A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21300 results · page 370 of 710
Ullal SD, Thomas AG, Acharya SD et al. · 2026 · Pharmacology research & perspectives
Epilepsy is a common neurologic disorder; its incidence in childhood is 2.5 per 1000 children. Levetiracetam (LEV) is an antiepileptic drug with a broad spectrum of action used in localized and generalized epilepsies in both adults and…
Hawkey AB, Fan R, Nwachukwu K et al. · 2025 · Neurotoxicology and teratology
Neurotoxic risks in the environment come from many toxicants, which are often found together in complex mixtures. However, nearly all experimental studies evaluate one chemical at a time. Neurobehavioral effects of developmental exposure…
Jacover A, Beller T, Mahamid N et al. · 2025 · Annals of surgical oncology
Introduction Neoadjuvant therapy (NT) is generally preferred over upfront surgery for borderline resectable pancreatic ductal adenocarcinoma (BR-PDAC), but many patients fail to reach surgical resection. This study evaluates real-world…
Tanisaka Y, Ryozawa S, Mizuide M et al. · 2025 · Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
Endoscopic sphincterotomy (EST) is challenging for patients with surgically altered anatomy (SAA). The blades of conventional sphincterotomes designed for SAA do not always face the correct direction of EST. We aimed to evaluate the…
Sandby K, Magkos F, Chabanova E et al. · 2024 · Clinical nutrition (Edinburgh, Scotland)
Background & aims In recent years, epidemiological studies have reported links between the consumption of fermented dairy products, such as yogurt, and health; however, evidence from human intervention trials is scarce and inconsistent. We…
Buck AN, Fleiner T, Rosskothen-Kuhl N et al. · 2026 · Trends in hearing
It is widely known that users of cochlear implants (CIs) often show deficits in binaural hearing. In particular, interaural time difference (ITD) discrimination tends to be substantially worse in CI users. However, only very few studies…
Chen Y, Gao J, Wang X et al. · 2024 · Frontiers in nutrition
Background Evidence from observational studies on the association between folate and metabolic dysfunction-associated steatotic liver disease (MASLD) is conflicting. Aims This study aimed to investigate the association between serum folate…
Castillo L, Berrozpe-Villabona C, Miserachs-García S et al. · 2024 · Acta ophthalmologica
Purpose The role of the choroid in Leber hereditary optic neuropathy (LHON) remains unclear. The literature is scarce, with conflicting results and lacks axial length measurements. Therefore, we aimed to analyse the choriocapillaris (CC)…
Ding L, Reiher M · 2026 · Journal of chemical theory and computation
Neural quantum states (NQS) are a promising ansatz for solving many-body quantum problems due to their inherent expressiveness. Yet this expressiveness can only be harnessed efficiently for treating identical particles if the suitable…
Widjaja L, Hornfeck J, Siegmund SC et al. · 2026 · European journal of nuclear medicine and molecular imaging
Purpose This study aimed to evaluate the efficacy and safety of Lutetium-177/Actinium-225 prostate-specific membrane antigen tandem radioligand therapy ([ 177 Lu]Lu/[ 225 Ac]Ac-PSMA tandem RLT) and to explore clinical and imaging-based…
El-Haffaf I, Laverdière J, Albert M et al. · 2024 · Canadian journal of physiology and pharmacology
Augmented renal clearance (ARC) is commonly described in critically ill patients, making drug pharmacokinetics even harder to predict in this population. This case report displays the value of therapeutic drug monitoring (TDM) of…
Zöller M, Mastalerz M, Dick E et al. · 2026 · Scientific reports
The airway epithelium is the first site of injury from cigarette smoke (CS), a major risk factor for chronic lung disease including idiopathic pulmonary fibrosis (IPF). Here, we report the first intracellular proteomic analysis of CS…
Kawaguchi Y, Hana T, Hasegawa H et al. · 2025 · Journal of neurosurgery. Case lessons
Background High-grade gliomas, particularly isocitrate dehydrogenase-wildtype glioblastomas (GBMs), are highly aggressive brain tumors with limited treatment options and poor outcomes. A subset of these tumors, including epithelioid GBM,…
Pletta DR, Mayer KH, Chen JT et al. · 2024 · Transgender health
Purpose Transgender and nonbinary adults (TNB) are disproportionately burdened by sexually transmitted infections (STI) and the human immunodeficiency virus (HIV). This study investigated whether gender-affirming hormone therapy was…
