Negative / Null Result ReportOpen accessMedicine
Ebensperger M, Kreuzer M, Kratzer S et al. · 2025 · British journal of anaesthesia
Background The GE Entropy™ module uses frontal EEG to compute the processed indices state entropy (SE), response entropy (RE), and burst suppression ratio (BSR) to guide maintenance of anaesthesia by supposedly minimising overly 'deep' or…
View details →DOI: 10.1016/j.bja.2024.11.050 Negative / Null Result Report
Christiansen JR, Ferreira SA, Szymkowski DE et al. · 2024 · Preprint
ABSTRACT The underlying cause of neuronal loss in Parkinson’s disease (PD) remains unknown, but evidence implicates neuroinflammation in PD pathobiology. The pro-inflammatory cytokine soluble tumor necrosis factor (TNF) seems to play an…
View details →DOI: 10.1101/2024.10.11.617361 Negative / Null Result ReportMedicine
Gudziol H, Hummel T, Guntinas-Lichius O · 2025 · HNO
Background There are various views in the literature regarding the influence of chronic rhinosinusitis (CRS) as a comorbidity on the occurrence of COVID-19 disease. Objective Did CRS prevent or promote infection with severe acute…
View details →DOI: 10.1007/s00106-024-01534-8 Negative / Null Result ReportMedicine
Henriksen K, Jørgensen A, Kaur S et al. · 2025 · Molecular and cellular endocrinology
Immune-mediated beta-cell destruction and lack of alpha-cell responsiveness to hypoglycaemia are hallmarks of type 1 diabetes pathology. The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) may hold therapeutic potential…
View details →DOI: 10.1016/j.mce.2025.112522 Negative / Null Result ReportMedicine
Feldman S, Basra J, Lawani A et al. · 2025 · Ophthalmic surgery, lasers & imaging retina
Background and objective To determine if subthreshold micropulse laser (SML) therapy can prevent or delay vision loss in diabetic macular edema (DME) with good visual acuity (VA). Patients and methods Prospective, single-masked,…
View details →DOI: 10.3928/23258160-20240924-03 Negative / Null Result ReportOpen accessMedicine
Chen H, Huang X, Wang C et al. · 2025 · The Journal of infectious diseases
Assessing the time-varying effectiveness of coronavirus disease 2019 (COVID-19) vaccines is critical to guiding vaccine strategies and public health policies. We developed a Bayesian framework to estimate the waning vaccine effectiveness…
View details →DOI: 10.1093/infdis/jiaf207 Negative / Null Result ReportMedicine
Horizono J, Mizumoto K, Suico MA et al. · 2025 · Biological & pharmaceutical bulletin
Cyclodextrins (CDs) are cyclic oligosaccharides that encapsulate hydrophobic molecules such as cholesterol. Hydroxypropyl-β-cyclodextrin (HP-β-CD), a cyclic heptasaccharide, has gained attention as a protective agent for chronic kidney…
View details →DOI: 10.1248/bpb.b25-00417 Negative / Null Result ReportMedicine
Hojo FR, Martins TC, Vieira-Junior WF et al. · 2025 · Operative dentistry
This study evaluated the influence of six resin composite coating agents on color stability and surface roughness after toothbrushing abrasion. Discs (Ø6 mm x 2 mm) of nanofilled resin composite (Filtek Z350XT) were prepared for…
View details →DOI: 10.2341/24-069-l Negative / Null Result Report
Chen A, Chou TY, Chen Y et al. · 2024 · Preprint
Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc) is a major disease affecting banana production around the globe. To study the movement of Foc in planta and investigate potential physical mechanisms of deterrence, the roots…
View details →DOI: 10.20944/preprints202410.2171.v1 Negative / Null Result Report
Giles C, Lee J · 2024 · Preprint
Abstract Nearly 90% of cancer deaths are due to metastasis. Conventional cancer therapeutics including chemotherapy, surgery, and radiotherapy, are effective in treating primary tumors, but may aggravate disseminated tumor cells (DTCs)…
View details →DOI: 10.21203/rs.3.rs-4719290/v1 Negative / Null Result ReportMedicine
