e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21300 results · page 363 of 710

Negative / Null Result ReportMedicine

Poller K-Wires versus Screws in Distal Tibial Nailing: Non-Inferior Union with Superior Efficiency and Better Alignment.

Yildirim AM, Bayram S, Karaçam MI et al. · 2026 · Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca

Purpose of the study To compare the short-term outcomes and complications of the poller screw (PS) and the poller K-wire (PW) in distal tibia nailing. Material and methods In the present study, a retrospective analysis was performed on…

View details →DOI: 10.55095/achot2026/011
Negative / Null Result ReportOpen accessMedicine

The role of proinflammatory response and the kynurenine pathway in the association between childhood maltreatment and lifetime substance use disorder.

Östman L, Paul ER, Zhang H et al. · 2026 · Neurobiology of stress

Introduction Childhood maltreatment (CM) is a risk factor for adult psychiatric and substance use disorders (SUD). Retrospectively assessed CM has been linked to increased proinflammatory cytokines, including IL-6. Induced by inflammation,…

View details →DOI: 10.1016/j.ynstr.2026.100820
Negative / Null Result ReportMedicine

Lactate Dynamic Changes as a Predictive Tool for Early Primary Graft Dysfunction After Lung Transplantation: A Retrospective Study.

Lin T, Liu S, Zhao Y et al. · 2026 · Transplantation proceedings

Background Primary graft dysfunction (PGD) is one of the most common and severe complications after lung transplantation. However, beyond the ratio of partial pressure of oxygen to fraction of inspired oxygen, there is a lack of objective…

View details →DOI: 10.1016/j.transproceed.2026.05.025
Negative / Null Result ReportOpen accessMedicine

Efficacy of mesotherapy in patients with acute and subacute neck pain: A randomized controlled trial.

Gonultas D, Kulcu DG, Kaymaz EP et al. · 2026 · Turkish journal of physical medicine and rehabilitation

Objectives This study aims to investigate the effectiveness of mesotherapy in patients with acute or subacute neck pain compared to oral medications with the same active ingredients. Patients and methods In this randomized, single-blind…

View details →DOI: 10.5606/tftrd.2025.16956
Negative / Null Result ReportOpen accessMedicine

Modulation of the gut microbiota as a novel strategy to prevent anastomotic leak after colorectal surgery: Systematic scoping review.

Helliwell JA, Sciberras P, Dosis A et al. · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Background Anastomotic leak (AL) remains a major source of morbidity following colorectal surgery. Increasing evidence implicates the gut microbiome in the pathogenesis of AL, with certain microbial species disrupting tissue repair through…

View details →DOI: 10.1111/codi.70472
Negative / Null Result ReportOpen accessMedicine

Efficacy of insecticide-infused hydrogel baits in managing European earwig (Dermaptera: Forficulidae) in citrus.

Dhungana SK, Gautam SG · 2026 · Journal of economic entomology

European earwig (Forficula auricularia L.) is an omnivorous insect commonly found in California citrus orchards. Often considered a beneficial predator, earwigs can damage young fruit, causing rind scarring and reducing the market value.…

View details →DOI: 10.1093/jee/toag108
Negative / Null Result ReportOpen accessMedicine

Fracture Resistance of Mineral Trioxide Aggregate- and Biodentine-Pulpotomized teeth with Different Restorative Techniques: An in vitro Study.

Farhadpour H, Ghahramani Y, Jahani M et al. · 2026 · Journal of dentistry (Shiraz, Iran)

Background Preserving the radicular pulp in traumatically or mechanically exposed teeth through coronal pulpotomy (CP) is an advantageous endodontic procedure. Purpose This study compared the fracture resistance (FR) of mineral trioxide…

View details →DOI: 10.30476/dentjods.2025.105152.2573
Negative / Null Result ReportOpen accessMedicine

Dexmedetomidine for improving postpartum sleep quality following cesarean section in women: a randomized controlled trial.

Gao J, Hu CC, Wang XY et al. · 2026 · Frontiers in medicine

Background Perinatal sleep disturbance is highly prevalent among women undergoing elective cesarean section. Dexmedetomidine has been proven effective in improving sleep quality in patients undergoing general surgery, and this study aimed…

View details →DOI: 10.3389/fmed.2026.1823100
Negative / Null Result ReportMedicine

The evaluation of sexual dysfunction in patients with spinopelvic dissociation underwent triangular osteosynthesis: A single-center retrospective study.

