e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21309 results · page 375 of 711

Negative / Null Result ReportMedicine

Posttraumatic cognitions and PTSD symptom change in massed prolonged exposure: The impact of treatment delivery on mechanisms of change.

Burton M, Haft S, Fiskeaux M et al. · 2026 · Journal of anxiety disorders

Background Prolonged Exposure (PE) is an effective treatment for PTSD and clarification of mechanisms of change can inform training and continued improvements. Posttraumatic cognitions have been shown to predict subsequent symptom change…

View details →DOI: 10.1016/j.janxdis.2026.103186
Negative / Null Result ReportMedicine

Thalamic Volume Asymmetry as a Potential Predictor of Vagus Nerve Stimulation Outcomes in Refractory Epilepsy.

Ujihara M, Kawabori M, Nakajima M et al. · 2026 · Neurologia medico-chirurgica

Vagus nerve stimulation is an established treatment for refractory epilepsy, but predictors of treatment response remain unclear. Given that left-sided vagus nerve stimulation preferentially modulates the left thalamus and that epileptic…

View details →DOI: 10.2176/jns-nmc.2025-0409
Negative / Null Result ReportMedicine

Longitudinal profiles of parental self- and child-focused emotion regulation.

Jordan G, Stockinger K, Schiltz C et al. · 2026 · Communications psychology

Parenting is an emotion-eliciting experience that requires parents to navigate the dual demands of regulating their own and their children's emotions, drawing on regulatory strategies such as reappraisal and rumination. However, patterns…

View details →DOI: 10.1038/s44271-026-00469-w
Negative / Null Result ReportMedicine

Assessing Knowledge About Living Kidney Donation Among Transplant Candidates and Relationship to Seeking a Living Donor.

Werenski H, Stratta R, McCracken E et al. · 2026 · Clinical transplantation

Introduction Despite well-established advantages of living-donor kidney transplantation (LDKT), LDKT growth has stagnated. Barriers to seeking a living donor include insufficient knowledge among candidates and discomfort discussing LDKT.…

View details →DOI: 10.1111/ctr.70591
Negative / Null Result Report

Longitudinal brain structural changes during clozapine treatment: associations with neuroreceptor architecture and clinical response

King B, Cannon DM, Crossley NA et al. · 2026 · Preprint

In treatment-resistant schizophrenia, clozapine treatment has been associated with longitudinal reductions in subcortical volumes, ventricular enlargement, and widespread cortical thinning. However, it is unknown how these structural…

View details →DOI: 10.64898/2026.06.06.26354980
Negative / Null Result ReportMedicine

Long-term outcomes after recovery from pediatric acute sinusitis with orbital complications.

Phung C, Wei K, Rizzi MD et al. · 2026 · International journal of pediatric otorhinolaryngology

Objective This study aims to assess whether an occurrence of acute sinusitis with orbital complications in childhood is associated with the development of long-term complications, including the development of chronic rhinosinusitis (CRS),…

View details →DOI: 10.1016/j.ijporl.2026.112881
Negative / Null Result ReportMedicine

Nightmares, insomnia, and suicide within a trauma-exposed sample.

West Staples V, Angle E, Pickering A et al. · 2026 · Psychological trauma : theory, research, practice and policy

Objective The literature is mixed regarding the relationship between nightmares and suicide, with some suggesting that the variance in nightmares is explained by fear of sleep (FoS), insomnia, and/or obstructive sleep apnea (OSA). We add…

View details →DOI: 10.1037/tra0002202
Negative / Null Result ReportMedicine

Do Child Communicative Abilities Predict Subjective Wellbeing and Satisfaction With Family Life in Caregivers of Minimally Verbal Children?

Saul J, McGuinness L, Cooke M et al. · 2026 · Journal of autism and developmental disorders

Purpose Caregivers of children with neurodevelopmental conditions often experience poor mental wellbeing, which may be influenced by their child's behavioural or communicative profile. Few studies have focussed exclusively on caregivers of…

View details →DOI: 10.1007/s10803-026-07351-y
Negative / Null Result ReportMedicine

Exposure to Feline Viruses in European Wildcats (<i>Felis s. silvestris</i>) in Germany: Spatial Patterns and Environmental Risk Factors.

