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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20240 results in Negative / Null Result Report · page 366 of 675

Negative / Null Result Report

Increasing clinical utility of prenatal exome sequencing: the potential power of phenotype-driven Artificial Intelligence analysis

Suerink M, Hoffer M, Dingemans A et al. · 2026 · Preprint

Abstract Prenatal exome sequencing (pES) is challenging due to rapid turnaround requirements and limited phenotype information. Analysis strategies span gene panels through exome-wide review, with Artificial Intelligence (AI) as optional…

View details →DOI: 10.21203/rs.3.rs-9634215/v1
Negative / Null Result ReportMedicine

Day-case versus conventional inpatient artificial urinary sphincter implantation: A single-center comparative study of 177 patients.

Youssef MW, Perrin L, Denormandie AC et al. · 2026 · The French journal of urology

Purpose Ambulatory artificial urinary sphincter (AUS) implantation has been proposed as an alternative to conventional inpatient surgery, but comparative data remain limited. We aimed to compare early postoperative outcomes between…

View details →DOI: 10.1016/j.fjurol.2026.103135
Negative / Null Result ReportMedicine

The benefit of robotic gastrectomy in minimally invasive surgery for elderly patients: a propensity score-matched analysis.

Jinushi K, Saito T, Fujikawa K et al. · 2026 · Surgery today

Purposes Robotic gastrectomy (RG) offers superior dexterity and visualization compared with laparoscopic gastrectomy (LG). However, its high cost requires careful patient selection. This study aimed to evaluate whether these advantages…

View details →DOI: 10.1007/s00595-026-03292-2
Negative / Null Result ReportMedicine

Antioxidant, Redox, and Immunomodulatory Effects of <i>Hypericum perforatum</i> in the <i>Galleria mellonella</i>: A 3R-Oriented Invertebrate Model.

Battal F, Kaya S, Kiraz HA · 2026 · Biomedicines

Background/Objectives : Hypericum perforatum L. (St. John's Wort) is extensively utilized in ethnopharmacology due to its anti-inflammatory and immunomodulatory properties. However, its effects on the interaction between innate immunity…

View details →DOI: 10.3390/biomedicines14061297
Negative / Null Result ReportMedicine

Evaluating junior medical staff confidence in assessment and management of mental health presentations in an Australian paediatric emergency department.

Daoud J, Greenwood J, Botha T et al. · 2026 · Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

ObjectiveTo evaluate confidence levels of junior doctors working in the paediatric emergency department (ED) in the assessment and management of acute mental health presentations.MethodsThis cross-sectional study invited 89 eligible junior…

View details →DOI: 10.1177/10398562261424122
Negative / Null Result ReportMedicine

Artificial Intelligence Applications Versus Manual Methods For Literature Retrieval: A Comparative Analysis.

O'Rourke J, Byrne M, Schroers G · 2026 · Western journal of nursing research

Background Artificial intelligence (AI), particularly generative and large language models, is being used in nursing education, practice, and scholarly writing. Generative AI applications have been specifically examined for their use in…

View details →DOI: 10.1177/01939459261451723
Negative / Null Result ReportMedicine

Retrospective study on diagnostic yield and medical impact of diagnostic imaging in dogs with immune-mediated haemolytic anaemia in Belgium.

Vlassenbroek R, Peeters D, Matthewman L et al. · 2026 · The Journal of small animal practice

Objectives To assess the incidence of associative immune-mediated haemolytic anaemia in dogs diagnosed with immune-mediated haemolytic anaemia and to evaluate whether performing diagnostic imaging, specifically thoracic radiographs and…

View details →DOI: 10.1111/jsap.70159
Negative / Null Result ReportMedicine

Clinical Characteristics and Outcomes of Hemorrhagic Choroidal Detachments From 2003-2020: A Single Center Experience.

Tailor PD, Wang KY, Xu TT et al. · 2026 · Ophthalmic surgery, lasers & imaging retina

Background and objective This study aimed to characterize clinical characteristics and visual outcomes of patients with hemorrhagic choroidal detachments. Patients and methods Single-center retrospective case series of patients with…

View details →DOI: 10.3928/23258160-20260413-02
Negative / Null Result ReportMedicine

Comparison of Urodynamic Outcomes of Surgery Using the Photoselective Vaporization 180 W XPS System and Transurethral Resection of the Prostate: A Propensity Score-Matched Analysis in Real-World Clinical Practice.

Saito Y, Kyoda Y, Nofuji S et al. · 2026 · International journal of urology : official journal of the Japanese Urological Association

Objectives No previous studies have directly compared pre- and postoperative pressure flow study (PFS) outcomes between transurethral resection of the prostate (TURP) and photoselective vaporization of the prostate using the GreenLight XPS…

View details →DOI: 10.1111/iju.70532
Negative / Null Result ReportMedicine

Ultrasound structure function for quantitative assessment of steatotic liver disease based on total severity score.

