Negative / Null Result ReportNeuroscience
Matthew J. Hollocks, Catherine R. G. Jones, Andrew Pickles et al. · 2014 · Autism Research
While high levels of anxiety and depression are now recognized as major co-occurring problems in children and young people with an autism spectrum disorder (ASD), research examining possible associations with individual differences in…
View details →DOI: 10.1002/aur.1361Cited by 148 Negative / Null Result ReportOpen accessMedicine
Padhma Ranganathan, Paul A. Clark, John S. Kuo et al. · 2011 · Journal of Virology
Viruses are appreciated as etiological agents of certain human tumors, but the number of different cancer types induced or exacerbated by viral infections is unknown. Glioblastoma multiforme (GBM)/astrocytoma grade IV is a malignant and…
View details →DOI: 10.1128/jvi.06097-11Cited by 148 Negative / Null Result ReportOpen accessComputer Science
Mary McGlohon, Natalie Glance, Zach Reiter · 2010 · Proceedings of the International AAAI Conference on Web and Social Media
Given a set of reviews of products or merchants from a wide range of authors and several reviews websites, how can we measure the true quality of the product or merchant? How do we remove the bias of individual authors or sources? How do…
View details →DOI: 10.1609/icwsm.v4i1.14019Cited by 148 Negative / Null Result ReportOpen accessPhysics and Astronomy
Ladan Arissian, Christopher Smeenk, F. Turner et al. · 2010 · Physical Review Letters
Tunneling is often used to describe multiphoton ionization of rare gas atoms in infrared fields. We test the tunneling approximation and its nonadiabatic extension by measuring the unperturbed momentum distribution along the κ direction of…
View details →DOI: 10.1103/physrevlett.105.133002Cited by 147 Negative / Null Result ReportEconomics, Econometrics and Finance
Jill R. Horwitz, Brenna D. Kelly, John DiNardo · 2013 · Health Affairs
The Affordable Care Act encourages workplace wellness programs, chiefly by promoting programs that reward employees for changing health-related behavior or improving measurable health outcomes. Recognizing the risk that unhealthy employees…
View details →DOI: 10.1377/hlthaff.2012.0683Cited by 147 Negative / Null Result ReportOpen accessMedicine
Nicholas J. Short, Naval Daver, Courtney D. DiNardo et al. · 2024 · Journal of Clinical Oncology
PURPOSE Azacitidine plus venetoclax is a standard of care for patients with newly diagnosed AML who are unfit for intensive chemotherapy. However, FLT3 mutations are a common mechanism of resistance to this regimen. The addition of…
View details →DOI: 10.1200/jco.23.01911Cited by 146 Negative / Null Result ReportEconomics, Econometrics and Finance
Scott Baker, Andrey Fradkin · 2017 · The Review of Economics and Statistics
Job search is a key choice variable in theories of labor markets but is difficult to measure directly. We develop a job search activity index based on Google search data, the Google Job Search Index (GJSI). We validate the GJSI with both…
View details →DOI: 10.1162/rest_a_00674Cited by 146 Negative / Null Result ReportOpen accessMedicine
Zhongheng Zhang, Gensheng Zhang, Hemant Goyal et al. · 2018 · Critical Care
BACKGROUND AND OBJECTIVE: Sepsis is a heterogeneous disease and identification of its subclasses may facilitate and optimize clinical management. This study aimed to identify subclasses of sepsis and its responses to different amounts of fluid resuscitation. METHODS: This was a retrospective study conducted in an intensive care unit at a large tertiary care hospital. The patients fulfilling the diagnostic criteria of sepsis from June 1, 2001 to October 31, 2012 were included. Clinical and laboratory variables were used to perform the latent profile analysis (LPA). A multivariable logistic regr
View details →DOI: 10.1186/s13054-018-2279-3Cited by 146 Negative / Null Result ReportBusiness, Management and Accounting
Zhongju Liao, Manting Zhang, Xiaopeng Wang · 2018 · Corporate Social Responsibility and Environmental Management
Abstract As more and more females join boards of directors, their decisions concerning environmental innovation have also become the focus of scholars. Based on the upper echelons theory, feminist caring theory, and social role theory,…
View details →DOI: 10.1002/csr.1677Cited by 146 Negative / Null Result ReportOpen accessSocial Sciences
Elizabeth Asiedu · 2014 · Journal of African Development
