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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

AllReplication FailureNegative / Null Result ReportFailed Experiment ReportAbandoned HypothesisMethods Dead-EndShort NoteNull DatasetProtocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,382Computer Science 768Biochemistry, Genetics and Molecular Biology 478Psychology 327Social Sciences 327Physics 280Neuroscience 270Economics, Econometrics and Finance 223Environmental Science 195Agricultural and Biological Sciences 164Mathematics 163Engineering 159

21720 results · page 375 of 724

Negative / Null Result ReportOpen accessMedicine

The brief pain inventory-Interference Subscale has acceptable reliability but questionable validity in acute back and neck pain populations.

Jones CMP, Lin CC, Zadro J et al. · 2024 · Brazilian journal of physical therapy

Background The Brief Pain Inventory-Interference Subscale (BPI-IS) is a subscale of the BPI assessment tool developed to rapidly assess the impact of a person's pain on their function. It is uncertain whether it has one or two factors, and…

View details →DOI: 10.1016/j.bjpt.2024.101150
Negative / Null Result ReportMedicine

Finland's Flexible Partial Pension - A Bridge to Full-Time Retirement, a Pathway Out of Paid Employment, or an Income Supplement?

Ilmakunnas I, Sten-Gahmberg S · 2026 · Journal of aging & social policy

Flexible partial retirement schemes are intended to give individuals the opportunity to reduce working hours before moving into full retirement, the expectation being that the reduced workload will contribute to postponed old-age…

View details →DOI: 10.1080/08959420.2026.2643643
Negative / Null Result ReportMedicine

Letter to the Editor Regarding Article "Prior to Initiation of Chemotherapy, Can We Predict Breast Tumor Response? Deep Learning Convolutional Neural Networks Approach Using a Breast MRI Tumor Dataset".

Brunekreef J · 2024 · Journal of imaging informatics in medicine

The cited article reports on a convolutional neural network trained to predict response to neoadjuvant chemotherapy from pre-treatment breast MRI scans. The proposed algorithm attains impressive performance on the test dataset with a mean…

View details →DOI: 10.1007/s10278-024-01129-3
Negative / Null Result ReportOpen accessMedicine

The evolution of vestibular function and health-related quality of life in bilateral vestibulopathy.

Loos E, Van Stiphout L, Lucieer F et al. · 2025 · Scientific reports

Little is known about the evolution of vestibular dysfunction and health-related quality of life in bilateral vestibulopathy patients over time. Furthermore, it is unknown whether etiology influences the evolution. A retrospective study…

View details →DOI: 10.1038/s41598-025-92109-2
Negative / Null Result ReportMedicine

The protective effects of hyperoxic pre-treatment in human-derived adipose tissue mesenchymal stem cells against in vitro oxidative stress and a rat model of renal ischaemia-reperfusion.

Ahmadi Somaghian S, Pajouhi N, Dezfoulian O et al. · 2024 · Archives of physiology and biochemistry

Objective Improvement of cell survival is essential for achieving better clinical outcomes in stem cell therapy. We investigated the effects of hyperoxic pre-treatment (HP) on the viability of human adipose stromal stem cells (ASCs).…

View details →DOI: 10.1080/13813455.2023.2238918
Negative / Null Result ReportMedicine

The effect of the plasma methotrexate concentration during high-dose methotrexate therapy in childhood acute lymphoblastic leukemia.

Liao C, Nie J, Xu XJ et al. · 2024 · Leukemia & lymphoma

Two hundred and thirty-one acute lymphoblastic leukemia (ALL) children with 1376 high-dose methotrexate (HD-MTX) courses (3-5 g/m 2 ) were enrolled to analyze the influence of the plasma MTX concentration ( C MTX ) in ALL. The 24-h target…

View details →DOI: 10.1080/10428194.2023.2266075
Negative / Null Result ReportOpen accessMedicine

Androgen Receptor Signaling Inhibitors for Metastatic Hormone Sensitive Prostate Cancer in Asians: Indirect Comparison.

