Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Peipei Liu, Guoqing Dong, Mingzhu Li et al. · 2026 · Frontiers in Endocrinology
ObjectiveTo investigate the association between estrogen receptor β (ERβ) gene RsaI (rs1256049) and AluI (rs4986938) polymorphisms and the risk of idiopathic central precocious puberty (ICPP) in girls, and to provide potential molecular genetic references for early risk prediction and individualized management of ICPP.MethodsA total of 100 girls with ICPP from the Pediatric Endocrinology Clinic and Inpatient Ward of Shenzhen Maternity & Child Healthcare Hospital were enrolled, and 100 agematched healthy girls undergoing routine physical examinations during the same period served as controls. T
View details →DOI: 10.3389/fendo.2026.1809152 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Xingquan Zhao, Qian Zhang, Shengyun Chen et al. · 2025 · BMJ Open Diabetes Research & Care
Introduction The effects of different glucose metabolic states and diabetes-controlled status on asymptomatic carotid atherosclerosis has not been well investigated. Herein, we aimed to investigate the association of different diabetes status with asymptomatic carotid plaques and carotid intima–media thickness (CIMT).Research design and methods 4752 participants aged over 40 years, free of stroke or myocardial infarction, from the China National Stroke Screen Survey programme were enrolled. Carotid plaque and CIMT were assessed using duplex ultrasonography. Logistic regression analysis was use
View details →DOI: 10.1136/bmjdrc-2024-004786 Negative / Null Result ReportOpen accessSports medicine
Joshua Choe MS, Saji Azerf MD, Pamela Lang MD · 2022 · Orthopaedic Journal of Sports Medicine
Background: The COVID-19 pandemic and related lockdowns in 2020 negatively impacted high school students, with increased depression and anxiety especially in athletes who participated in team sports. For adolescents with disabilities, physical activity provides physical and mental health benefits; however, the impact of COVID-19 related adaptive sports cancellations have not been thoroughly investigated. Hypothesis: Adaptive athletes with lower activity levels during a period of COVID-19 related restrictions will have worse scores of depression, anxiety, and quality of life. Methods: Instituti
View details →DOI: 10.1177/2325967121s00507 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Salustiano Gomes Lins · 1971 · Arquivos de Neuro-Psiquiatria
Inicialmente é feita breve exposição dos cinco principais tipos de atividade lenta posterior descritas na literatura eletrencefalográfica: variedade lenta do ritmo alfa, ritmo theta posterior, ondas lentas posteriores a 4 hertz, ritmo delta associado ao pequeno mal e ondas Pi. Em seguida o autor expõe seus achados, baseado num material clínico composto por 760 pacientes, colhidos ao acaso, dos dois sexos e com idades variáveis entre 5 e 24 anos. Excetuando a variedade lenta do ritmo alfa, um ou mais dos outros quatro grafo-elementos referidos foram observados em 131 destes pacientes (80 do sex
Negative / Null Result ReportOpen accessMedicine (General)
Wicensius Parulian Hasudungan, Andhika Rachman, Alvina Widhani et al. · 2025 · Jurnal Penyakit Dalam Indonesia
Introduction. The available data currently is not adequate to show the differences in vitamin D levels across various clinical stages of COVID-19 in Indonesia. Therefore, this study was conducted to determine the profile of vitamin D levels and its relationship with the clinical severity and inflammatory parameters in confirmed COVID-19 patients. Methods. The study was conducted at Cipto Mangunkusumo Hospital and Wisma Atlet COVID-19 Emergency Hospital from January to December 2021. Subjects who were 18 years old and above and had confirmed COVID-19 status through COVID-19 Polymerase Chain Rea
View details →DOI: 10.7454/jpdi.v12i1.1627 Negative / Null Result ReportOpen accessPharmacy and materia medica
Maryam Hassan Al-Zahrani, Nawal Marzoog Almutairi · 2023 · Journal of Pharmacy and Bioallied Sciences
Background/Objective/Methods: Glutathione-S-transferase Mu1 (GSTM1) and glutathione peroxidase 1 (GPX1) are known antioxidant enzymes that help protect cells from the oxidative damage that occurs from smoking. This study explored the correlation between GSTM1 and GPX1 levels between a group of smokers with the GSTM1 and GPX1 genes in the Saudi population and a control group and investigated the genetic risk factors in the group of smokers. Results: The control and smokers' group (n = 50; aged 22.3 ± 3.1 years; BMI 24.6 ± 5.9 kg/m2) were genotyped using quantitative polymerase chain reaction (q
