A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20240 results in Negative / Null Result Report · page 378 of 675
Zierke L, John D, Gischke M et al. · 2024 · Cell. Mol. Life Sci
The co-localization of the lysosomal protease cathepsin B (CTSB) and the digestive zymogen trypsinogen is a prerequisite for the initiation of acute pancreatitis. However, the exact molecular mechanisms of co-localization are not fully…
Wang F, Gao T, Yang X et al. · 2025 · Aquaculture.
The significance of DNA methylation in fish sex determination and differentiation is increasingly being recognized. Exploring the role of DNA methylation in sex determination and differentiation is advantageous for the advancement of sex…
Shimada T, Iwahashi T, Suzuki K et al. · 2025 · Journal of pharmacological sciences
Chronic nerve compression disorders, such as carpal tunnel syndrome, are common and can significantly impair daily activities due to motor and sensory dysfunctions. Currently, no systemic pharmacotherapy exists for preventing or treating…
Guo Z, Hu Y, Zhou J et al. · 2025 · Biochemical and biophysical research communications
Iron overload leads to apoptosis and increased expression of receptor activator of nuclear factor kappa-Β ligand (RANKL) in osteocytes, which in turn accelerates osteoclastogenesis. Since osteocytes are the main RANKL producers, we…
Rumanova VS, Foppen E, Okuliarova M et al. · 2025 · Physiology & behavior
Exposure to artificial light at night (ALAN) disrupts natural darkness and desynchronizes daily rhythms in physiological processes and behavior. Previously, in rats, we have shown that dim ALAN disturbed the central circadian control and…
Lima da Silva AP, de Oliveira TP, Nogueira RD et al. · 2025 · Journal of clinical and experimental dentistry
Background The objective was to evaluate the surface hardness of white spot lesions (WSL) treated with different caries prevention methods. Material and methods The Knoop microhardness (µKH) of 50 bovine dental enamel fragments was…
Correia de Lima Junior N, Fernandes-Batista T, Ferreira-Serra L et al. · 2025 · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
The consumption of Western diet, characterized by high sugar and saturated fat content, often leads to weight gain and promotes oxidative stress. Intermittent fasting has emerged as a potential strategy to combat obesity, but its effects…
Dubourg V, Akhtar N, Kopf M et al. · 2026 · iScience
Vascular smooth muscle cells (VSMCs) are at the center of vascular diseases but studies on VSMCs from human females are rare and the medical need for female-specific vascular research is urgent. VSMCs are simultaneously subjected to…
Lyons J, Chatha HN, Boutros C et al. · 2025 · Surgical endoscopy
Background Fundoplication at the time of paraesophageal hernia (PEH) repair is thought to help prevent the development or persistence of postoperative gastroesophageal reflux (GERD) and might also prevent hernia recurrence. However, the…
Weerts EM, Jenkins BW, Kuang RY et al. · 2024 · Pharmacology, biochemistry, and behavior
Cannabigerol (CBG) is a phytocannabinoid found in cannabis that is promoted for medical use and other health benefits, but current empirical data on the behavioral effects of CBG are lacking. The purpose of this study was to evaluate the…
Maier KS, Schiener T, Frigg A · 2025 · Journal of orthopaedic surgery and research
Background Short femoral stems were introduced for total hip arthroplasty (THA) to preserve bone stock, increase proximal load transfer, and enable minimal invasive approaches. However, after implanting the short curved Fitmore hip stem,…
Comboni LM, Glover ES, Napolitano SC et al. · 2026 · Foods (Basel, Switzerland)
We assessed whether consuming UV light-exposed mushrooms (UVMs) would offset the seasonal decline in circulating total 25-hydroxyvitamin D (25OHD), an index of vitamin D status. During late fall and winter, 41 adults (19 M/22 F, age 43 ±…
Tuffs C, Dupovac M, Richter K et al. · 2025 · The American journal of pathology
Liver fibrosis is characterized by excessive deposition of extracellular matrix due to chronic inflammation of the liver. Hepatic stellate cells (HSCs) become activated and produce increased amounts of extracellular matrix. Loss of…
Quan J, Kriebel M, Anunu R et al. · 2026 · Scientific reports
The Median Raphe (MR) provides a major, mainly serotonergic, input to the hippocampus, particularly influencing the dentate gyrus (DG), but its specific role remains unclear. Here, focusing on the dorsal DG, we investigated its…
Chia A, Burkill S, Ling Y et al. · 2026 · The British journal of ophthalmology
