A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21300 results · page 366 of 710
Quévreux P, Zou K, Barot S et al. · 2025 · Freshwater Biology
The classical concepts of top‐down and bottom‐up cascading effects in ecosystems are challenged by the interactions between green and brown food webs. The green food web relies on photosynthesis and the brown food web relies on the…
Amindarolzarbi A, Satcowitz K, Khalil A et al. · 2025 · Nuclear medicine communications
Objective The appropriate clinical management of indeterminate small renal masses can be improved based on accurate risk stratification. This study aimed to investigate the impact of renal function on the uptake of technetium-99m ( 99m…
Prieto ML, Madison DV, Maduke M · 2025 · Biophysical journal
Ultrasound neuromodulation is a rapidly developing tool for noninvasive control of brain activity. An in vitro model recapitulating the effects of ultrasound on neural tissue in vivo would be extremely valuable in guiding the development…
Medina Poeliniz C, Hoban R, Janes J et al. · 2025 · Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
Objective: To determine if cumulative measures of pumping behaviors over the first 5 days postpartum predicted lactation outcomes by postpartum days 7 (achievement of secretory activation [SA] and pumped milk volume) and 14 (achievement of…
Prasifka JR, Fugate KK, Hulke BS · 2025 · Crop Science.
Variation in the quality, quantity, or accessibility of nectar and pollen within plant species is a potential target for plant breeding, both to enhance pollination and to support nutritional needs of pollinators. A biparental population…
Shi J, Chen M, Zhang Y et al. · 2026 · Psychopharmacology
Rationale Autism spectrum disorder (ASD) is characterized by cognitive deficits, repetitive behaviors, and social impairments. The SH3 and multiple ankyrin repeat domains protein 3B-deficient (Shank3B -/- ) mouse model displays ASD-related…
Park SJ, Manson JE, Kim E et al. · 2026 · Thrombosis and haemostasis
Epidemiological and experimental studies suggest cocoa flavanols and multivitamin-multimineral (MVM) supplements may confer arterial vascular benefits. However, their effects on clinical venous thromboembolic events have been infrequently…
McGregor D, Shynkaruk T, Adler CAB et al. · 2026 · Poultry science
Commercial transport of newly hatched poultry species typically occurs under darkness. The impact of providing light during chick transportation has not been investigated and previous research suggests blue light may have a calming effect…
Prandin G, Naccarato M, Furlanis G et al. · 2025 · Clinical autonomic research : official journal of the Clinical Autonomic Research Society
Background Sympathetic activation, inflammation, and neuro-endocrine response after an ischemic stroke contribute to the development of the stroke heart syndrome (SHS). One marker of SHS is a troponin "rise and fall pattern" > 30%. Among…
McAnena AP, McClennen T, Gala RJ · 2026 · North American Spine Society journal
Background ISDs treat spinal stenosis via a minimally invasive approach, but limited studies assess their efficacy and durability. The objective of this study was to characterize the incidence of adverse event reports (AERs) compared to…
Ahiatsi M, Milot MH, Flaive A et al. · 2026 · BMC neurology
Purpose Chronic pain is a common consequence of stroke, often impairing survivors' quality of life. By targeting cranial nerves and brainstem regions involved in pain modulation, cranial nerve non-invasive neuromodulation (CN-NINM) offers…
Dinleyici EC, Indrio F, Szajewska H et al. · 2026 · Journal of pediatric gastroenterology and nutrition
For many years, biotics (including probiotics, prebiotics, human identical milk oligosaccharides, synbiotics, and postbiotics) have been added to infant formula to influence the gut microbiota of formula-fed infants, aiming to bring it…
Brizuela M, Bony AR, Garcia-Caraballo S et al. · 2026 · Experimental physiology
Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage-gated calcium and potassium channels by G protein-coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the…
Lemper M, Luetjens CM, Fuchs A et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)
To further understand the safety profile of zilucoplan, reproductive toxicology studies in non-human primates (NHPs) were performed, including a male fertility study and a combined embryo-foetal development (EFD) and enhanced pre- and…
Alshuweishi Y, Binzomah Alghamdi F, Patrick K et al. · 2025 · Cells