View details →DOI: 10.4103/jpbs.jpbs_365_23 Negative / Null Result ReportOpen accessGynecology and obstetrics
Nafiseh Saghafi, Leila Pourali, Kiarash Ghazvini et al. · 2018 · International Journal of Reproductive BioMedicine
Background: One of the most important etiologies in pretermpremature rupture of membranes (PPROM) is cervical bacterial colonization. Objective: This study evaluated cervical bacterial colonization in women with PPROM and the pregnancy outcomes. Materials and Methods: In this cohort study, 200 pregnant women with PPROM at 27-37 wk of gestation who were admitted in an academic hospital of Mashhad University of Medical Sciences from March 2015 to July 2016 were studied. samples were obtained from endocervical canal for detection of routine bacteria and Gram staining. Also, we obtained one blood
Negative / Null Result ReportOpen accessMedicine
Muhammad Hussain Iqbal, Tanveer Hussain, Fariha Khalid et al. · 2020 · Pakistan Armed Forces Medical Journal
Objective: To determine the frequency of diastasis recti abdominis and its associated risk factors in postpartum women. Study Design: Cross-sectional study. Place and Duration of Study: Omar Medical Center Lahore, Yaseen Medical Center Lahore and Social Security Hospital Lahore, from Sep 2019 to Dec 2019. Methodology: This study included 128 participants fulfilling the eligibility criteria. The assessment of diastasis recti abdominis was done manually by a female physiotherapist using single finger, double finger and three finger methods on abdomen at three levels: at the umbilicus, 4.5 cm bel
Negative / Null Result ReportOpen accessPublic aspects of medicine
Tao Yi, Zi Lin, Feng Hu et al. · 2025 · BMC Public Health
Abstract Background Data for the study cohort were sourced from the National Health and Nutrition Examination Survey (1999–2018). Study participants were classified as obese (BMI ≥ 30 kg/m²) or nonobese (BMI < 30 kg/m²) then further categorized as metabolically healthy or unhealthy on the basis of metabolic syndrome criteria, resulting in four groups: metabolically healthy obese (MHO), metabolically unhealthy obese (MUO), metabolically healthy nonobese (MHNO), and metabolically unhealthy nonobese (MUNO). Complex sampling statistical methods were employed for descriptive analysis. The associati
View details →DOI: 10.1186/s12889-025-22901-2 Negative / Null Result ReportOpen accessInternal medicine
Richard Lowry, Danice K. Eaton, Kathryn Foti et al. · 2012 · Journal of Obesity
Increasing attention is being focused on sleep duration as a potential modifiable risk factor associated with obesity in children and adolescents. We analyzed data from the national Youth Risk Behavior Survey to describe the association of obesity (self-report BMI ≥95th percentile) with self-reported sleep duration on an average school night, among a representative sample of US high school students. Using logistic regression to control for demographic and behavioral confounders, among female students, compared to 7 hours of sleep, both shortened (≤4 hours of sleep; adjusted odds ratio (95% con
View details →DOI: 10.1155/2012/476914 Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Gustav Torisson, MD, PhD, Martin Bruun Madsen, MD, PhD, Agnes Schmidt Davidsen, MD et al. · 2021 · Critical Care Explorations
Objectives:. To explore the association between antibiotic combination therapy and in-hospital mortality in patients with septic shock in two tertiary ICUs in different countries. Design:. Retrospective observational study. Setting:. ICUs of two tertiary hospitals, Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia, and Rigshospitalet, Copenhagen, Denmark. Patients:. Adult patients with antibiotic treatment greater than or equal to 72 hours and vasopressor therapy greater than or equal to 24 hours. Intervention:. Combination versus mono antibiotic therapy. Measurements and Main Resu
View details →DOI: 10.1097/cce.0000000000000383 Negative / Null Result ReportOpen accessSurgery
Sandro Hügli, Philip C. Müller, Matthias Pfister et al. · 2023 · Transplantology
Background: Despite great progress in graft survival and complication rates, pronounced inflammatory responses are common after pancreas transplantation (PT). Subsequent to the first postoperative increase in inflammatory markers, we have frequently observed a second peak of C-reactive protein (CRP) and white blood cells (WBCs) following PT. This analysis is to assess the incidence and clinical relevance of late-onset increases in inflammatory markers following PT. Materials and methods: We analyzed all consecutive PTs over a 20-year period. The second peak of CRP (SCP) and WBCs (SWP) was defi
