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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21300 results · page 361 of 710

Negative / Null Result ReportOpen accessMedicine

Accounting for Time-Varying Confounding in a Self-Controlled Case Series of Fluoroquinolone Treatment for Uncomplicated Urinary Tract Infections and Risk of Collagen-Related Events.

Schultze A, Ju S, Drysdale M et al. · 2025 · Pharmacology research & perspectives

We report findings from three SCCS conducted to quantify the association between fluoroquinolone (FQ) use for the treatment of uncomplicated urinary tract infection (uUTI) and tendon rupture, retinal detachment, and uveitis. Female…

View details →DOI: 10.1002/prp2.70124
Negative / Null Result ReportOpen accessMedicine

Cerebrospinal fluid haptoglobin levels and outcome after aneurysmal subarachnoid haemorrhage: Evidence from Mendelian randomization.

Kayode GA, Zagkos L, Oboli G et al. · 2025 · PloS one

Background Subarachnoid haemorrhage (SAH) poses a life-threatening risk, contributing to half of all haemorrhagic strokes, with aneurysmal SAH (aSAH) affecting approximately 6 individuals per 100,000 annually. Following aSAH, the influx of…

View details →DOI: 10.1371/journal.pone.0329287
Negative / Null Result ReportMedicine

Y-Balance Test after ACL Reconstruction: The relationship with knee and hip muscle strength, ankle dorsiflexion range of motion and postural stability.

Rodrigues CAS, Albano TR, Pereira Melo AK et al. · 2024 · Journal of bodywork and movement therapies

Background Y-Balance Test (YBT) assesses postural stability. When is applied to patients after anterior cruciate ligament reconstruction (ACLR), it is not clear which variables influence its result. Objective To connect YBT and postural…

View details →DOI: 10.1016/j.jbmt.2024.10.016
Negative / Null Result ReportOpen accessMedicine

Patient-Surgeon Sex Concordance and Clinical Outcomes After Adult Cardiac Surgery.

Harik L, Gregg AC, Wu Y et al. · 2026 · Journal of the American Heart Association

Background Patient-surgeon sex concordance influences postoperative outcomes in general surgery, but its relevance in cardiac surgery is unknown. Methods This was a cohort study of 223 065 Medicare beneficiaries undergoing coronary artery…

View details →DOI: 10.1161/jaha.125.048015
Negative / Null Result ReportOpen accessMedicine

Associations between usual source of care characteristics and health outcomes in diabetes mellitus: a focus on medication adherence and healthy behaviors in Korea.

Lee SE, Kim CW, Bae JE et al. · 2025 · Epidemiology and health

Objectives This study investigated the associations between usual source of care (USC) characteristics, which incorporate primary care functions, and medication adherence and healthy behaviors in Korean adults with diabetes. Methods We…

View details →DOI: 10.4178/epih.e2025063
Negative / Null Result ReportOpen accessMedicine

Early recurrence of febrile seizures during acute illness: risk factors and lack of association with long-term epilepsy in a Pediatric cohort.

Jiang W, Cheng A, Wang J et al. · 2025 · Frontiers in neurology

Background Febrile seizures (FSs) are a common neurological manifestation in children, affecting 2%-5% of children worldwide. While acute-phase recurrences during the same febrile illness are frequent, their risk factors and implications…

View details →DOI: 10.3389/fneur.2025.1733941
Negative / Null Result ReportOpen accessMedicine

MRI-Based Evaluation of PRP Therapy in Knee Osteoarthritis: WORMS and Synovial Changes at 6 Months.

Wakayama T, Saita Y, Uchino S et al. · 2025 · Journal of clinical medicine

Objective: Platelet-rich plasma (PRP) therapy has become a popular treatment for knee osteoarthritis. We aimed to determine the outcomes of knee osteoarthritis patients following PRP therapy using magnetic resonance imaging (MRI) findings…

View details →DOI: 10.3390/jcm14186408
Negative / Null Result ReportMedicine

Lack of association between nonalcoholic fatty liver disease and intracerebral hemorrhage: A community-based cohort study.