AMP-activated protein kinase (AMPK) is activated by reduced cellular energy charge and mimics the action of insulin in muscle by stimulating increased trafficking of GLUT4 to the plasma membrane. In contrast, we have previously reported…
Kishinevsky M, Ferrer-Suay M, Ives AR · 2024 · Preprint
The enemy release hypothesis, that the success of invading species is due to release from natural enemies that occur in their home range but not in the new range, can be an important explanation for successful invasions. Testing this…
Almutairi NM, Hayes J, Hampson KM et al. · 2025 · Vision research
Individuals with mild traumatic brain injury (mTBI) exhibit significant accommodative abnormalities. Accommodation microfluctuation (MFs) plays an important role in the accommodation steady-state control. This study was set to investigate…
Kim AR, Jamka J, Jackson WF et al. · 2026 · Cells
Anticontractile factors secreted by perivascular adipose tissue (PVAT) play an important role in regulating vascular tone. This process is driven by the neurotransmitter norepinephrine (NE), but recent data show that adrenergic innervation…
Mockett BG, Davies JWT, Mills ZB et al. · 2024 · Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Group I metabotropic glutamate receptors (Gp1-mGluRs) exert a host of effects on cellular functions, including enhancement of protein synthesis and the associated facilitation of long-term potentiation (LTP) and induction of long-term…
Fu SJ, Cheng KM, Hsiao CT et al. · 2024 · Cell communication and signaling : CCS
Loss-of-function mutations in the human gene encoding the neuron-specific Ca 2+ channel Ca V 2.1 are linked to the neurological disease episodic ataxia type 2 (EA2), as well as neurodevelopmental disorders such as developmental delay and…
Videtta G, Sasia C, Quadrino S et al. · 2026 · Molecules (Basel, Switzerland)
Activation of microglia and resulting neuroinflammation are central processes that significantly contribute to neurodegenerative disease progression. Treatments capable of attenuating neuroinflammation are therefore an urgent medical need.…
Nguyen AP, Hadi DL, Todd DA et al. · 2026 · Clinical pharmacology and therapeutics
Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5-fold…
Xu C, Annapureddy H, Carson L et al. · 2026 · JCI insight
Antiretroviral therapy (ART) has prolonged the life expectancy of persons living with HIV, the majority of whom are now older than 50 years. Aging people with HIV are at increased risk for cardiovascular events driven by HIV-related…
Brandt RB, Lansbergen CS, Kollenburg L et al. · 2025 · Headache
Background/objective Occipital nerve stimulation (ONS) has become an established therapy for medically intractable chronic cluster headache (MICCH), but unfortunately, one third of the patients do not respond satisfactorily. Reliable…
Hagedoorn L, Ruiz-Rodríguez A, Leijen I et al. · 2025 · Experimental gerontology
Background Perturbation-based training improves reactive stepping responses to prevent falling following a loss-of-balance. As there is currently no safe and feasible method for home-based practice, this randomized study investigated…
Chiang Yu Y, Lu D, Rege B et al. · 2024 · Journal of pharmaceutical sciences
The addition of antioxidants to pharmaceutical products is a potential approach to inhibit nitrosamine formation, particularly in solid oral dosage forms like tablets and capsules. The objective was to assess the effect of ten antioxidants…
Gootjes C, Zwaginga JJ, Nikolic T et al. · 2026 · PloS one
Iscalimab is a nondepleting anti-CD40 monoclonal antibody, expected to suppress immune responses by blocking the costimulation by antigen-presenting cells through CD40-CD40L ligation. This therapeutic antibody indeed inhibited…
Forde G, Brucker BM, Becker Ifantides K et al. · 2024 · Toxins
OnabotulinumtoxinA (onabotA) is approved in the US for 12 therapeutic indications. Real-world data on onabotA multi-indication use are limited, often leading to delayed or reduced treatment. This study provides real-world evidence on the…
Goettel M, Werner C, Honarvar N et al. · 2024 · Toxicology
The fungicide fluxapyroxad (BAS 700 F) has been shown to significantly increase the incidence of liver tumours in male Wistar rats at dietary levels of 1500 and 3000 ppm and in female rats at a dietary level of 3000 ppm via a non-genotoxic…
Kornienko TE, Chepanova AA, Kolobenko MV et al. · 2026 · Current issues in molecular biology
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a key enzyme for the repair of stalled topoi-somerase 1 (TOP1)-DNA complexes. We have previously developed a TDP1 inhibitor, compound OL9-116, which is capable of enhancing the action of the…