View details →DOI: 10.3390/transplantology4020010 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Haohui Zhu, Jianjun Yuan, Yisa Wang et al. · 2014 · Brazilian Journal of Infectious Diseases
Objective: To evaluate whether or not highly active antiretroviral therapy is associated with carotid artery stiffness in human immunodeficiency virus-positive patients in Henan Province, China. Method: Fifty human immunodeficiency virus-positive patients with at least a 5-year history of highly active antiretroviral therapy use and 50 human immunodeficiency virus-positive patients without a history of highly active antiretroviral therapy use were enrolled in this study. Carotid artery intima-media thickness and stiffness were determined by quantitative inter-media thickness and quantitative a
View details →DOI: 10.1016/j.bjid.2014.02.007 Negative / Null Result ReportOpen accessDentistry
Reza Pourabbas, Samin Farajzadeh, Amirreza Babaloo et al. · 2023 · Journal of Dental Research, Dental Clinics, Dental Prospects
Background. Studies have suggested a correlation between periodontitis and reduced male fertility. Inflammation has been described as the link between these ailments. Oral inflammatory load (OIL) can be measured through oral polymorphonuclear neutrophil (oPMN) count, which is associated with periodontal diseases. This cross-sectional study assessed the possible correlation between OIL and the functional parameters of sperm cells. Methods. In 229 volunteers, oral rinse and semen samples were assessed for oPMN, semen polymorphonuclears (sPMNs), sperm concentration, total sperm count, motility, m
View details →DOI: 10.34172/joddd.2023.37106 Negative / Null Result Report
S. Saini, Sarita Pandey, Kanika · 2026 · Journal of Clinical and Diagnostic Research
Introduction: Rehabilitation plays a vital role in managing Parkinson’s Disease (PD), particularly in addressing both motor and cognitive impairments. Dual Task Training (DTT) improves motor symptoms and cognitive performance, while…
View details →DOI: 10.7860/jcdr/2026/89283.23743 Negative / Null Result ReportOpen accessPediatrics
Ahmed E. Abdulgalil, Noha H. Elnagdy, Nehal M. Ramadan et al. · 2025 · Pediatric Rheumatology Online Journal
Abstract Introduction Mycophenolate Mofetil (MMF) has become one of the cornerstone treatments of lupus nephritis (LN). It is converted into mycophenolic acid (MPA), an active metabolite, that displays high inter- and intra-individual pharmacokinetic variability. However, the routine monitoring of MPA trough level is still debatable. Objectives The present study aims to evaluate the relationship between MPA trough levels and both clinical outcomes and drug-related adverse effects during the maintenance phase of LN in Egyptian patients. Methods We included thirty-five adults and twenty-nine chi
View details →DOI: 10.1186/s12969-025-01074-7 Negative / Null Result ReportOpen accessMedicine
Tao Li, Xiaodong Zhou, Zhi Wang et al. · 2016 · PLoS ONE
To evaluate retinal thickness (RT), retinal volume (RV) and choroidal thickness (ChT) in Chinese children using Cirrus-HD optical coherence tomography (OCT), and assess their associations with spherical equivalent (SE), age and gender.This was a prospective study that recruited 193 healthy Chinese children (193 eyes) with no ophthalmic disease history between December 2012 and December 2013. RT and RV were acquired using OCT. Subfoveal ChT (SFCT) and ChT1-mm and 2-mm temporal, nasal, superior and inferior to the fovea were measured manually.RT in the inner temporal and nasal regionsdiffered si
View details →DOI: 10.1371/journal.pone.0158948 Negative / Null Result ReportOpen accessMicrobiology
Mamta Soni, Supraja Sundaram, Sindhuja Kesavan · 2021 · National Journal of Laboratory Medicine
Introduction: Haemophagocytic Lymphohistiocytosis (HLH) is a rapidly progressive life threatening condition in which activated macrophages engulf haematopoietic cells. HLH is often overlooked because of its rarity and lack of awareness of this prevailing condition. Though previously attempts have been made to quantify hemophagocytes in marrow aspirates, to the best of present knowledge, none of the studies have correlated the number of hemophagocytes with the clinical outcomes of the patients. Aim: To study the role of laboratory parameters and number of hemophagocytes detected in bone marrow