Wu J, Guo J, Wang A et al. · 2023 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Background The association between nonalcoholic fatty liver disease (NAFLD) and intracerebral hemorrhage (ICH) remains unclear. This study aimed to investigate whether NAFLD and its severity predict incident ICH. Methods Participants free…

View details →DOI: 10.1016/j.jocn.2023.09.027
Negative / Null Result ReportMedicine

Insulin resistance and beta-cell dysfunction in adults with different patterns of diet: a cross-sectional study in north-western Tanzania.

Malindisa EK, Dika H, Rehman AM et al. · 2025 · European journal of clinical nutrition

Background The diabetes burden in sub-Saharan Africa is rising, but there is little African data on associations between diet, insulin resistance, and beta-cell dysfunction. Objective We investigated the association between dietary…

View details →DOI: 10.1038/s41430-024-01518-5
Negative / Null Result ReportOpen accessMedicine

Lack of association of ABO and RhD blood groups with COVID-19 mortality: A 2-center cross-sectional study in Saudi Arabia.

Halawani AJ, Alhamoud AH, Kabrah SM et al. · 2024 · Medicine

Several diseases, including both noninfectious diseases and bacterial and viral diseases, are associated with the ABO and RH blood group systems. Previous studies have shown a link between blood type and the probability of coronavirus…

View details →DOI: 10.1097/md.0000000000039673
Negative / Null Result ReportOpen accessMedicine

Lack of association between prior or concurrent malignancies and overall survival in gastroesophageal cancer: evidence from a large European single-center cohort.

Puhr HC, Berchtold L, Zingerle L et al. · 2026 · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Background History of malignant disease is a common exclusion criterion in clinical cancer trials, yet data on the impact of cancer survivorship on outcome in gastroesophageal cancer patients are scarce. Methods Retrospective association…

View details →DOI: 10.1007/s12094-025-04036-3
Negative / Null Result ReportOpen accessMedicine

Impact of Prediabetes on In-Hospital Mortality and Clinical Outcomes in Acute Pancreatitis: Insights from a Nationwide Inpatient Sample.

Dakkak T, Silin N, Mahmood R et al. · 2025 · Journal of clinical medicine

Background/Objectives : Prediabetes is characterized by insulin resistance and systemic inflammation, which may increase susceptibility to acute pancreatitis (AP). However, limited data exist on how prediabetes influences in-hospital…

View details →DOI: 10.3390/jcm14124271
Negative / Null Result ReportOpen accessMedicine

Association of Gallstone and Polymorphisms of ABCB11 Gene among the Adult Patients in Iran: A Case Control Study : Gallstone and ABCB11 Gene.

Yektamoghaddam S, Forghanifard MM, Zrrinpour V et al. · 2025 · Galen medical journal

Background Background: Gallstone disease (GSD) is a prevalent gastrointestinal condition influenced by genetic, environmental, and dietary factors. The ATP-binding cassette subfamily B member 11 (ABCB11) gene, encoding the bile salt export…

View details →DOI: 10.31661/gmj.v14i.4066
Negative / Null Result ReportOpen accessMedicine

Impact of Parathyroidectomy on Vascular Stiffness: Exploring Pulse Wave Velocity and Renal Resistive Index.

Huber A, Pasquier T, Demarchi M et al. · 2026 · The Journal of clinical endocrinology and metabolism

Context Primary hyperparathyroidism (PHPT), characterized by elevated parathyroid hormone (PTH) and hypercalcemia, has been implicated in vascular calcification and increased arterial stiffness. Carotid-femoral pulse wave velocity (PWV) is…

View details →DOI: 10.1210/clinem/dgaf687
Negative / Null Result ReportOpen accessMedicine

Ejaculate Ejection by Female Fruit Flies Does Not Correlate With Mating Latency or Male Presence, Irrespective of How Ejection Is Measured.

Sanghvi K, Todorova B, Sepil I · 2025 · Ecology and evolution

Sexual selection operates across pre- and post-mating episodes, driven by intra-sexual competition and inter-sexual choice for mates or gametes. While these episodes can act in the same direction, this is not always the case; for example,…

View details →DOI: 10.1002/ece3.72281
Negative / Null Result ReportOpen accessMedicine

Dissociation between the expression of cGAS/STING and a senescence-associated signature in colon cancer.

