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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21300 results · page 362 of 710

Negative / Null Result ReportMedicine

Preoperative Use of Glucagon-Like Peptide-1 Receptor Agonists Is Not Protective Against Pseudoarthrosis Following Small Joint Hand Arthrodesis: A Propensity-Matched Analysis.

Stump K, Morar H, Talsania A et al. · 2026 · Hand (New York, N.Y.)

Background Glucagon-like peptide-1 receptor agonist (GLP-1 RA) use has demonstrated positive effects on bone metabolism and pseudoarthrosis following fusion surgery. There is, however, little evidence regarding the preoperative use of…

View details →DOI: 10.1177/15589447261415646
Negative / Null Result Report

Second Replication of Finn & Hudson Kam (2008) Experiment 3

Ricketts W, Hartshorne JK · 2022 · Preprint

We replicated Experiment 3 of Finn & Hudson Kam (2008) The curse of knowledge: First language knowledge impairs adult learners' use of novel statistics for word segmentation, Cognition, 108(2), 477-499. This is part of a larger project…

View details →DOI: 10.31234/osf.io/yt9n8
Negative / Null Result Report

Second Replication of Finn & Hudson Kam (2008) Experiment 1

Ricketts W, Hartshorne JK · 2022 · Preprint

We replicated Experiment 1 of Finn & Hudson Kam (2008) The curse of knowledge: First language knowledge impairs adult learners’ use of novel statistics for word segmentation, Cognition, 108(2), 477-499. This is part of a larger project…

View details →DOI: 10.31234/osf.io/eu9cj
Negative / Null Result Report

Is musical engagement enough to keep the brain young?

Matziorinis AM, Gaser C, Koelsch S · 2022 · Preprint

Music-making and engagement in music-related activities have shown procognitive benefits for healthy and pathological populations, suggesting reductions in brain aging. A previous brain aging study, using Brain Age Gap Estimation…

View details →DOI: 10.21203/rs.3.rs-1991605/v1
Negative / Null Result ReportOpen accessMedicine

Genome-wide Association Study of Susceptibility to Respiratory Syncytial Virus Hospitalization in Young Children <5 Years of age.

Egeskov-Cavling AM, van Wijhe M, Yakimov V et al. · 2024 · The Journal of infectious diseases

Background Worldwide, respiratory syncytial virus (RSV) infections are among the most common causes of infant hospitalization. Host genetic factors influencing the risk and severity of RSV infection are not well known. Methods We conducted…

View details →DOI: 10.1093/infdis/jiad370
Negative / Null Result ReportOpen accessMedicine

Nicotinamide for Skin Cancer Chemoprevention: The Jury Was Out and Still is.

Tan E, Williams HC · 2026 · American journal of clinical dermatology

Nicotinamide has been widely promoted as a low-cost safe chemopreventive agent against non-melanoma skin cancer. A recent large retrospective study of more than 33,000 US veterans reported a 14% reduction in overall skin cancer risk and a…

View details →DOI: 10.1007/s40257-025-01005-y
Failed Experiment Report

Engineering Alignment has Mixed Effects on hiPSC-CM Maturation

Kalkunte NG, Delabmbre TE, Sohn S et al. · 2022 · Preprint

The potential of human induced pluripotent stem cell differentiated cardiomyocytes (hiPSC-CMs) is greatly limited by their functional immaturity. Strong relationships exist between CM structure and function, leading many in the field to…

View details →DOI: 10.1101/2022.09.26.509194
Negative / Null Result ReportOpen accessMedicine

Newborns' Language Discrimination May Not Reflect Sensitivity to Speech Rhythm: Evidence From Computational Modeling.

Famularo RL, Aboelata A, Schatz T et al. · 2026 · Developmental science

Human newborns are able to discriminate between certain languages but not others. This ability has long been attributed to sensitivity to rhythm-the temporal regularities in speech of different languages. Here, we demonstrate through a…

View details →DOI: 10.1111/desc.70220
Negative / Null Result ReportOpen accessMedicine

Is there a lower visual field advantage for object affordances? A registered report.

Warman A, Clark A, Malcolm GL et al. · 2024 · Quarterly journal of experimental psychology (2006)

It's been repeatedly shown that pictures of graspable objects can facilitate visual processing, even in the absence of reach-to-grasp actions, an effect often attributed to the concept of affordances. A classic demonstration of this is the…

View details →DOI: 10.1177/17470218241230812
Negative / Null Result ReportMedicine

Does interpersonal liking lead to interpersonal synchrony in musical contexts?