Erkan S, Kurt C, Kaçmaz SE et al. · 2026 · Injury

Background Spinopelvic dissociation (SPD) is an infrequent high-energy injury, which is often associated with lumbosacral plexus and cauda equina deficits Sexual dysfunction (SD) is a common comorbidity of the SPD, caused by direct or…

View details →DOI: 10.1016/j.injury.2026.113165
Negative / Null Result ReportOpen accessMedicine

Attentional modulation of sensory gating during a visuomotor task.

Nguyen Van C, Le Trung D, Okamoto T et al. · 2026 · The journal of physiological sciences : JPS

Attention is crucial for motor performance because it enhances task-relevant processing while suppressing distractions. However, physiological markers of attentional engagement during motor activity remain incompletely understood. The…

View details →DOI: 10.1016/j.jphyss.2026.100080
Negative / Null Result ReportOpen accessMedicine

Eltrombopag Combined With Cyclosporine A in the Treatment of Pediatric Patients With SAA: Establishing the Range for Eltrombopag Concentrations.

Li F, Li N, Tang X et al. · 2026 · Clinical and translational science

Eltrombopag (ELT), as an oral thrombopoietin receptor agonist, in combination with cyclosporine A (CsA) provides a novel therapeutic option for pediatric severe aplastic anemia (SAA). However, current clinical protocols predominantly adopt…

View details →DOI: 10.1111/cts.70631
Negative / Null Result ReportOpen accessMedicine

Performance of Youth Athletes Is Not Consistently Determined by Maturity or Training Experience: A Cross-Sectional Study.

Lykidis A, Pechlivanos RG, Angelou A et al. · 2026 · Journal of functional morphology and kinesiology

Objective: The purpose of this study was to compare the influence of biological maturity status and training experience on motor performance in young athletes of different sport disciplines. Methods: Youth athletes (n = 84, 23 females)…

View details →DOI: 10.3390/jfmk11020166
Negative / Null Result ReportOpen accessMedicine

Colchicine has Dose-Dependent Therapeutic Effects in a LPS-Induced Experimental Endotoxemia Model.

Demir M, Gocmen AY, Ozcelebi E et al. · 2026 · Pharmacology research & perspectives

Colchicine is an ancient medication that has long been used for anti-inflammatory properties. Because of unfavorable and toxic consequences of colchicine, selecting an appropriate dose is critical. The effects of three different doses…

View details →DOI: 10.1002/prp2.70239
Negative / Null Result ReportOpen accessMedicine

Effects of different intensities of repetitive peripheral magnetic stimulation on corticospinal excitability and motor performance in healthy humans.

Omiya A, Shitara K, Miyazaki D et al. · 2026 · PloS one

Repetitive peripheral magnetic stimulation (rPMS) has been applied in clinical settings to enhance the recovery of motor function following central nervous system lesions. However, the optimal intensity of rPMS for inducing neural…

View details →DOI: 10.1371/journal.pone.0349300
Negative / Null Result ReportMedicine

Low Vision Assessment in Virtual Reality (LVAVR): Spatial Computing in Virtual Reality and Real-World.

Bailey E, Roy P, Shifflett K et al. · 2026 · 2026 IEEE Conference on Virtual Reality and 3D User Interfaces Abstracts and Workshops

The Low Vision Assessment in Virtual Reality project aims to create performance assessments of activities of daily living for a broad low vision population in virtual reality. In this study, our goal is to validate representative virtual…

View details →DOI: 10.1109/vrw70859.2026.00284
Negative / Null Result Report

Efficacy and safety of rituximab combined with glucocorticoids in patients with primary membranous nephropathy: a single-center retrospective cohort study

Zhao C, Feng S, Hu Z et al. · 2026 · Preprint

Abstract Background To compare the clinical efficacy and safety of rituximab (RTX) monotherapy versus the combination of RTX and glucocorticoids (GC) in the treatment of primary membranous nephropathy (PMN). Methods This retrospective,…

View details →DOI: 10.21203/rs.3.rs-9750129/v1
Negative / Null Result ReportMedicine

Quantitative assessment of tumor burden in multiple myeloma using MY-RADS from whole-body MRI: comparison with established prognostic biomarkers.

