brooker et al. · 2013 · American Journal of Tropical Medicine and Hygiene
We conducted a cluster-randomized trial to assess the impact of a school-based water treatment, hygiene, and sanitation program on reducing infection with soil-transmitted helminths (STHs) after school-based deworming. We assessed…
Stefan L. Frank · 2013 · Topics in Cognitive Science
The entropy-reduction hypothesis claims that the cognitive processing difficulty on a word in sentence context is determined by the word's effect on the uncertainty about the sentence. Here, this hypothesis is tested more thoroughly than…
Raphaël Moëne, Fabien Décaillet, E. Andersen et al. · 2010 · Journal of Periodontology
BACKGROUND: The purpose of this study is to evaluate the safety, patient acceptance, and short-term microbiologic effect of a new air-polishing device in subjects in maintenance care with residual pockets > or =5 mm. METHODS: This was an…
Rakesh Awasthi, Lida Pacaud, Edward Waldron et al. · 2020 · Blood Advances
The anti-CD19 chimeric antigen receptor (CAR)-T cell therapy tisagenlecleucel was evaluated in the global, phase 2 JULIET study in adult patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). We correlated…
Ben Jones, Marie Juul Petersen · 2011 · Third World Quarterly
Abstract There is a growing body of research on religion and development, primarily from development scholars and practitioners. In many ways this represents a new departure for development studies, which has been largely uninterested in…
Paula Pérez Sobrino · 2016 · Metaphor and Symbol
This article offers the first large-scale study of a multimodal corpus of 210 advertisements. First, the reader is presented with a description of the corpus in terms of the distribution of conceptual operations (for the purposes of this…
U. Müller, James B. Rowe, Timothy Rittman et al. · 2012 · Neuropharmacology
BACKGROUND: Modafinil, a putative cognitive enhancing drug, has previously been shown to improve performance of healthy volunteers as well as patients with attention deficit disorder and schizophrenia, mainly in tests of executive functions. The aim of this study was to investigate the effects of modafinil on non-verbal cognitive functions in healthy volunteers, with a particular focus on variations of cognitive load, measures of motivational factors and the effects on creative problem-solving. METHODS: A double-blind placebo-controlled parallel design study evaluated the effect of 200 mg of m
Tobias Ceulemans, Carly Stevens, Luc Duchateau et al. · 2014 · Global Change Biology
Nutrient pollution presents a serious threat to biodiversity conservation. In terrestrial ecosystems, the deleterious effects of nitrogen pollution are increasingly understood and several mitigating environmental policies have been…
Miquel Pujol, J. M. Miró, Evelyn Shaw et al. · 2020 · Clinical Infectious Diseases
BACKGROUND: We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than daptomycin alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and endocarditis. METHODS: A randomized (1:1)…
Patricia Funk, Christina Gathmann · 2011 · The Economic Journal
Using new historical data from Swiss cantons, we estimate the effect of direct democracy on government spending. We use fixed effects to control for unobserved heterogeneity and new instruments to address potential endogeneity concerns. We…
Ravi A. Madan, James L. Gulley, Tito Fojo et al. · 2010 · The Oncologist
Therapeutic cancer vaccines represent a new class of agents in the treatment of cancer. Sipuleucel-T is an antigen-presenting cell-based vaccine that recently demonstrated a significant 4.8-month improvement in overall survival in advanced…
Joanna J. Wykrzykowska, Scot Garg, Yoshinobu Onuma et al. · 2011 · Circulation Cardiovascular Interventions
BACKGROUND: The age, creatinine, and ejection fraction (ACEF) score (age/left ventricular ejection fraction+1 if creatinine >2.0 mg/dL) has been established as an effective predictor of clinical outcomes in patients undergoing elective…
Christophe Dessimoz, Manuel Gil · 2010 · Genome biology
BACKGROUND: The alignment of biological sequences is of chief importance to most evolutionary and comparative genomics studies, yet the two main approaches used to assess alignment accuracy have flaws: reference alignments are derived from the biased sample of proteins with known structure, and simulated data lack realism. RESULTS: Here, we introduce tree-based tests of alignment accuracy, which not only use large and representative samples of real biological data, but also enable the evaluation of the effect of gap placement on phylogenetic inference. We show that (i) the current belief that
Sutao Song, Zhichao Zhan, Zhiying Long et al. · 2011 · PLoS ONE
BACKGROUND: Support vector machine (SVM) has been widely used as accurate and reliable method to decipher brain patterns from functional MRI (fMRI) data. Previous studies have not found a clear benefit for non-linear (polynomial kernel) SVM versus linear one. Here, a more effective non-linear SVM using radial basis function (RBF) kernel is compared with linear SVM. Different from traditional studies which focused either merely on the evaluation of different types of SVM or the voxel selection methods, we aimed to investigate the overall performance of linear and RBF SVM for fMRI classification