Gangeri L, Alfieri S, Anselmi V et al. · 2025 · Tumori
Background As part of the improvement plan of the Organisation of European Cancer Institutes at the Fondazione IRCCS Istituto Nazionale dei Tumori of Milan (INT) a Committee composed of patients, caregivers, and representatives of patient…
Sambol S, Suleyman E, Scarfo J et al. · 2023 · Acta psychologica
The unity/diversity framework, originally published by Miyake et al. (2000) has become the most cited model of executive functioning. Consequently, when researchers operationalise executive function (EF) they often exclusively assess the…
Murugesan M, Niveditha LP, Sindhu ER et al. · 2026 · Hematology, transfusion and cell therapy
Introduction Derived hematological indices reflect immune activation, but their dynamics during the plerixafor era and their predictive value for stem cell yield remain unclear. Objectives To assess changes in derived hematological…
Kumar S, Kumar A, Ameta N et al. · 2026 · Annals of cardiac anaesthesia
Background In-hospital cardiac arrest demands immediate response to improve survival outcomes. The Code Blue Response System (CBRS) was designed to streamline emergency interventions by reducing response times. This study aimed to evaluate…
Minion S, Kiene J, Dellavalle R · 2023 · JMIR dermatology
Gender disparities exist across all facets of academic medicine including within the editorial boards of dermatology journals. Only 22% of these editorial boards comprised women, even though 51% of full-time, faculty dermatologists are…
Bloch RJ, Traficante M, Mariot V et al. · 2025 · Neuromuscular disorders : NMD
Facioscapulohumeral muscular dystrophy is a progressive muscle disorder that is likely linked to aberrant DUX4 expression. Losmapimod, a p38 kinase inhibitor, was utilized to suppress DUX4 and its downstream effects. Phase I/II clinical…
de Barros B, Sultana F, Maximus N et al. · 2026 · Preprint
ABSTRACT Background Erythema nodosum leprosum (ENL) is a severe inflammatory complication of leprosy that often requires prolonged corticosteroid therapy which is associated with adverse effects. Methotrexate is an affordable…
Garg AX · 2026 · Annals of internal medicine
Clinical impact ratings GIM/FP/GP: [Formula: see text] Critical Care: [Formula: see text] Nephrology: [Formula: see text].
Dodd TS, Borzak S · 2026 · Annals of internal medicine
Clinical impact ratings GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text] Hematology: [Formula: see text].
Jain S, Jha AK, Chawla D et al. · 2026 · Indian journal of pediatrics
OBJECTIVES: To determine the effect of prone positioning on the duration of respiratory support in neonates receiving non-invasive mode of ventilation. METHODS: This open label randomized controlled trial was conducted in the NICU of a…
Brasher MI, Patil MS · 2026 · Acta paediatrica (Oslo, Norway : 1992)
The LAKANA trial: a randomized control trial evaluating the impact of mass administration of azithromycin to infants 1 to 11 months of age in Mali showed no reduction in mortality.
Legnani C, Ventura A, Oriani G · 2026 · Journal of clinical practice and research
A retrospective study was conducted to evaluate the need for perioperative autotransfusions and the amount of blood loss by comparing patients receiving different tranexamic acid (TXA) regimens following total joint replacement (TJR). A…
Holl CK, Bonilla Yanez M, Finley JM et al. · 2026 · Preprint
Background and Purpose Walking after stroke is often characterized by persistent biomechanical impairments and reduced walking capacity. While visual biofeedback can improve gait mechanics and fast walking can enhance capacity, it is…
Greenway RR, Coulter AA, Zhang D et al. · 2026 · Journal of medicinal food
Gallic acid, a catechin polyphenol in tea, completely inhibited angiogenesis in assays of human tissue at 10 -3 M. Psoriasis is a skin disease caused by excessive secretion of angiogenenic factors by keratinocytes and stromal skin cells.…
Fantasia ME, Penick CA · 2026 · Journal of economic entomology
Climate change intensifies drought frequency, posing risks to pollinators both directly and indirectly through changes in floral resource availability. We tested how water limitation alters pollinator-relevant floral traits, visitation,…
Kasige RH, Johnson SN, Frew A · 2026 · Preprint
Abstract Background and aims. Plant susceptibility to insect herbivores is shaped by interacting soil-based biotic and abiotic factors, particularly arbuscular mycorrhizal (AM) fungi and silicon (Si) availability. AM fungi influence plant…