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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20240 results in Negative / Null Result Report · page 374 of 675

Negative / Null Result ReportMedicine

Implantation of Infant Platelet-Rich Plasma/Fibrin with Gingivoperiosteoplasty in Patients with Unilateral Cleft Lip and Alveolus.

Kobayashi, Yabuki, Sugiyama et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveNo studies have examined the effectiveness of platelet-rich plasma (PRP) alone and platelet-rich fibrin (PRF) without alveolar bone grafting or other bone substitutes for alveolar cleft repair during infancy. This study evaluated…

View details →DOI: 10.1177/10556656261417033
Negative / Null Result ReportMedicine

Enhanced Recovery After Surgery (ERAS) Outcomes After Liver and Pancreas Surgery Based on Regional Perioperative Pain Modalities.

Sulciner, Wang, Fairweather et al. · 2026 · Cureus

ON-Q pumps, or surgically placed wound catheters, provide analgesia without the side effects of epidural catheters. This study aimed to evaluate perioperative outcomes, including total postoperative oral morphine milligram equivalents…

View details →DOI: 10.7759/cureus.109129
Negative / Null Result ReportMedicine

Is surgery always warranted for high-grade acromioclavicular dislocations?

Jamei-Martel, Garibaldi, Castroviejo Fernández et al. · 2026 · JSES international

The optimal management of high-grade acromioclavicular (AC) joint dislocations remains controversial. While surgical treatment improves radiographic alignment, its impact on functional outcomes remains debated. This study prospectively…

View details →DOI: 10.1016/j.jseint.2026.101722
Negative / Null Result ReportMedicine

Ocular Microstructural Alterations in Children With Spina Bifida: An Optical Coherence Tomography Study.

Ucan Gunduz, Nizam Tekcan, Erdem et al. · 2026 · Journal of pediatric ophthalmology and strabismus

To investigate microstructural alterations in the retina, choroid, and optic nerve head in children with spina bifida using optical coherence tomography. Thirty-eight children with spina bifida and 32 children without spina bifida were…

View details →DOI: 10.3928/01913913-20260417-01
Negative / Null Result ReportMedicine

Effect of dual trigger on pregnancy outcomes in women with diminished ovarian reserve: A single-blind randomized clinical trial.

Zamaniyan, Abbasi, Habibpour et al. · 2026 · International journal of reproductive biomedicine

Diminished ovarian reserve is one of the most important issues in in vitro fertilization cycles. Some authors have reported beneficial effects of dual triggering in women with poor ovarian response, whereas other investigators have…

View details →DOI: 10.18502/ijrm.v24i4.21171
Negative / Null Result ReportMedicine

Rotator Cuff Surgery and Artificial Intelligence: A Comparative Analysis of Quality and Readability Between ChatGPT and Gemini.

Alencar, Teles, Cunha et al. · 2026 · Revista brasileira de ortopedia

Artificial intelligence (AI) tools based on natural language, such as ChatGPT 4.1 mini (OpenAI Group PBC) and Gemini 2.5 Flash (Alphabet Inc.), are used by patients as sources of medical information. The current study aimed to evaluate and…

View details →DOI: 10.1055/s-0046-1820460
Negative / Null Result ReportMedicine

[Rotator Cuff Surgery and Artificial Intelligence: A Comparative Analysis of Quality and Readability Between ChatGPT and Gemini].

Alencar, Teles, Cunha et al. · 2026 · Revista brasileira de ortopedia

Artificial intelligence (AI) tools based on natural language, such as ChatGPT 4.1 mini (OpenAI Group PBC) and Gemini 2.5 Flash (Alphabet Inc.), are used by patients as sources of medical information. The current study aimed to evaluate and…

View details →DOI: 10.1055/s-0046-1820461
Negative / Null Result ReportMedicine

Vaginal Microbiota and Cytokines Among Pregnant and Breastfeeding Women in Clinical Trials of the Dapivirine Vaginal Ring and Oral Tenofovir Disoproxil Fumarate/Emtricitabine.

Petrina, Dong, Beamer et al. · 2026 · Open forum infectious diseases

Vaginal dysbiosis is associated with HIV acquisition and preterm delivery. Our objective was to evaluate prevalent vaginal infections, and changes in microbiota and cytokines among pregnant and breastfeeding women from 4 African countries…

View details →DOI: 10.1093/ofid/ofag329
Negative / Null Result ReportMedicine

The Association of Ramadan Fasting on Relative Leukocyte Telomere Length in Type 2 Diabetes Mellitus.

Hardika, Kurniawan, Laksmi et al. · 2026 · Journal of the ASEAN Federation of Endocrine Societies

Leukocyte telomere length (LTL) is considered a biomarker of cellular senescence. Previous studies have reported the associations between shortened telomere length and type 2 diabetes mellitus (T2DM). However, the role of underlying…

View details →DOI: 10.15605/jafes.041.01.5071
Negative / Null Result ReportMedicine

Comparison of wear behavior of 3D printed permanent resin, milled zirconia, and primary tooth enamel on antagonist primary canines: in vitro study.

Akdogan, Aydin · 2026 · BMC oral health

Data comparing the wear of 3D printed permanent resin (PR) and milled zirconia (Z) to that of primary tooth enamel are limited. This study aimed to investigate the wear behavior of two materials and their effect on antagonist primary…

View details →DOI: 10.1186/s12903-026-08916-0
Negative / Null Result ReportMedicine

Effects of Topical Lidocaine and Benzocaine on Pain Level and Injection Satisfaction in Arteriovenous Fistula Catheter Applications.