Chen W, Yoshida S, Fujii Y · 2026 · Cancer reports (Hoboken, N.J.)

Background Androgen receptor signaling inhibitors (ARSI) combined with androgen deprivation therapy (ADT) have demonstrated significant survival benefits in metastatic hormone-sensitive prostate cancer (mHSPC) in several clinical trials.…

View details →DOI: 10.1002/cnr2.70496
Negative / Null Result ReportMedicine

Predictors of Durable Remission After Successful Surgery for Cushing Disease: Results From the Multicenter RAPID Registry.

Findlay MC, Tenhoeve S, Alt J et al. · 2024 · Neurosurgery

Background and objective Cushing disease (CD) affects mortality and quality of life along with limited long-term remission, underscoring the need to better identify recurrence risk. The identification of surgical or imaging predictors for…

View details →DOI: 10.1227/neu.0000000000003042
Negative / Null Result ReportMedicine

Assessing the Quality of Metagenomic Next-Generation Sequencing for Pathogen Detection in Lower Respiratory Infections.

Diao Z, Zhang Y, Chen Y et al. · 2023 · Clinical chemistry

Background Laboratory-developed metagenomic next-generation sequencing (mNGS) assays are increasingly being used for the diagnosis of infectious disease. To ensure comparable results and advance the quality control for the mNGS assay, we…

View details →DOI: 10.1093/clinchem/hvad072
Negative / Null Result ReportOpen accessMedicine

Association Between Patient Sex and Familial Hypercholesterolemia and Long-Term Cardiovascular Risk Factor Management 5 Years After Acute Coronary Syndrome.

Krasieva K, Gencer B, Locatelli I et al. · 2024 · Circulation. Cardiovascular quality and outcomes

Background Long-term control of cardiovascular risk factors after acute coronary syndrome (ACS) is the cornerstone for preventing recurrence. We investigated the extent of cardiovascular risk factor management in males and females with and…

View details →DOI: 10.1161/circoutcomes.123.010790
Negative / Null Result ReportOpen accessMedicine

Refining the clinical utility of [<sup>177</sup>Lu]Lu/[<sup>225</sup>Ac]Ac-PSMA tandem RLT in patients with metastatic castration resistant prostate cancer.

Widjaja L, Hornfeck J, Siegmund SC et al. · 2026 · European journal of nuclear medicine and molecular imaging

Purpose This study aimed to evaluate the efficacy and safety of Lutetium-177/Actinium-225 prostate-specific membrane antigen tandem radioligand therapy ([ 177 Lu]Lu/[ 225 Ac]Ac-PSMA tandem RLT) and to explore clinical and imaging-based…

View details →DOI: 10.1007/s00259-025-07632-1
Negative / Null Result ReportMedicine

Potential benefits of therapeutic drug monitoring for beta-lactam antibiotics in augmented renal clearance patients: a case report.

El-Haffaf I, Laverdière J, Albert M et al. · 2024 · Canadian journal of physiology and pharmacology

Augmented renal clearance (ARC) is commonly described in critically ill patients, making drug pharmacokinetics even harder to predict in this population. This case report displays the value of therapeutic drug monitoring (TDM) of…

View details →DOI: 10.1139/cjpp-2023-0109
Negative / Null Result ReportOpen accessMedicine

Nuclear protein 1 is a cell death regulator in primary human airway epithelial cells and reduced in idiopathic pulmonary fibrosis.

Zöller M, Mastalerz M, Dick E et al. · 2026 · Scientific reports

The airway epithelium is the first site of injury from cigarette smoke (CS), a major risk factor for chronic lung disease including idiopathic pulmonary fibrosis (IPF). Here, we report the first intracellular proteomic analysis of CS…

View details →DOI: 10.1038/s41598-026-51510-1
Negative / Null Result ReportOpen accessMedicine

Rapid response to BRAF/MEK inhibitor therapy within 2 weeks for high-grade glioma with leptomeningeal metastasis: illustrative case.

