Negative / Null Result ReportMedicine
Stub M, Ramhøj L, Axelstad M et al. · 2026 · Reproductive toxicology (Elmsford, N.Y.)
Perfluorooctane sulfonate (PFOS) and tetrabromobisphenol A (TBBPA) are environmental pollutants with known endocrine disrupting potential. Both substances display various thyroid hormone (TH) system disrupting effects, both in vitro and in…
View details →DOI: 10.1016/j.reprotox.2026.109170 Negative / Null Result ReportOpen accessMedicine
Panzenböck LF, Abdel Nour G, Dürrschnabel DL et al. · 2026 · Global spine journal
Study DesignRandomized controlled trial.ObjectivesTo characterize postoperative C-reactive protein (CRP) trajectories as predictors of surgical site infection (SSI) following lumbar spine surgery, to determine optimal CRP thresholds, and…
View details →DOI: 10.1177/21925682261450878 Failed Experiment Report
Barbosa APO, Santos LM, Catelli AM et al. · 2026 · Preprint
Abstract Background Patients with chronic kidney failure (CKF) present changes in physical capacity and low exercise tolerance. Photobiomodulation therapy (PBMT) has shown an ergogenic effect on exercise in studies with different…
View details →DOI: 10.21203/rs.3.rs-8149683/v1 Failed Experiment ReportMedicine
Reis-Silva LL, Tomeo RA, Barreto-de-Souza L et al. · 2026 · Autonomic neuroscience : basic & clinical
The present study investigated the contribution of corticotropin-releasing factor (CRF) neurotransmission acting through local CRF₁ receptors in the anterior (aIC), rostral-posterior (rpIC), and caudal-posterior (cpIC) subregions of the…
View details →DOI: 10.1016/j.autneu.2026.103403 Negative / Null Result ReportMedicine
Yardimci A, Ertugrul NU, Akkoc RF et al. · 2026 · Reproductive biology
Ozone (O₃) has been used to treat various diseases for many years, with most preclinical studies focusing on its effects in conditions such as testicular torsion and ischemia-reperfusion injury; however, its impact on male reproductive…
View details →DOI: 10.1016/j.repbio.2026.101185 Negative / Null Result ReportMedicine
Wang CI, Cho YC, Lin YP · 2025 · Environmental Technology & Innovation
Harmful asbestos-containing waste is generated during old building demolition. This study aims to develop a thermal-chemical treatment method to detoxify asbestos-containing waste and explore the potential use of detoxified…
Negative / Null Result ReportMedicine
Kęska P, Zielińska D, Karbowiak M et al. · 2025 · Food Chemistry
The aim of this study was to evaluate the effectiveness of cell-free supernatants (CFS) produced by selected lactic acid bacteria (LAB) strains: Lacticaseibacillus paracasei B1 and Lactiplantibacillus plantarum O24 as antioxidant and…
Negative / Null Result ReportOpen accessMedicine
Patoglu OR, Horne RSC, Mann DL et al. · 2026 · European journal of pediatrics
A hallmark of Prader-Willi syndrome (PWS) is hypothalamic-pituitary axis dysfunction, which can result in reduced growth hormone (GH) production. While GH replacement therapy is common in children with PWS, it has also been implicated in…
View details →DOI: 10.1007/s00431-026-06857-y Negative / Null Result ReportMedicine
Eser M, Yazıcı C, Kandemir Ü et al. · 2026 · Research in veterinary science
Ivermectin (IVR) is a semi-synthetic macrocyclic lactone widely used against nematodes. Under physiological conditions, its central nervous system (CNS) penetration is limited by P-glycoprotein-mediated efflux at the blood-brain barrier…
View details →DOI: 10.1016/j.rvsc.2026.106105 Negative / Null Result Report
Targhetta VP, Vieira RdS, Ranfley H et al. · 2025 · Preprint
Inflammasomes are multiprotein complexes that activate pro-caspase-1, leading to the maturation of the pro-inflammatory cytokines IL-1β and IL-18. Nlrp1 , the first receptor identified with inflammasome-forming capacity, is highly…
View details →DOI: 10.1101/2025.11.24.690170 Negative / Null Result ReportMedicine
Farber C, Jackson C, Renteria K et al. · 2026 · Nutrition (Burbank, Los Angeles County, Calif.)