Salman Farisi, Juli Irnawati, Muhammad Fahmi · 2020 · Jurnal Humaniora Jurnal Ilmu Sosial Ekonomi dan Hukum
To achieve company goals, human resource management which has the potential to affect the performance of employees which will ultimately affect the performance of the company. To be able to show the performance of the employees PT. Perkebunan Nusantara V (Persero) Kebun Tanah Putih at Riau Province, the company is required to uphold the motivation and work discipline of the employees. The purpose of this study was to determine and analyze the influence of motivation and work discipline on the performance of employees of PT. Perkebunan Nusantara V (Persero) Kebun Tanah Putih Provinsi Riau. The
Ida Ayu Gede Dika Martami Sari · 2020 · International Research Journal of Management IT and Social Sciences
This study aims to determine the effect of profitability and liquidity on firm value and determine the role of capital structure in mediating the effect of profitability and liquidity on firm value in the construction and building…
Matteo Calgaro, Chiara Romualdi, Levi Waldron et al. · 2020 · Genome biology
BACKGROUND: The correct identification of differentially abundant microbial taxa between experimental conditions is a methodological and computational challenge. Recent work has produced methods to deal with the high sparsity and compositionality characteristic of microbiome data, but independent benchmarks comparing these to alternatives developed for RNA-seq data analysis are lacking. RESULTS: We compare methods developed for single-cell and bulk RNA-seq, and specifically for microbiome data, in terms of suitability of distributional assumptions, ability to control false discoveries, concord
Allison J. Pieja, Eric Sundström, Craig S. Criddle · 2011 · Applied and Environmental Microbiology
Differences in carbon assimilation pathways and reducing power requirements among organisms are likely to affect the role of the storage polymer poly-3-hydroxybutyrate (PHB). Previous researchers have demonstrated that PHB functions as a…
Robyn L. Gobin, Jennifer J. Freyd · 2013 · Psychological Trauma Theory Research Practice and Policy
Early experiences of violation perpetrated by close others, or betrayal traumas, may interfere with developing social capacities, including the ability to make healthy decisions about whom to trust. Betrayal trauma theory posits that…
Wim Van Paesschen, Édouard Hirsch, Martin Johnson et al. · 2012 · Epilepsia
PURPOSE: To evaluate the efficacy and tolerability of adjunctive brivaracetam (BRV), a novel high-affinity synaptic vesicle protein 2A ligand that also displays inhibitory activity at neuronal voltage-dependent sodium channels, in adult…
Yuchao Zhang, Atahualpa Castillo-Morales, Min Jiang et al. · 2013 · Molecular Biology and Evolution
In female mammals most X-linked genes are subject to X-inactivation. However, in humans some X-linked genes escape silencing, these escapees being candidates for the phenotypic aberrations seen in polyX karyotypes. These escape genes have…
Clare Sutherland, Xizi Liu, Lingshan Zhang et al. · 2017 · Personality and Social Psychology Bulletin
People form first impressions from facial appearance rapidly, and these impressions can have considerable social and economic consequences. Three dimensions can explain Western perceivers' impressions of Caucasian faces: approachability,…
Petra Langerbeins, Michael Hallek · 2022 · Blood
The coronavirus infectious disease (COVID-19) shows a remarkable symptomatic heterogeneity. Several risk factors including advanced age, previous illnesses, and a compromised immune system contribute to an unfavorable outcome. In patients…
Sandra E. Black, Paul J. Devereux, Kjell G. Salvanes · 2015 · American Economic Journal Applied Economics
Using population data from Norway, we examine the effects of stress induced by the death of the mother's parent during pregnancy on both the short-run and the long-run outcomes of the infant. Using a variety of empirical strategies to…
Yukinori Kurokawa, Mitsuru Sasako, Takeshi Sano et al. · 2015 · British journal of surgery
BACKGROUND: The optimal surgical approach for treatment of oesophagogastric junction (OGJ) cancer is controversial. A randomized clinical trial (JCOG9502) comparing transhiatal (TH) and left thoracoabdominal (LTA) approaches was stopped…
Timothy F. Cloughesy, Kevin Petrecca, Tobias Walbert et al. · 2020 · JAMA Oncology
Importance: New treatments are needed to improve the prognosis of patients with recurrent high-grade glioma. Objective: To compare overall survival for patients receiving tumor resection followed by vocimagene amiretrorepvec (Toca 511)…
Davidson Heath, Daniele Macciocchi, Roni Michaely et al. · 2023 · European Finance Review
Abstract Using micro-level data, we examine the behavior of socially responsible investment (SRI) funds. SRI funds select firms with lower pollution, more board diversity, higher employee satisfaction, and better workplace safety. Yet,…