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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19850 results in Negative / Null Result Report · page 340 of 662

Negative / Null Result Report

Changes in anthropometric nutritional status and physical activity levels and five-year survival in women with endometrioid endometrial cancer: a prospective cohort study

Conteville LV, Fernandes JPA, Frajacomo FT et al. · 2026 · Preprint

Abstract OBJECTIVES To examine the association between longitudinal trajectories of anthropometric nutritional status, physical activity, and overall survival among women with endometrial cancer. METHODS In a prospective cohort study, we…

View details →DOI: 10.21203/rs.3.rs-9438420/v1
Negative / Null Result ReportMedicine

Seroprevalence of hepatitis B, hepatitis C and HIV among male injecting drug users in Afghanistan.

Hakim MS, Hashimi MH, Saeed KM et al. · 2026 · Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit

Background Viral hepatitis and HIV infections are common public health concerns among injecting drug users, however, there is limited evidence on their seroprevalence in Afghanistan. Aim To determine the seroprevalence of hepatitis B,…

View details →DOI: 10.26719/2026.32.2.61
Negative / Null Result ReportMedicine

County-Level Environmental Quality and Risk of Hypospadias in Arkansas.

Famuyide L, Patel J, Nembhard WN · 2026 · Birth defects research

Background Hypospadias is one of the most common genital defects in boys, affecting about 1 in 125 live-born boys. Several studies have examined the association between a single environmental exposure and risk of hypospadias, but few have…

View details →DOI: 10.1002/bdr2.70022
Negative / Null Result ReportMedicine

The relationship between serum neopterin levels and disease activity in patients with spondyloarthropathy.

Kılıç A, Koçak Ulucaköy R, Osmanov Z et al. · 2026 · Biomarkers in medicine

Objective Biomarkers that accurately reflect disease activity and inflammatory burden are needed, particularly in the early stages of spondyloarthropathy (SpA). This study aimed to evaluate the association between serum neopterin levels…

View details →DOI: 10.1080/17520363.2026.2686306
Negative / Null Result ReportMedicine

Prevalence and Clinical Relevance of Alström Syndrome Protein 1 Gene Variant and Feline Hypertrophic Cardiomyopathy in Sphynx Cats in Thailand.

Sussadee M, Jarudecha T, Muikaew R et al. · 2026 · Animals : an open access journal from MDPI

Feline hypertrophic cardiomyopathy (HCM) is the most common cardiac disease in cats, causing morbidity and mortality. Recently, a variant in the Alström syndrome protein 1 ( ALMS1 ) gene has been reported to be associated with HCM in…

View details →DOI: 10.3390/ani16121815
Negative / Null Result ReportMedicine

Modular guided tibial plateau-leveling osteotomy improves osteotomy centering accuracy compared to a freehand technique.

McCaw K, Fink B, Danis D et al. · 2026 · American journal of veterinary research

Objective To compare the accuracy of a tibial plateau-leveling osteotomy (TPLO) using a modular guide (OssAbility) compared to the traditional freehand method. We hypothesized that guide use would improve TPLO centering and accuracy in the…

View details →DOI: 10.2460/ajvr.26.03.0128
Negative / Null Result ReportOpen accessMedicine

Bacteriological Profiles of Post-mortem Blood Cultures and Their Relationship to the Cause of Death: A Study of 100 Autopsies.

Gaba K, Kumar K, Kaushik R et al. · 2026 · Cureus

Background The use of post-mortem blood culture as a diagnostic tool in medico-legal autopsies is limited. Differentiating true infection from contamination or post-mortem bacterial translocation remains a challenge. This study aimed to…

View details →DOI: 10.7759/cureus.104988
Negative / Null Result Report

The Mannheim Peritonitis Index: a prognostic scoring system for in-hospital mortality in peritonitis secondary to hollow viscus perforation

Zehra J, Kumari C, Bibi A et al. · 2026 · Preprint

Abstract Objective This study aimed to investigate in-hospital mortality rates among different Mannheim Peritonitis Index (MPI) score groups in patients who underwent emergency laparotomy due to hollow viscus perforation. Methods We…

View details →DOI: 10.21203/rs.3.rs-9066416/v1
Negative / Null Result ReportOpen accessMedicine

The association of pathological findings in HPV-31 positive women with high-grade squamous intraepithelial lesions.

