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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21309 results · page 376 of 711

Negative / Null Result ReportOpen accessMedicine

Mirror exposure in adolescents with anorexia nervosa: a feasibility study on body image disturbance and attentional bias.

Pelzer M, Werthmann J, Svaldi J et al. · 2026 · Eating and weight disorders : EWD

Purpose Body image disturbances (BID) are central to anorexia nervosa (AN), influencing its development, maintenance and relapse. While mirror exposure (ME) has been shown to reduce BID in adults, research in adolescents is limited. This…

View details →DOI: 10.1007/s40519-026-01880-2
Failed Experiment ReportOpen accessMedicine

Inhibition of p38α MAPK increases short-term astrocyte reactivity: the exploratory VIP trial in early Alzheimer's disease.

Gouilly D, Da-Costa A, Vrillon A et al. · 2025 · Journal of neuroinflammation

BACKGROUND: Neuro-inflammation is an early mechanistic target in Alzheimer’s disease (AD). However, the effect of anti-inflammatory drugs on biomarkers of neuro-inflammation has yet to be described. Biomarkers of neuro-inflammation showed…

View details →DOI: 10.1186/s12974-025-03625-x
Negative / Null Result ReportOpen accessMedicine

A randomized digital behavioral intervention for prenatal and postpartum weight outcomes in women with overweight or obesity: the GROWell trial.

Simmons LA, Phipps JE, Castro-Alvarez S et al. · 2026 · BMC pregnancy and childbirth

Background Rising rates of overweight and obesity globally have led to an increasing number of women who enter pregnancy with excess weight, posing significant health risks to mothers and infants. Mobile health interventions, such as…

View details →DOI: 10.1186/s12884-026-08846-3
Negative / Null Result ReportMedicine

Effect of genistein and coenzyme Q10 in oxidative damage and mitochondrial membrane potential in an attenuated type II mucopolysaccharidosis cellular model.

Delgado CA, Poletto E, Vera LNP et al. · 2024 · Cell biochemistry and function

Mucopolysaccharidosis type II (MPS II) is an inborn error of the metabolism resulting from several possible mutations in the gene coding for iduronate-2-sulfatase (IDS), which leads to a great clinical heterogeneity presented by these…

View details →DOI: 10.1002/cbf.3932
Negative / Null Result ReportOpen accessMedicine

Plasma von Willebrand Factor and ADAMTS13 Interact With <i>APOE</i>-ε4 in Predicting Longitudinal Brain Atrophy and Cognitive Decline Over a 9-Year Follow-Up.

Adegboye HA, Sun Y, Zhang P et al. · 2026 · Journal of the American Heart Association

Background Von Willebrand factor (VWF) and ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, 13) are linked to dementia risk, and limited evidence suggests apolipoprotein E ( APOE )-ε4 alters VWF release. This…

View details →DOI: 10.1161/jaha.125.043186
Negative / Null Result ReportOpen accessMedicine

Democratic backsliding damages favorable US image among the global public.

Goldsmith BE, Horiuchi Y, Matush K et al. · 2025 · PNAS nexus

US democracy appears to have weakened during the 21st century. Scholars have raised concerns that this democratic backsliding will reduce favorable views of the United States among foreign citizens in other democracies. In turn, observers…

View details →DOI: 10.1093/pnasnexus/pgaf104
Negative / Null Result ReportMedicine

A Field of Her Own: Property Rights and Women's Agency in Myanmar.

Fertig A, Hartman A, Iyer L et al. · 2026 · The journal of politics

Can financial incentives lead households to register land in women's names, thereby providing them with formal property rights? Can formal property ownership improve women's economic outcomes and change decision-making dynamics within the…

View details →DOI: 10.1086/734236
Negative / Null Result ReportOpen accessMedicine

Naturalistic investigation of cannabis strains varying in THC and CBD ratios and verbal recognition memory.

Paulich KN, Place C, Giordano G et al. · 2025 · Frontiers in psychology

Introduction Cannabis, which contains cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), has become the third-most-commonly used psychoactive substance in the United States. The legal market has grown alongside the…

View details →DOI: 10.3389/fpsyg.2025.1685412
Negative / Null Result ReportOpen accessMedicine

No Association Between Hypnotizability and Basal Ganglia Morphometry.

