Negative / Null Result ReportMedicine
Abd Elghany AA, Kamel Eyada MM, Maher SA et al. · 2026 · Cytokine
Background Alopecia areata (AA) is a common autoimmune disease which causes non-scarring patches of hair loss and has a 2% lifetime risk. Its chronic, recurrent nature makes treatment difficult. Potential roles of the JAK/STAT pathway,…
View details →DOI: 10.1016/j.cyto.2026.157121 Failed Experiment ReportMedicine
García-Moronta C, Rodríguez-Sanna A, Muñoz-Barba D et al. · 2026 · Dermatitis : contact, atopic, occupational, drug
Background Conventional systemic therapies, including cyclosporine and methotrexate, have traditionally been used for moderate-to-severe atopic dermatitis (AD). However, their real-world effectiveness and treatment persistence in the era…
View details →DOI: 10.1177/17103568261452370 Negative / Null Result ReportMedicine
Gundrosen KF, Taraldsen K, Sverdrup K et al. · 2026 · European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity
Background This longitudinal study explored the one-year change in device-measured daily physical activity in patients attending a memory clinic. Methods Physical activity was recorded in 27 memory clinic patients over four days using…
View details →DOI: 10.1186/s11556-026-00414-0 Negative / Null Result ReportMedicine
Silverii H, Ahn J, Gopalan M et al. · 2026 · Journal of pediatric urology
Background While surgical coaching has been proven beneficial, the impact of a faculty focused coaching model on a surgeon's teaching ability and trainee education is unknown. In this study we aim to evaluate whether a surgeon's teaching…
View details →DOI: 10.1016/j.jpurol.2026.105732 Negative / Null Result ReportMedicine
Gan F, Zhang Q, Luo H et al. · 2026 · Orthopaedics & traumatology, surgery & research : OTSR
Introduction The SuperPATH approach for total hip arthroplasty (THA) is promoted as tissue-preserving, but objective evidence of its impact on periarticular muscles is lacking. This study aimed to evaluate periarticular muscle damage one…
View details →DOI: 10.1016/j.otsr.2026.104772 Negative / Null Result ReportMedicine
Boone C, Robicsek A · 2026 · JAMA internal medicine
Importance Quality metrics with financial incentives are widely used, but their impact on clinical care and patient health remains challenging to isolate. Objective To evaluate the association of a physician-facing quality metric and…
View details →DOI: 10.1001/jamainternmed.2026.1637 Negative / Null Result ReportMedicine
Kocuk M, Kopuz D, Alp S et al. · 2026 · American journal of dentistry
Purpose To evaluate the laboratory cleaning efficacy of six commonly used non-invasive methods for removing stains from occlusal fissures before caries diagnosis. Methods 60 extracted, caries-free permanent molars with visible occlusal…
Negative / Null Result ReportMedicine
Bhakta T, Jain K, Sudanabonia P et al. · 2026 · Investigative ophthalmology & visual science
The purpose of this study was to test the hypotheses that (1) monocular blur-driven accommodation is attenuated in keratoconus due to weaker defocus-blur signals arising from degraded image quality (IQ) compared with non-keratoconic…
View details →DOI: 10.1167/iovs.67.6.52 Negative / Null Result ReportMedicine
Englisch CN, Wakili P, Langenbucher A et al. · 2026 · Journal of refractive surgery (Thorofare, N.J. : 1995)
Purpose To assess the short-term impact of stand-alone MINIject (iSTAR Medical SA) implantation on astigmatism in a single-center retrospective study. Methods Refractive and corneal astigmatism was investigated based on preoperative and…
View details →DOI: 10.3928/1081597x-20260413-01 Negative / Null Result Report
shi x, Jiang B, Huang C et al. · 2026 · Preprint
Abstract Objective： To evaluate changes in ciliary muscle morphology before and after accommodative training in premyopic school-age children and assess associations with myopia-related indicators. Design: Prospective controlled study.…