Beningaza AM, Di Benedetto IMD, Babino L et al. · 2025 · Acta tropica
Chagas disease, vectored by kissing bugs, poses a public health problem across the Americas. The best way for reducing disease transmission is through vector control, which is currently based on the use of insecticides. However,…
View details →DOI: 10.1016/j.actatropica.2024.107520 Negative / Null Result ReportMedicine
Asadikorayem M, Weber P, Zhang S et al. · 2025 · Biomaterials advances
Osteoarthritis (OA) is one of the most common degenerative joint diseases, with no effective therapeutic options available. In this study, we aimed to develop an interpenetrating, in-situ-forming hydrogel based on biocompatible and…
View details →DOI: 10.1016/j.bioadv.2024.214151 Negative / Null Result ReportMedicine
Baudat M, Joosten EAJ, Simons SHP · 2025 · Pediatric research
Background While the incidence of neonatal intensive care unit (NICU) admission steadily increases, neonatology lacks evidence of a safe, effective, and preventive analgesic for treating procedural pain. Given its role in nociception and…
View details →DOI: 10.1038/s41390-024-03680-9 Negative / Null Result ReportOpen accessMedicine
Moksi L, Sissala N, Ojala R et al. · 2026 · Journal of orthopaedic surgery and research
Background Avascular necrosis (AVN) of the femoral head is a progressive condition that leads to collapse of the femoral head in 85% of symptomatic patients when left untreated. As it is typically a disease that occurs among the younger…
View details →DOI: 10.1186/s13018-025-06647-6 Negative / Null Result ReportMedicine
Shimada T, Iwahashi T, Suzuki K et al. · 2025 · Journal of pharmacological sciences
Chronic nerve compression disorders, such as carpal tunnel syndrome, are common and can significantly impair daily activities due to motor and sensory dysfunctions. Currently, no systemic pharmacotherapy exists for preventing or treating…
View details →DOI: 10.1016/j.jphs.2024.12.006 Negative / Null Result ReportMedicine
Guo Z, Hu Y, Zhou J et al. · 2025 · Biochemical and biophysical research communications
Iron overload leads to apoptosis and increased expression of receptor activator of nuclear factor kappa-Β ligand (RANKL) in osteocytes, which in turn accelerates osteoclastogenesis. Since osteocytes are the main RANKL producers, we…
View details →DOI: 10.1016/j.bbrc.2024.151152 Failed Experiment Report
Rheims S, Chorfa F, Michel V et al. · 2024 · Preprint
ABSTRACT Purpose Evaluating the efficacy of an opioid antagonist, naloxone (NLX), to reduce the severity of post-ictal hypoxemia and immobility after focal to bilateral tonic-clonic seizures (FBTCS). Methods ENALEPSY is a double-blind…
View details →DOI: 10.1101/2024.12.16.24319102 Failed Experiment ReportMedicine
Wilson KF, Fox AE · 2024 · Appetite
A high-fat diet has negative effects on physical, neurological, and behavioral outcomes. One consistent finding is that a diet high in fat increases impulsive choice behavior-behavior that is linked to a wide range of other negative health…
View details →DOI: 10.1016/j.appet.2024.107668 Failed Experiment ReportOpen accessMedicine
Shatsnimitkul E, Laopeamthong I, Tansawet A et al. · 2024 · BJS open
Background Adverse events after endoscopic retrograde cholangiopancreatography (ERCP) are rare, and post-ERCP pancreatitis is a serious adverse event. This study aimed to determine the role of aggressive intravenous hydration with lactated…
View details →DOI: 10.1093/bjsopen/zrae149 Failed Experiment ReportOpen accessMedicine
Dragan E, Ghinea M, Haba D et al. · 2025 · Dentistry journal
Background: Maxillary sinus floor augmentation (MSFA) is frequently required for implant placement in the atrophic posterior maxilla. However, limited bone quality and volume can compromise long-term success. Strontium ranelate (SrR), a…
View details →DOI: 10.3390/dj13120565 Replication FailureOpen accessMedicine
Ramasubbu D, Lewney J · 2025 · Evidence-based dentistry