View details →DOI: 10.7860/njlm/2021/48806:2511 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Paula Melariri, Chioma Ihemanma, Udoka Chigbo et al. · 2024 · Journal of Parasitology Research
Malaria presents a huge threat to pregnant women, their foetus, and children below five years. This study is aimed at assessing malaria prevalence, associated clinical symptoms, and urine abnormalities among pregnant women in Aba metropolis, Abia State, Nigeria. A cross-sectional study involving 450 pregnant women purposively selected from nine health care centres was conducted. Data were analysed using SPSS version 26. The overall malaria prevalence rate was 68.4% (n=308). Age group of 21-25 years had the highest prevalence rate of 20.4% (n=92) while the least was recorded among the age group
View details →DOI: 10.1155/2024/6681943 Negative / Null Result ReportOpen accessOphthalmology
Neoh Yee Ling, Tan Ee Ling, Syed Mudassar Imran Bukhari et al. · 2015 · Journal of Clinical Ophthalmology and Research
Introduction: Systemic diseases such as hypertension and diabetes mellitus (DM) have been identified as the risk factor for glaucoma. However, there is minimal knowledge on the impact of systemic diseases on severity of glaucoma. This study aimed to determine the association between systemic disease and systemic treatment and severity of glaucoma. Materials and Methods: A cross-sectional study was conducted involving 298 primary open-angle glaucoma (POAG; 169 high tension glaucoma (HTG) and 129 normal tension glaucoma (NTG)) patients presented at the eye clinic of two tertiary hospitals in Mal
View details →DOI: 10.4103/2320-3897.163270 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Jian Sun, Zhiyong Shi, Lebao Yu et al. · 2022 · BMC Neurology
Abstract Objective To explore potential risk factors of preoperative cognitive dysfunction in adult patients with moyamoya disease (MMD) and discuss significance of moyamoya vessels. Methods The author reviewed adult MMD patients harboring no parenchymal infarction or hemorrhage underwent a standardized neuropsychological assessment test battery from December 2018 to May 2019. The authors defined patients with cognitive dysfunction as cognitive impairment shown on 3 or more neuropsychological tests. According to the presence of cerebral angiography, arterial stenosis, moyamoya vessels, and com
View details →DOI: 10.1186/s12883-021-02511-2 Negative / Null Result ReportOpen accessNursing
Parul Sharma, Bindu Shaiju, Jahanara Rahman et al. · 2024 · Indian Journal of Psychiatric Nursing
Introduction: Nurses make up the largest group of health-care workers, so it is important to rule out compassion fatigue (CF) and compassion satisfaction among nursing officers. Methodology: A descriptive study was adopted, and purposive sampling technique was used. The present study’s sample included 134 nursing officers. The data were gathered in January 2022 using the Structured CF Scale and the Structured Compassion Satisfaction Scale. The data were analyzed using descriptive and inferential statistics. Results: The findings of the research revealed that the majority of the nursing officer
View details →DOI: 10.4103/iopn.iopn_50_22 Negative / Null Result ReportOpen accessMedicine (General)
Katarzyna Budzynska, Daniel Passerman, Denise White-Perkins et al. · 2018 · BMC Family Practice
Abstract Background Colorectal cancer (CRC) develops from colorectal adenomatous polyps. This study is to determine if diabetes mellitus (DM), its treatment, and hemoglobin A1c (HbA1c) level are associated with increased risk of colorectal adenomatous polyps. Methods This was a retrospective cohort study that included patients who had at least one colonoscopy and were continuously enrolled in a single managed care organization during a 10-year period (2002–2012). Of these patients (N = 11,933), 1800 were randomly selected for chart review to examine the details of colonoscopy and pathology fin
View details →DOI: 10.1186/s12875-018-0835-1 Negative / Null Result ReportOpen accessPsychiatry
U. Raja, A. Misra, N. Kar · 2024 · European Psychiatry
Introduction The Crisis and Home Treatment Teams (CRHT) in psychiatry manages patients with risk to self and others in the community. The number of patents under CRHT who attempt or die of suicide is high in the UK (Hunt et al BJPsych Bull. 2016;40:172-4). The CRHT is an option to help support patients in managing their risk using various interventions and also aim to prevent admission to acute psychiatric wards where possible. Objectives We intended to study the change in risk to self and others and the factors associated with it during the intervention from a CRHT taking care of adult patien