Background Exposure to a Western diet during gestation and lactation adversely impacts offspring mood, learning, and memory. We determined if high dose maternal methyl donor nutrient (MDN) supplementation ameliorated the effects of a high…
View details →DOI: 10.1016/j.nut.2026.113149 Negative / Null Result ReportMedicine
Khaliji E, Marycz K, Horna M et al. · 2025 · American journal of veterinary research
Objective To evaluate IA autologous platelet-derived mitochondrial preparation versus vehicle control in a bilateral lipopolysaccharide (LPS)-induced model of equine synovitis. Methods 2 ng of LPS was injected into bilateral intercarpal…
View details →DOI: 10.2460/ajvr.25.05.0187 Negative / Null Result Report
Rodriguez CG, Choolani M, Illanes S · 2025 · Preprint
Objective: To study variation in moral attitudes toward selective abortion in case of prenatal diagnosis of a disability in the general population. Methods: 926 participants completed a survey in which they expressed their moral views…
View details →DOI: 10.31234/osf.io/avs6c_v2 Negative / Null Result Report
Rodriguez CG, Choolani M, Illanes S · 2025 · Preprint
Objective: To study variation in moral attitudes toward selective abortion in case of prenatal diagnosis of a disability in the general population. Methods: 926 participants completed a survey in which they expressed their moral views…
View details →DOI: 10.31234/osf.io/avs6c_v1 Negative / Null Result Report
VanRyzin JW, Laraia GA, Gyawali U et al. · 2025 · Preprint
ABSTRACT Astrocyte dysfunction within the nucleus accumbens (NAc) has been increasingly implicated in maladaptive reward processing and the development of addiction-like behaviors. In this study, we investigated how impairing astrocyte…
View details →DOI: 10.1101/2025.10.20.683571 Negative / Null Result ReportMedicine
Quan F, Ma J, Zhao Y et al. · 2025 · Aquaculture international
This study investigated the effects of supplementing high soybean meal diets with alpha-ketoglutaric acid (AKG) on the intestinal health and growth performance of spotted sea bass (Lateolabrax maculatus). A total of 270 fish (average…
Negative / Null Result ReportMedicine
Zoughaib WS, Fry MJ, Singhal A et al. · 2026 · Medicine and science in sports and exercise
Purpose Increasing nitric oxide bioavailability via nitrate (NO 3- ) ingestion enhances muscle contractility, which may be due to phosphorylation of the regulatory light chain of myosin. If so, there should be an interaction between NO 3-…
View details →DOI: 10.1249/mss.0000000000003932 Negative / Null Result Report
Svigruha R, Yañez-Guerra LA, Caña-Bozada VH et al. · 2025 · Preprint
Abstract Ecdysone-controlled pathways regulate ecdysozoan development through both a nuclear (nEcR) and a membrane receptor (mEcR). Ecdysone signaling was long thought to be exclusive to ecdysozoans; however, studies since 2010 have…
View details →DOI: 10.21203/rs.3.rs-8193722/v1 Negative / Null Result ReportMedicine
Wackernagel D, Gavelli V, Nydert P · 2025 · Clinical nutrition ESPEN
Background & aims In preterm and sick newborn infants, peripherally inserted central catheters (PICC) are used for the delivery of concentrated parenteral nutrition and other high risk drugs. Despite the precaution issued by the ESPGHAN…
View details →DOI: 10.1016/j.clnesp.2025.03.024 Negative / Null Result ReportMedicine
Barbosa MG, Vos DY, Verzijl CRC et al. · 2026 · Cellular and molecular gastroenterology and hepatology
Background & aims Hepatocellular carcinoma is the third leading cause of cancer-related mortality worldwide. Therapeutic options for hepatocellular carcinoma remain limited, and the mechanisms underlying hepatocellular carcinoma are not…
View details →DOI: 10.1016/j.jcmgh.2026.101788 Negative / Null Result ReportMedicine
Wooliver R, Neupane A, DeBruyn JM et al. · 2026 · Journal of environmental quality
Microplastics derived from agricultural plastic films accumulate in soils, potentially impacting ecosystem functions such as soil organic carbon (SOC) storage. Microbial degradation of biodegradable plastics, which are intentionally tilled…
View details →DOI: 10.1002/jeq2.70135 Negative / Null Result Report
Inoue H · 2025 · Preprint
Abstract The novel coronavirus SARS-CoV-2, commonly referred to as COVID-19, triggered a global pandemic. Although understanding the nature of international infection spread is critically important, extracting diffusion networks from…
View details →DOI: 10.21203/rs.3.rs-7395229/v1 Negative / Null Result ReportMedicine
Zhao X, Tian Q, Michelsen A et al. · 2025 · Applied Soil Ecology.