Wallig MA, Kabir MR, Han A et al. · 2026 · The Journal of the Acoustical Society of America

Quantitative ultrasound parameters offer effective tools to evaluate microstructural changes in liver tissue and noninvasively assess tissue health. We examined the relationship between steatotic liver disease severity, measured by the…

View details →DOI: 10.1121/10.0043904
Negative / Null Result ReportMedicine

Predictors of Missed Appointments in Digestive Health: A Comparative Analysis of Telehealth and In-Person Visits.

Zaver HB, Reszczynski O, Singh A et al. · 2026 · Clinical and translational gastroenterology

Introduction Telehealth access is integral to digestive health care. This study examined demographic, insurance, and social determinants of health associated with missed telehealth appointments, with secondary comparisons with missed…

View details →DOI: 10.14309/ctg.0000000000001032
Negative / Null Result ReportMedicine

Rose danio (Danio roseus): A native Mekong basin alternative to zebrafish for acute, developmental, and neurobehavioral toxicity testing.

Seetapan K, Nobsathian S, Bullangpoti V et al. · 2026 · Environmental toxicology and chemistry

The fish embryo toxicity test is widely used as an alternative to conventional acute fish toxicity assays, but its ecological relevance may be limited when the model species is nonnative to the region of interest. Here, we evaluated rose…

View details →DOI: 10.1093/etojnl/vgag077
Negative / Null Result ReportMedicine

Advancements in Breast Lipofilling: A 12-Year Retrospective Comparative Analysis of Patient Satisfaction and Complication Rates across Fat Preparation Methods.

Loucas R, Loucas M, Müller R et al. · 2026 · Plastic and reconstructive surgery

Background Breast lipofilling is a commonly utilized method in plastic surgery for breast reconstruction and augmentation. However, the procedure is often limited by the unpredictable survival of fat grafts, leading to dissatisfied…

View details →DOI: 10.1097/prs.0000000000013135
Negative / Null Result ReportMedicine

Balancing relief and reflux: A prospective comparative study on gastric myotomy length and post-operative outcomes in laparoscopic Heller's myotomy for achalasia.

Yadav S, Kiran SP, Gurjar SK et al. · 2026 · Journal of minimal access surgery

Introduction Laparoscopic Heller's myotomy (LHM) with a partial fundoplication is the standard surgical therapy for achalasia cardia. However, the ideal gastric extension of the myotomy remains controversial, as it may influence both…

View details →DOI: 10.4103/jmas.jmas_534_25
Negative / Null Result ReportMedicine

Association Between Epicardial Adipose Tissue Thickness and Early Arrhythmia Recurrence After Electrical Cardioversion for Atrial Fibrillation and Atrial Flutter in Patients With and Without Heart Failure-An Observational Study.

Kadum F, Benko K, Batičić L et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Atrial fibrillation (AF) and atrial flutter are associated with significant morbidity. While electrical cardioversion (ECV) is a standard treatment for sinus rhythm restoration, early arrhythmia recurrence is…

View details →DOI: 10.3390/medicina62061130
Negative / Null Result ReportMedicine

The interplay of APOE genotype, plasma levels, and cognitive functions in middle-aged adults with a parental history of Alzheimer's disease.

Mattar YA, Refaat O, El-Makawi S et al. · 2026 · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

Background Family history and APOE ε4 carriage represent the strongest non-modifiable Alzheimer's disease (AD) risk factors after advancing age. Early identification of cognitive markers in individuals at risk is essential for effective…

View details →DOI: 10.1080/15622975.2026.2666647
Negative / Null Result ReportMedicine

Axial Force Transmission Through Orthosis Straps in a Neonatal Hip Flexion-Abduction Orthosis: An Exploratory In Vivo Study in Infants with Developmental Dysplasia of the Hip.

Schwanitz von Keitz P, Liebau KH, Mittelmeier W et al. · 2026 · Children (Basel, Switzerland)

Background: Developmental dysplasia of the hip (DDH) is the most common congenital musculoskeletal disorder in newborns. Flexion-abduction orthoses are widely used in early treatment; however, in vivo data on their biomechanical load…

View details →DOI: 10.3390/children13060777
Negative / Null Result Report

Longitudinal Interaction Between Frailty and Postoperative Symptom Burden in Elderly Patients Undergoing Colorectal Cancer Surgery: A Random Intercept Cross-Lagged Panel Model Study

Li P, Ge L, Liu Y et al. · 2026 · Preprint

Background: /Objectives: Frailty and postoperative symptom burden are prevalent in older adults undergoing colorectal cancer (CRC) surgery, but their temporal, within-person interplay remains unclear. We aimed to investigate this…

View details →DOI: 10.20944/preprints202606.0136.v1
Negative / Null Result ReportMedicine

Tibial-Sided Suspension Fixation increases Risk of Cyclops Lesion following Anterior Cruciate Ligament Reconstruction.

Hansen BK, Sandefur EP, Garcia AR et al. · 2026 · The journal of knee surgery

Abstract Cyclops lesions are a common postoperative complication that occurs in up to 47% of patients after anterior cruciate ligament reconstruction (ACLR), often resulting in painful extension loss. While risk factors for cyclops lesions…

View details →DOI: 10.1055/a-2886-8022