View details →DOI: 10.1192/j.eurpsy.2024.1188 Negative / Null Result ReportOpen accessMedicine
Hoda Shamsaddin, Fatemeh Jahanimoghadam, Hamidreza Poureslami et al. · 2017 · Journal of Oral Health and Oral Epidemiology
BACKGROUND AND AIM: Early childhood caries (ECC) is a specific form of rampant dental caries affecting infants and young children. ECC is still a problem that threatens the health of the community and its management is important. It is believed that the majorities of children with ECC also suffer from malnutrition, anemia, low weight and altered physical growth patterns. This study was undertaken to compare blood indices [mean corpuscular volume (MCV), hemoglobin and serum ferritin] in a population of children in Kerman, Iran, and the association between growth factors, blood parameters, and E
Negative / Null Result ReportOpen accessMedicine
Yousef Roosta, Ahmad Nazarpour, Farhad Behzadi et al. · 2025 · Disease and Diagnosis
Background: The number of individuals undergoing dialysis is rising. Impaired renal function has been linked to a heightened risk of cancer. This study aimed to examine cancer incidence among hemodialysis (HD) patients. Materials and Methods: This retrospective cross-sectional study analyzed the medical records of individuals with newly diagnosed end-stage renal disease (ESRD) who initiated HD sessions between July 2018 and December 2023 at Urmia Imam Khomeini hospital. The data collected for this study included patient demographics, underlying diseases, malignancy status, and duration of mali
View details →DOI: 10.34172/ddj.1643 Negative / Null Result ReportOpen accessOrthopedic surgery
Koichiro Yanai, MD, Tsuyoshi Tajika, MD, PhD, Yuhei Hatori, MD et al. · 2025 · JSES International
Background: An increase in carrying angle (CA) on the throwing side has been reported in professional baseball pitchers. However, no reports have investigated high school baseball pitchers, and the associated factors remain unknown. This study aimed to examine the difference in the CA between the throwing and nonthrowing sides in high school baseball pitchers and to investigate the association between the CA and medial instability of the elbow and general joint laxity (GJL). Methods: We surveyed 216 high school baseball pitchers who underwent medical checkups during the 2023-24 off-season. All
View details →DOI: 10.1016/j.jseint.2025.02.023 Negative / Null Result ReportOpen accessMedicine (General)
Shichong Jia, Xuyang Wen, Min Zhou et al. · 2021 · Frontiers in Medicine
Purpose: To evaluate the efficacy of an external carotid artery (ECA) alternative route in intra-arterial chemotherapy (IAC) for treatment of retinoblastoma.Methods: In this retrospective, single-centre, case-control study, 98 retinoblastoma patients who received successful IAC were included. The drug delivery routes were the primary ophthalmic artery (OA) route and the ECA route when OA catheterization was not feasible.Results: A total of 337 successful IAC procedures were performed in our study, of which 32 (9.5%) procedures were performed through the ECA route. Eighteen eyes (18.4%) accepte
View details →DOI: 10.3389/fmed.2021.658305 Negative / Null Result ReportOpen accessMedicine
Arno C Hessels, Abraham Rutgers, Jan Stephan F Sanders et al. · 2018 · PLoS ONE
Azathioprine is a widely used immunosuppressive drug. Genetic polymorphisms and activity of the enzyme thiopurine methyltransferase (TPMT) have been associated with azathioprine efficacy and toxicity in several populations. We investigated whether these associations also exist for ANCA associated vasculitis (AAV) patients, who receive azathioprine maintenance therapy after remission induction with cyclophosphamide.207 AAV patients treated with cyclophosphamide induction and azathioprine maintenance therapy were included and followed for 60 months. TPMT genotype and tertiles of TPMT activity we
View details →DOI: 10.1371/journal.pone.0195524 Negative / Null Result ReportOpen accessMedicine (General)
Almansour A, Alagil J, Alamoudi NB et al. · 2022 · Journal of Multidisciplinary Healthcare
Abdulelah Almansour,1 Jumana Alagil,2 Naela B Alamoudi,3 Rahmah M Alamrie,3 Sundus Alarifi,4 Sarah AlUrifan,4 Abdullatif Althunyan,1 Abdullah Alghumlas,1 Abdullah Alreedy,1 Adam Aldhawyan,1 Shaher Alshehri,1 Arwa Alumran5 1Family and Community Medicine Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 3College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 4General Dentist, Ministry of Health, Dammam, Saudi Arabia; 5Health Information Man