Picerni E, Piras F, Laricchiuta D et al. · 2026 · Brain sciences

Background: Hypnotizability is a psychophysiological trait measured by standardized scales whose scores indicate the proneness to modify perception, memory, and behavior according to specific suggestions, and to experience the hypnotic…

View details →DOI: 10.3390/brainsci16030287
Negative / Null Result ReportOpen accessMedicine

How robust are egocentric and altercentric interference effects in social cognition? a test with explicit and implicit versions of a continuous false belief task.

Haskaraca FN, Proft M, Liszkowski U et al. · 2023 · Frontiers in psychology

It has been long assumed that meta-representational theory of mind (ToM) -our ability to ascribe mental states to ourselves and other people- emerges around age four as indicated in performance on explicit verbal false belief tasks. In…

View details →DOI: 10.3389/fpsyg.2023.1142302
Negative / Null Result ReportOpen accessMedicine

Administration of ketogenic intervention as a potential treatment during post-traumatic brain injury recovery: a scoping review.

Quddus DY, Aydin S, Waheed AA et al. · 2026 · Frontiers in nutrition

Background Traumatic brain injury (TBI) affects 69 million individuals annually and represents a major global health burden. Ketogenic interventions have emerged as a potential therapy to address deficits following TBI. This scoping review…

View details →DOI: 10.3389/fnut.2026.1848682
Negative / Null Result ReportOpen accessMedicine

The impact of cardiac rehabilitation on rehospitalization and mortality rates in heart failure with preserved ejection fraction.

Liu F, Wang Q, Han S et al. · 2026 · Frontiers in cardiovascular medicine

Introduction Heart failure with preserved ejection fraction (HFpEF) is associated with substantial functional limitation and recurrent hospitalization, while effective pharmacological options remain limited. Exercise-based cardiac…

View details →DOI: 10.3389/fcvm.2026.1799035
Negative / Null Result ReportMedicine

Effects of the Visual Fidelity of Virtual Environments on Presence, Context-dependent Forgetting, and Source-monitoring Error.

Mizuho T, Narumi T, Kuzuoka H · 2023 · IEEE transactions on visualization and computer graphics

Advances in virtual reality technology have enabled the creation of virtual environments (VEs) with significantly high visual fidelity when compared to real environments (REs). In this study, we use a high-fidelity VE to examine two…

View details →DOI: 10.1109/tvcg.2023.3247063
Negative / Null Result ReportMedicine

Socio-emotional well-being is associated with cognitive function and informant-rated cognitive decline: Results from the Harmonized Cognitive Assessment Protocol in Europe.

Luchetti M, Terracciano A, Karakose S et al. · 2026 · Journal of the International Neuropsychological Society : JINS

Objective This study examines how multiple dimensions of socio-emotional well-being relate to cognitive functioning in older adults, and whether the associations vary by cognitive status, depression, and socio-demographic factors. Methods…

View details →DOI: 10.1017/s1355617726101933
Negative / Null Result ReportOpen accessMedicine

No immediate attentional bias towards or choice bias for male secondary sexual characteristics in Bornean orang-utans (Pongo pygmaeus).

Roth TS, Samara I, Perea-Garcia JO et al. · 2024 · Scientific reports

Primate faces provide information about a range of variant and invariant traits, including some that are relevant for mate choice. For example, faces of males may convey information about their health or genetic quality through symmetry or…

View details →DOI: 10.1038/s41598-024-62187-9
Negative / Null Result ReportOpen accessMedicine

Effects of one avocado a day for six months on cognitive performance in overweight adults: A randomized controlled trial.

Lee GJ, Morrell HER, Adams M et al. · 2026 · The journal of nutrition, health & aging

Background With the rising incidence of neurodegenerative diseases and aging of the global population, it is important to investigate foods that may preserve cognitive function with advancing years. Avocados are rich in fiber, carotenoids,…

View details →DOI: 10.1016/j.jnha.2026.100847
Negative / Null Result ReportOpen accessMedicine

Dietary supplement for mood symptoms in early postpartum: a double-blind randomized placebo controlled trial.

Meyer JH, Wang Z, Santhirakumar A et al. · 2024 · EClinicalMedicine

Background Postpartum blues (PPB) is a frequent syndrome of sad mood, crying spells, anxiety, restlessness, reduced appetite, and irritability, typically peaking day 5 postpartum. When severe, it greatly increases risk for later postpartum…

View details →DOI: 10.1016/j.eclinm.2024.102593
Negative / Null Result ReportOpen accessMedicine

Immunotherapy for Peritoneal Metastases from Gastric Cancer: Rationale, Current Practice and Ongoing Trials.