Aim To evaluate the effectiveness of atropine 0.01% in young premyopic and low-myopic children. Methods Children (5-9 years old) with premyopia (spherical equivalent refraction, SER+1.00 to -0.49D, n 156) or low myopia (SER -0.50 to…
McDaniel AL, Gadoury DM, Moyer MM · 2024 · Crop Protection
Germicidal ultraviolet-C light (UV–C) has been used to effectively suppress grapevine powdery mildew (Erysiphe necator). However, effects on arthropod pests that would be simultaneously exposed to UV-C during applications directed at E.…
Cao Y, Li Q, Guo W et al. · 2025 · Frontiers in immunology
To evaluate the efficacy of COVID-19 convalescent plasma (CCP) in preventing SARS-CoV-2 infection in hematopoietic stem cell transplantation (HSCT) recipients during the early post-transplant period, a single-center, randomized controlled…
Lin S, Lytle KA, Fink N et al. · 2026 · Diabetes
Adipose tissue (AT) lipolysis insulin resistance results in excess free fatty acid (FFA) release. We tested the hypothesis that the ability of insulin to suppress AT lipolysis is unrelated to the ability of niacin to suppress lipolysis,…
Takemura A, Egawa T, Uemichi K et al. · 2025 · Biochemistry and biophysics reports
Mild hyperbaric oxygen (MHO) attenuates the muscle atrophy caused by muscle disuse. Training cessation results in the partial or complete loss of training-induced adaptations, including mitochondrial enzyme activities. The present study…
van de Wetering R, Alder AF, Biggerstaff A et al. · 2025 · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
The development of safer mu opioid receptor (MOR) agonists with reduced side effects is a key focus of pain research. Some studies have suggested that MOR agonists with reduced β-arrestin 2 (βArr2) signaling (i.e. G-protein biased…
Bearzi E, Sola S, Defferrari C et al. · 2026 · Dermatology reports
Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin tumor, mainly linked to Merkel cell polyomavirus (MCPyV) and less often to ultraviolet exposure. Additional risk factors include advanced age and immunosuppression.…
Stringari C, Stringari H, de Queiroz E Silva TF et al. · 2026 · Inflammopharmacology
INTRODUCTION: There is a marked overlap among the neuronal pathogenetic pathways involved in ulcer genesis and depression, and antidepressants can also exert a protective effect against gastric ulcers. OBJECTIVE: To summarize and…
Nocera FP, Fantini O, Abate G et al. · 2026 · Veterinary medicine and science
Background Traumatic and surgical wounds are common in cats, but their management is often challenging due to anatomical factors, delayed presentation, behavioural issues and frequent bacterial colonization. Objectives This prospective,…
Orji C · 2025 · Cureus
Vericiguat is used as an adjunct therapy for patients with heart failure with reduced ejection fraction (HFrEF). Despite its availability in clinical practice, it remains underutilized among eligible patients. This case report describes…
Flores Ramos S, Fogelson KA, Muti VB et al. · 2026 · Journal of biological rhythms
Time-restricted feeding (TRF), a dietary intervention that consolidates food intake to specific hours of the day, ameliorates key metabolic risk factors for metabolic-associated steatohepatitis (MASH), including adiposity, insulin…
Nikolaev MV, Fedorova IM, Chistyakova OV et al. · 2025 · International journal of molecular sciences
The search for novel compounds with anticonvulsant properties remains a key focus in neuropharmacology. Recently, the diazepine-benzimidazole derivative, DAB-19, has emerged as a promising candidate due to its demonstrated anxiolytic and…
Aung T, Cheah JX · 2025 · Cureus
Livedoid vasculopathy (LV) is a rare, chronic occlusive dermopathy causing recurrent painful ulcerations, impaired healing, and significant morbidity. Historically considered a thrombotic microangiopathy, emerging evidence suggests an…
Tupciauskas R, Orlovskis Z, Blums KT et al. · 2024 · Preprint
The present study evaluates mold fungal resistance of newly developed loose-fill thermal insulation materials from wheat straw, corn stalk and water reed. Three different processing methods of raw materials was performed by mechanical…
Ayusso LL, Girol AP, Ribeiro Souza H et al. · 2024 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
We assessed in vivo the protective effects and underlying antioxidant and anti-inflammatory properties of dry green tee extract (GTE) on glomerular and tubular kidney function and structure in an experimental model of gentamicin…
Ruzal K, Trachtenberg E, Kantor B et al. · 2023 · Preprint
Summary A prosocial response to others in distress is an important driver of behavior across social species. To investigate the neurobiological mechanism leading to prosocial behavior, we use a helping behavior test wherein rats may…