Buran A, Altaş H, Özkaya Uçar Y et al. · 2026 · Journal of the Turkish German Gynecological Association

Objective To evaluate pathological findings in patients positive for human papillomavirus (HPV)-31. Material and methods This retrospective study included patients evaluated in a tertiary colposcopy clinic. The 3,546 patients tested for…

View details →DOI: 10.4274/jtgga.galenos.2026.2025-12-2
Negative / Null Result ReportOpen accessMedicine

A high rate of falls and traumatic fractures occurs after extensor mechanism reconstruction: a cohort study including both allograft and synthetic mesh grafts.

Braun S, Selkridge I, Nocon A et al. · 2026 · Arthroplasty (London, England)

Background Extensor mechanism disruption following total knee arthroplasty (TKA) significantly impairs knee function and quality of life. Extensor mechanism reconstruction (EMR) is effective but carries risks, including post-operative…

View details →DOI: 10.1186/s42836-026-00393-8
Negative / Null Result ReportMedicine

rs6897932 (C>T) and rs987106 (A>T) variants in the <i>IL7RA</i> gene are correlated with the susceptibility and the clinical features of systemic lupus erythematosus.

Sarpeleh F, Ehtesham N, Mirjani R et al. · 2026 · Lupus

ObjectiveThe dysfunction of interleukin-7 receptor alpha (IL-7Rα), which is encoded by the IL7RA gene, has been implicated in the development of systemic lupus erythematosus (SLE). This study aimed to investigate the relationship between…

View details →DOI: 10.1177/09612033261429135
Negative / Null Result ReportOpen accessMedicine

Impact of weekend admission on in-hospital mortality in chronic kidney disease: a nationwide analysis of 184 299 hospitalisations in Poland (2017-2021).

Mazurek A, Jankowski M, Grudziąż-Sękowska J · 2026 · BMC nephrology

BACKGROUND: The weekend effect refers to the observation that patients admitted to the hospital on the weekend experience poorer clinical outcomes than patients admitted during the workweek. This effect has not been previously studied…

View details →DOI: 10.1186/s12882-026-04885-2
Negative / Null Result ReportOpen accessMedicine

Plantar Heel Pain Is Not Associated With Fatty Infiltration of the Abductor Digiti Minimi Muscle on Magnetic Resonance Imaging: A Cross-Sectional Observational Study.

Chen JSC, Osborne JWA, Menz HB et al. · 2026 · Journal of foot and ankle research

Background Fatty infiltration, or fatty atrophy, of the abductor digiti minimi (ADM) muscle of the foot is proposed to be associated with entrapment of the first branch of the lateral plantar nerve (i.e., Baxter's neuropathy) as part of…

View details →DOI: 10.1002/jfa2.70155
Negative / Null Result ReportMedicine

Institutional educational climate and MIR examination outcomes: a multicenter ecological study in Spanish medical schools.

Millán J, Gal B, Esquerda M et al. · 2026 · BMC medical education

Background In Spain, access to specialized medical training is determined through a highly competitive national examination (MIR). While the educational climate of medical schools has been associated with students' learning outcomes and…

View details →DOI: 10.1186/s12909-026-09516-w
Negative / Null Result Report

Fast Food Consumption Habits Knowledge Attitudes and Their Association with Body Mass Index Among Health Sciences Students in Oman

Mahaboob L, Chehade H, Gnanamuthu SS et al. · 2026 · Preprint

Abstract Background Fast-food consumption has become increasingly prevalent among university students, contributing to unhealthy dietary patterns and rising obesity rates. Understanding students' fast-food consumption habits, knowledge,…

View details →DOI: 10.21203/rs.3.rs-9610403/v1
Negative / Null Result ReportMedicine

Relationship between <i>APOE</i> Genotype Status and Imaging Features in Patients with Alzheimer Disease Being Considered for Antiamyloid β Therapy.