Heddergott M, Pikalo J, Müller F et al. · 2026 · Viruses

While viral diseases of domestic cats ( Felis catus ) can threaten the recovery of the European wildcat ( Felis s. silvestris ), their epidemiology in wildcat populations remains poorly understood. Here, we analyzed 428 road-killed…

View details →DOI: 10.3390/v18060627
Negative / Null Result Report

Predictive Value of Polypharmacy and Inappropriate Medication Use in Older Emergency Department Patients: A Retrospective Observational Study

Holstein R, Hongisto M, Jämsen E et al. · 2026 · Preprint

Abstract Background. Polypharmacy and potentially inappropriate medication (PIM) use are well-known risk factors for drug-related problems among older adults, but their association with clinical outcomes of older emergency department (ED)…

View details →DOI: 10.21203/rs.3.rs-9326583/v1
Negative / Null Result ReportMedicine

The temporal interplay between physical activity, emotional well-being, and health-related quality of life in individuals with recently diagnosed type 2 diabetes mellitus: a cross-lagged panel analysis.

Kristoffersen SF, Domazet SL, Pouwer F et al. · 2026 · Diabetes research and clinical practice

Aims We investigated longitudinal, bidirectional associations between objectively measured moderate to vigorous physical activity (MVPA), health-related quality of life (HRQoL), and emotional well-being (EWB) in individuals recently…

View details →DOI: 10.1016/j.diabres.2026.113185
Negative / Null Result Report

Long-Term Outcomes of Immediate Implants in Endodontic, Periodontal, Endo–Perio Compromised Extraction Sockets and Failed Implant Sites: A Retrospective Single-Center Cohort Study

KARAASLAN F, BİNBAŞIOĞLU DD, ÇEKİÇ EC et al. · 2026 · Preprint

Abstract Objective To assess long-term outcomes of immediate implant placement in endodontic, periodontal and endo–perio compromised sockets and in sites immediately replaced after failed implant explantation, and to examine the roles of…

View details →DOI: 10.21203/rs.3.rs-9259324/v1
Negative / Null Result ReportMedicine

Physical activity and patient-reported outcomes after decompressive endoscopic lumbar spine surgery.

Noroozi Gilandehi S, Shoubash L, Leyendecker J et al. · 2026 · Journal of neurosurgery. Spine

Objective Although patients often report improvements in pain and functional capacity after endoscopic lumbar spine surgery, objectively measured real-life physical activity may differ from that reported. This multicenter prospective study…

View details →DOI: 10.3171/2026.1.spine25926
Negative / Null Result ReportMedicine

Parsing apart the effects of anxiety and intolerance of uncertainty on the acquisition of fear during category fear conditioning.

Sullivan AJ, Whalen M, Cooper SE et al. · 2026 · Biological psychology

Fear conditioning research can provide insight into how individuals with clinically relevant traits learn to distinguish between threatening and safe stimuli. Prior studies have found higher anxiety symptoms to be associated with increased…

View details →DOI: 10.1016/j.biopsycho.2026.109282
Negative / Null Result ReportOpen accessMedicine

Alpha-linolenic acid associations with disability and brain volume in multiple sclerosis: a brief replication report.

Korbmacher M, Myhr KM, Wergeland S et al. · 2026 · Frontiers in neurology

Objective To replicate and extend recent findings, suggesting that higher serum alpha-linolenic acid (ALA) levels are associated with reduced disease activity and progression in multiple sclerosis (MS). Methods We reanalysed clinical trial…

View details →DOI: 10.3389/fneur.2026.1796427
Negative / Null Result ReportMedicine

Percutaneous Screw Fixation of Scaphoid Nonunion Without Bone Grafting.

Munsch MA, Nguyen DM, Crowley S et al. · 2026 · Hand (New York, N.Y.)

Background This study evaluated the results of minimally invasive headless compression screw (HCS) fixation for treatment of scaphoid delayed union or nonunion. A minimally invasive approach has several potential benefits, including…

View details →DOI: 10.1177/15589447261437823