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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21713 results · page 327 of 724

Negative / Null Result ReportOpen accessMedicine

Sorry, Am I Intruding? Comparing Performance and Intrusion Rates for Pretested and Posttested Information.

James KK, Storm BC · 2025 · Behavioral sciences (Basel, Switzerland)

Pretesting and posttesting have long been implemented in classrooms as methods of testing and improving learning. Prior research has been mixed on the relative benefits of pretesting versus posttesting, with some studies finding pretesting…

View details →DOI: 10.3390/bs15081060
Negative / Null Result ReportMedicine

Emotion regulation strategy use and forecasting in response to dynamic, multimodal stimuli.

Mitchell WJ, Stasiak J, Martinez S et al. · 2025 · Journal of experimental psychology. General

Successful emotion regulation (ER) requires effective strategy selection. Research suggests that disengagement strategies (e.g., distraction) are more often selected than engagement strategies (e.g., reappraisal) as emotional experiences…

View details →DOI: 10.1037/xge0001715
Negative / Null Result ReportOpen accessMedicine

Cognitive Therapy vs. Short-Term Dynamic Psychotherapy in a Community Mental Health Setting: A Preliminary Analysis of Effects in Several Severity Domains.

Gibbons MBC, Kodkany N, Liow Y et al. · 2026 · Clinical psychology & psychotherapy

Objective To investigate the effectiveness of cognitive therapy (CT) and short-term dynamic psychotherapy (STDP) among patients with greater severity, defined in several ways, in a community mental health setting. Method Using data from a…

View details →DOI: 10.1002/cpp.70254
Negative / Null Result ReportMedicine

White matter integrity and verbal memory following a first episode of psychosis: A longitudinal study.

Ghanem J, Totzek JF, Henri-Bellemare C et al. · 2025 · Progress in neuro-psychopharmacology & biological psychiatry

Psychotic disorders are heterogeneous disorders for which there is evidence of structural and functional brain abnormalities. The role of white matter integrity, often measured via Fractional Anisotropy (FA), has played a controversial…

View details →DOI: 10.1016/j.pnpbp.2025.111294
Negative / Null Result ReportMedicine

Associations Between the Legalization and Implementation of Medical Aid in Dying and Suicide Rates in the United States.

Sutton OP, Kious BM · 2025 · AJOB empirical bioethics

Background Some have hypothesized that changing attitudes toward medical aid in dying (MAID) contribute to increased suicide rates, perhaps by increasing interest in dying or the perceived acceptability of suicide. This would represent a…

View details →DOI: 10.1080/23294515.2024.2433474
Negative / Null Result ReportOpen accessMedicine

The Correlation Between Macular Vessel Density and Its Clinical Parameters in Diabetes Mellitus Type 2.

Dewi NA, Arfan M, Rahmasari H et al. · 2025 · Clinical ophthalmology (Auckland, N.Z.)

Purpose To evaluate macular vessel density using clinical parameters in patients with type 2 diabetes mellitus (DM) without retinopathy. Patients and methods This cross-sectional study enrolled 32 participants (63 eyes) aged 40-60 years…

View details →DOI: 10.2147/opth.s532859
Negative / Null Result ReportOpen accessMedicine

Plasma Neurofilament Light Chain Is Associated with Cognitive Functions but Not Patient-Reported Outcomes in Multiple Sclerosis.

Nicolella V, Novarella F, Falco F et al. · 2025 · Neurology international

Objective We aimed to explore associations between plasma neurofilament light chain (pNfL) and cognition through patient-reported outcomes (PROs) in multiple sclerosis (MS). Methods In this cross-sectional study, we included 211 people…

View details →DOI: 10.3390/neurolint17090144
Negative / Null Result ReportOpen accessMedicine

Do We Look Like Our Siblings' Names? A Socio-Onomastic Perspective on the Face-Name Matching Effect.

Verheyen S, Van den Berckt J, Heyman T · 2026 · International review of social psychology

This Registered Report pertains to the face-name matching effect (Zwebner et al. 2017), according to which people can match the first name to an unknown target face above chance level. The purpose of the Registered Report was twofold: (i)…

View details →DOI: 10.5334/irsp.1243
Negative / Null Result ReportOpen accessMedicine

Cryoanalgesia to treat phantom limb pain following a trans-femoral (above-knee) amputation: a randomized, sham-controlled pilot study.

Ilfeld BM, Finneran JJ, Abdullah B et al. · 2026 · Regional anesthesia and pain medicine

Background A previous clinical trial applied percutaneous cryoneurolysis to lower limb amputees with phantom pain. The primary outcome measure was negative, but a secondary analysis suggested that patients with a below-knee amputation…

View details →DOI: 10.1136/rapm-2025-107116
Negative / Null Result ReportMedicine

Semantic-to-autobiographical memory priming: the role of cue repetition.