Roots and extraradical mycelium (EMM) influence the soil carbon (C) cycle, but it remains unclear how warming alters their effects on soil organic carbon (SOC) and its composition in alpine swamp meadows. A three-year ingrowth core…
Negative / Null Result ReportMedicine
Bertrand-Ndoye M, Girard H, Hakim F et al. · 2026 · Forensic science international
In forensic thanatology, post-mortem blood is often stored for long periods, leading to in vitro variations in drug concentrations. This study evaluated the use of dried blood microsampling supports dried (Dried Blood Spot - DBS and…
View details →DOI: 10.1016/j.forsciint.2025.112798 Negative / Null Result ReportOpen accessMedicine
Fukunaga N, Takanishi T, Wakami T et al. · 2026 · Circulation reports
Background The impact of emergency surgery for acute type A aortic dissection (ATAAD) on renal function in patients with autosomal dominant polycystic kidney disease (ADPKD) remains unclear. Methods and results The renal function of 4…
View details →DOI: 10.1253/circrep.cr-25-0255 Failed Experiment Report
Bradley A, Gmiro Y, Stoakes A et al. · 2026 · Preprint
Concerns about the impact of social media on young adult mental health persists despite weak and inconclusive empirical evidence. This study aimed to replicate a highly-cited study showing improved well-being after limiting time on social…
View details →DOI: 10.31234/osf.io/pehxw_v2 Replication FailureMedicine
Nguyen TT, Kanemoto Y, Sawada T et al. · 2026 · Bioscience, biotechnology, and biochemistry
Vitamin D (VD) and Wnt signaling both play important roles in bone metabolism and are targeted in osteoporosis therapy. Combination treatment with VD derivatives and anti-sclerostin antibodies that activate Wnt signaling improves clinical…
View details →DOI: 10.1093/bbb/zbag084 Replication Failure
Gama de Matos D, de Santana JL, Aidar FJ et al. · 2026 · Preprint
Background: Frailty is a multifactorial condition that significantly impacts older adults' health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…
View details →DOI: 10.20944/preprints202602.0236.v1 Replication FailureMedicine
Yang Y, Zeng L, Ren R et al. · 2026 · Veterinary sciences
Dental calculus is a highly prevalent oral condition in dogs and is widely recognized as an important risk factor for gingival inflammation and periodontal disease. Effective strategies for its prevention and treatment remain limited,…
View details →DOI: 10.3390/vetsci13060593 Replication Failure
Leonov G, Malvina A, Kosyura S et al. · 2026 · Preprint
Background Obesity is a modifiable risk factor for osteoarthritis and may contribute to pain, functional impairment, inflammation, and cartilage degradation. Resveratrol has potential anti-inflammatory and chondroprotective effects, but…
View details →DOI: 10.64898/2026.06.09.26355282 