Kawaguchi Y, Hana T, Hasegawa H et al. · 2025 · Journal of neurosurgery. Case lessons

Background High-grade gliomas, particularly isocitrate dehydrogenase-wildtype glioblastomas (GBMs), are highly aggressive brain tumors with limited treatment options and poor outcomes. A subset of these tumors, including epithelioid GBM,…

View details →DOI: 10.3171/case25247
Negative / Null Result ReportMedicine

Gender-Affirming Hormone Therapy Is Associated with Increased Odds of Screening for Sexually Transmitted Infections in a Clinical Cohort of Transgender and Nonbinary Adults.

Pletta DR, Mayer KH, Chen JT et al. · 2024 · Transgender health

Purpose Transgender and nonbinary adults (TNB) are disproportionately burdened by sexually transmitted infections (STI) and the human immunodeficiency virus (HIV). This study investigated whether gender-affirming hormone therapy was…

View details →DOI: 10.1089/trgh.2023.0159
Negative / Null Result ReportMedicine

A true reflection of executive functioning or a representation of task-specific variance? Re-evaluating the unity/diversity framework.

Sambol S, Suleyman E, Scarfo J et al. · 2023 · Acta psychologica

The unity/diversity framework, originally published by Miyake et al. (2000) has become the most cited model of executive functioning. Consequently, when researchers operationalise executive function (EF) they often exclusively assess the…

View details →DOI: 10.1016/j.actpsy.2023.103934
Negative / Null Result ReportOpen accessMedicine

Derived hematological indices during peripheral blood stem cell mobilization in the plerixafor era: insightful dynamics but limited predictive value.

Murugesan M, Niveditha LP, Sindhu ER et al. · 2026 · Hematology, transfusion and cell therapy

Introduction Derived hematological indices reflect immune activation, but their dynamics during the plerixafor era and their predictive value for stem cell yield remain unclear. Objectives To assess changes in derived hematological…

View details →DOI: 10.1016/j.htct.2026.106474
Negative / Null Result ReportOpen accessMedicine

Impact of Introduction of Code Blue Response System in a Cardiorespiratory Center: Before-After Study.

Kumar S, Kumar A, Ameta N et al. · 2026 · Annals of cardiac anaesthesia

Background In-hospital cardiac arrest demands immediate response to improve survival outcomes. The Code Blue Response System (CBRS) was designed to streamline emergency interventions by reducing response times. This study aimed to evaluate…

View details →DOI: 10.4103/aca.aca_102_25
Negative / Null Result ReportMedicine

Vitamin D lowers the number of intestinal tumours in adult intestine-specific Apc-mutant mice only during early tumour initiation in gestation and juvenility.

Rebel HG, de Gruijl FR · 2026 · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

We reported earlier that adult FabplCre;Apc 15lox/+ mice with either daily UV exposure or vitamin D supplementation developed not significantly fewer intestinal tumours but less tumour bulk (reduced outgrowth) than control mice that…

View details →DOI: 10.1007/s43630-026-00935-8
Negative / Null Result ReportMedicine

Effects of Ultrasound-Mediated Treatments on Dental Biofilm Attachment and Viability.

De Grandi D, LuTheryn G, Stoffels M et al. · 2026 · Ultrasound in medicine & biology

Objective Dental biofilms are responsible for the majority of oral cavity diseases (e.g., caries, periodontitis and gingivitis). In this work, we evaluate the effects of therapeutic ultrasound on a Streptococcus mutans biofilm model. The…

View details →DOI: 10.1016/j.ultrasmedbio.2026.05.008
Negative / Null Result ReportMedicine

Omega-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Did Not Reduce Inflammation to Improve Iron Absorption in South African Women Living with Overweight or Obesity.

Uyoga MA, Baumgartner J, Malan L et al. · 2026 · The Journal of nutrition

Background Young South African women face a double-burden of overweight or obesity and iron deficiency, with the former predicting the latter. Omega-3 long-chain polyunsaturated fatty acid (LCPUFA) supplementation can reduce inflammation.…

View details →DOI: 10.1016/j.tjnut.2025.101280