View details →DOI: 10.21203/rs.3.rs-9746088/v1 Negative / Null Result Report
Nie J, Chen Y, Du Y et al. · 2026 · Preprint
Abstract Background Cystic echinococcosis (CE) is a zoonotic parasitic disease caused by the larval stage of Echinococcus granulosus. The liver is the organ most commonly affected, whereas pancreatic involvement is extremely rare. When a…
View details →DOI: 10.21203/rs.3.rs-9189492/v1 Negative / Null Result ReportOpen accessMedicine
Yu J, Grude O, Berg EAR et al. · 2026 · Intensive care medicine experimental
Background Measuring mitral annular plane systolic excursion (MAPSE) serially in a single wall may be an effective method for monitoring global left ventricular (LV) function, especially when automated with a novel deep learning method…
View details →DOI: 10.1186/s40635-026-00898-1 Negative / Null Result ReportMedicine
Ekinci EI, Maldonado SG, Unseld A et al. · 2026 · Diabetes, obesity & metabolism
Aims This post hoc analysis evaluated the effect of survodutide on beta-cell function, insulin sensitivity, and glucose biomarkers in two phase 2 trial populations. Materials and methods Trial 1404-0002 randomised 413 participants with…
View details →DOI: 10.1111/dom.70861 Negative / Null Result ReportMedicine
Pyasik M, Marini E, Ippolito G et al. · 2026 · Acta psychologica
In a predictive processing framework, religiosity and spirituality (R&S) have been linked to increased reliance on prior knowledge and decreased prediction error monitoring. In addition, R&S might be differentially related to processing…
View details →DOI: 10.1016/j.actpsy.2026.107185 Negative / Null Result ReportMedicine
Piri K, Gholamzadeh Jofreh M, Haghighizadeh MH et al. · 2026 · BMC psychology
Introduction Fear of childbirth (FOC) is a significant factor contributing to requests for elective cesarean sections. This study aimed to compare the effectiveness of internet-based cognitive behavioral therapy (ICBT) versus in-person…
View details →DOI: 10.1186/s40359-026-04903-w Negative / Null Result ReportMedicine
Dijksterhuis J, Hurmuz MZM, van Dartel D et al. · 2026 · European geriatric medicine
Purpose Older hip fracture patients are often frail, complicating their recovery trajectories. Insight into patients' resilience may help in getting more understanding of their predicted recovery and adjusting their treatment plan…
View details →DOI: 10.1007/s41999-026-01514-x Negative / Null Result ReportOpen accessMedicine
Shanmugasundaram D, Wang RA · 2026 · Journal of toxicology
Objective Zylaria comprises a blend of botanical components, including Xylaria Nigripes (mycelium), Cuscuta Chinensis (seed) and Panax Notoginseng (root). This study aimed to evaluate the potential toxicity of Zylaria when administered…
View details →DOI: 10.1155/jt/6989296 Negative / Null Result ReportOpen accessMedicine
Motomura T, Higashi M, Hattori A et al. · 2026 · Internal medicine (Tokyo, Japan)
Objective Hyperuricemia is associated with cardiovascular disease and chronic kidney disease (CKD). Dotinurad is a new uricosuric drug that has not been evaluated in clinical trials in patients with advanced CKD (CKD G3b-G5). This study…
View details →DOI: 10.2169/internalmedicine.5834-25 Negative / Null Result ReportMedicine
Pedersen TA, Mori Y, Botteri E et al. · 2026 · Endoscopy
Background The effect of computer-aided detection (CADe) on performance of endoscopists with different experience levels is not well understood. This study assessed whether CADe use promotes learning or deskilling. Methods We performed a…
View details →DOI: 10.1055/a-2858-7084 Negative / Null Result ReportMedicine
Hoskens S, Bamps K, Herteleer M · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie
Objectives The percutaneous placement of iliosacral (IS) and transsacral (TS) screws has become a standard practice for the treatment of pelvic fractures. Due to the complex sacral anatomy, accurate screw placement is essential to avoid…