Ruiz Hispán E, Pedregal M, Cristobal I et al. · 2021 · Journal of clinical medicine

Peritoneal metastases from gastric cancer play a key role in the fatal prognosis of the disease. The lack of efficacy of actual therapeutic approaches together with the outcomes achieved with checkpoint inhibitors in gastric cancer compel…

View details →DOI: 10.3390/jcm10204649
Negative / Null Result ReportOpen accessMedicine

Stride Velocity 95th Centile Detects Decline in Ambulatory Function Over Shorter Intervals than the 6-Minute Walk Test or North Star Ambulatory Assessment in Duchenne Muscular Dystrophy.

Rabbia M, Guridi Ormazabal M, Staunton H et al. · 2024 · Journal of neuromuscular diseases

Background Stride Velocity 95th Centile (SV95C) is the first wearable device-derived clinical outcome assessment (COA) to receive European Medicines Agency (EMA) qualification as a primary endpoint in ambulant patients with Duchenne…

View details →DOI: 10.3233/jnd-230188
Negative / Null Result ReportOpen accessMedicine

Patient-reported outcomes of a randomized phase III clinical trial of adjuvant radiation versus chemoradiation in intermediate risk, stage I/IIA cervical cancer patients treated with initial radical hysterectomy and pelvic lymphadenectomy (NRG/GOG-0263).

Chase DM, Huang HQ, Deng W et al. · 2025 · Gynecologic oncology

Objective To prospectively evaluate the impact of adjuvant chemoradiation (RT + CIS) versus radiation (RT) on quality of life (QOL) and patient-reported outcomes (PROs) among patients with intermediate-risk, stage I-IIA cervical cancer…

View details →DOI: 10.1016/j.ygyno.2025.09.014
Negative / Null Result ReportOpen accessMedicine

A pediatric near-infrared spectroscopy brain-computer interface based on the detection of emotional valence.

Floreani ED, Orlandi S, Chau T · 2022 · Frontiers in human neuroscience

Brain-computer interfaces (BCIs) are being investigated as an access pathway to communication for individuals with physical disabilities, as the technology obviates the need for voluntary motor control. However, to date, minimal research…

View details →DOI: 10.3389/fnhum.2022.938708
Negative / Null Result ReportOpen accessMedicine

Associations between ambient pollen exposure and measures of cognitive performance.

Corpening B, Bürgler A, Tamási B et al. · 2025 · Environmental epidemiology (Philadelphia, Pa.)

Background Prior research suggests pollen allergies may be associated with cognitive function, although the effect sizes and specific cognitive outcomes varied across studies. With pollen seasons starting earlier and intensifying due to…

View details →DOI: 10.1097/ee9.0000000000000374
Negative / Null Result ReportOpen accessMedicine

The role of long-term hair steroids as diagnostic and intervention-related biomarkers in a multimorbid inpatient sample with posttraumatic stress disorder.

Shkreli L, Woud ML, Bergunde L et al. · 2025 · European journal of psychotraumatology

Background: Steroid hormone dysregulations have frequently been implicated in posttraumatic stress disorder (PTSD) pathogenesis. However, the translation into naturalistic clinical settings as markers of symptomatology and treatment…

View details →DOI: 10.1080/20008066.2025.2457295
Negative / Null Result ReportOpen accessMedicine

Long-term effects of cooking with liquefied petroleum gas or biomass on linear growth trajectories from birth to the pre-school years in Puno, Peru: a prospective cohort study.

Nicolaou L, Reuland CJ, Yang M et al. · 2026 · Lancet regional health. Americas

Background Household air pollution (HAP) is a major global health risk. Observational studies link HAP exposure to impaired child growth, but randomized controlled trial (RCT) evidence is inconsistent. Methods We followed children born…

View details →DOI: 10.1016/j.lana.2026.101382
Negative / Null Result ReportOpen accessMedicine

No gene by stressful life events interaction on individual differences in adults' self-control.

Willems YE, Raffington L, Ligthart L et al. · 2024 · Frontiers in psychiatry

Background Difficulty with self-control, or the ability to alter impulses and behavior in a goal-directed way, predicts interpersonal conflict, lower socioeconomic attainments, and more adverse health outcomes. Etiological understanding,…

View details →DOI: 10.3389/fpsyt.2024.1388264