Xiong X, Yan Z, Wang J et al. · 2026 · Cancer imaging : the official publication of the International Cancer Imaging Society

Background To explore the value of MY-RADS from whole-body MRI in assessing tumor burden in MM with reference to established prognostic biomarkers. Methods 108 consecutive newly diagnosed MM patients were retrospectively enrolled. Bone…

View details →DOI: 10.1186/s40644-026-01076-y
Negative / Null Result ReportMedicine

Feasibility and signal quality of the Minder® implantable continuous EEG monitoring® system compared to 10-20 scalp electrodes over extended monitoring periods.

Ganguly TM, Lai A, Niemiec A et al. · 2026 · Epilepsia

Objective To evaluate the signal quality of the Minder implantable continuous EEG monitoring (iCEM) system compared to traditional scalp EEG in the context of long-term, continuous monitoring in individuals with epilepsy. Methods…

View details →DOI: 10.1002/epi.70290
Negative / Null Result ReportOpen accessMedicine

Enhancing wheat bran deconstruction with enzyme cocktails from Penicillium spp. and Trichoderma harzianum: the impact of β-glucosidase supplementation.

Hamann PRV, Martins HS, da Costa PHC et al. · 2026 · Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

Forests and natural environments are valuable sources of organisms capable of degrading plant cell wall carbohydrates. In the present study, two isolates, Penicillium polonicum and Penicillium chrysogenum, obtained from Brazilian Cerrado…

View details →DOI: 10.1007/s42770-026-01974-0
Negative / Null Result ReportMedicine

Comparison of 2% lidocaine with epinephrine and 4% articaine with epinephrine in local anesthesia of maxillary molars affected by molar incisor hypomineralization: a randomized controlled trial.

Haidar M, Raslan N · 2026 · Scientific reports

The use of local anesthesia is essential for pain control during the treatment of MIH-affected molars. This study aimed to compare injection-related pain and anesthetic efficacy between 2% lidocaine with epinephrine (LE) and 4% articaine…

View details →DOI: 10.1038/s41598-026-54698-4
Negative / Null Result ReportOpen accessMedicine

Protective role of lycopene against salinity-induced oxidative stress in Medicago sativa L. seedlings.

de Araujo Monteiro AA, da Silva Teles BR, Kamdem JP et al. · 2026 · Scientific reports

Soil salinization is one of the major challenges to agriculture, reducing productivity and directly affecting plant growth, germination, and physiology, especially in economically important crops such as Medicago sativa. Conventional soil…

View details →DOI: 10.1038/s41598-026-42699-2
Replication FailureMedicine

The Effect of a Mobile-Based Lymphedema Self-care Support Program in Women With Breast Cancer-Related Lymphedema: A Single-blind Randomized Controlled Study.

Deveci Koçbilek Z, Karayurt Ö, Bilik Ö et al. · 2026 · Computers, informatics, nursing : CIN

This single-blind, randomized controlled design study aims to examine the effect of a mobile-based Lymphedema Self-care Support Program on self-care, the quality of life, and lymphedema symptoms in women with breast cancer-related…

View details →DOI: 10.1097/cin.0000000000001336
Negative / Null Result ReportOpen accessMedicine

Effect of yeast selenium on autophagy and PINK1/Parkin expression in Diquat-induced chicken liver and kidney cells.

Jin Y, Cheng X, Tan Y et al. · 2026 · Poultry science

(Objective) This study aims to explore the effect of yeast selenium on alleviating autophagy and PINK1/Parkin expression in chicken liver and kidney cells induced by diquat. (Method) A total of 120 180-day-old Kangle Yellow chickens were…

View details →DOI: 10.1016/j.psj.2026.106786
Negative / Null Result ReportMedicine

The impact of couple-focused counseling based on the Ex-PLISSIT model on the sexual self-concept of infertile couples: a randomized trial.

Dalvand R, Otogara M, Shayan A et al. · 2026 · Scientific reports

The negative impact of infertility and its treatments on sexual health is well-documented. Self-concept plays a crucial role in sexual behavior and overall sexual health. This study aims to investigate how couple-oriented counseling, using…

View details →DOI: 10.1038/s41598-026-43203-6
Negative / Null Result ReportMedicine

Observational study on the therapeutic effects of two different negative pressure drainage devices on skin graft donor sites.

Chen P, Wang L, Gao S et al. · 2026 · Journal of tissue viability

Objective To conduct a retrospective analysis of patients who received treatment with two types of negative pressure materials for intermediate-thickness skin graft donor sites, comparing the clinical efficacy and exploring potential…

View details →DOI: 10.1016/j.jtv.2026.101005