Vejdani-Jahromi M, Calle E, Ganem O et al. · 2026 · AJNR. American journal of neuroradiology

Background and purpose Alzheimer disease (AD) is a progressive neurodegenerative disorder that predominantly affects the aging population. Anti-amyloid β (anti-Aβ) therapies, such as lecanemab, have been developed to slow disease…

View details →DOI: 10.3174/ajnr.a9056
Negative / Null Result ReportOpen accessMedicine

Intubation exposure associated with first-pass success - understanding practitioner-related characteristics in South African EMS.

Brown J, Abdullah N, Sobuwa S · 2026 · International journal of emergency medicine

BACKGROUND: Endotracheal intubation is a critical life-saving intervention in prehospital emergency care, yet evidence supporting its safe implementation by prehospital practitioners in lower- to middle-income countries remains limited.…

View details →DOI: 10.1186/s12245-026-01183-4
Negative / Null Result ReportMedicine

Direct and indirect assessment: comparison of different methods to estimate staff equivalent dose to the lens during different interventional procedures.

Fedeli L, Magistrelli A, Vaiano A et al. · 2026 · Journal of radiological protection : official journal of the Society for Radiological Protection

The reduction of the annual equivalent dose limit to the lens of the eye from 150 to 20 mSv has increased the need for reliable assessment of occupational eye lens exposure, particularly in interventional radiology. Lens absorbed dose is…

View details →DOI: 10.1088/1361-6498/ae6277
Negative / Null Result ReportMedicine

Immunohistochemical Assay Variability and Human Epidermal Growth Factor Receptor 2 (HER2)-Low Breast Cancer Detection: A Laboratory Comparison in the Netherlands.

Kain ZE, Schuurman E, Baez-Navarro X et al. · 2026 · Laboratory investigation; a journal of technical methods and pathology

Purpose HER2-low breast cancer has gained clinical relevance owing to the efficacy of trastuzumab deruxtecan. However, variability in detecting low HER2 expression may affect patient eligibility. This nationwide study in the Netherlands…

View details →DOI: 10.1016/j.labinv.2026.106136
Negative / Null Result Report

Myostatin and irisin levels in predicting the outcome of patients with systemic inflammation: A prospective observational study

Psenicka O, Brutvan T, Vitkova H et al. · 2026 · Preprint

Abstract Background : Systemic inflammatory response syndrome (SIRS) is associated with changes in muscle metabolism. Resulting muscle weakness is linked with adverse outcomes, e.g. prolonged mechanical ventilation, length of hospital stay…

View details →DOI: 10.21203/rs.3.rs-8991519/v1
Negative / Null Result ReportMedicine

Dynamic navigation system accuracy in orthodontic miniscrew insertion in the palatal vault: a prospective single-arm clinical study.

Brilli D, Giansanti M, Bertoldo S et al. · 2026 · International journal of computerized dentistry

Aim The aim of the present study was to evaluate the accuracy of dynamic navigation (DN) in miniscrew insertion in the palatal vault by comparing the deviation between planned and placed miniscrew positions. The secondary outcome was to…

View details →DOI: 10.3290/j.ijcd.b6329377
Negative / Null Result ReportOpen accessMedicine

Discordance in diagnostic assessment of Achilles tendon thickening between soft X-ray radiography and ultrasonography among patients with coronary artery disease.

Itagaki T, Ueki Y, Oyama Y et al. · 2026 · Scientific reports

Achilles tendon (AT) xanthomas are characteristic manifestations of familial hypercholesterolemia (FH). Although soft X-ray radiography (XR) and ultrasonography (US) are used to assess AT thickness, data comparing their diagnostic…

View details →DOI: 10.1038/s41598-026-49444-9
Negative / Null Result ReportOpen accessMedicine

p53 Immunohistochemistry Expression in Epithelial Ovarian Tumors.

Madini S, Suresh TN, Kattepur AK · 2026 · Cureus

Introduction Epithelial ovarian carcinoma usually has TP53 expression. The TP53 gene is the most frequently mutated gene in ovarian cancer and therapies targeting these mutations may improve treatment outcomes, but there are only few…

View details →DOI: 10.7759/cureus.107496