View details →DOI: 10.1007/s00590-026-04768-0 Negative / Null Result Report
Sacconi R, Saladino S, Forte P et al. · 2026 · Preprint
Abstract There is a lack of knowledge about the effect of smoking activity on the anatomy and functionality of retinal vessels. The aim of this low-risk, single-center, case-control, interventional clinical trial (ClinicalTrials.gov ID…
View details →DOI: 10.21203/rs.3.rs-8916335/v1 Negative / Null Result Report
Cagini C, Messina M, Fiore T et al. · 2026 · Preprint
Abstract Purpose This study investigates the efficacy of a liposomal ophthalmic solution containing cross-linked hyaluronic acid, trehalose, and stearylamine in reducing the occurrence of dry eye-like signs and symptoms in patients…
View details →DOI: 10.21203/rs.3.rs-9533021/v1 Negative / Null Result ReportMedicine
Lu J, Shorey A, Uduba R et al. · 2026 · Clinical transplantation and research
Background Up to 23% of renal transplant recipients may develop transplant renal artery stenosis (TRAS). However, diagnosis requires angiography, and the contrast used may be nephrotoxic. We aimed to identify predictors of TRAS and clarify…
View details →DOI: 10.4285/ctr.25.0052 Negative / Null Result ReportMedicine
Feng J, Li S, Li X et al. · 2026 · Journal of agricultural and food chemistry
The effects of dietary supplementation with conjugated linoleic acid (CLA) on broiler duck growth performance and the quality of dry-cured products were investigated. Ten days preslaughter with the supplementation of 2 mL/d CLA was more…
View details →DOI: 10.1021/acs.jafc.6c02008 Negative / Null Result ReportOpen accessMedicine
To B, Prasath V, Veney D et al. · 2026 · NPJ breast cancer
Circulating tumor DNA (ctDNA) 'tumor fraction' (TF) may correlate with therapy response, but little is known regarding TF dynamics immediately after therapy initiation. Plasma samples from a single-arm clinical trial enrolling patients…
View details →DOI: 10.1038/s41523-026-00953-w Negative / Null Result ReportMedicine
Mace C, Deighton R · 2026 · Death studies
Empirical evidence is lacking on the effectiveness of grief telephone counseling, particularly in Australia. This study addresses an important gap by evaluating the effectiveness of the Integrating Grief Program-Victoria (IGP-V), an…
View details →DOI: 10.1080/07481187.2026.2646872 Negative / Null Result ReportMedicine
Ajai S, Agnihotri R · 2026 · Journal of dental hygiene : JDH
Purpose Recently, charcoal-based oral hygiene products, such as toothpastes, have gained popularity due to their whitening and antibacterial properties. However, there is limited data on charcoal-bristle electric toothbrushes. The purpose…
Negative / Null Result ReportMedicine
Lee BC, Lee J, Cho KH et al. · 2026 · Gerontology
Introduction Sarcopenia and osteosarcopenia are increasingly prevalent among older adults. Exercise and nutritional support are key non-pharmacological treatments; however, their benefits may diminish after discontinuation. This study…
View details →DOI: 10.1159/000552519 Negative / Null Result Report
Ma P, Wu Q, Xin W et al. · 2026 · Preprint
Purpose Comparison of ocular parameters (ACD, AL, LT, VL, CCT, ASD, LC, LT/ACD) in preterm infants with retinopathy after treatment, those with spontaneous regression, and those without retinopathy, at postmenstrual (ages of 0 (40 weeks),…
View details →DOI: 10.64898/2026.05.14.26353221 Negative / Null Result ReportOpen accessMedicine
Nalbant A, Olgun HE, Hendek M et al. · 2026 · Lasers in medical science
The aim of this study was to compare the effectiveness of diode laser and combined treatment protocols, applied in addition to mechanical debridement, in the treatment of peri-implantitis on clinical periodontal parameters and S100A8…
View details →DOI: 10.1007/s10103-026-04925-1 