Abstract This paper examines whether foreign aid in education has a significant effect on growth in Sub-Saharan Africa. Our analysis covers 38 countries over the period 1990–2004 and we control for initial per capita income, inflation,…
View details →DOI: 10.5325/jafrideve.16.1.0037Cited by 146 Negative / Null Result ReportNeuroscience
Jack D. Wang, El‐Sayed Khafagy, Khalil Khanafer et al. · 2016 · Molecular Pharmaceutics
The endothelial cells lining the capillaries supplying the brain with oxygen and nutrients form a formidable barrier known as the blood-brain barrier (BBB), which exhibits selective permeability to small drug molecules and virtually…
View details →DOI: 10.1021/acs.molpharmaceut.5b00805Cited by 146 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Wang Xi, Surabhi Sonam, Thuan Beng Saw et al. · 2017 · Nature Communications
Collective epithelial behaviors are essential for the development of lumens in organs. However, conventional assays of planar systems fail to replicate cell cohorts of tubular structures that advance in concerted ways on out-of-plane curved and confined surfaces, such as ductal elongation in vivo. Here, we mimic such coordinated tissue migration by forming lumens of epithelial cell sheets inside microtubes of 1-10 cell lengths in diameter. We show that these cell tubes reproduce the physiological apical-basal polarity, and have actin alignment, cell orientation, tissue organization, and migrat
View details →DOI: 10.1038/s41467-017-01390-xCited by 146 Negative / Null Result ReportOpen accessSocial Sciences
Stephen J. Macdonald, John Clayton · 2012 · Disability & Society
The aim of this article is to explore disability and the digital divide using a quantitative methodology. The research investigates what impact digital technologies have had in improving the life-chances for disabled people from deprived neighbourhoods in the northeast of England. The study explores how disabled people engage with digital and assistive technologies in order to overcome disabling barriers and social exclusion. Unfortunately, the analysis found no evidence that digital and assistive technologies had any impact on reducing social exclusion for disabled people. In fact, the resear
View details →DOI: 10.1080/09687599.2012.732538Cited by 146 Negative / Null Result ReportOpen accessMedicine
Ignacio Illán‐Gala, Alberto Lleó, Anna Karydas et al. · 2020 · Neurology
OBJECTIVE: To test the hypothesis that plasma total tau (t-tau) and neurofilament light chain (NfL) concentrations may have a differential role in the study of frontotemporal lobar degeneration syndromes (FTLD-S) and clinically diagnosed…
View details →DOI: 10.1212/wnl.0000000000011226Cited by 145 Negative / Null Result ReportOpen accessMathematics
Valentijn M. T. de Jong, Marinus J.C. Eijkemans, Ben Van Calster et al. · 2019 · Statistics in Medicine
Multinomial Logistic Regression (MLR) has been advocated for developing clinical prediction models that distinguish between three or more unordered outcomes. We present a full-factorial simulation study to examine the predictive…
View details →DOI: 10.1002/sim.8063Cited by 145 Negative / Null Result ReportOpen accessMedicine
Xiaoyi Huang, Jian Zhao, Jinyi Bai et al. · 2019 · Journal of bone oncology
Osteosarcoma is the most common primary sarcoma of the bone. Lung osteosarcoma metastases at diagnosis have a significantly poor prognosis, even when surgery plus chemotherapy are performed. Our goal was to analyze clinical and sarcoma…
View details →DOI: 10.1016/j.jbo.2019.100230Cited by 145 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Maarten R.C. van Oordt, Chen Zhou · 2016 · Journal of Financial and Quantitative Analysis
Abstract We test for the presence of a systematic tail risk premium in the cross section of expected returns by applying a measure of the sensitivity of assets to extreme market downturns, the tail beta. Empirically, historical tail betas…
View details →DOI: 10.1017/s0022109016000193Cited by 145 Negative / Null Result ReportOpen accessMedicine
Andrea B. Apolo, Karla V. Ballman, Guru Sonpavde et al. · 2024 · New England Journal of Medicine
BACKGROUND: Muscle-invasive urothelial carcinoma is an aggressive disease with high rates of relapse. Whether pembrolizumab as adjuvant therapy would be effective in patients with high-risk muscle-invasive urothelial carcinoma after…
View details →DOI: 10.1056/nejmoa2401726Cited by 145 Negative / Null Result ReportOpen accessPhysics and Astronomy