Mace JH, Keller SR, Ingle KE · 2024 · Memory (Hove, England)

It is now well established that general information processing causes the activation of memories in the autobiographical memory system, and these memories on occasion emerge as involuntary autobiographical memories. This priming phenomenon…

View details →DOI: 10.1080/09658211.2024.2393782
Negative / Null Result Report

Potentially traumatic events and substance use independently but not interactively predict changes in resting state functional connectivity in early adolescence

Patel H, Aks IR, Kemp EC et al. · 2024 · Preprint

Potentially traumatic events (PTEs) and substance use (SU) are commonly endorsed in early adolescence, a crucial period for neurodevelopment. Separately, they have been shown to alter within- and between-network connectivity in the three…

View details →DOI: 10.31234/osf.io/g294f
Negative / Null Result ReportOpen accessMedicine

Intergenerational associations in inhibitory control in <i>FMR1</i> families.

Hunt EE, Arnold HP, Cortez KB et al. · 2026 · Frontiers in psychiatry

Inhibitory control (IC), the capacity to resist or suppress a dominant or automatic response, is a central component of self-regulation and executive functioning. Greater IC capacity in early development is also associated with a number of…

View details →DOI: 10.3389/fpsyt.2026.1820723
Negative / Null Result ReportMedicine

Salinization and low-dose levels of pesticides alter brain shape of larval amphibians.

Woodley SK, Agostini G, Jones DK et al. · 2024 · Environmental pollution (Barking, Essex : 1987)

Wetland communities are increasingly threatened by multiple stressors simultaneously, such as pesticides and salinization. We examined the effects of ecologically-relevant exposures to broad-spectrum insecticides and salinization on…

View details →DOI: 10.1016/j.envpol.2024.125027
Negative / Null Result ReportMedicine

Face masks and protection against COVID-19 and other viral respiratory infections: Assessment of benefits and harms in children.

Sandlund J, Duriseti R, Ladhani SN et al. · 2025 · Paediatric respiratory reviews

Mask mandates for children were implemented at schools and childcare centers during the COVID-19 pandemic, and the US continues to recommend masking down to the age of two in certain settings. Medical interventions should be informed by…

View details →DOI: 10.1016/j.prrv.2024.08.003
Failed Experiment ReportMedicine

Efficient CRISPR-mediated genome editing can be initiated by embryonic injection but not by ovarian delivery in the beetle Tribolium castaneum.

Liu ZL, Zhou YY, Xu QX et al. · 2025 · Insect science

The clustered regularly interspaced small palindromic repeats (CRISPR) / CRISPR-associated nuclease 9 (Cas9)-mediated gene editing technology has revolutionized the study of fundamental biological questions in various insects. Diverse…

View details →DOI: 10.1111/1744-7917.13447
Negative / Null Result ReportOpen accessMedicine

Model-based planning is unaffected by ketamine, antidepressant and internet delivered cognitive behavioural therapy treatments in depression.

Donegan KR, Hossein S, Panny BM et al. · 2025 · Translational psychiatry

Cognitive impairments have been observed in patients with depression. These include deficits in inhibition, shifting, and updating; cognitive processes that are critical for goal-directed control over behavior ('model-based planning').…

View details →DOI: 10.1038/s41398-025-03722-8
Negative / Null Result ReportOpen accessMedicine

No Impact of COVID-19 Pandemic on Early Mortality for Thyroid Cancer in the US. Comment on Lee et al. Impact of the COVID-19 Pandemic on Thyroid Cancer Surgery. <i>Curr. Oncol.</i> 2024, <i>31</i>, 3579-3590.

Nocini R, Lippi G, Mattiuzzi C · 2024 · Current oncology (Toronto, Ont.)

Thyroid cancer is relatively rare in the general population compared to other malignancies, but its incidence appears to have increased in recent decades [...].

View details →DOI: 10.3390/curroncol31100466
Negative / Null Result ReportOpen accessMedicine

Cognitive and physiological impacts of psychotherapy incorporating human-equine interactions during substance withdrawal: A scoping review.

Friend MM, Nicodemus MC, Cavinder CA et al. · 2025 · Journal of equine rehabilitation

The use of psychotherapy incorporating equine interaction (PIE) is becoming widely utilized for the treatment of a range of conditions; however, evidence supporting the efficacy of this treatment is highly variable, inconsistently defined,…

View details →DOI: 10.1016/j.eqre.2025.100022
Negative / Null Result ReportMedicine

Synthetic Versus Biologic Mesh for Complex Open Ventral Hernia Repair: 3-Year Follow-Up of a Pilot Randomized Controlled Trial.

Dhanani NH, Lyons NB, Lee KH et al. · 2025 · HCA healthcare journal of medicine

Background Biologic mesh is often used in complex hernia repair, but there has been limited clinical evidence to date to support this practice. The aim of this study was to compare clinical and patient-reported outcomes of biologic versus…

View details →DOI: 10.36518/2689-0216.1761
Negative / Null Result ReportMedicine

Derailment in adolescence: Factor analytic structure and correlates.

Ratner K, Zhu G, Li Q et al. · 2024 · Journal of research on adolescence : the official journal of the Society for Research on Adolescence

Derailment is the sense of being "off-course" in life. But what could this mean for adolescents, who are often establishing identity and self-direction for the first time? We examined the structure and correlates of the Derailment Scale…

View details →DOI: 10.1111/jora.12954