Design The Brushing RemInder 4 Good oral HealTh (BRIGHT) multi-centre randomized controlled trial was based in state-funded secondary schools in England, Wales and Scotland. It had two arms, aiming to assess the clinical and cost…
View details →DOI: 10.1038/s41432-024-01066-8 Negative / Null Result ReportMedicine
Rumanova VS, Foppen E, Okuliarova M et al. · 2025 · Physiology & behavior
Exposure to artificial light at night (ALAN) disrupts natural darkness and desynchronizes daily rhythms in physiological processes and behavior. Previously, in rats, we have shown that dim ALAN disturbed the central circadian control and…
View details →DOI: 10.1016/j.physbeh.2024.114780 Negative / Null Result ReportOpen accessMedicine
Lima da Silva AP, de Oliveira TP, Nogueira RD et al. · 2025 · Journal of clinical and experimental dentistry
Background The objective was to evaluate the surface hardness of white spot lesions (WSL) treated with different caries prevention methods. Material and methods The Knoop microhardness (µKH) of 50 bovine dental enamel fragments was…
View details →DOI: 10.4317/jced.62588 Negative / Null Result ReportMedicine
Correia de Lima Junior N, Fernandes-Batista T, Ferreira-Serra L et al. · 2025 · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
The consumption of Western diet, characterized by high sugar and saturated fat content, often leads to weight gain and promotes oxidative stress. Intermittent fasting has emerged as a potential strategy to combat obesity, but its effects…
View details →DOI: 10.1055/a-2634-0201 Negative / Null Result ReportOpen accessMedicine
Dubourg V, Akhtar N, Kopf M et al. · 2026 · iScience
Vascular smooth muscle cells (VSMCs) are at the center of vascular diseases but studies on VSMCs from human females are rare and the medical need for female-specific vascular research is urgent. VSMCs are simultaneously subjected to…
View details →DOI: 10.1016/j.isci.2026.115886 Negative / Null Result ReportMedicine
Lyons J, Chatha HN, Boutros C et al. · 2025 · Surgical endoscopy
Background Fundoplication at the time of paraesophageal hernia (PEH) repair is thought to help prevent the development or persistence of postoperative gastroesophageal reflux (GERD) and might also prevent hernia recurrence. However, the…
View details →DOI: 10.1007/s00464-024-11317-5 Failed Experiment Report
Khajehzadehshoushtar S, Delfinis LJ, Rahman FA et al. · 2024 · Preprint
The degree to which mitochondrial-linked cell death pathways contribute to skeletal muscle atrophy during cancer remain unknown. Here, we combined a novel and robust mouse model of metastatic ovarian cancer with chronic administration of…
View details →DOI: 10.1101/2024.10.22.617245 Negative / Null Result ReportMedicine
Weerts EM, Jenkins BW, Kuang RY et al. · 2024 · Pharmacology, biochemistry, and behavior
Cannabigerol (CBG) is a phytocannabinoid found in cannabis that is promoted for medical use and other health benefits, but current empirical data on the behavioral effects of CBG are lacking. The purpose of this study was to evaluate the…
View details →DOI: 10.1016/j.pbb.2024.173883 Negative / Null Result ReportOpen accessMedicine
Maier KS, Schiener T, Frigg A · 2025 · Journal of orthopaedic surgery and research
Background Short femoral stems were introduced for total hip arthroplasty (THA) to preserve bone stock, increase proximal load transfer, and enable minimal invasive approaches. However, after implanting the short curved Fitmore hip stem,…
View details →DOI: 10.1186/s13018-025-06064-9 Negative / Null Result ReportOpen accessMedicine
Comboni LM, Glover ES, Napolitano SC et al. · 2026 · Foods (Basel, Switzerland)
We assessed whether consuming UV light-exposed mushrooms (UVMs) would offset the seasonal decline in circulating total 25-hydroxyvitamin D (25OHD), an index of vitamin D status. During late fall and winter, 41 adults (19 M/22 F, age 43 ±…
View details →DOI: 10.3390/foods15091572 