B. P. Abbott, R. Abbott, T. D. Abbott et al. · 2019 · Physical review. D/Physical review. D.
We present results of an all-sky search for continuous gravitational waves (CWs), which can be produced by fast-spinning neutron stars with an asymmetry around their rotation axis, using data from the second observing run of the Advanced…
View details →DOI: 10.1103/physrevd.100.024004Cited by 145 Negative / Null Result ReportOpen accessEnvironmental Science
Zorana Jovanovic Andersen, Massimo Stafoggia, Gudrun Weinmayr et al. · 2017 · Environmental Health Perspectives
BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent. OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women. METHODS: ); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses. RESULTS: =0.04]. CONCLUSI
View details →DOI: 10.1289/ehp1742Cited by 145 Negative / Null Result ReportMedicine
David S.P. Tan, Marjan Iravani, W. Glenn McCluggage et al. · 2011 · Clinical Cancer Research
PURPOSE: Ovarian clear cell carcinomas (OCCC) are a drug-resistant and aggressive type of epithelial ovarian cancer. We analyzed the molecular genetic profiles of OCCCs to determine whether distinct genomic subgroups of OCCCs exist.…
View details →DOI: 10.1158/1078-0432.ccr-10-1688Cited by 144 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Muhammad Fahim Raza, Yichen Wang, Zhaohui Cai et al. · 2020 · PLoS Pathogens
Gut symbiotic bacteria have a substantial impact on host physiology and ecology. However, the contribution of gut microbes to host fitness during long-term low-temperature stress is still unclear. This study examined the role of gut microbiota in host low-temperature stress resistance at molecular and biochemical levels in the oriental fruit fly Bactrocera dorsalis. The results showed that after the gut bacteria of flies were removed via antibiotic treatment, the median survival time was significantly decreased to approximately 68% of that in conventional flies following exposure to a temperat
View details →DOI: 10.1371/journal.ppat.1008441Cited by 144 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Geir H. Bolstad, Thomas F. Hansen, Christophe Pélabon et al. · 2014 · Philosophical Transactions of the Royal Society B Biological Sciences
If genetic constraints are important, then rates and direction of evolution should be related to trait evolvability. Here we use recently developed measures of evolvability to test the genetic constraint hypothesis with quantitative…
View details →DOI: 10.1098/rstb.2013.0255Cited by 144 Negative / Null Result ReportSocial Sciences
Colleen M. Ganley, Leigh A. Mingle, Allison M. Ryan et al. · 2013 · Developmental Psychology
Stereotype threat has been proposed as 1 potential explanation for the gender difference in standardized mathematics test performance among high-performing students. At present, it is not entirely clear how susceptibility to stereotype…
View details →DOI: 10.1037/a0031412Cited by 144 Negative / Null Result ReportOpen accessMedicine
Clara Montagut, Guillem Argilés, Fortunato Ciardiello et al. · 2018 · JAMA Oncology
IMPORTANCE: Acquired resistance to anti-EGFR therapy (epidermal growth factor receptor) is frequently due to RAS and EGFR extracellular domain (ECD) mutations in metastatic colorectal cancer (mCRC). Some anti-EGFR-refractory patients…
View details →DOI: 10.1001/jamaoncol.2017.5245Cited by 144 Negative / Null Result ReportOpen accessHealth Professions
Jahidur Rahman Khan, Nabil Awan, Md. Mazharul Islam et al. · 2020 · Frontiers in Public Health
Background The rapid growth in cases of COVID-19 has challenged national healthcare capacity, testing systems at an advanced ICU, and public health infrastructure level. This global study evaluates the association between multi-factorial healthcare capacity and case fatality of COVID-19 patients by adjusting for demographic, health expenditure, population density and prior burden of noncommunicable disease. It also explores the impact of government relationships with civil society as a predictor of infection and mortality rates. Methods Data were extracted from the Johns Hopkins University dat
View details →DOI: 10.3389/fpubh.2020.00347Cited by 144 Negative / Null Result ReportOpen accessMedicine
María‐Victoria Mateos, Albert Oriol, Joaquín Martínez‐López et al. · 2012 · Blood
Maintenance therapy has become a hot field in myeloma, and it may be particularly relevant in elderly patients because the major benefit results from the initial therapy. We report the results of a randomized comparison of maintenance with…
View details →DOI: 10.1182/blood-2012-05-427815Cited by 144 Negative / Null Result ReportOpen accessMedicine
Sergio Livigni, Guido Bertolini, Carlotta Rossi et al. · 2014 · BMJ Open
OBJECTIVES: Coupled plasma filtration adsorption (CPFA, Bellco, Italy), to remove inflammatory mediators from blood, has been proposed as a novel treatment for septic shock. This multicenter, randomised, non-blinded trial compared CPFA…
View details →DOI: 10.1136/bmjopen-2013-003536Cited by 144 Negative / Null Result ReportOpen accessNursing
James A. Berkley, Moses M. Ngari, Johnstone Thitiri et al. · 2016 · The Lancet Global Health
BACKGROUND: Children with complicated severe acute malnutrition (SAM) have a greatly increased risk of mortality from infections while in hospital and after discharge. In HIV-infected children, mortality and admission to hospital are prevented by daily co-trimoxazole prophylaxis, despite locally reported bacterial resistance to co-trimoxazole. We aimed to assess the efficacy of daily co-trimoxazole prophylaxis on survival in children without HIV being treated for complicated SAM. METHODS: We did a multicentre, double-blind, randomised, placebo-controlled study in four hospitals in Kenya (two r
View details →DOI: 10.1016/s2214-109x(16)30096-1Cited by 144 Negative / Null Result ReportHealth Professions
Heribert Limm, Harald Gündel, Mechthild Heinmüller et al. · 2010 · Occupational and Environmental Medicine
OBJECTIVE: To examine the long-term effects of a stress management intervention (SMI) based on the effort-reward imbalance (ERI) model, on psychological and biological reactions to work stress. METHODS: 174 lower or middle management…
View details →DOI: 10.1136/oem.2009.054148Cited by 143 