Al Shboul S, Abu Al Karsaneh O, Alrjoub M et al. · 2025 · International journal of immunopathology and pharmacology

Objective The effect of the cGAS/STING pathway on antitumor immunity and its connection to senescence in vivo necessitates further investigation. Introduction Cellular senescence and its secretory phenotype (the SASP) are implicated in…

View details →DOI: 10.1177/03946320251324821
Negative / Null Result ReportOpen accessMedicine

Association of Previne Brasil Program with prenatal care and maternal-child mortality.

Arato CVB, Guerra LM, Probst LF et al. · 2025 · Revista de saude publica

Objective To investigate the impact of prenatal care on the reduction of maternal-child mortality in Brazilian municipalities following the new primary health care financing model, the Previne Brasil program. Methods This study comprised a…

View details →DOI: 10.11606/s1518-8787.2025059006735
Negative / Null Result ReportOpen accessMedicine

Longitudinal Adipokine and Lipid Profiles in Fabry Disease.

Gatterer C, Allmer D, Beitzke D et al. · 2026 · Journal of clinical medicine

Background/Objectives: Fabry disease (FD) is a lysosomal storage disorder characterized by progressive renal and cardiac involvement and an increased burden of cardiovascular and cerebrovascular events. While cardiac magnetic resonance…

View details →DOI: 10.3390/jcm15062390
Negative / Null Result ReportOpen accessMedicine

Changes in circulating miR-199a, cardiac troponin I, NT-proBNP, and left ventricular ejection fraction during anthracycline therapy in breast cancer patients.

Kamian S, Azadeh P, Anbiaee R et al. · 2026 · Cardio-oncology (London, England)

BACKGROUND: Anthracyclines are widely used in the treatment of breast cancer but are associated with myocardial injury that may progress to cardiac dysfunction. Surveillance has traditionally relied on left ventricular ejection fraction…

View details →DOI: 10.1186/s40959-026-00448-4
Negative / Null Result ReportMedicine

Chronic ankle instability affects the association between knee joint angle and loading: musculoskeletal simulation study.

Kim H, Kipp K · 2025 · Computer methods in biomechanics and biomedical engineering

The purpose of this study was to calculate and compare (1) knee loads, (2) muscle-specific contributions to knee loads, and (3) effects of knee flexion angle on knee loads and muscle-specific load contributions during a forward…

View details →DOI: 10.1080/10255842.2024.2327632
Negative / Null Result ReportOpen accessMedicine

Lack of association between SLFN11 expression and treatment efficacy or survival outcomes in patients with pancreatic ductal adenocarcinoma.

Nakamura T, Hatanaka KC, Kawamoto Y et al. · 2025 · Journal of cancer research and clinical oncology

Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Despite the use of aggressive combination chemotherapy regimens, outcomes remain unsatisfactory. Schlafen family member 11 (SLFN11) has been reported to regulate the DNA…

View details →DOI: 10.1007/s00432-025-06216-8
Negative / Null Result ReportMedicine

Metabolically healthy obesity and risks of cardiovascular disease and all-cause mortality, a matched cohort study: the Shizuoka study.

Tabara Y, Shoji-Asahina A, Ogawa A et al. · 2024 · International journal of obesity (2005)

Background Metabolically healthy obesity is not always a benign condition. It is associated with an increased incidence of cardiovascular disease and all-cause mortality. We investigated the prognostic significance of metabolically healthy…

View details →DOI: 10.1038/s41366-024-01541-3
Negative / Null Result ReportOpen accessMedicine

Association of Hormone Replacement Therapy with Inflammatory Bowel Disease Risk in Women with Menopausal Disorders: A Population-Based Retrospective Cohort Study.

Tseng YT, Chen II, Wang CH · 2025 · Healthcare (Basel, Switzerland)

Background : The long-term effects of hormone replacement therapy (HRT) on inflammatory bowel disease (IBD) remain unclear, necessitating further investigations of the association between HRT and the development of ulcerative colitis and…

View details →DOI: 10.3390/healthcare13050578
Negative / Null Result ReportMedicine

Association between pregnancy intention and postpartum contraceptive interest among pregnant people with opioid use disorder.

Schiff DM, Wheeler A, Lewis D et al. · 2026 · Journal of substance use and addiction treatment

Objective Identify sociodemographic and substance use characteristics associated with pregnancy intention and explore the relationship between pregnancy intent and postpartum contraception interest among pregnant individuals with opioid…

View details →DOI: 10.1016/j.josat.2026.209899