Güler, Kaplan, Şahan et al. · 2026 · Pain management nursing : official journal of the American Society of Pain Management Nurses

Pain during arteriovenous fistula (AVF) catheterization is a common discomfort faced by hemodialysis patients and can negatively affect treatment adherence, satisfaction, and overall quality of life. Effective pain management strategies…

View details →DOI: 10.1016/j.pmn.2026.05.016
Negative / Null Result ReportMedicine

Comparison between the fast and the traditional nitroglycerin head-up tilt test in paediatric population.

Russo, Comune, Di Nardo et al. · 2026 · International journal of cardiology

The shortened protocol of Nitroglycerin (NTG)-potentiated head-up tilt testing (HUTT), the so-called "fast Italian protocol," has been shown to significantly reduce test duration while maintaining diagnostic yield and safety in adults with…

View details →DOI: 10.1016/j.ijcard.2026.134623
Negative / Null Result ReportMedicine

Adjunctive GLP1 Receptor Agonists in Patients with Inflammatory Bowel Diseases and Obesity and/or Diabetes: A Target Trial Emulation.

Yeh, Ahuja, Patel et al. · 2026 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

We conducted a target trial emulation study to examine the effect of two glucagon-like peptide-1 receptor agonists (GLP1RAs) (semaglutide and tirzepatide) on clinical outcomes in patients with inflammatory bowel diseases (IBD) with obesity…

View details →DOI: 10.1016/j.cgh.2026.06.008
Negative / Null Result ReportMedicine

Pulmonary venoocclusive disease/pulmonary capillary hemangiomatosis: Inadequacy of clinico-radiologic features in diagnosis.

Hurst, White, Ryu et al. · 2026 · Human pathology

Pulmonary venoocclusive disease (PVOD)/pulmonary capillary hemangiomatosis (PCH) belongs to the WHO group 1 pulmonary hypertension (PH), labeled as pulmonary arterial hypertension (PAH), though it mainly involves pulmonary veins, venules…

View details →DOI: 10.1016/j.humpath.2026.106203
Negative / Null Result ReportMedicine

Decoding marginal adaptation and microleakage: A field emission scanning electron microscopy and stereomicroscopic evaluation of cavity liners under class II composite restorations.

Mann, Sharma, Jhamb et al. · 2026 · Journal of conservative dentistry and endodontics

Esthetics are in high demand in modern dentistry; conservative dentistry offers tooth-colored restorative materials; however, drawbacks such as polymerization shrinkage can lead to microleakage. To minimize this problem, cavity liners are…

View details →DOI: 10.4103/jcde.jcde_180_26
Negative / Null Result ReportMedicine

Periodontal status, oral inflammatory biomarker, and relative expression of red complex bacteria in periodontitis-rheumatoid arthritis: a cross-sectional preliminary study.

Mahardika, Rakhmawati, Sulijaya et al. · 2026 · Frontiers in cellular and infection microbiology

To determine the differences in periodontal status-Probing Depth (PD), Clinical Attachment Loss (CAL), Bleeding on Probing (BOP); oral inflammatory biomarkers-Tumor Necrosis Factor Alpha (TNF-α), Interleukin 1 Beta (IL-1β),…

View details →DOI: 10.3389/fcimb.2026.1824946
Negative / Null Result ReportMedicine

Association Between Advanced Age and Perioperative Complications Among Women Operated for Pelvic Organ Prolapse in Urogynecology Camps in Uganda.

Kato, Ngonzi, Byamukama et al. · 2026 · Cureus

The burden of pelvic organ prolapse (POP) is the highest among elderly women compared to their young and middle-aged counterparts. These women are also faced with various medical comorbidities. Surgery in these women presents a…

View details →DOI: 10.7759/cureus.108822
Negative / Null Result ReportMedicine

Artificial Intelligence for Molecular Subtyping in Unresectable Gallbladder Cancer: A Proof-of-Concept Study for CT-based HER2 Status Prediction.

Gupta, Madan, Dutta et al. · 2026 · Journal of clinical and experimental hepatology

Human epidermal growth factor receptor 2 (HER2) overexpression is a critical therapeutic target in gallbladder cancer (GBC), but detection requires invasive sampling. We developed a fully automated computed tomography (CT)-based framework…

View details →DOI: 10.1016/j.jceh.2026.103563
Negative / Null Result ReportMedicine

Impact of language concordant care on comprehension and adherence to infection prevention protocols among hospitalized patients: A multicentre survey.

Reason, Rizvi, Chawla et al. · 2026 · Canada communicable disease report = Releve des maladies transmissibles au Canada

Language concordant care can influence patient outcomes. The level of language concordant care and its impact on adherence to infection prevention protocols has not been well described. To assess whether patients' preferred language…

View details →DOI: 10.14745/ccdr.v52i04a05
Negative / Null Result ReportMedicine

Screening criteria for drainage-free patients after retroperitoneal laparoscopic adrenal tumor resection and their prospective validation study value.

Zhao, He, Li et al. · 2026 · Experimental and therapeutic medicine

Retroperitoneal laparoscopic resection is the preferred minimally invasive surgery for adrenal tumors. Patients vary greatly in postoperative drain output, but no clear criteria exist to select candidates for a drainage-free strategy. The…

View details →DOI: 10.3892/etm.2026.13200
Negative / Null Result ReportMedicine

Relationship Between Position, Shape, and Deformation of Papillary Muscles and Mitral Regurgitation After Transcatheter Aortic Valve Replacement.

Li, Chen, Zhou et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Moderate/severe mitral regurgitation (MR) can affect the prognosis of patients with transcatheter aortic valve replacement (TAVR). However, few studies have focused on the role played by papillary muscles (PMs). We intend to explore the…

View details →DOI: 10.1002/ccd.70703