Melton ZJ, Chaffin R, Kangas-Dick K et al. · 2023 · Quarterly journal of experimental psychology (2006)

The causal relationship of interpersonal liking affecting interpersonal synchrony is inconsistently documented. This study tests whether (a) interpersonal liking increases both behavioural and perceived synchrony and (b) people will…

View details →DOI: 10.1177/17470218221094306
Negative / Null Result ReportMedicine

Genome scan reveals several loci associated with torus palatinus.

Lee MK, El Sergani AM, Herrick N et al. · 2025 · Orthodontics & craniofacial research

Objective Torus Palatinus (TP) is a common trait with an unclear aetiology. Although prior studies suggest a hereditary component, the genetic factors that influence TP risk remain unknown. The purpose of this study is to identify genetic…

View details →DOI: 10.1111/ocr.12857
Negative / Null Result ReportMedicine

Evaluating factors associated with paediatric cochlear implant outcome in four cochlear implant satellite centres in Malaysia.

Tengku Kamalden TMI, Azali MZ, Chong LC et al. · 2022 · The Medical journal of Malaysia

Introduction Many factors are associated with cochlear implant (CI) outcomes and various methods of assessment for auditory and speech performance outcomes in CI are available globally. The objective of this study is to identify factors…

Negative / Null Result Report

Genome-wide determination of barriers to horizontal gene transfer

Burch CL, Romanchuk A, Kelly M et al. · 2022 · Preprint

Horizontal gene transfer (HGT) is a major contributor to bacterial genome evolution, generating phenotypic diversity, driving the expansion of protein families, and facilitating the evolution of new phenotypes, new metabolic pathways, and…

View details →DOI: 10.1101/2022.06.29.498157
Negative / Null Result ReportMedicine

Generalizability and Out-of-Sample Predictive Ability of Associations Between Neuromelanin-Sensitive Magnetic Resonance Imaging and Psychosis in Antipsychotic-Free Individuals.

Wengler K, Baker SC, Velikovskaya A et al. · 2024 · JAMA psychiatry

Importance The link between psychosis and dopaminergic dysfunction is established, but no generalizable biomarkers with clear potential for clinical adoption exist. Objective To replicate previous findings relating neuromelanin-sensitive…

View details →DOI: 10.1001/jamapsychiatry.2023.4305
Negative / Null Result Report

Little Support for Discrete Item Limits in Visual Working Memory

Oberauer K · 2021 · Preprint

Some theorists argue that working memory is limited to a discrete number of items, and additional items are not encoded at all. Others assume that all items are represented with variable quality. Adam, Vogel, and Awh (2017) presented…

View details →DOI: 10.31234/osf.io/c9baj
Negative / Null Result ReportOpen accessMedicine

Antibiotic-Induced Microbial Dysbiosis Worsened Outcomes in the Activity-Based Anorexia Model.

Kooij KL, Andreani NA, Keller L et al. · 2025 · The International journal of eating disorders

Objective Anorexia nervosa (AN) is a complex psychiatric disorder characterized by persistent dieting and reduced food intake, leading to significantly low body weight. Dysbiosis in the gut microbiome of patients with AN has been suggested…

View details →DOI: 10.1002/eat.24452
Failed Experiment ReportMedicine

Task measuring implicit attractiveness as a function of skin tone and facial features: a failed replication.

Stepanova EV, Strube MJ, Mazur KD · 2023 · The Journal of social psychology

In two studies, participants completed an implicit attractiveness task with faces as primes varying on (a) facial features from Afrocentric to Eurocentric and (b) skin tone from dark to light, and target pictures of environmental scenes…

View details →DOI: 10.1080/00224545.2021.2000355
Negative / Null Result ReportOpen accessMedicine

Mast cell activation within the mesentery depends on vagal signaling following abdominal surgery.

Woestemeier A, Schwandt T, Lingohr P et al. · 2026 · Surgery open science

Introduction Abdominal surgery causes an inflammatory reaction in the intestines, resulting in a postoperative ileus. Mast cells can be divided into mucosal mast cells and connective tissue mast cells. In this study, we investigated mast…

View details →DOI: 10.1016/j.sopen.2026.03.005
Negative / Null Result ReportMedicine

Polygenic risk and trajectories of depressive symptoms in diverse adolescents: Gene-environment interplay with family conflict and parental acceptance.

Jamil B, Su J, Elam K et al. · 2025 · Development and psychopathology

Introduction Past research suggests that polygenic scores for major depressive disorder (MDD-PGS), family conflict, and parental acceptance may all predict depressive outcomes among adolescents. Few studies have examined the interplay of…

View details →DOI: 10.1017/s0954579425101028